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Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family.

Bastard K, Isabet T, Stura EA, Legrand P, Zaparucha A.

Sci Rep. 2018 Nov 8;8(1):16587. doi: 10.1038/s41598-018-34795-9.


Copper mediated amyloid-β binding to Transthyretin.

Ciccone L, Fruchart-Gaillard C, Mourier G, Savko M, Nencetti S, Orlandini E, Servent D, Stura EA, Shepard W.

Sci Rep. 2018 Sep 13;8(1):13744. doi: 10.1038/s41598-018-31808-5.


Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies.

Nuti E, Cuffaro D, Bernardini E, Camodeca C, Panelli L, Chaves S, Ciccone L, Tepshi L, Vera L, Orlandini E, Nencetti S, Stura EA, Santos MA, Dive V, Rossello A.

J Med Chem. 2018 May 24;61(10):4421-4435. doi: 10.1021/acs.jmedchem.8b00096. Epub 2018 May 16.


Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease.

Ciolek J, Reinfrank H, Quinton L, Viengchareun S, Stura EA, Vera L, Sigismeau S, Mouillac B, Orcel H, Peigneur S, Tytgat J, Droctové L, Beau F, Nevoux J, Lombès M, Mourier G, De Pauw E, Servent D, Mendre C, Witzgall R, Gilles N.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7154-7159. doi: 10.1073/pnas.1620454114. Epub 2017 Jun 19.


Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins.

Blanchet G, Alili D, Protte A, Upert G, Gilles N, Tepshi L, Stura EA, Mourier G, Servent D.

Sci Rep. 2017 Jun 2;7(1):2701. doi: 10.1038/s41598-017-02953-0.


Bifunctional Inhibitors as a New Tool To Reduce Cancer Cell Invasion by Impairing MMP-9 Homodimerization.

Nuti E, Rosalia L, Cuffaro D, Camodeca C, Giacomelli C, Da Pozzo E, Tuccinardi T, Costa B, Antoni C, Vera L, Ciccone L, Orlandini E, Nencetti S, Dive V, Martini C, Stura EA, Rossello A.

ACS Med Chem Lett. 2017 Feb 7;8(3):293-298. doi: 10.1021/acsmedchemlett.6b00446. eCollection 2017 Mar 9.


Comparison of helical scan and standard rotation methods in single-crystal X-ray data collection strategies.

Polsinelli I, Savko M, Rouanet-Mehouas C, Ciccone L, Nencetti S, Orlandini E, Stura EA, Shepard W.

J Synchrotron Radiat. 2017 Jan 1;24(Pt 1):42-52. doi: 10.1107/S1600577516018488. Epub 2017 Jan 1.


Zinc-Metalloproteinase Inhibitors: Evaluation of the Complex Role Played by the Zinc-Binding Group on Potency and Selectivity.

Rouanet-Mehouas C, Czarny B, Beau F, Cassar-Lajeunesse E, Stura EA, Dive V, Devel L.

J Med Chem. 2017 Jan 12;60(1):403-414. doi: 10.1021/acs.jmedchem.6b01420. Epub 2016 Dec 20.


Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.

Sirigu S, Hartman JJ, Planelles-Herrero VJ, Ropars V, Clancy S, Wang X, Chuang G, Qian X, Lu PP, Barrett E, Rudolph K, Royer C, Morgan BP, Stura EA, Malik FI, Houdusse AM.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7448-E7455. Epub 2016 Nov 4.


Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes.

Bordenave T, Helle M, Beau F, Georgiadis D, Tepshi L, Bernes M, Ye Y, Levenez L, Poquet E, Nozach H, Razavian M, Toczek J, Stura EA, Dive V, Sadeghi MM, Devel L.

Bioconjug Chem. 2016 Oct 19;27(10):2407-2417. Epub 2016 Sep 14.


Human TTR conformation altered by rhenium tris-carbonyl derivatives.

Ciccone L, Policar C, Stura EA, Shepard W.

J Struct Biol. 2016 Sep;195(3):353-364. doi: 10.1016/j.jsb.2016.07.002. Epub 2016 Jul 16.


Sugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors.

Nuti E, Cuffaro D, D'Andrea F, Rosalia L, Tepshi L, Fabbi M, Carbotti G, Ferrini S, Santamaria S, Camodeca C, Ciccone L, Orlandini E, Nencetti S, Stura EA, Dive V, Rossello A.

