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The dominant protein phosphatase PP1c isoform in smooth muscle cells, PP1cβ, is essential for smooth muscle contraction.

Chang AN, Gao N, Liu Z, Huang J, Nairn AC, Kamm KE, Stull JT.

J Biol Chem. 2018 Oct 26;293(43):16677-16686. doi: 10.1074/jbc.RA118.003083. Epub 2018 Sep 5.


Variants of Unknown Significance in Genes Associated with Heritable Thoracic Aortic Disease Can Be Low Penetrant "Risk Variants".

Kwartler CS, Gong L, Chen J, Wang S, Kulmacz R, Duan XY, Janda A, Huang J, Kamm KE, Stull JT, Guo D, Milewicz DM.

Am J Hum Genet. 2018 Jul 5;103(1):138-143. doi: 10.1016/j.ajhg.2018.05.012. Epub 2018 Jun 28.


Genetic approaches to identify pathological limitations in aortic smooth muscle contraction.

Huang J, Gao N, Wang S, Milewicz DM, Kamm KE, Stull JT.

PLoS One. 2018 Mar 1;13(3):e0193769. doi: 10.1371/journal.pone.0193769. eCollection 2018.


Physiological vs. pharmacological signalling to myosin phosphorylation in airway smooth muscle.

Gao N, Tsai MH, Chang AN, He W, Chen CP, Zhu M, Kamm KE, Stull JT.

J Physiol. 2017 Oct 1;595(19):6231-6247. doi: 10.1113/JP274715. Epub 2017 Aug 24.


Vascular disease-causing mutation, smooth muscle α-actin R258C, dominantly suppresses functions of α-actin in human patient fibroblasts.

Liu Z, Chang AN, Grinnell F, Trybus KM, Milewicz DM, Stull JT, Kamm KE.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5569-E5578. doi: 10.1073/pnas.1703506114. Epub 2017 Jun 26.


Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections.

Milewicz DM, Trybus KM, Guo DC, Sweeney HL, Regalado E, Kamm K, Stull JT.

Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):26-34. doi: 10.1161/ATVBAHA.116.303229. Epub 2016 Nov 22. Review. Erratum in: Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):e12.


Role of myosin light chain phosphatase in cardiac physiology and pathophysiology.

Chang AN, Kamm KE, Stull JT.

J Mol Cell Cardiol. 2016 Dec;101:35-43. doi: 10.1016/j.yjmcc.2016.10.004. Epub 2016 Oct 11. Review.


Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities.

Chang AN, Mahajan P, Knapp S, Barton H, Sweeney HL, Kamm KE, Stull JT.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3824-33. doi: 10.1073/pnas.1600633113. Epub 2016 Jun 20.


Physiological signalling to myosin phosphatase targeting subunit-1 phosphorylation in ileal smooth muscle.

Gao N, Chang AN, He W, Chen CP, Qiao YN, Zhu M, Kamm KE, Stull JT.

J Physiol. 2016 Jun 15;594(12):3209-25. doi: 10.1113/JP271703. Epub 2016 Mar 4.


Interaction of posttetanic potentiation and the catchlike property in mouse skeletal muscle.

Gittings W, Bunda J, Stull JT, Vandenboom R.

Muscle Nerve. 2016 Aug;54(2):308-16. doi: 10.1002/mus.25053. Epub 2016 Jun 28.


The α1A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium.

Cowley PM, Wang G, Chang AN, Makwana O, Swigart PM, Lovett DH, Stull JT, Simpson PC, Baker AJ.

Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H888-96. doi: 10.1152/ajpheart.00042.2015. Epub 2015 Jun 26.


Constitutive phosphorylation of cardiac myosin regulatory light chain in vivo.

Chang AN, Battiprolu PK, Cowley PM, Chen G, Gerard RD, Pinto JR, Hill JA, Baker AJ, Kamm KE, Stull JT.

J Biol Chem. 2015 Apr 24;290(17):10703-16. doi: 10.1074/jbc.M115.642165. Epub 2015 Mar 2.


