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Items: 1 to 50 of 94

1.

Drug Metabolism and Toxicology Special Issue Call for Papers.

Blomme E, Sturla SJ.

Chem Res Toxicol. 2019 Jun 17;32(6):943. doi: 10.1021/acs.chemrestox.9b00138. No abstract available.

PMID:
31203610
2.

Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation.

Zhang J, Lacroix C, Wortmann E, Ruscheweyh HJ, Sunagawa S, Sturla SJ, Schwab C.

BMC Microbiol. 2019 May 16;19(1):99. doi: 10.1186/s12866-019-1483-x.

3.

Determining Steady-State Kinetics of DNA Polymerase Nucleotide Incorporation.

Gahlon HL, Sturla SJ.

Methods Mol Biol. 2019;1973:299-311. doi: 10.1007/978-1-4939-9216-4_19.

PMID:
31016710
4.

DNA Adduct-Directed Synthetic Nucleosides.

Räz MH, Aloisi CMN, Gahlon HL, Sturla SJ.

Acc Chem Res. 2019 May 21;52(5):1391-1399. doi: 10.1021/acs.accounts.9b00054. Epub 2019 Apr 9.

PMID:
30964643
5.

Gut microbial transformation of the dietary mutagen MeIQx may reduce exposure levels without altering intestinal transport.

Zhang J, Empl MT, Schneider M, Schröder B, Stadnicka-Michalak J, Breves G, Steinberg P, Sturla SJ.

Toxicol In Vitro. 2019 Sep;59:238-245. doi: 10.1016/j.tiv.2019.04.004. Epub 2019 Apr 4.

PMID:
30954653
6.

Reflections on 2018 from Chemical Research in Toxicology.

Sturla SJ.

Chem Res Toxicol. 2018 Dec 17;31(12):1289. doi: 10.1021/acs.chemrestox.8b00380. No abstract available.

PMID:
30888830
7.

A gene-targeted polymerase-mediated strategy to identify O6-methylguanine damage.

Aloisi CMN, Sturla SJ, Gahlon HL.

Chem Commun (Camb). 2019 Apr 7;55(27):3895-3898. doi: 10.1039/c9cc00278b. Epub 2019 Mar 12.

PMID:
30860216
8.

Impact of DNA Oxidation on Toxicology: From Quantification to Genomics.

Wu J, Sturla SJ, Burrows CJ, Fleming AM.

Chem Res Toxicol. 2019 Mar 18;32(3):345-347. doi: 10.1021/acs.chemrestox.9b00046. Epub 2019 Feb 26.

PMID:
30807111
9.

Adduct Fluorescence as a Tool to Decipher Sequence Impact on Frameshift Mutations Mediated by a C-Linked C8-Biphenyl-Guanine Lesion.

Berger FD, Manderville RA, Sturla SJ.

Chem Res Toxicol. 2019 Apr 15;32(4):784-791. doi: 10.1021/acs.chemrestox.9b00016. Epub 2019 Mar 18.

PMID:
30785283
10.

High Sensitivity of Human Translesion DNA Synthesis Polymerase κ to Variation in O6-Carboxymethylguanine Structures.

Räz MH, Sandell ES, Patil KM, Gillingham DG, Sturla SJ.

ACS Chem Biol. 2019 Feb 15;14(2):214-222. doi: 10.1021/acschembio.8b00802. Epub 2019 Feb 5.

PMID:
30645109
11.

Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O6-methylguanine in vivo.

Kraus A, McKeague M, Seiwert N, Nagel G, Geisen SM, Ziegler N, Trantakis IA, Kaina B, Thomas AD, Sturla SJ, Fahrer J.

Arch Toxicol. 2019 Feb;93(2):559-572. doi: 10.1007/s00204-018-2355-0. Epub 2018 Nov 16.

PMID:
30446773
12.

Hydrogen-Bonding Interactions at the DNA Terminus Promote Extension from Methylguanine Lesions by Human Extender DNA Polymerase ζ.

Räz MH, Sturla SJ, Gahlon HL.

Biochemistry. 2018 Oct 16;57(41):5978-5988. doi: 10.1021/acs.biochem.8b00861. Epub 2018 Sep 28.

PMID:
30222325
13.

The Base Pairing Partner Modulates Alkylguanine Alkyltransferase.

McKeague M, Otto C, Räz MH, Angelov T, Sturla SJ.

ACS Chem Biol. 2018 Sep 21;13(9):2534-2541. doi: 10.1021/acschembio.8b00446. Epub 2018 Aug 8.

PMID:
30040894
14.