ChemMedChem. 2016 Aug 5;11(15):1626-37. doi: 10.1002/cmdc.201600235. Epub 2016 Jun 30.


Synthesis and structural analysis of halogen substituted fibril formation inhibitors of Human Transthyretin (TTR).

Ciccone L, Nencetti S, Rossello A, Stura EA, Orlandini E.

J Enzyme Inhib Med Chem. 2016;31(sup1):40-51. Epub 2016 Apr 11.


Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models.

Camodeca C, Nuti E, Tepshi L, Boero S, Tuccinardi T, Stura EA, Poggi A, Zocchi MR, Rossello A.

Eur J Med Chem. 2016 Mar 23;111:193-201. doi: 10.1016/j.ejmech.2016.01.053. Epub 2016 Jan 29.


A new crystal form of human transthyretin obtained with a curcumin derived ligand.

Polsinelli I, Nencetti S, Shepard W, Ciccone L, Orlandini E, Stura EA.

J Struct Biol. 2016 Apr;194(1):8-17. doi: 10.1016/j.jsb.2016.01.007. Epub 2016 Jan 18.


Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition.

Mourier G, Salinas M, Kessler P, Stura EA, Leblanc M, Tepshi L, Besson T, Diochot S, Baron A, Douguet D, Lingueglia E, Servent D.

J Biol Chem. 2016 Feb 5;291(6):2616-29. doi: 10.1074/jbc.M115.702373. Epub 2015 Dec 17.


N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity.

Nuti E, Cantelmo AR, Gallo C, Bruno A, Bassani B, Camodeca C, Tuccinardi T, Vera L, Orlandini E, Nencetti S, Stura EA, Martinelli A, Dive V, Albini A, Rossello A.

J Med Chem. 2015 Sep 24;58(18):7224-40. doi: 10.1021/acs.jmedchem.5b00367. Epub 2015 Aug 28.


X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors.

Ciccone L, Nencetti S, Rossello A, Tepshi L, Stura EA, Orlandini E.

J Enzyme Inhib Med Chem. 2016 Oct;31(5):824-33. doi: 10.3109/14756366.2015.1070265. Epub 2015 Aug 3.


Multicomponent mixtures for cryoprotection and ligand solubilization.

Ciccone L, Vera L, Tepshi L, Rosalia L, Rossello A, Stura EA.

Biotechnol Rep (Amst). 2015 Jun 23;7:120-127. doi: 10.1016/j.btre.2015.05.008. eCollection 2015 Sep.


Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures.

Ciccone L, Tepshi L, Nencetti S, Stura EA.

N Biotechnol. 2015 Jan 25;32(1):54-64. doi: 10.1016/j.nbt.2014.09.002. Epub 2014 Sep 16.


Diversified targets of FKBP25 and its complex with rapamycin.

Galat A, Thai R, Stura EA.

Int J Biol Macromol. 2014 Aug;69:344-52. doi: 10.1016/j.ijbiomac.2014.05.060. Epub 2014 May 29.


Halogen bonding controls selectivity of FRET substrate probes for MMP-9.

Tranchant I, Vera L, Czarny B, Amoura M, Cassar E, Beau F, Stura EA, Dive V.

Chem Biol. 2014 Mar 20;21(3):408-13. doi: 10.1016/j.chembiol.2014.01.008. Epub 2014 Feb 27.


Mutants with higher stability and specific activity from a single thermosensitive variant of T7 RNA polymerase.

Boulain JC, Dassa J, Mesta L, Savatier A, Costa N, Muller BH, L'hostis G, Stura EA, Troesch A, Ducancel F.

Protein Eng Des Sel. 2013 Nov;26(11):725-34. doi: 10.1093/protein/gzt040. Epub 2013 Sep 4.


Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain.

Stura EA, Visse R, Cuniasse P, Dive V, Nagase H.

FASEB J. 2013 Nov;27(11):4395-405. doi: 10.1096/fj.13-233601. Epub 2013 Aug 2.


Crystallization of recombinant green mamba ρ-Da1a toxin during a lyophilization procedure and its structure determination.

