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Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution.

Su XZ, Lane KD, Xia L, Sá JM, Wellems TE.

Clin Microbiol Rev. 2019 Jul 31;32(4). pii: e00019-19. doi: 10.1128/CMR.00019-19. Print 2019 Sep 18. Review.


ESRP1 Induces Cervical Cancer Cell G1-Phase Arrest Via Regulating Cyclin A2 mRNA Stability.

Chen ZH, Jing YJ, Yu JB, Jin ZS, Li Z, He TT, Su XZ.

Int J Mol Sci. 2019 Jul 29;20(15). pii: E3705. doi: 10.3390/ijms20153705.


Generation and functional characterisation of Plasmodium yoelii csp deletion mutants using a microhomology-based CRISPR/Cas9 method.

Xu R, Liu Y, Fan R, Liang R, Yue L, Liu S, Su XZ, Li J.

Int J Parasitol. 2019 Aug;49(9):705-714. doi: 10.1016/j.ijpara.2019.04.003. Epub 2019 Jun 13.


Astaxanthin Combine with Human Serum Albumin to Abrogate Cell Proliferation, Migration, and Drug-resistant in Human Ovarian Carcinoma SKOV3 Cells.

Su XZ, Chen R, Wang CB, Ouyang XL, Jiang Y, Zhu MY.

Anticancer Agents Med Chem. 2019;19(6):792-801. doi: 10.2174/1871520619666190225123003.


Inflammasome activation negatively regulates MyD88-IRF7 type I IFN signaling and anti-malaria immunity.

Yu X, Du Y, Cai C, Cai B, Zhu M, Xing C, Tan P, Lin M, Wu J, Li J, Wang M, Wang HY, Su XZ, Wang RF.

Nat Commun. 2018 Nov 23;9(1):4964. doi: 10.1038/s41467-018-07384-7.


Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model.

Sá JM, Kaslow SR, Krause MA, Melendez-Muniz VA, Salzman RE, Kite WA, Zhang M, Moraes Barros RR, Mu J, Han PK, Mershon JP, Figan CE, Caleon RL, Rahman RS, Gibson TJ, Amaratunga C, Nishiguchi EP, Breglio KF, Engels TM, Velmurugan S, Ricklefs S, Straimer J, Gnädig NF, Deng B, Liu A, Diouf A, Miura K, Tullo GS, Eastman RT, Chakravarty S, James ER, Udenze K, Li S, Sturdevant DE, Gwadz RW, Porcella SF, Long CA, Fidock DA, Thomas ML, Fay MP, Sim BKL, Hoffman SL, Adams JH, Fairhurst RM, Su XZ, Wellems TE.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):12513-12518. doi: 10.1073/pnas.1813386115. Epub 2018 Nov 19.


Detection of host pathways universally inhibited after Plasmodium yoelii infection for immune intervention.

Xia L, Wu J, Pattaradilokrat S, Tumas K, He X, Peng YC, Huang R, Myers TG, Long CA, Wang R, Su XZ.

Sci Rep. 2018 Oct 16;8(1):15280. doi: 10.1038/s41598-018-33599-1.


Novel strategy of sirolimus plus thymalfasin and huaier granule on tumor recurrence of hepatocellular carcinoma beyond the UCSF criteria following liver transplantation: A single center experience.

Zhou L, Pan LC, Zheng YG, Du GS, Fu XQ, Zhu ZD, Song JY, Liu ZJ, Su XZ, Chen W, Zheng DH, Suo LL, Yang SZ.

Oncol Lett. 2018 Oct;16(4):4407-4417. doi: 10.3892/ol.2018.9226. Epub 2018 Jul 27.


ISP1-Anchored Polarization of GCβ/CDC50A Complex Initiates Malaria Ookinete Gliding Motility.

Gao H, Yang Z, Wang X, Qian P, Hong R, Chen X, Su XZ, Cui H, Yuan J.

Curr Biol. 2018 Sep 10;28(17):2763-2776.e6. doi: 10.1016/j.cub.2018.06.069. Epub 2018 Aug 23.


