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The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors.

Sturgill TW, Stoddard PB, Cohn SM, Mayo MW.

Mol Cancer. 2010 May 11;9:104. doi: 10.1186/1476-4598-9-104.


Activating mutations in TOR are in similar structures as oncogenic mutations in PI3KCalpha.

Sturgill TW, Hall MN.

ACS Chem Biol. 2009 Dec 18;4(12):999-1015. doi: 10.1021/cb900193e.


The Vam6 GEF controls TORC1 by activating the EGO complex.

Binda M, Péli-Gulli MP, Bonfils G, Panchaud N, Urban J, Sturgill TW, Loewith R, De Virgilio C.

Mol Cell. 2009 Sep 11;35(5):563-73. doi: 10.1016/j.molcel.2009.06.033.


Intestinal cell kinase, a MAP kinase-related kinase, regulates proliferation and G1 cell cycle progression of intestinal epithelial cells.

Fu Z, Kim J, Vidrich A, Sturgill TW, Cohn SM.

Am J Physiol Gastrointest Liver Physiol. 2009 Oct;297(4):G632-40. doi: 10.1152/ajpgi.00066.2009. Epub 2009 Aug 20.


Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR.

Wang L, Lawrence JC Jr, Sturgill TW, Harris TE.

J Biol Chem. 2009 May 29;284(22):14693-7. doi: 10.1074/jbc.C109.002907. Epub 2009 Apr 3.


TOR1 and TOR2 have distinct locations in live cells.

Sturgill TW, Cohen A, Diefenbacher M, Trautwein M, Martin DE, Hall MN.

Eukaryot Cell. 2008 Oct;7(10):1819-30. doi: 10.1128/EC.00088-08. Epub 2008 Aug 22.


Inhibition of tristetraprolin deadenylation by poly(A) binding protein.

Rowlett RM, Chrestensen CA, Schroeder MJ, Harp MG, Pelo JW, Shabanowitz J, DeRose R, Hunt DF, Sturgill TW, Worthington MT.

Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G421-30. doi: 10.1152/ajpgi.00508.2007. Epub 2008 May 8.


MAP kinase: it's been longer than fifteen minutes.

Sturgill TW.

Biochem Biophys Res Commun. 2008 Jun 20;371(1):1-4. doi: 10.1016/j.bbrc.2008.04.002. Epub 2008 Apr 10. Review.


MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages.

Rowlett RM, Chrestensen CA, Nyce M, Harp MG, Pelo JW, Cominelli F, Ernst PB, Pizarro TT, Sturgill TW, Worthington MT.

Am J Physiol Gastrointest Liver Physiol. 2008 Feb;294(2):G452-9. Epub 2007 Nov 21.


Holding back TOR advances mitosis.

Sturgill TW, Hall MN.

Nat Cell Biol. 2007 Nov;9(11):1221-2. No abstract available.


Loss of MNK function sensitizes fibroblasts to serum-withdrawal induced apoptosis.

Chrestensen CA, Eschenroeder A, Ross WG, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Sturgill TW.

Genes Cells. 2007 Oct;12(10):1133-40.


Golgi manganese transport is required for rapamycin signaling in Saccharomyces cerevisiae.

Devasahayam G, Burke DJ, Sturgill TW.

Genetics. 2007 Sep;177(1):231-8. Epub 2007 Jul 1.


MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines.

Chrestensen CA, Shuman JK, Eschenroeder A, Worthington M, Gram H, Sturgill TW.

J Biol Chem. 2007 Feb 16;282(7):4243-52. Epub 2006 Nov 27.


Pmr1, a Golgi Ca2+/Mn2+-ATPase, is a regulator of the target of rapamycin (TOR) signaling pathway in yeast.

Devasahayam G, Ritz D, Helliwell SB, Burke DJ, Sturgill TW.

Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17840-5. Epub 2006 Nov 9.


Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase.

Fu Z, Larson KA, Chitta RK, Parker SA, Turk BE, Lawrence MW, Kaldis P, Galaktionov K, Cohn SM, Shabanowitz J, Hunt DF, Sturgill TW.

Mol Cell Biol. 2006 Nov;26(22):8639-54. Epub 2006 Sep 5.


Phorbol 12-myristate 13-acetate and serum synergize to promote rapamycin-insensitive cell proliferation via protein kinase C-eta.

Martin PM, Aeder SE, Chrestensen CA, Sturgill TW, Hussaini IM.

Oncogene. 2007 Jan 18;26(3):407-14. Epub 2006 Jul 10.


The MAP kinase ERK5 binds to and phosphorylates p90 RSK.

Ranganathan A, Pearson GW, Chrestensen CA, Sturgill TW, Cobb MH.

Arch Biochem Biophys. 2006 May 15;449(1-2):8-16. Epub 2006 Mar 13.


Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase.

Fu Z, Schroeder MJ, Shabanowitz J, Kaldis P, Togawa K, Rustgi AK, Hunt DF, Sturgill TW.

Mol Cell Biol. 2005 Jul;25(14):6047-64.


Glucose regulates interleukin-8 production in aortic endothelial cells through activation of the p38 mitogen-activated protein kinase pathway in diabetes.

Srinivasan S, Bolick DT, Hatley ME, Natarajan R, Reilly KB, Yeh M, Chrestensen C, Sturgill TW, Hedrick CC.

J Biol Chem. 2004 Jul 23;279(30):31930-6. Epub 2004 May 15.


MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding.

Chrestensen CA, Schroeder MJ, Shabanowitz J, Hunt DF, Pelo JW, Worthington MT, Sturgill TW.