Maïga A, Vera L, Marchetti C, Lorphelin A, Bellanger L, Mourier G, Servent D, Gilles N, Stura EA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):704-9. doi: 10.1107/S1744309113011470. Epub 2013 May 29.


Crystallization of bi-functional ligand protein complexes.

Antoni C, Vera L, Devel L, Catalani MP, Czarny B, Cassar-Lajeunesse E, Nuti E, Rossello A, Dive V, Stura EA.

J Struct Biol. 2013 Jun;182(3):246-54. doi: 10.1016/j.jsb.2013.03.015. Epub 2013 Apr 6.


Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies.

Czarny B, Stura EA, Devel L, Vera L, Cassar-Lajeunesse E, Beau F, Calderone V, Fragai M, Luchinat C, Dive V.

J Med Chem. 2013 Feb 14;56(3):1149-59. doi: 10.1021/jm301574d. Epub 2013 Feb 5.


Structural framework for covalent inhibition of Clostridium botulinum neurotoxin A by targeting Cys165.

Stura EA, Le Roux L, Guitot K, Garcia S, Bregant S, Beau F, Vera L, Collet G, Ptchelkine D, Bakirci H, Dive V.

J Biol Chem. 2012 Sep 28;287(40):33607-14. Epub 2012 Aug 6.


Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors.

Fruchart-Gaillard C, Mourier G, Blanchet G, Vera L, Gilles N, Ménez R, Marcon E, Stura EA, Servent D.

PLoS One. 2012;7(6):e39166. doi: 10.1371/journal.pone.0039166. Epub 2012 Jun 14.


Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins.

Devel L, Beau F, Amoura M, Vera L, Cassar-Lajeunesse E, Garcia S, Czarny B, Stura EA, Dive V.

J Biol Chem. 2012 Aug 3;287(32):26647-56. doi: 10.1074/jbc.M112.380782. Epub 2012 Jun 11.


Effect of zinc on human IgG1 and its FcγR interactions.

Sibéril S, Ménez R, Jorieux S, de Romeuf C, Bourel D, Fridman WH, Ducancel F, Stura EA, Teillaud JL.

Immunol Lett. 2012 Mar 30;143(1):60-9.


Structural insights into the neutralization mechanism of a higher primate antibody against dengue virus.

Cockburn JJ, Navarro Sanchez ME, Goncalvez AP, Zaitseva E, Stura EA, Kikuti CM, Duquerroy S, Dussart P, Chernomordik LV, Lai CJ, Rey FA.

EMBO J. 2012 Feb 1;31(3):767-79. doi: 10.1038/emboj.2011.439. Epub 2011 Dec 2.


X-ray structure of the arenavirus glycoprotein GP2 in its postfusion hairpin conformation.

Igonet S, Vaney MC, Vonrhein C, Bricogne G, Stura EA, Hengartner H, Eschli B, Rey FA.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):19967-72. doi: 10.1073/pnas.1108910108. Epub 2011 Nov 28. Erratum in: Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12156. Vonhrein, Clemens [corrected to Vonrhein, Clemens].


Crystal structure of human prostate-specific antigen in a sandwich antibody complex.

Stura EA, Muller BH, Bossus M, Michel S, Jolivet-Reynaud C, Ducancel F.

J Mol Biol. 2011 Dec 9;414(4):530-44. doi: 10.1016/j.jmb.2011.10.007. Epub 2011 Oct 20.


In vitro affinity maturation of an anti-PSA antibody for prostate cancer diagnostic assay.

Muller BH, Savatier A, L'Hostis G, Costa N, Bossus M, Michel S, Ott C, Becquart L, Ruffion A, Stura EA, Ducancel F.

J Mol Biol. 2011 Dec 9;414(4):545-62. doi: 10.1016/j.jmb.2011.10.008. Epub 2011 Oct 12.


Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding.

Chruszcz M, Chapman MD, Vailes LD, Stura EA, Saint-Remy JM, Minor W, Pomés A.

J Mol Biol. 2009 Feb 20;386(2):520-30. doi: 10.1016/j.jmb.2008.12.049. Epub 2008 Dec 30.


Irditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon-specific neurotoxicity.

Pawlak J, Mackessy SP, Sixberry NM, Stura EA, Le Du MH, Ménez R, Foo CS, Ménez A, Nirthanan S, Kini RM.