Large-scale Artemisinin-Piperaquine Mass Drug Administration With or Without Primaquine Dramatically Reduces Malaria in a Highly Endemic Region of Africa.

Deng C, Huang B, Wang Q, Wu W, Zheng S, Zhang H, Li D, Feng D, Li G, Xue L, Yang T, Tuo F, Mohadji F, Su XZ, Xu Q, Wu Z, Lin L, Zhou J, Yan H, Bacar A, Said Abdallah K, Kéké RA, Msa Mliva A, Mohamed M, Wang X, Huang S, Oithik F, Li XB, Lu F, Fay MP, Liu XH, Wellems TE, Song J.

Clin Infect Dis. 2018 Nov 13;67(11):1670-1676. doi: 10.1093/cid/ciy364.


Artemisinin and its derivatives in treating helminthic infections beyond schistosomiasis.

Lam NS, Long X, Su XZ, Lu F.

Pharmacol Res. 2018 Jul;133:77-100. doi: 10.1016/j.phrs.2018.04.025. Epub 2018 May 1. Review.


A Cas9 transgenic Plasmodium yoelii parasite for efficient gene editing.

Qian P, Wang X, Yang Z, Li Z, Gao H, Su XZ, Cui H, Yuan J.

Mol Biochem Parasitol. 2018 Jun;222:21-28. doi: 10.1016/j.molbiopara.2018.04.003. Epub 2018 Apr 21.


Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk.

Zhang DL, Wu J, Shah BN, Greutélaers KC, Ghosh MC, Ollivierre H, Su XZ, Thuma PE, Bedu-Addo G, Mockenhaupt FP, Gordeuk VR, Rouault TA.

Science. 2018 Mar 30;359(6383):1520-1523. doi: 10.1126/science.aal2022.


Radial shockwave treatment promotes human mesenchymal stem cell self-renewal and enhances cartilage healing.

Zhang H, Li ZL, Yang F, Zhang Q, Su XZ, Li J, Zhang N, Liu CH, Mao N, Zhu H.

Stem Cell Res Ther. 2018 Mar 9;9(1):54. doi: 10.1186/s13287-018-0805-5.


Subchondral bone derived mesenchymal stem cells display enhanced osteo-chondrogenic differentiation, self-renewal and proliferation potentials.

Zhang H, Li ZL, Su XZ, Ding L, Li J, Zhu H.

Exp Anim. 2018 Jul 30;67(3):349-359. doi: 10.1538/expanim.17-0137. Epub 2018 Mar 8.


Temporal changes in genetic diversity of msp-1, msp-2, and msp-3 in Plasmodium falciparum isolates from Grande Comore Island after introduction of ACT.

Huang B, Tuo F, Liang Y, Wu W, Wu G, Huang S, Zhong Q, Su XZ, Zhang H, Li M, Bacar A, Abdallah KS, Mliva AMSA, Wang Q, Yang Z, Zheng S, Xu Q, Song J, Deng C.

Malar J. 2018 Feb 20;17(1):83. doi: 10.1186/s12936-018-2227-3.


[Clinical research of popliteal cyst excision combined with debridement of the knee under arthroscopy with local anesthesia].

Li J, Li ZL, Zhang H, Wang KT, Yang YM, Su XZ.

Zhongguo Gu Shang. 2017 Oct 25;30(10):920-925. doi: 10.3969/j.issn.1003-0034.2017.10.009. Chinese.


Systematic CRISPR-Cas9-Mediated Modifications of Plasmodium yoelii ApiAP2 Genes Reveal Functional Insights into Parasite Development.

Zhang C, Li Z, Cui H, Jiang Y, Yang Z, Wang X, Gao H, Liu C, Zhang S, Su XZ, Yuan J.

MBio. 2017 Dec 12;8(6). pii: e01986-17. doi: 10.1128/mBio.01986-17.


The roles of galectins in parasitic infections.

Shi W, Xue C, Su XZ, Lu F.

