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Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.

Schmidleithner L, Thabet Y, Schönfeld E, Köhne M, Sommer D, Abdullah Z, Sadlon T, Osei-Sarpong C, Subbaramaiah K, Copperi F, Haendler K, Varga T, Schanz O, Bourry S, Bassler K, Krebs W, Peters AE, Baumgart AK, Schneeweiss M, Klee K, Schmidt SV, Nüssing S, Sander J, Ohkura N, Waha A, Sparwasser T, Wunderlich FT, Förster I, Ulas T, Weighardt H, Sakaguchi S, Pfeifer A, Blüher M, Dannenberg AJ, Ferreirós N, Muglia LJ, Wickenhauser C, Barry SC, Schultze JL, Beyer M.

Immunity. 2019 May 21;50(5):1232-1248.e14. doi: 10.1016/j.immuni.2019.03.014. Epub 2019 Apr 23.


Prostaglandin E2 down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity-breast cancer connection.

Subbaramaiah K, Iyengar NM, Morrow M, Elemento O, Zhou XK, Dannenberg AJ.

J Biol Chem. 2019 Jan 4;294(1):361-371. doi: 10.1074/jbc.RA118.005866. Epub 2018 Nov 8.


Pioglitazone Inhibits Periprostatic White Adipose Tissue Inflammation in Obese Mice.

Miyazawa M, Subbaramaiah K, Bhardwaj P, Zhou XK, Wang H, Falcone DJ, Giri DD, Dannenberg AJ.

Cancer Prev Res (Phila). 2018 Apr;11(4):215-226. doi: 10.1158/1940-6207.CAPR-17-0296. Epub 2017 Dec 8.


Leptin regulation of the p53-HIF1α/PKM2-aromatase axis in breast adipose stromal cells: a novel mechanism for the obesity-breast cancer link.

Zahid H, Subbaramaiah K, Iyengar NM, Zhou XK, Chen IC, Bhardwaj P, Gucalp A, Morrow M, Hudis CA, Dannenberg AJ, Brown KA.

Int J Obes (Lond). 2018 Apr;42(4):711-720. doi: 10.1038/ijo.2017.273. Epub 2017 Nov 6.


Menopause Is a Determinant of Breast Aromatase Expression and Its Associations With BMI, Inflammation, and Systemic Markers.

Brown KA, Iyengar NM, Zhou XK, Gucalp A, Subbaramaiah K, Wang H, Giri DD, Morrow M, Falcone DJ, Wendel NK, Winston LA, Pollak M, Dierickx A, Hudis CA, Dannenberg AJ.

J Clin Endocrinol Metab. 2017 May 1;102(5):1692-1701. doi: 10.1210/jc.2016-3606.


Metabolic Obesity, Adipose Inflammation and Elevated Breast Aromatase in Women with Normal Body Mass Index.

Iyengar NM, Brown KA, Zhou XK, Gucalp A, Subbaramaiah K, Giri DD, Zahid H, Bhardwaj P, Wendel NK, Falcone DJ, Wang H, Williams S, Pollak M, Morrow M, Hudis CA, Dannenberg AJ.

Cancer Prev Res (Phila). 2017 Apr;10(4):235-243. doi: 10.1158/1940-6207.CAPR-16-0314. Epub 2017 Mar 7.


Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells.

Subbaramaiah K, Brown KA, Zahid H, Balmus G, Weiss RS, Herbert BS, Dannenberg AJ.

J Biol Chem. 2016 Jul 29;291(31):16011-23. doi: 10.1074/jbc.M115.698902. Epub 2016 Jun 1.


Id1 expression in endothelial cells of the colon is required for normal response to injury.

Zhang N, Subbaramaiah K, Yantiss RK, Zhou XK, Chin Y, Scherl EJ, Bosworth BP, Benezra R, Dannenberg AJ.

Am J Pathol. 2015 Nov;185(11):2983-93. doi: 10.1016/j.ajpath.2015.07.005. Epub 2015 Sep 5.


Estrogen Protects against Obesity-Induced Mammary Gland Inflammation in Mice.