FASEB J. 2009 Feb;23(2):534-45. doi: 10.1096/fj.08-113555. Epub 2008 Oct 24.


Structural basis for the NAD-hydrolysis mechanism and the ARTT-loop plasticity of C3 exoenzymes.

Ménétrey J, Flatau G, Boquet P, Ménez A, Stura EA.

Protein Sci. 2008 May;17(5):878-86. doi: 10.1110/ps.073398508. Epub 2008 Mar 27.


Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody.

Ménez R, Michel S, Muller BH, Bossus M, Ducancel F, Jolivet-Reynaud C, Stura EA.

J Mol Biol. 2008 Feb 29;376(4):1021-33. doi: 10.1016/j.jmb.2007.11.052. Epub 2007 Nov 22.


Crystal structure of a human autoimmune complex between IgM rheumatoid factor RF61 and IgG1 Fc reveals a novel epitope and evidence for affinity maturation.

Duquerroy S, Stura EA, Bressanelli S, Fabiane SM, Vaney MC, Beale D, Hamon M, Casali P, Rey FA, Sutton BJ, Taussig MJ.

J Mol Biol. 2007 May 18;368(5):1321-31. Epub 2007 Mar 6.


A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics.

le Maire A, Schiltz M, Stura EA, Pinon-Lataillade G, Couprie J, Moutiez M, Gondry M, Angulo JF, Zinn-Justin S.

J Mol Biol. 2006 Dec 8;364(4):764-76. Epub 2006 Sep 16.


Structural studies of human alkaline phosphatase in complex with strontium: implication for its secondary effect in bones.

Llinas P, Masella M, Stigbrand T, Ménez A, Stura EA, Le Du MH.

Protein Sci. 2006 Jul;15(7):1691-700.


Crystal structure of the complex between the monomeric form of Toxoplasma gondii surface antigen 1 (SAG1) and a monoclonal antibody that mimics the human immune response.

Graille M, Stura EA, Bossus M, Muller BH, Letourneur O, Battail-Poirot N, Sibaï G, Gauthier M, Rolland D, Le Du MH, Ducancel F.

J Mol Biol. 2005 Nov 25;354(2):447-58. Epub 2005 Sep 30.


Structural studies of human placental alkaline phosphatase in complex with functional ligands.

Llinas P, Stura EA, Ménez A, Kiss Z, Stigbrand T, Millán JL, Le Du MH.

J Mol Biol. 2005 Jul 15;350(3):441-51.


Comparison of the crystallization and crystal packing of two Fab single-site mutant protein L complexes.

Granata V, Housden NG, Harrison S, Jolivet-Reynaud C, Gore MG, Stura EA.

Acta Crystallogr D Biol Crystallogr. 2005 Jun;61(Pt 6):750-4. Epub 2005 May 26.


Different crystal packing in Fab-protein L semi-disordered peptide complex.

Ménez R, Housden NG, Harrison S, Jolivet-Reynaud C, Gore MG, Stura EA.

Acta Crystallogr D Biol Crystallogr. 2005 Jun;61(Pt 6):744-9. Epub 2005 May 26.


Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide.

Llinas P, Le Du MH, Gårdsvoll H, Danø K, Ploug M, Gilquin B, Stura EA, Ménez A.

EMBO J. 2005 May 4;24(9):1655-63. Epub 2005 Apr 7.


Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation.

Bressanelli S, Stiasny K, Allison SL, Stura EA, Duquerroy S, Lescar J, Heinz FX, Rey FA.

EMBO J. 2004 Feb 25;23(4):728-38. Epub 2004 Feb 12.


Crystal structure of a hydrophobic immunodominant antigenic site on hepatitis C virus core protein complexed to monoclonal antibody 19D9D6.

Ménez R, Bossus M, Muller BH, Sibaï G, Dalbon P, Ducancel F, Jolivet-Reynaud C, Stura EA.

J Immunol. 2003 Feb 15;170(4):1917-24.


Protein L mutants for the crystallization of antibody fragments.

Stura EA, Graille M, Housden NG, Gore MG.

Acta Crystallogr D Biol Crystallogr. 2002 Oct;58(Pt 10 Pt 1):1744-8. Epub 2002 Sep 26.


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