In vivo roles for myosin phosphatase targeting subunit-1 phosphorylation sites T694 and T852 in bladder smooth muscle contraction.

Chen CP, Chen X, Qiao YN, Wang P, He WQ, Zhang CH, Zhao W, Gao YQ, Chen C, Tao T, Sun J, Wang Y, Gao N, Kamm KE, Stull JT, Zhu MS.

J Physiol. 2015 Feb 1;593(3):681-700. doi: 10.1113/jphysiol.2014.283853. Epub 2014 Dec 23.


The force dependence of isometric and concentric potentiation in mouse muscle with and without skeletal myosin light chain kinase.

Gittings W, Aggarwal H, Stull JT, Vandenboom R.

Can J Physiol Pharmacol. 2015 Jan;93(1):23-32. doi: 10.1139/cjpp-2014-0118.


Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure.

Qiao YN, He WQ, Chen CP, Zhang CH, Zhao W, Wang P, Zhang L, Wu YZ, Yang X, Peng YJ, Gao JM, Kamm KE, Stull JT, Zhu MS.

J Biol Chem. 2014 Aug 8;289(32):22512-23. doi: 10.1074/jbc.M113.525444. Epub 2014 Jun 20.


Constitutive phosphorylation of myosin phosphatase targeting subunit-1 in smooth muscle.

Tsai MH, Chang AN, Huang J, He W, Sweeney HL, Zhu M, Kamm KE, Stull JT.

J Physiol. 2014 Jul 15;592(14):3031-51. doi: 10.1113/jphysiol.2014.273011. Epub 2014 May 16.


Reply: To PMID 23499953.

He WQ, Stull JT, Zhu MS.

Gastroenterology. 2013 Dec;145(6):1495. No abstract available.


Myosin phosphorylation and force potentiation in skeletal muscle: evidence from animal models.

Vandenboom R, Gittings W, Smith IC, Grange RW, Stull JT.

J Muscle Res Cell Motil. 2013 Dec;34(5-6):317-32. doi: 10.1007/s10974-013-9363-8. Epub 2013 Oct 27. Review.


The effects of neuregulin on cardiac Myosin light chain kinase gene-ablated hearts.

Chang AN, Huang J, Battiprolu PK, Hill JA, Kamm KE, Stull JT.

PLoS One. 2013 Jun 11;8(6):e66720. doi: 10.1371/journal.pone.0066720. Print 2013.


Altered contractile phenotypes of intestinal smooth muscle in mice deficient in myosin phosphatase target subunit 1.

He WQ, Qiao YN, Peng YJ, Zha JM, Zhang CH, Chen C, Chen CP, Wang P, Yang X, Li CJ, Kamm KE, Stull JT, Zhu MS.

Gastroenterology. 2013 Jun;144(7):1456-65, 1465.e1-5. doi: 10.1053/j.gastro.2013.02.045. Epub 2013 Mar 13.


Signaling through myosin light chain kinase in smooth muscles.

Gao N, Huang J, He W, Zhu M, Kamm KE, Stull JT.

J Biol Chem. 2013 Mar 15;288(11):7596-605. doi: 10.1074/jbc.M112.427112. Epub 2013 Jan 28.


Signalling to contractile proteins by muscarinic and purinergic pathways in neurally stimulated bladder smooth muscle.

Tsai MH, Kamm KE, Stull JT.

J Physiol. 2012 Oct 15;590(20):5107-21. doi: 10.1113/jphysiol.2012.235424. Epub 2012 Aug 13.


Rare, nonsynonymous variant in the smooth muscle-specific isoform of myosin heavy chain, MYH11, R247C, alters force generation in the aorta and phenotype of smooth muscle cells.

Kuang SQ, Kwartler CS, Byanova KL, Pham J, Gong L, Prakash SK, Huang J, Kamm KE, Stull JT, Sweeney HL, Milewicz DM.