Bhardwaj P, Du B, Zhou XK, Sue E, Giri D, Harbus MD, Falcone DJ, Hudis CA, Subbaramaiah K, Dannenberg AJ.

Cancer Prev Res (Phila). 2015 Aug;8(8):751-9. doi: 10.1158/1940-6207.CAPR-15-0082. Epub 2015 Jun 2.


Menopause is a determinant of breast adipose inflammation.

Iyengar NM, Morris PG, Zhou XK, Gucalp A, Giri D, Harbus MD, Falcone DJ, Krasne MD, Vahdat LT, Subbaramaiah K, Morrow M, Hudis CA, Dannenberg AJ.

Cancer Prev Res (Phila). 2015 May;8(5):349-58. doi: 10.1158/1940-6207.CAPR-14-0243. Epub 2015 Feb 26.


Id1 Deficiency Protects against Tumor Formation in Apc(Min/+) Mice but Not in a Mouse Model of Colitis-Associated Colon Cancer.

Zhang N, Subbaramaiah K, Yantiss RK, Zhou XK, Chin Y, Benezra R, Dannenberg AJ.

Cancer Prev Res (Phila). 2015 Apr;8(4):303-11. doi: 10.1158/1940-6207.CAPR-14-0411. Epub 2015 Jan 26.


ID1 is a functional marker for intestinal stem and progenitor cells required for normal response to injury.

Zhang N, Yantiss RK, Nam HS, Chin Y, Zhou XK, Scherl EJ, Bosworth BP, Subbaramaiah K, Dannenberg AJ, Benezra R.

Stem Cell Reports. 2014 Nov 11;3(5):716-24. doi: 10.1016/j.stemcr.2014.09.012. Epub 2014 Oct 23.


p53 modulates Hsp90 ATPase activity and regulates aryl hydrocarbon receptor signaling.

Kochhar A, Kopelovich L, Sue E, Guttenplan JB, Herbert BS, Dannenberg AJ, Subbaramaiah K.

Cancer Prev Res (Phila). 2014 Jun;7(6):596-606. doi: 10.1158/1940-6207.CAPR-14-0051. Epub 2014 Apr 15.


p53 protein regulates Hsp90 ATPase activity and thereby Wnt signaling by modulating Aha1 expression.

Okayama S, Kopelovich L, Balmus G, Weiss RS, Herbert BS, Dannenberg AJ, Subbaramaiah K.

J Biol Chem. 2014 Mar 7;289(10):6513-25. doi: 10.1074/jbc.M113.532523. Epub 2014 Jan 22.


Molecular pathways: adipose inflammation as a mediator of obesity-associated cancer.

Howe LR, Subbaramaiah K, Hudis CA, Dannenberg AJ.

Clin Cancer Res. 2013 Nov 15;19(22):6074-83. doi: 10.1158/1078-0432.CCR-12-2603. Epub 2013 Aug 19.


Dietary polyphenols suppress elevated levels of proinflammatory mediators and aromatase in the mammary gland of obese mice.

Subbaramaiah K, Sue E, Bhardwaj P, Du B, Hudis CA, Giri D, Kopelovich L, Zhou XK, Dannenberg AJ.

Cancer Prev Res (Phila). 2013 Sep;6(9):886-97. doi: 10.1158/1940-6207.CAPR-13-0140. Epub 2013 Jul 23.


Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis.

Howe LR, Subbaramaiah K, Kent CV, Zhou XK, Chang SH, Hla T, Jakobsson PJ, Hudis CA, Dannenberg AJ.

Prostaglandins Other Lipid Mediat. 2013 Oct;106:99-105. doi: 10.1016/j.prostaglandins.2013.04.002. Epub 2013 Apr 25.


Caloric restriction reverses obesity-induced mammary gland inflammation in mice.

Bhardwaj P, Du B, Zhou XK, Sue E, Harbus MD, Falcone DJ, Giri D, Hudis CA, Kopelovich L, Subbaramaiah K, Dannenberg AJ.