J Biol Chem. 2004 Mar 12;279(11):10176-84. Epub 2003 Dec 19.


Methylpyridinium (MPP(+))- and nerve growth factor-induced changes in pro- and anti-apoptotic signaling pathways in SH-SY5Y neuroblastoma cells.

Halvorsen EM, Dennis J, Keeney P, Sturgill TW, Tuttle JB, Bennett JB Jr.

Brain Res. 2002 Oct 11;952(1):98-110.


Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase.

Chrestensen CA, Sturgill TW.

J Biol Chem. 2002 Aug 2;277(31):27733-41. Epub 2002 May 16.


ERK2- and p90(Rsk2)-dependent pathways regulate the CCAAT/enhancer-binding protein-beta interaction with serum response factor.

Hanlon M, Sturgill TW, Sealy L.

J Biol Chem. 2001 Oct 19;276(42):38449-56. Epub 2001 Aug 10.


A different function for a critical tryptophan in c-Raf and Hck.

McPherson RA, Taylor MM, Hershey ED, Sturgill TW.

Oncogene. 2000 Jul 27;19(32):3616-22.


Interaction among mitochondria, mitogen-activated protein kinases, and nuclear factor-kappaB in cellular models of Parkinson's disease.

Cassarino DS, Halvorsen EM, Swerdlow RH, Abramova NN, Parker WD Jr, Sturgill TW, Bennett JP Jr.

J Neurochem. 2000 Apr;74(4):1384-92.


Generation of constitutively active p90 ribosomal S6 kinase in vivo. Implications for the mitogen-activated protein kinase-activated protein kinase family.

Poteet-Smith CE, Smith JA, Lannigan DA, Freed TA, Sturgill TW.

J Biol Chem. 1999 Aug 6;274(32):22135-8. Erratum in: J Biol Chem 1999 Nov 26;274(48):34506.


pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167.

Joel PB, Smith J, Sturgill TW, Fisher TL, Blenis J, Lannigan DA.

Mol Cell Biol. 1998 Apr;18(4):1978-84.


S49 cells endogenously express subtype 2 somatostatin receptors which couple to increase protein tyrosine phosphatase activity in membranes and down-regulate Raf-1 activity in situ.

Dent P, Wang Y, Gu YZ, Wood SL, Reardon DB, Mangues R, Pellicer A, Schonbrunn A, Sturgill TW.

Cell Signal. 1997 Nov;9(7):539-49.


The activating dual phosphorylation of MAPK by MEK is nonprocessive.

Burack WR, Sturgill TW.

Biochemistry. 1997 May 20;36(20):5929-33.


Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling.

Rani CS, Wang F, Fuior E, Berger A, Wu J, Sturgill TW, Beitner-Johnson D, LeRoith D, Varticovski L, Spiegel S.

J Biol Chem. 1997 Apr 18;272(16):10777-83.


Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase.

Sprenkle AB, Davies SP, Carling D, Hardie DG, Sturgill TW.

FEBS Lett. 1997 Feb 24;403(3):254-8.


Activation of Raf by ionizing radiation.

Kasid U, Suy S, Dent P, Ray S, Whiteside TL, Sturgill TW.

Nature. 1996 Aug 29;382(6594):813-6.


Developmental and tissue-specific expression of mouse pelle-like protein kinase.

Trofimova M, Sprenkle AB, Green M, Sturgill TW, Goebl MG, Harrington MA.

J Biol Chem. 1996 Jul 26;271(30):17609-12.


Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin.

Reardon DB, Wood SL, Brautigan DL, Bell GI, Dent P, Sturgill TW.

Biochem J. 1996 Mar 1;314 ( Pt 2):401-4.


Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation.

Jelinek T, Dent P, Sturgill TW, Weber MJ.

Mol Cell Biol. 1996 Mar;16(3):1027-34. Erratum in: Mol Cell Biol 1997 May;17(5):2971.


Inactivation of raf-1 by a protein-tyrosine phosphatase stimulated by GTP and reconstituted by Galphai/o subunits.

Dent P, Reardon DB, Wood SL, Lindorfer MA, Graber SG, Garrison JC, Brautigan DL, Sturgill TW.

J Biol Chem. 1996 Feb 9;271(6):3119-23.


Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro.

Dent P, Reardon DB, Morrison DK, Sturgill TW.

Mol Cell Biol. 1995 Aug;15(8):4125-35. Erratum in: Mol Cell Biol 1995 Sep;15(9):5203.


Modulation of c-Myb-induced transcription activation by a phosphorylation site near the negative regulatory domain.

Aziz N, Miglarese MR, Hendrickson RC, Shabanowitz J, Sturgill TW, Hunt DF, Bender TP.

Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6429-33.


Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases.

Dent P, Jelinek T, Morrison DK, Weber MJ, Sturgill TW.

Science. 1995 Jun 30;268(5219):1902-6. Erratum in: Science 1995 Sep 22;269(5231):1657.


Functional mapping of the N-terminal regulatory domain in the human Raf-1 protein kinase.

Chow YH, Pumiglia K, Jun TH, Dent P, Sturgill TW, Jove R.

J Biol Chem. 1995 Jun 9;270(23):14100-6.


Preparation and use of semiintact mammalian cells for analysis of signal transduction.

Dent P, Romero G, Castle D, Sturgill TW.

Methods Enzymol. 1995;255:265-73. No abstract available.


The MPM-2 antibody inhibits mitogen-activated protein kinase activity by binding to an epitope containing phosphothreonine-183.

Taagepera S, Dent P, Her JH, Sturgill TW, Gorbsky GJ.

Mol Biol Cell. 1994 Nov;5(11):1243-51.


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