Circ Res. 2012 May 25;110(11):1411-22. doi: 10.1161/CIRCRESAHA.111.261743. Epub 2012 Apr 17.


Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension.

He WQ, Qiao YN, Zhang CH, Peng YJ, Chen C, Wang P, Gao YQ, Chen C, Chen X, Tao T, Su XH, Li CJ, Kamm KE, Stull JT, Zhu MS.

Am J Physiol Heart Circ Physiol. 2011 Aug;301(2):H584-91. doi: 10.1152/ajpheart.01212.2010. Epub 2011 May 13.


Myosin light chain kinase and the role of myosin light chain phosphorylation in skeletal muscle.

Stull JT, Kamm KE, Vandenboom R.

Arch Biochem Biophys. 2011 Jun 15;510(2):120-8. doi: 10.1016/ Epub 2011 Feb 1. Review.


Signaling to myosin regulatory light chain in sarcomeres.

Kamm KE, Stull JT.

J Biol Chem. 2011 Mar 25;286(12):9941-7. doi: 10.1074/jbc.R110.198697. Epub 2011 Jan 21. Review.


Thematic minireview series on signaling in cardiac sarcomeres in health and disease.

Solaro RJ, Stull JT.

J Biol Chem. 2011 Mar 25;286(12):9895. doi: 10.1074/jbc.R110.214403. Epub 2011 Jan 21. No abstract available.


Mutations in myosin light chain kinase cause familial aortic dissections.

Wang L, Guo DC, Cao J, Gong L, Kamm KE, Regalado E, Li L, Shete S, He WQ, Zhu MS, Offermanns S, Gilchrist D, Elefteriades J, Stull JT, Milewicz DM.

Am J Hum Genet. 2010 Nov 12;87(5):701-7. doi: 10.1016/j.ajhg.2010.10.006. Epub 2010 Nov 4. Erratum in: Am J Hum Genet. 2011 Apr 8;88(4):516.


Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivo.

Ding P, Huang J, Battiprolu PK, Hill JA, Kamm KE, Stull JT.

J Biol Chem. 2010 Dec 24;285(52):40819-29. doi: 10.1074/jbc.M110.160499. Epub 2010 Oct 13.


Cardiac myosin is a substrate for zipper-interacting protein kinase (ZIPK).

Chang AN, Chen G, Gerard RD, Kamm KE, Stull JT.

J Biol Chem. 2010 Feb 19;285(8):5122-6. doi: 10.1074/jbc.C109.076489. Epub 2009 Dec 28.


Myosin light chain kinase is necessary for tonic airway smooth muscle contraction.

Zhang WC, Peng YJ, Zhang GS, He WQ, Qiao YN, Dong YY, Gao YQ, Chen C, Zhang CH, Li W, Shen HH, Ning W, Kamm KE, Stull JT, Gao X, Zhu MS.

J Biol Chem. 2010 Feb 19;285(8):5522-31. doi: 10.1074/jbc.M109.062836. Epub 2009 Dec 14.


Signaling processes for initiating smooth muscle contraction upon neural stimulation.

Ding HL, Ryder JW, Stull JT, Kamm KE.

J Biol Chem. 2009 Jun 5;284(23):15541-8. doi: 10.1074/jbc.M900888200. Epub 2009 Apr 6.


Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice.

He WQ, Peng YJ, Zhang WC, Lv N, Tang J, Chen C, Zhang CH, Gao S, Chen HQ, Zhi G, Feil R, Kamm KE, Stull JT, Gao X, Zhu MS.

Gastroenterology. 2008 Aug;135(2):610-20. doi: 10.1053/j.gastro.2008.05.032. Epub 2008 May 15.


Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo.

Mizuno Y, Isotani E, Huang J, Ding H, Stull JT, Kamm KE.

Am J Physiol Cell Physiol. 2008 Aug;295(2):C358-64. doi: 10.1152/ajpcell.90645.2007. Epub 2008 Jun 4.


Myosin regulatory light chain phosphorylation attenuates cardiac hypertrophy.