Cancer Prev Res (Phila). 2013 Apr;6(4):282-9. doi: 10.1158/1940-6207.CAPR-12-0467. Epub 2013 Feb 19.


Metabolic profiling, a noninvasive approach for the detection of experimental colorectal neoplasia.

Montrose DC, Zhou XK, Kopelovich L, Yantiss RK, Karoly ED, Subbaramaiah K, Dannenberg AJ.

Cancer Prev Res (Phila). 2012 Dec;5(12):1358-67. doi: 10.1158/1940-6207.CAPR-12-0160. Epub 2012 Sep 7.


Breast cancer risk reduction: no pain, no gain?

Hudis CA, Subbaramaiah K, Morris PG, Dannenberg AJ.

J Clin Oncol. 2012 Oct 1;30(28):3436-8. Epub 2012 Aug 27. No abstract available.


Pioglitazone, a PPARγ agonist, suppresses CYP19 transcription: evidence for involvement of 15-hydroxyprostaglandin dehydrogenase and BRCA1.

Subbaramaiah K, Howe LR, Zhou XK, Yang P, Hudis CA, Kopelovich L, Dannenberg AJ.

Cancer Prev Res (Phila). 2012 Oct;5(10):1183-94. doi: 10.1158/1940-6207.CAPR-12-0201. Epub 2012 Jul 10.


Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women.

Subbaramaiah K, Morris PG, Zhou XK, Morrow M, Du B, Giri D, Kopelovich L, Hudis CA, Dannenberg AJ.

Cancer Discov. 2012 Apr;2(4):356-65. doi: 10.1158/2159-8290.CD-11-0241. Epub 2012 Jan 27.


Carnosol, a constituent of Zyflamend, inhibits aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and mutagenesis.

Mohebati A, Guttenplan JB, Kochhar A, Zhao ZL, Kosinska W, Subbaramaiah K, Dannenberg AJ.

Cancer Prev Res (Phila). 2012 Apr;5(4):593-602. doi: 10.1158/1940-6207.CAPR-12-0002. Epub 2012 Feb 28.


The effect of HIV and HPV coinfection on cervical COX-2 expression and systemic prostaglandin E2 levels.

Fitzgerald DW, Bezak K, Ocheretina O, Riviere C, Wright TC, Milne GL, Zhou XK, Du B, Subbaramaiah K, Byrt E, Goodwin ML, Rafii A, Dannenberg AJ.

Cancer Prev Res (Phila). 2012 Jan;5(1):34-40. doi: 10.1158/1940-6207.CAPR-11-0496. Epub 2011 Dec 1.


Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer.

Morris PG, Hudis CA, Giri D, Morrow M, Falcone DJ, Zhou XK, Du B, Brogi E, Crawford CB, Kopelovich L, Subbaramaiah K, Dannenberg AJ.

Cancer Prev Res (Phila). 2011 Jul;4(7):1021-9. doi: 10.1158/1940-6207.CAPR-11-0110. Epub 2011 May 27.


Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland.

Subbaramaiah K, Howe LR, Bhardwaj P, Du B, Gravaghi C, Yantiss RK, Zhou XK, Blaho VA, Hla T, Yang P, Kopelovich L, Hudis CA, Dannenberg AJ.

Cancer Prev Res (Phila). 2011 Mar;4(3):329-46. doi: 10.1158/1940-6207.CAPR-10-0381.


Macrophages induce COX-2 expression in breast cancer cells: role of IL-1β autoamplification.

Hou Z, Falcone DJ, Subbaramaiah K, Dannenberg AJ.

Carcinogenesis. 2011 May;32(5):695-702. doi: 10.1093/carcin/bgr027. Epub 2011 Feb 10.


The prostaglandin transporter regulates adipogenesis and aromatase transcription.

Subbaramaiah K, Hudis CA, Dannenberg AJ.

Cancer Prev Res (Phila). 2011 Feb;4(2):194-206. doi: 10.1158/1940-6207.CAPR-10-0367. Epub 2011 Jan 6.


