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Items: 1 to 50 of 77

1.

The complexity of a monogenic neurodegenerative disease: More than two decades of therapeutic driven research into Niemann-Pick type C disease.

Hammond N, Munkacsi AB, Sturley SL.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Aug;1864(8):1109-1123. doi: 10.1016/j.bbalip.2019.04.002. Epub 2019 Apr 17. Review.

PMID:
31002946
2.

Exacerbating and reversing lysosomal storage diseases: from yeast to humans.

Rajakumar T, Munkacsi AB, Sturley SL.

Microb Cell. 2017 Aug 25;4(9):278-293. doi: 10.15698/mic2017.09.588. Review.

3.

Normalization of Hepatic Homeostasis in the Npc1nmf164 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat.

Munkacsi AB, Hammond N, Schneider RT, Senanayake DS, Higaki K, Lagutin K, Bloor SJ, Ory DS, Maue RA, Chen FW, Hernandez-Ono A, Dahlson N, Repa JJ, Ginsberg HN, Ioannou YA, Sturley SL.

J Biol Chem. 2017 Mar 17;292(11):4395-4410. doi: 10.1074/jbc.M116.770578. Epub 2016 Dec 28.

4.

Deletion of murine Arv1 results in a lean phenotype with increased energy expenditure.

Lagor WR, Tong F, Jarrett KE, Lin W, Conlon DM, Smith M, Wang MY, Yenilmez BO, McCoy MG, Fields DW, O'Neill SM, Gupta R, Kumaravel A, Redon V, Ahima RS, Sturley SL, Billheimer JT, Rader DJ.

Nutr Diabetes. 2015 Oct 19;5:e181. doi: 10.1038/nutd.2015.32.

5.

ATP-binding cassette transporters and sterol O-acyltransferases interact at membrane microdomains to modulate sterol uptake and esterification.

Gulati S, Balderes D, Kim C, Guo ZA, Wilcox L, Area-Gomez E, Snider J, Wolinski H, Stagljar I, Granato JT, Ruggles KV, DeGiorgis JA, Kohlwein SD, Schon EA, Sturley SL.

FASEB J. 2015 Nov;29(11):4682-94. doi: 10.1096/fj.14-264796. Epub 2015 Jul 28.

6.

A functional, genome-wide evaluation of liposensitive yeast identifies the "ARE2 required for viability" (ARV1) gene product as a major component of eukaryotic fatty acid resistance.

Ruggles KV, Garbarino J, Liu Y, Moon J, Schneider K, Henneberry A, Billheimer J, Millar JS, Marchadier D, Valasek MA, Joblin-Mills A, Gulati S, Munkacsi AB, Repa JJ, Rader D, Sturley SL.

J Biol Chem. 2014 Feb 14;289(7):4417-31. doi: 10.1074/jbc.M113.515197. Epub 2013 Nov 22.

7.

Mapping the functional yeast ABC transporter interactome.

Snider J, Hanif A, Lee ME, Jin K, Yu AR, Graham C, Chuk M, Damjanovic D, Wierzbicka M, Tang P, Balderes D, Wong V, Jessulat M, Darowski KD, San Luis BJ, Shevelev I, Sturley SL, Boone C, Greenblatt JF, Zhang Z, Paumi CM, Babu M, Park HO, Michaelis S, Stagljar I.

Nat Chem Biol. 2013 Sep;9(9):565-72. doi: 10.1038/nchembio.1293. Epub 2013 Jul 7.

8.

Making, baking, and breaking: the synthesis, storage, and hydrolysis of neutral lipids.

Ruggles KV, Turkish A, Sturley SL.

Annu Rev Nutr. 2013;33:413-51. doi: 10.1146/annurev-nutr-071812-161254. Epub 2013 May 22. Review.

PMID:
23701589
9.

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease.

Area-Gomez E, Del Carmen Lara Castillo M, Tambini MD, Guardia-Laguarta C, de Groof AJ, Madra M, Ikenouchi J, Umeda M, Bird TD, Sturley SL, Schon EA.