Huang J, Shelton JM, Richardson JA, Kamm KE, Stull JT.

J Biol Chem. 2008 Jul 11;283(28):19748-56. doi: 10.1074/jbc.M802605200. Epub 2008 May 12.


Enhanced skeletal muscle contraction with myosin light chain phosphorylation by a calmodulin-sensing kinase.

Ryder JW, Lau KS, Kamm KE, Stull JT.

J Biol Chem. 2007 Jul 13;282(28):20447-54. Epub 2007 May 15.


ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice.

Huang G, Yao J, Zeng W, Mizuno Y, Kamm KE, Stull JT, Harding HP, Ron D, Muallem S.

J Cell Sci. 2006 Jan 1;119(Pt 1):153-61. Epub 2005 Dec 13.


Myosin light chain kinase and myosin phosphorylation effect frequency-dependent potentiation of skeletal muscle contraction.

Zhi G, Ryder JW, Huang J, Ding P, Chen Y, Zhao Y, Kamm KE, Stull JT.

Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17519-24. Epub 2005 Nov 18.


Myosin phosphatase targeting subunit 1 affects cell migration by regulating myosin phosphorylation and actin assembly.

Xia D, Stull JT, Kamm KE.

Exp Cell Res. 2005 Apr 1;304(2):506-17. Epub 2004 Dec 30.


Real-time evaluation of myosin light chain kinase activation in smooth muscle tissues from a transgenic calmodulin-biosensor mouse.

Isotani E, Zhi G, Lau KS, Huang J, Mizuno Y, Persechini A, Geguchadze R, Kamm KE, Stull JT.

Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6279-84. Epub 2004 Apr 7.


Quantitative measurements of Ca(2+)/calmodulin binding and activation of myosin light chain kinase in cells.

Geguchadze R, Zhi G, Lau KS, Isotani E, Persechini A, Kamm KE, Stull JT.

FEBS Lett. 2004 Jan 16;557(1-3):121-4.


Skeletal muscle basement membrane-sarcolemma-cytoskeleton interaction minireview series.

Campbell KP, Stull JT.

J Biol Chem. 2003 Apr 11;278(15):12599-600. Epub 2003 Jan 29. Review. No abstract available.


Navigating the signalling network in mouse cardiac myocytes.

Sambrano GR, Fraser I, Han H, Ni Y, O'Connell T, Yan Z, Stull JT.

Nature. 2002 Dec 12;420(6916):712-4.


Overview of the Alliance for Cellular Signaling.

Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR; Participating investigators and scientists of the Alliance for Cellular Signaling.

Nature. 2002 Dec 12;420(6916):703-6.


Fast-twitch skeletal muscles of dystrophic mouse pups are resistant to injury from acute mechanical stress.

Grange RW, Gainer TG, Marschner KM, Talmadge RJ, Stull JT.

Am J Physiol Cell Physiol. 2002 Oct;283(4):C1090-101.


Properties of long myosin light chain kinase binding to F-actin in vitro and in vivo.

Smith L, Parizi-Robinson M, Zhu MS, Zhi G, Fukui R, Kamm KE, Stull JT.

J Biol Chem. 2002 Sep 20;277(38):35597-604. Epub 2002 Jul 10.


Structure and regulation of calcium/calmodulin-dependent protein kinases.

Soderling TR, Stull JT.

Chem Rev. 2001 Aug;101(8):2341-52. Review. No abstract available.


Functional and molecular adaptations in skeletal muscle of myoglobin-mutant mice.

Grange RW, Meeson A, Chin E, Lau KS, Stull JT, Shelton JM, Williams RS, Garry DJ.

Am J Physiol Cell Physiol. 2001 Nov;281(5):C1487-94.


Myosin light chain kinase binding to a unique site on F-actin revealed by three-dimensional image reconstruction.

Hatch V, Zhi G, Smith L, Stull JT, Craig R, Lehman W.

J Cell Biol. 2001 Aug 6;154(3):611-7. Epub 2001 Jul 30.

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