UV radiation inhibits 15-hydroxyprostaglandin dehydrogenase levels in human skin: evidence of transcriptional suppression.

Judson BL, Miyaki A, Kekatpure VD, Du B, Gilleaudeau P, Sullivan-Whalen M, Mohebati A, Nair S, Boyle JO, Granstein RD, Subbaramaiah K, Krueger JG, Dannenberg AJ.

Cancer Prev Res (Phila). 2010 Sep;3(9):1104-11. doi: 10.1158/1940-6207.CAPR-10-0089. Epub 2010 Jul 19.


Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents.

Uddin MJ, Crews BC, Blobaum AL, Kingsley PJ, Gorden DL, McIntyre JO, Matrisian LM, Subbaramaiah K, Dannenberg AJ, Piston DW, Marnett LJ.

Cancer Res. 2010 May 1;70(9):3618-27. doi: 10.1158/0008-5472.CAN-09-2664.


Effects of cigarette smoke on the human oral mucosal transcriptome.

Boyle JO, Gümüs ZH, Kacker A, Choksi VL, Bocker JM, Zhou XK, Yantiss RK, Hughes DB, Du B, Judson BL, Subbaramaiah K, Dannenberg AJ.

Cancer Prev Res (Phila). 2010 Mar;3(3):266-78. doi: 10.1158/1940-6207.CAPR-09-0192. Epub 2010 Feb 23.


Elevated levels of urinary prostaglandin e metabolite indicate a poor prognosis in ever smoker head and neck squamous cell carcinoma patients.

Kekatpure VD, Boyle JO, Zhou XK, Duffield-Lillico AJ, Gross ND, Lee NY, Subbaramaiah K, Morrow JD, Milne G, Lippman SM, Dannenberg AJ.

Cancer Prev Res (Phila). 2009 Nov;2(11):957-65. doi: 10.1158/1940-6207.CAPR-09-0093. Epub 2009 Oct 20.


UVR exposure sensitizes keratinocytes to DNA adduct formation.

Nair S, Kekatpure VD, Judson BL, Rifkind AB, Granstein RD, Boyle JO, Subbaramaiah K, Guttenplan JB, Dannenberg AJ.

Cancer Prev Res (Phila). 2009 Oct;2(10):895-902. doi: 10.1158/1940-6207.CAPR-09-0125. Epub 2009 Sep 29.


Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes.

Miyaki A, Yang P, Tai HH, Subbaramaiah K, Dannenberg AJ.

Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G559-66. doi: 10.1152/ajpgi.00133.2009. Epub 2009 Jul 16.


Levels of prostaglandin E metabolite and leukotriene E(4) are increased in the urine of smokers: evidence that celecoxib shunts arachidonic acid into the 5-lipoxygenase pathway.

Duffield-Lillico AJ, Boyle JO, Zhou XK, Ghosh A, Butala GS, Subbaramaiah K, Newman RA, Morrow JD, Milne GL, Dannenberg AJ.

Cancer Prev Res (Phila). 2009 Apr;2(4):322-9. doi: 10.1158/1940-6207.CAPR-09-0005. Epub 2009 Mar 31.


HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling.

Kekatpure VD, Dannenberg AJ, Subbaramaiah K.

J Biol Chem. 2009 Mar 20;284(12):7436-45. doi: 10.1074/jbc.M808999200. Epub 2009 Jan 21.


Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation.

Hughes D, Guttenplan JB, Marcus CB, Subbaramaiah K, Dannenberg AJ.

Cancer Prev Res (Phila). 2008 Nov;1(6):485-93. doi: 10.1158/1940-6207.CAPR-08-0149.


NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer.

Hughes D, Otani T, Yang P, Newman RA, Yantiss RK, Altorki NK, Port JL, Yan M, Markowitz SD, Mazumdar M, Tai HH, Subbaramaiah K, Dannenberg AJ.

Cancer Prev Res (Phila). 2008 Sep;1(4):241-9. doi: 10.1158/1940-6207.CAPR-08-0055.