Acta Trop. 2018 Jan;177:97-104. doi: 10.1016/j.actatropica.2017.09.027. Epub 2017 Oct 3. Review.


Mechanism of splenic cell death and host mortality in a Plasmodium yoelii malaria model.

Lacerda-Queiroz N, Riteau N, Eastman RT, Bock KW, Orandle MS, Moore IN, Sher A, Long CA, Jankovic D, Su XZ.

Sci Rep. 2017 Sep 5;7(1):10438. doi: 10.1038/s41598-017-10776-2.


A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence.

Nair SC, Xu R, Pattaradilokrat S, Wu J, Qi Y, Zilversmit M, Ganesan S, Nagarajan V, Eastman RT, Orandle MS, Tan JC, Myers TG, Liu S, Long CA, Li J, Su XZ.

Nat Commun. 2017 Aug 9;8(1):223. doi: 10.1038/s41467-017-00267-3.


Long-term Outcome of Multiple Small-diameter Drilling Decompression Combined with Hip Arthroscopy versus Drilling Alone for Early Avascular Necrosis of the Femoral Head.

Li J, Li ZL, Zhang H, Su XZ, Wang KT, Yang YM.

Chin Med J (Engl). 2017 Jun 20;130(12):1435-1440. doi: 10.4103/0366-6999.207470.


[Effects of Shock Wave on the Proliferation and Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells].

Yang YM, Zhang H, Liao WX, Su XZ, Li J, Wang KT, Liu YL, Mao N, Zhang Y, Zhang N, Zhang GQ, Zhu H, Li ZL.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Feb;25(1):209-213. doi: 10.7534/j.issn.1009-2137.2017.01.037. Chinese.


FOSL1 Inhibits Type I Interferon Responses to Malaria and Viral Infections by Blocking TBK1 and TRAF3/TRIF Interactions.

Cai B, Wu J, Yu X, Su XZ, Wang RF.

MBio. 2017 Jan 3;8(1). pii: e02161-16. doi: 10.1128/mBio.02161-16.


CRISPR/Cas9 mediated sequential editing of genes critical for ookinete motility in Plasmodium yoelii.

Zhang C, Gao H, Yang Z, Jiang Y, Li Z, Wang X, Xiao B, Su XZ, Cui H, Yuan J.

Mol Biochem Parasitol. 2017 Mar;212:1-8. doi: 10.1016/j.molbiopara.2016.12.010. Epub 2016 Dec 26.


Neuromuscular effect of dexmedetomidine on sevoflurane: an open-label, dose-escalation clinical trial.

Ke HH, Wu HH, Zhu Q, Zhang Y, Xiao JR, Su XZ, Zheng WJ, Cai YP, Wu XZ, Wang YT, Chen GZ.

Minerva Anestesiol. 2017 Aug;83(8):790-797. doi: 10.23736/S0375-9393.16.11580-9. Epub 2016 Dec 22.


Artemisinin and its derivatives in treating protozoan infections beyond malaria.

Loo CS, Lam NS, Yu D, Su XZ, Lu F.

Pharmacol Res. 2017 Mar;117:192-217. doi: 10.1016/j.phrs.2016.11.012. Epub 2016 Nov 17. Review.


Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality.

Yu X, Cai B, Wang M, Tan P, Ding X, Wu J, Li J, Li Q, Liu P, Xing C, Wang HY, Su XZ, Wang RF.

Immunity. 2016 Nov 15;45(5):1093-1107. doi: 10.1016/j.immuni.2016.10.001. Epub 2016 Oct 25.


Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model.

Yao X, Wu J, Lin M, Sun W, He X, Gowda C, Bolland S, Long CA, Wang R, Su XZ.

PLoS Pathog. 2016 Oct 7;12(10):e1005930. doi: 10.1371/journal.ppat.1005930. eCollection 2016 Oct.


Genome-wide association analysis identifies genetic loci associated with resistance to multiple antimalarials in Plasmodium falciparum from China-Myanmar border.