Nucleotide-Resolution Genome-Wide Mapping of Oxidative DNA Damage by Click-Code-Seq.

Wu J, McKeague M, Sturla SJ.

J Am Chem Soc. 2018 Aug 8;140(31):9783-9787. doi: 10.1021/jacs.8b03715. Epub 2018 Jul 26.

PMID:
29944356
15.

Drug-DNA adducts as biomarkers for metabolic activation of the nitro-aromatic nitrogen mustard prodrug PR-104A.

Stornetta A, Deng KK, Danielli S, Liyanage HDS, Sturla SJ, Wilson WR, Gu Y.

Biochem Pharmacol. 2018 Aug;154:64-74. doi: 10.1016/j.bcp.2018.04.004. Epub 2018 Apr 7.

PMID:
29630868
16.

Who Are the New Editors of Chemical Research in Toxicology?

Sturla SJ.

Chem Res Toxicol. 2018 Feb 19;31(2):67. doi: 10.1021/acs.chemrestox.8b00015. No abstract available.

PMID:
29455538
17.

Point of Departure.

Sturla SJ.

Chem Res Toxicol. 2018 Jan 16;31(1):2-3. doi: 10.1021/acs.chemrestox.7b00341. No abstract available.

PMID:
29334740
18.

Conformational Preference and Fluorescence Response of a C-Linked C8-Biphenyl-Guanine Lesion in the NarI Mutational Hotspot: Evidence for Enhanced Syn Adduct Formation.

Berger FD, Sturla SJ, Kung RW, Montina T, Wetmore SD, Manderville RA.

Chem Res Toxicol. 2018 Jan 16;31(1):37-47. doi: 10.1021/acs.chemrestox.7b00266. Epub 2017 Dec 14.

PMID:
29186656
19.

Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase.

Betz K, Nilforoushan A, Wyss LA, Diederichs K, Sturla SJ, Marx A.

Chem Commun (Camb). 2017 Nov 23;53(94):12704-12707. doi: 10.1039/c7cc07173f.

PMID:
29136072
20.

Mechanism of RNA polymerase II stalling by DNA alkylation.

Malvezzi S, Farnung L, Aloisi CMN, Angelov T, Cramer P, Sturla SJ.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12172-12177. doi: 10.1073/pnas.1706592114. Epub 2017 Oct 30.

21.

Gut Microbial Transformation of the Dietary Imidazoquinoxaline Mutagen MelQx Reduces Its Cytotoxic and Mutagenic Potency.

Zhang J, Empl MT, Schwab C, Fekry MI, Engels C, Schneider M, Lacroix C, Steinberg P, Sturla SJ.

Toxicol Sci. 2017 Sep 1;159(1):266-276. doi: 10.1093/toxsci/kfx132.

22.

Copper carbenes alkylate guanine chemoselectively through a substrate directed reaction.

Geigle SN, Wyss LA, Sturla SJ, Gillingham DG.

Chem Sci. 2017 Jan 1;8(1):499-506. doi: 10.1039/c6sc03502g. Epub 2016 Sep 7.

23.

Systems Toxicology II: A Special Issue.

Hartung T, Kavlock R, Sturla SJ.

Chem Res Toxicol. 2017 Apr 17;30(4):869. doi: 10.1021/acs.chemrestox.7b00038. No abstract available.

PMID:
28412820
24.

Iron phosphate nanoparticles for food fortification: Biological effects in rats and human cell lines.

von Moos LM, Schneider M, Hilty FM, Hilbe M, Arnold M, Ziegler N, Mato DS, Winkler H, Tarik M, Ludwig C, Naegeli H, Langhans W, Zimmermann MB, Sturla SJ, Trantakis IA.

Nanotoxicology. 2017 May;11(4):496-506. doi: 10.1080/17435390.2017.1314035. Epub 2017 Apr 20.

PMID:
28368214
25.

Systems Toxicology: Real World Applications and Opportunities.

Hartung T, FitzGerald RE, Jennings P, Mirams GR, Peitsch MC, Rostami-Hodjegan A, Shah I, Wilks MF, Sturla SJ.

Chem Res Toxicol. 2017 Apr 17;30(4):870-882. doi: 10.1021/acs.chemrestox.7b00003. Epub 2017 Mar 31.

26.

DNA Adduct Profiles Predict in Vitro Cell Viability after Treatment with the Experimental Anticancer Prodrug PR104A.

Stornetta A, Villalta PW, Gossner F, Wilson WR, Balbo S, Sturla SJ.