Combination chemoprevention of HER2/neu-induced breast cancer using a cyclooxygenase-2 inhibitor and a retinoid X receptor-selective retinoid.

Brown PH, Subbaramaiah K, Salmon AP, Baker R, Newman RA, Yang P, Zhou XK, Bissonnette RP, Dannenberg AJ, Howe LR.

Cancer Prev Res (Phila). 2008 Aug;1(3):208-14. doi: 10.1158/1940-6207.CAPR-08-0021.


Effects of tobacco smoke on gene expression and cellular pathways in a cellular model of oral leukoplakia.

Gümüş ZH, Du B, Kacker A, Boyle JO, Bocker JM, Mukherjee P, Subbaramaiah K, Dannenberg AJ, Weinstein H.

Cancer Prev Res (Phila). 2008 Jul;1(2):100-11. doi: 10.1158/1940-6207.CAPR-08-0007. Epub 2008 Mar 31.


Cyclooxygenase-2-derived prostaglandin E2 stimulates Id-1 transcription.

Subbaramaiah K, Benezra R, Hudis C, Dannenberg AJ.

J Biol Chem. 2008 Dec 5;283(49):33955-68. doi: 10.1074/jbc.M805490200. Epub 2008 Oct 8.


Sulindac derivatives that activate the peroxisome proliferator-activated receptor gamma but lack cyclooxygenase inhibition.

Felts AS, Siegel BS, Young SM, Moth CW, Lybrand TP, Dannenberg AJ, Marnett LJ, Subbaramaiah K.

J Med Chem. 2008 Aug 28;51(16):4911-9. doi: 10.1021/jm700969c. Epub 2008 Jul 30.


EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells. Evidence of a BRCA1 and p300 exchange.

Subbaramaiah K, Hudis C, Chang SH, Hla T, Dannenberg AJ.

J Biol Chem. 2008 Feb 8;283(6):3433-44. Epub 2007 Dec 14.


Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors.

Fukata M, Chen A, Vamadevan AS, Cohen J, Breglio K, Krishnareddy S, Hsu D, Xu R, Harpaz N, Dannenberg AJ, Subbaramaiah K, Cooper HS, Itzkowitz SH, Abreu MT.

Gastroenterology. 2007 Dec;133(6):1869-81. Epub 2007 Sep 14.


Inhibition of Jun NH2-terminal kinases suppresses the growth of experimental head and neck squamous cell carcinoma.

Gross ND, Boyle JO, Du B, Kekatpure VD, Lantowski A, Thaler HT, Weksler BB, Subbaramaiah K, Dannenberg AJ.

Clin Cancer Res. 2007 Oct 1;13(19):5910-7.


Potentially reduced exposure cigarettes accelerate atherosclerosis: evidence for the role of nicotine.

Catanzaro DF, Zhou Y, Chen R, Yu F, Catanzaro SE, De Lorenzo MS, Subbaramaiah K, Zhou XK, Pratico D, Dannenberg AJ, Weksler BB.

Cardiovasc Toxicol. 2007;7(3):192-201.


Tobacco smoke induces urokinase-type plasminogen activator and cell invasiveness: evidence for an epidermal growth factor receptor dependent mechanism.

Du B, Leung H, Khan KM, Miller CG, Subbaramaiah K, Falcone DJ, Dannenberg AJ.

Cancer Res. 2007 Sep 15;67(18):8966-72.


Desmethyl derivatives of indomethacin and sulindac as probes for cyclooxygenase-dependent biology.

Felts AS, Ji C, Stafford JB, Crews BC, Kingsley PJ, Rouzer CA, Washington MK, Subbaramaiah K, Siegel BS, Young SM, Dannenberg AJ, Marnett LJ.

ACS Chem Biol. 2007 Jul 20;2(7):479-83. Epub 2007 Jun 29.


NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells.

Yan Y, Li J, Ouyang W, Ma Q, Hu Y, Zhang D, Ding J, Qu Q, Subbaramaiah K, Huang C.

J Cell Sci. 2006 Jul 15;119(Pt 14):2985-94. Epub 2006 Jun 27.

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