Wang Z, Cabrera M, Yang J, Yuan L, Gupta B, Liang X, Kemirembe K, Shrestha S, Brashear A, Li X, Porcella SF, Miao J, Yang Z, Su XZ, Cui L.

Sci Rep. 2016 Oct 3;6:33891. doi: 10.1038/srep33891.


Monitoring the Prevalence of Leucocytozoon sabrazesi in Southern China and Testing Tricyclic Compounds against Gametocytes.

Zhao W, Pang Q, Xu R, Liu J, Liu S, Li J, Su XZ.

PLoS One. 2016 Aug 29;11(8):e0161869. doi: 10.1371/journal.pone.0161869. eCollection 2016.


Blockage of Galectin-receptor Interactions by α-lactose Exacerbates Plasmodium berghei-induced Pulmonary Immunopathology.

Liu J, Huang S, Su XZ, Song J, Lu F.

Sci Rep. 2016 Aug 24;6:32024. doi: 10.1038/srep32024.


Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum.

Miles A, Iqbal Z, Vauterin P, Pearson R, Campino S, Theron M, Gould K, Mead D, Drury E, O'Brien J, Ruano Rubio V, MacInnis B, Mwangi J, Samarakoon U, Ranford-Cartwright L, Ferdig M, Hayton K, Su XZ, Wellems T, Rayner J, McVean G, Kwiatkowski D.

Genome Res. 2016 Sep;26(9):1288-99. doi: 10.1101/gr.203711.115. Epub 2016 Aug 16.


Prevalence of crt and mdr-1 mutations in Plasmodium falciparum isolates from Grande Comore island after withdrawal of chloroquine.

Huang B, Wang Q, Deng C, Wang J, Yang T, Huang S, Su XZ, Liu Y, Pan L, Li G, Li D, Zhang H, Bacar A, Abdallah KS, Attoumane R, Mliva AM, Zheng S, Xu Q, Lu F, Guan Y, Song J.

Malar J. 2016 Aug 15;15(1):414. doi: 10.1186/s12936-016-1474-4.


PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers.

Eastman RT, Khine P, Huang R, Thomas CJ, Su XZ.

Sci Rep. 2016 May 5;6:25379. doi: 10.1038/srep25379.


UTR introns, antisense RNA and differentially spliced transcripts between Plasmodium yoelii subspecies.

Li J, Cai B, Qi Y, Zhao W, Liu J, Xu R, Pang Q, Tao Z, Hong L, Liu S, Leerkes M, Quiñones M, Su XZ.

Malar J. 2016 Jan 20;15:30. doi: 10.1186/s12936-015-1081-9.


Polymorphisms of the artemisinin resistant marker (K13) in Plasmodium falciparum parasite populations of Grande Comore Island 10 years after artemisinin combination therapy.

Huang B, Deng C, Yang T, Xue L, Wang Q, Huang S, Su XZ, Liu Y, Zheng S, Guan Y, Xu Q, Zhou J, Yuan J, Bacar A, Abdallah KS, Attoumane R, Mliva AM, Zhong Y, Lu F, Song J.

Parasit Vectors. 2015 Dec 15;8:634. doi: 10.1186/s13071-015-1253-z.


The discovery of artemisinin and the Nobel Prize in Physiology or Medicine.

Su XZ, Miller LH.

Sci China Life Sci. 2015 Nov;58(11):1175-9. No abstract available.


Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts.

Cheng KC, Cao S, Raveh A, MacArthur R, Dranchak P, Chlipala G, Okoneski MT, Guha R, Eastman RT, Yuan J, Schultz PJ, Su XZ, Tamayo-Castillo G, Matainaho T, Clardy J, Sherman DH, Inglese J.

J Nat Prod. 2015 Oct 23;78(10):2411-22. doi: 10.1021/acs.jnatprod.5b00489. Epub 2015 Oct 14.


Translating Basic Research into Clinical Applications: Malaria Research at an NIH Lab.

Su XZ.

PLoS Pathog. 2015 Oct 8;11(10):e1005190. doi: 10.1371/journal.ppat.1005190. eCollection 2015 Oct. No abstract available.