Chem Res Toxicol. 2017 Mar 20;30(3):830-839. doi: 10.1021/acs.chemrestox.6b00412. Epub 2017 Feb 19.

27.

Modulation of Cytotoxicity by Transcription-Coupled Nucleotide Excision Repair Is Independent of the Requirement for Bioactivation of Acylfulvene.

Otto C, Spivak G, Aloisi CM, Menigatti M, Naegeli H, Hanawalt PC, Tanasova M, Sturla SJ.

Chem Res Toxicol. 2017 Mar 20;30(3):769-776. doi: 10.1021/acs.chemrestox.6b00240. Epub 2017 Feb 16.

PMID:
28076683
28.

Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity.

Mentegari E, Crespan E, Bavagnoli L, Kissova M, Bertoletti F, Sabbioneda S, Imhof R, Sturla SJ, Nilforoushan A, Hübscher U, van Loon B, Maga G.

Nucleic Acids Res. 2017 Mar 17;45(5):2600-2614. doi: 10.1093/nar/gkw1275.

29.

DNA Adducts from Anticancer Drugs as Candidate Predictive Markers for Precision Medicine.

Stornetta A, Zimmermann M, Cimino GD, Henderson PT, Sturla SJ.

Chem Res Toxicol. 2017 Jan 17;30(1):388-409. doi: 10.1021/acs.chemrestox.6b00380. Epub 2017 Jan 3.

30.

Minor Groove 3-Deaza-Adenosine Analogues: Synthesis and Bypass in Translesion DNA Synthesis.

Malvezzi S, Angelov T, Sturla SJ.

Chemistry. 2017 Jan 23;23(5):1101-1109. doi: 10.1002/chem.201604289. Epub 2016 Dec 16.

PMID:
27862447
31.

Acrolein contributes strongly to antimicrobial and heterocyclic amine transformation activities of reuterin.

Engels C, Schwab C, Zhang J, Stevens MJ, Bieri C, Ebert MO, McNeill K, Sturla SJ, Lacroix C.

Sci Rep. 2016 Nov 7;6:36246. doi: 10.1038/srep36246.

32.

Torsional Constraints of DNA Substrates Impact Cas9 Cleavage.

Räz MH, Hidaka K, Sturla SJ, Sugiyama H, Endo M.

J Am Chem Soc. 2016 Oct 26;138(42):13842-13845. doi: 10.1021/jacs.6b08915. Epub 2016 Oct 13.

PMID:
27709924
33.

Bypass of Mutagenic O(6)-Carboxymethylguanine DNA Adducts by Human Y- and B-Family Polymerases.

Räz MH, Dexter HR, Millington CL, van Loon B, Williams DM, Sturla SJ.

Chem Res Toxicol. 2016 Sep 19;29(9):1493-503. doi: 10.1021/acs.chemrestox.6b00168. Epub 2016 Aug 24.

34.

The use of an artificial nucleotide for polymerase-based recognition of carcinogenic O6-alkylguanine DNA adducts.

Wyss LA, Nilforoushan A, Williams DM, Marx A, Sturla SJ.

Nucleic Acids Res. 2016 Aug 19;44(14):6564-73. doi: 10.1093/nar/gkw589. Epub 2016 Jul 4.

35.

In-Gene Quantification of O(6)-Methylguanine with Elongated Nucleoside Analogues on Gold Nanoprobes.

Trantakis IA, Nilforoushan A, Dahlmann HA, Stäuble CK, Sturla SJ.

J Am Chem Soc. 2016 Jul 13;138(27):8497-504. doi: 10.1021/jacs.6b03599. Epub 2016 Jul 1.

36.

Sulforaphane Preconditioning Sensitizes Human Colon Cancer Cells towards the Bioreductive Anticancer Prodrug PR-104A.

Erzinger MM, Bovet C, Hecht KM, Senger S, Winiker P, Sobotzki N, Cristea S, Beerenwinkel N, Shay JW, Marra G, Wollscheid B, Sturla SJ.

PLoS One. 2016 Mar 7;11(3):e0150219. doi: 10.1371/journal.pone.0150219. eCollection 2016.

37.

Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair.

Crespan E, Furrer A, Rösinger M, Bertoletti F, Mentegari E, Chiapparini G, Imhof R, Ziegler N, Sturla SJ, Hübscher U, van Loon B, Maga G.

Nat Commun. 2016 Feb 26;7:10805. doi: 10.1038/ncomms10805.

38.

The strict anaerobic gut microbe Eubacterium hallii transforms the carcinogenic dietary heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

Fekry MI, Engels C, Zhang J, Schwab C, Lacroix C, Sturla SJ, Chassard C.