EMBO J. 2012 Nov 5;31(21):4106-23. doi: 10.1038/emboj.2012.202. Epub 2012 Aug 14.

10.

Lipid droplet formation on opposing sides of the endoplasmic reticulum.

Sturley SL, Hussain MM.

J Lipid Res. 2012 Sep;53(9):1800-10. doi: 10.1194/jlr.R028290. Epub 2012 Jun 14. Review.

11.

Phosphatidate phosphatase activity plays key role in protection against fatty acid-induced toxicity in yeast.

Fakas S, Qiu Y, Dixon JL, Han GS, Ruggles KV, Garbarino J, Sturley SL, Carman GM.

J Biol Chem. 2011 Aug 19;286(33):29074-85. doi: 10.1074/jbc.M111.258798. Epub 2011 Jun 27.

12.

An "exacerbate-reverse" strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease.

Munkacsi AB, Chen FW, Brinkman MA, Higaki K, Gutiérrez GD, Chaudhari J, Layer JV, Tong A, Bard M, Boone C, Ioannou YA, Sturley SL.

J Biol Chem. 2011 Jul 8;286(27):23842-51. doi: 10.1074/jbc.M111.227645. Epub 2011 Apr 13.

13.

Niemann-Pick type C pathogenesis and treatment: from statins to sugars.

Madra M, Sturley SL.

Clin Lipidol. 2010 Jun 1;5(3):387-395.

14.

Loss of subcellular lipid transport due to ARV1 deficiency disrupts organelle homeostasis and activates the unfolded protein response.

Shechtman CF, Henneberry AL, Seimon TA, Tinkelenberg AH, Wilcox LJ, Lee E, Fazlollahi M, Munkacsi AB, Bussemaker HJ, Tabas I, Sturley SL.

J Biol Chem. 2011 Apr 8;286(14):11951-9. doi: 10.1074/jbc.M110.215038. Epub 2011 Jan 25.

15.

Decreased expression of ARV1 results in cholesterol retention in the endoplasmic reticulum and abnormal bile acid metabolism.

Tong F, Billheimer J, Shechtman CF, Liu Y, Crooke R, Graham M, Cohen DE, Sturley SL, Rader DJ.

J Biol Chem. 2010 Oct 29;285(44):33632-41. doi: 10.1074/jbc.M110.165761. Epub 2010 Jul 27.

16.

Sterols and sphingolipids: dynamic duo or partners in crime?

Gulati S, Liu Y, Munkacsi AB, Wilcox L, Sturley SL.

Prog Lipid Res. 2010 Oct;49(4):353-65. doi: 10.1016/j.plipres.2010.03.003. Epub 2010 Apr 1. Review.

17.

Sterol and diacylglycerol acyltransferase deficiency triggers fatty acid-mediated cell death.

Garbarino J, Padamsee M, Wilcox L, Oelkers PM, D'Ambrosio D, Ruggles KV, Ramsey N, Jabado O, Turkish A, Sturley SL.

J Biol Chem. 2009 Nov 6;284(45):30994-1005. doi: 10.1074/jbc.M109.050443. Epub 2009 Aug 18.

18.

Spreading the wealth: Niemann-Pick type C proteins bind and transport cholesterol.

Munkacsi AB, Pentchev PG, Sturley SL.

Cell Metab. 2009 Jul;10(1):3-4. doi: 10.1016/j.cmet.2009.06.007.

19.

Unraveling the sterol-trafficking defect in Niemann-Pick C disease.

Sturley SL, Patterson MC, Pentchev P.

Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2093-4. doi: 10.1073/pnas.0812934106. Epub 2009 Feb 11. No abstract available.

20.

Saturated with fat: new perspectives on lipotoxicity.

Garbarino J, Sturley SL.

Curr Opin Clin Nutr Metab Care. 2009 Mar;12(2):110-6. doi: 10.1097/MCO.0b013e32832182ee. Review.