High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations.

Mott BT, Eastman RT, Guha R, Sherlach KS, Siriwardana A, Shinn P, McKnight C, Michael S, Lacerda-Queiroz N, Patel PR, Khine P, Sun H, Kasbekar M, Aghdam N, Fontaine SD, Liu D, Mierzwa T, Mathews-Griner LA, Ferrer M, Renslo AR, Inglese J, Yuan J, Roepe PD, Su XZ, Thomas CJ.

Sci Rep. 2015 Sep 25;5:13891. doi: 10.1038/srep13891.


The Gametocytes of Leucocytozoon sabrazesi Infect Chicken Thrombocytes, Not Other Blood Cells.

Zhao W, Liu J, Xu R, Zhang C, Pang Q, Chen X, Liu S, Hong L, Yuan J, Li X, Chen Y, Li J, Su XZ.

PLoS One. 2015 Jul 28;10(7):e0133478. doi: 10.1371/journal.pone.0133478. eCollection 2015. Erratum in: PLoS One. 2015;10(8):e0137490.


Genome-wide Analysis of Host-Plasmodium yoelii Interactions Reveals Regulators of the Type I Interferon Response.

Wu J, Cai B, Sun W, Huang R, Liu X, Lin M, Pattaradilokrat S, Martin S, Qi Y, Nair SC, Bolland S, Cohen JI, Austin CP, Long CA, Myers TG, Wang RF, Su XZ.

Cell Rep. 2015 Jul 28;12(4):661-72. doi: 10.1016/j.celrep.2015.06.058. Epub 2015 Jul 16.


Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection.

Askenase MH, Han SJ, Byrd AL, Morais da Fonseca D, Bouladoux N, Wilhelm C, Konkel JE, Hand TW, Lacerda-Queiroz N, Su XZ, Trinchieri G, Grainger JR, Belkaid Y.

Immunity. 2015 Jun 16;42(6):1130-42. doi: 10.1016/j.immuni.2015.05.011. Epub 2015 Jun 9.


Regulation of Plasmodium yoelii oocyst development by strain- and stage-specific small-subunit rRNA.

Qi Y, Zhu F, Eastman RT, Fu Y, Zilversmit M, Pattaradilokrat S, Hong L, Liu S, McCutchan TF, Pan W, Xu W, Li J, Huang F, Su XZ.

MBio. 2015 Mar 10;6(2):e00117. doi: 10.1128/mBio.00117-15.


Tracing the geographic origins of Plasmodium falciparum malaria parasites.

Su XZ.

Pathog Glob Health. 2014 Sep;108(6):261-2. doi: 10.1179/2047772414Z.000000000225. No abstract available.


[Case of Meige syndrome].

Su XZ, Qi LL.

Zhongguo Zhen Jiu. 2014 Jul;34(7):646. Chinese. No abstract available.


Molecular surveillance of pvdhfr, pvdhps, and pvmdr-1 mutations in Plasmodium vivax isolates from Yunnan and Anhui provinces of China.

Huang B, Huang S, Su XZ, Tong X, Yan J, Li H, Lu F.

Malar J. 2014 Sep 2;13:346. doi: 10.1186/1475-2875-13-346.


Efficient editing of malaria parasite genome using the CRISPR/Cas9 system.

Zhang C, Xiao B, Jiang Y, Zhao Y, Li Z, Gao H, Ling Y, Wei J, Li S, Lu M, Su XZ, Cui H, Yuan J.

MBio. 2014 Jul 1;5(4):e01414-14. doi: 10.1128/mBio.01414-14.


Multi-strain infections and 'relapse' of Leucocytozoon sabrazesi gametocytes in domestic chickens in southern China.

Zhao W, Cai B, Qi Y, Liu S, Hong L, Lu M, Chen X, Qiu C, Peng W, Li J, Su XZ.

PLoS One. 2014 Apr 11;9(4):e94877. doi: 10.1371/journal.pone.0094877. eCollection 2014.

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