Environ Microbiol Rep. 2016 Apr;8(2):201-9. doi: 10.1111/1758-2229.12369. Epub 2016 Jan 28.

PMID:
26711372
39.

Screening for DNA Alkylation Mono and Cross-Linked Adducts with a Comprehensive LC-MS(3) Adductomic Approach.

Stornetta A, Villalta PW, Hecht SS, Sturla SJ, Balbo S.

Anal Chem. 2015 Dec 1;87(23):11706-13. doi: 10.1021/acs.analchem.5b02759. Epub 2015 Nov 10.

40.

Data in support of quantification of pyrophosphate as a universal approach to determine polymerase activity and assay polymerase inhibitors.

Malvezzi S, Sturla SJ, Tanasova M.

Data Brief. 2015 Apr 22;4:14-8. doi: 10.1016/j.dib.2015.04.006. eCollection 2015 Sep.

41.

Development of a risk management tool for prioritizing chemical hazard-food pairs and demonstration for selected mycotoxins.

Stornetta A, Engeli BE, Zarn JA, Gremaud G, Sturla SJ.

Regul Toxicol Pharmacol. 2015 Jul;72(2):257-65. doi: 10.1016/j.yrtph.2015.04.014. Epub 2015 Apr 20.

PMID:
25908512
42.

Altered minor-groove hydrogen bonds in DNA block transcription elongation by T7 RNA polymerase.

Tanasova M, Goeldi S, Meyer F, Hanawalt PC, Spivak G, Sturla SJ.

Chembiochem. 2015 May 26;16(8):1212-8. doi: 10.1002/cbic.201500077. Epub 2015 Apr 16.

PMID:
25881991
43.

Nucleotides with altered hydrogen bonding capacities impede human DNA polymerase η by reducing synthesis in the presence of the major cisplatin DNA adduct.

Nilforoushan A, Furrer A, Wyss LA, van Loon B, Sturla SJ.

J Am Chem Soc. 2015 Apr 15;137(14):4728-34. doi: 10.1021/ja512547g. Epub 2015 Apr 6.

PMID:
25786104
44.

Quantification of pyrophosphate as a universal approach to determine polymerase activity and assay polymerase inhibitors.

Malvezzi S, Sturla SJ, Tanasova M.

Anal Biochem. 2015 Jun 1;478:1-7. doi: 10.1016/j.ab.2015.03.002. Epub 2015 Mar 12.

PMID:
25772306
45.

Specific incorporation of an artificial nucleotide opposite a mutagenic DNA adduct by a DNA polymerase.

Wyss LA, Nilforoushan A, Eichenseher F, Suter U, Blatter N, Marx A, Sturla SJ.

J Am Chem Soc. 2015 Jan 14;137(1):30-3. doi: 10.1021/ja5100542. Epub 2014 Dec 22.

PMID:
25490521
46.

Structural and biochemical impact of C8-aryl-guanine adducts within the NarI recognition DNA sequence: influence of aryl ring size on targeted and semi-targeted mutagenicity.

Sproviero M, Verwey AM, Rankin KM, Witham AA, Soldatov DV, Manderville RA, Fekry MI, Sturla SJ, Sharma P, Wetmore SD.

Nucleic Acids Res. 2014 Dec 1;42(21):13405-21. doi: 10.1093/nar/gku1093. Epub 2014 Oct 31.

47.

Gold nanoprobes for detecting DNA adducts.

Trantakis IA, Sturla SJ.

Chem Commun (Camb). 2014 Dec 21;50(98):15517-20. doi: 10.1039/c4cc07184k. Epub 2014 Oct 30.

PMID:
25354716
48.

O6-alkylguanine postlesion DNA synthesis is correct with the right complement of hydrogen bonding.

Gahlon HL, Boby ML, Sturla SJ.

ACS Chem Biol. 2014 Dec 19;9(12):2807-14. doi: 10.1021/cb500415q. Epub 2014 Oct 16.

PMID:
25259614
49.

Induction of complementary function reductase enzymes in colon cancer cells by dithiole-3-thione versus sodium selenite.

Erzinger MM, Bovet C, Uzozie A, Sturla SJ.

J Biochem Mol Toxicol. 2015 Jan;29(1):10-20. doi: 10.1002/jbt.21601. Epub 2014 Sep 1.

PMID:
25179160
50.

Systems toxicology: a special issue.

Sturla SJ, Hollenberg P.

Chem Res Toxicol. 2014 Mar 17;27(3):311. doi: 10.1021/tx500024u. No abstract available.

PMID:
24635561

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