PMID:
19202381
21.

The genetics of neutral lipid biosynthesis: an evolutionary perspective.

Turkish AR, Sturley SL.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E19-27. doi: 10.1152/ajpendo.90898.2008. Epub 2008 Dec 30. Review.

22.

Niemann-Pick type C disease proteins: orphan transporters or membrane rheostats?

Munkacsi AB, Porto AF, Sturley SL.

Future Lipidol. 2007 Jun;2(3):357-367.

23.

Regulation of triglyceride metabolism. I. Eukaryotic neutral lipid synthesis: "Many ways to skin ACAT or a DGAT".

Turkish A, Sturley SL.

Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G953-7. Epub 2006 Nov 9. Review.

24.

Cumulative mutations affecting sterol biosynthesis in the yeast Saccharomyces cerevisiae result in synthetic lethality that is suppressed by alterations in sphingolipid profiles.

Valachovic M, Bareither BM, Shah Alam Bhuiyan M, Eckstein J, Barbuch R, Balderes D, Wilcox L, Sturley SL, Dickson RC, Bard M.

Genetics. 2006 Aug;173(4):1893-908. Epub 2006 May 15.

25.

Homoeostatic systems for sterols and other lipids.

Garbarino J, Sturley SL.

Biochem Soc Trans. 2005 Nov;33(Pt 5):1182-5.

PMID:
16246077
26.

Sterol homeostasis in the budding yeast, Saccharomyces cerevisiae.

Henneberry AL, Sturley SL.

Semin Cell Dev Biol. 2005 Apr;16(2):155-61. Review.

PMID:
15797826
27.

Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily.

Turkish AR, Henneberry AL, Cromley D, Padamsee M, Oelkers P, Bazzi H, Christiano AM, Billheimer JT, Sturley SL.

J Biol Chem. 2005 Apr 15;280(15):14755-64. Epub 2005 Jan 25.

28.

A mutation in sphingolipid synthesis suppresses defects in yeast ergosterol metabolism.

Valachovic M, Wilcox LI, Sturley SL, Bard M.

Lipids. 2004 Aug;39(8):747-52.

PMID:
15638242
29.

Acyl-coenzymeA (CoA):cholesterol acyltransferase inhibition in rat and human aortic smooth muscle cells is nontoxic and retards foam cell formation.

Rong JX, Kusunoki J, Oelkers P, Sturley SL, Fisher EA.

Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):122-7. Epub 2004 Oct 21.

PMID:
15499046
30.

The pathophysiology and mechanisms of NP-C disease.

Sturley SL, Patterson MC, Balch W, Liscum L.

Biochim Biophys Acta. 2004 Oct 11;1685(1-3):83-7. Review.

PMID:
15465429
31.

Metazoan and microbial models of Niemann-Pick Type C disease.

Higaki K, Almanzar-Paramio D, Sturley SL.

Biochim Biophys Acta. 2004 Oct 11;1685(1-3):38-47. Review.

PMID:
15465425
32.

Intracellular trafficking of Niemann-Pick C proteins 1 and 2: obligate components of subcellular lipid transport.

Liscum L, Sturley SL.

Biochim Biophys Acta. 2004 Oct 11;1685(1-3):22-7. Review.

PMID:
15465423
33.
34.

Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution.

Malathi K, Higaki K, Tinkelenberg AH, Balderes DA, Almanzar-Paramio D, Wilcox LJ, Erdeniz N, Redican F, Padamsee M, Liu Y, Khan S, Alcantara F, Carstea ED, Morris JA, Sturley SL.

J Cell Biol. 2004 Feb 16;164(4):547-56.

35.

Nutritional genomics in yeast models.

Liu Y, Sturley SL.

Nutrition. 2004 Jan;20(1):166-72. Review. No abstract available.

PMID:
14698032
36.

Posttranscriptional control of the expression and function of diacylglycerol acyltransferase-1 in mouse adipocytes.

Yu YH, Zhang Y, Oelkers P, Sturley SL, Rader DJ, Ginsberg HN.

J Biol Chem. 2002 Dec 27;277(52):50876-84. Epub 2002 Oct 28.

37.

Identification of a pharmaceutical compound that partially corrects the Niemann-Pick C phenotype in cultured cells.

Liscum L, Arnio E, Anthony M, Howley A, Sturley SL, Agler M.

J Lipid Res. 2002 Oct;43(10):1708-17.

38.

Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1.

Swain E, Stukey J, McDonough V, Germann M, Liu Y, Sturley SL, Nickels JT Jr.

J Biol Chem. 2002 Sep 27;277(39):36152-60. Epub 2002 Jul 26.

39.

Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast.

Wilcox LJ, Balderes DA, Wharton B, Tinkelenberg AH, Rao G, Sturley SL.

J Biol Chem. 2002 Sep 6;277(36):32466-72. Epub 2002 Jun 20.

40.

The DGA1 gene determines a second triglyceride synthetic pathway in yeast.

Oelkers P, Cromley D, Padamsee M, Billheimer JT, Sturley SL.

J Biol Chem. 2002 Mar 15;277(11):8877-81. Epub 2001 Dec 18.

41.

HIV protease inhibitors protect apolipoprotein B from degradation by the proteasome: a potential mechanism for protease inhibitor-induced hyperlipidemia.

Liang JS, Distler O, Cooper DA, Jamil H, Deckelbaum RJ, Ginsberg HN, Sturley SL.

Nat Med. 2001 Dec;7(12):1327-31.

PMID:
11726973
42.

Transcriptional regulation of the two sterol esterification genes in the yeast Saccharomyces cerevisiae.

Jensen-Pergakes K, Guo Z, Giattina M, Sturley SL, Bard M.

J Bacteriol. 2001 Sep;183(17):4950-7.

43.
44.

Differential modulation of ACAT1 and ACAT2 transcription and activity by long chain free fatty acids in cultured cells.

Seo T, Oelkers PM, Giattina MR, Worgall TS, Sturley SL, Deckelbaum RJ.

Biochemistry. 2001 Apr 17;40(15):4756-62.

PMID:
11294643
45.

Hyperlipidemia and inhibitors of HIV protease.

Distler O, Cooper DA, Deckelbaum RJ, Sturley SL.

Curr Opin Clin Nutr Metab Care. 2001 Mar;4(2):99-103. Review.

PMID:
11224652
46.

Conservation of eukaryotic sterol homeostasis: new insights from studies in budding yeast.

Sturley SL.

Biochim Biophys Acta. 2000 Dec 15;1529(1-3):155-63. Review.

PMID:
11111085
47.

Mutations in yeast ARV1 alter intracellular sterol distribution and are complemented by human ARV1.

Tinkelenberg AH, Liu Y, Alcantara F, Khan S, Guo Z, Bard M, Sturley SL.

J Biol Chem. 2000 Dec 29;275(52):40667-70.

48.

Endogenously expressed apolipoprotein E has different effects on cell lipid metabolism as compared to exogenous apolipoprotein E carried on triglyceride-rich particles.

Ho YY, Al-Haideri M, Mazzone T, Vogel T, Presley JF, Sturley SL, Deckelbaum RJ.

Biochemistry. 2000 Apr 25;39(16):4746-54.

PMID:
10769131
49.

A lecithin cholesterol acyltransferase-like gene mediates diacylglycerol esterification in yeast.

Oelkers P, Tinkelenberg A, Erdeniz N, Cromley D, Billheimer JT, Sturley SL.

J Biol Chem. 2000 May 26;275(21):15609-12.

50.

Expression in yeast and tobacco of plant cDNAs encoding acyl CoA:diacylglycerol acyltransferase.

Bouvier-Navé P, Benveniste P, Oelkers P, Sturley SL, Schaller H.

Eur J Biochem. 2000 Jan;267(1):85-96.

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