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Items: 1 to 50 of 254

1.

Soluble Guanylate Cyclase Agonists Induce Bronchodilation in Human Small Airways.

Koziol-White CJ, Ghosh A, Sandner P, Erzurum SE, Stuehr DJ, Panettieri RA Jr.

Am J Respir Cell Mol Biol. 2019 Jul 24. doi: 10.1165/rcmb.2019-0001OC. [Epub ahead of print]

PMID:
31340135
2.

Heat shock protein 90 regulates soluble guanylyl cyclase maturation by a dual mechanism.

Dai Y, Schlanger S, Haque MM, Misra S, Stuehr DJ.

J Biol Chem. 2019 Aug 30;294(35):12880-12891. doi: 10.1074/jbc.RA119.009016. Epub 2019 Jul 15.

PMID:
31311859
3.

Metal binding and conformational studies of the calcium binding domain of NADPH oxidase 5 reveal its similarity and difference to calmodulin.

Wei CC, Fabry E, Hay E, Lloyd L, Kaufman N, Yang YP, Stuehr DJ.

J Biomol Struct Dyn. 2019 Jun 25:1-17. doi: 10.1080/07391102.2019.1633409. [Epub ahead of print]

PMID:
31203730
4.

Myoglobin maturation is driven by the hsp90 chaperone machinery and by soluble guanylyl cyclase.

Ghosh A, Dai Y, Biswas P, Stuehr DJ.

FASEB J. 2019 Sep;33(9):9885-9896. doi: 10.1096/fj.201802793RR. Epub 2019 Jun 6.

PMID:
31170354
5.

Mechanism and regulation of ferrous heme-nitric oxide (NO) oxidation in NO synthases.

Tejero J, Hunt AP, Santolini J, Lehnert N, Stuehr DJ.

J Biol Chem. 2019 May 10;294(19):7904-7916. doi: 10.1074/jbc.RA119.007810. Epub 2019 Mar 29.

PMID:
30926606
6.

Nitric oxide synthase enzymology in the 20 years after the Nobel Prize.

Stuehr DJ, Haque MM.

Br J Pharmacol. 2019 Jan;176(2):177-188. doi: 10.1111/bph.14533. Epub 2018 Dec 9. Review.

PMID:
30402946
7.

Glyceraldehyde-3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells.

Sweeny EA, Singh AB, Chakravarti R, Martinez-Guzman O, Saini A, Haque MM, Garee G, Dans PD, Hannibal L, Reddi AR, Stuehr DJ.

J Biol Chem. 2018 Sep 14;293(37):14557-14568. doi: 10.1074/jbc.RA118.004169. Epub 2018 Jul 16.

8.

Nitric oxide alters hyaluronan deposition by airway smooth muscle cells.

Majors AK, Chakravarti R, Ruple LM, Leahy R, Stuehr DJ, Lauer M, Erzurum SC, Janocha A, Aronica MA.

PLoS One. 2018 Jul 2;13(7):e0200074. doi: 10.1371/journal.pone.0200074. eCollection 2018.

9.

A cross-domain charge interaction governs the activity of NO synthase.

Haque MM, Tejero J, Bayachou M, Kenney CT, Stuehr DJ.

J Biol Chem. 2018 Mar 23;293(12):4545-4554. doi: 10.1074/jbc.RA117.000635. Epub 2018 Feb 2.

10.

Hsp90 chaperones hemoglobin maturation in erythroid and nonerythroid cells.

Ghosh A, Garee G, Sweeny EA, Nakamura Y, Stuehr DJ.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1117-E1126. doi: 10.1073/pnas.1717993115. Epub 2018 Jan 22.

11.

Endothelial nitric oxide synthase oxygenase on lipid nanodiscs: A nano-assembly reflecting native-like function of eNOS.

AlTawallbeh G, Haque MM, Streletzky KA, Stuehr DJ, Bayachou M.

Biochem Biophys Res Commun. 2017 Dec 2;493(4):1438-1442. doi: 10.1016/j.bbrc.2017.09.131. Epub 2017 Sep 25.

12.

Restricting the conformational freedom of the neuronal nitric-oxide synthase flavoprotein domain reveals impact on electron transfer and catalysis.

Dai Y, Haque MM, Stuehr DJ.

J Biol Chem. 2017 Apr 21;292(16):6753-6764. doi: 10.1074/jbc.M117.777219. Epub 2017 Feb 23.

13.

Nitric oxide synthases-from genes to function.

Stuehr DJ, Vasquez-Vivar J.

Nitric Oxide. 2017 Feb 28;63:29. doi: 10.1016/j.niox.2017.01.005. No abstract available.

14.

Phosphorylation Controls Endothelial Nitric-oxide Synthase by Regulating Its Conformational Dynamics.

Haque MM, Ray SS, Stuehr DJ.

J Biol Chem. 2016 Oct 28;291(44):23047-23057. Epub 2016 Sep 9.

15.

Tetrahydrobiopterin redox cycling in nitric oxide synthase: evidence supports a through-heme electron delivery.

Ramasamy S, Haque MM, Gangoda M, Stuehr DJ.

FEBS J. 2016 Dec;283(24):4491-4501. doi: 10.1111/febs.13933. Epub 2016 Nov 18.

16.

Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis.

Gupta I, Ganguly S, Rozanas CR, Stuehr DJ, Panda K.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):E4208-17. doi: 10.1073/pnas.1600056113. Epub 2016 Jul 5.

17.

Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone.

Rwere F, Xia C, Im S, Haque MM, Stuehr DJ, Waskell L, Kim JJ.

J Biol Chem. 2016 Jul 8;291(28):14639-61. doi: 10.1074/jbc.M116.724625. Epub 2016 May 9.

18.

Phosphorylation inactivation of endothelial nitric oxide synthesis in pulmonary arterial hypertension.

Ghosh S, Gupta M, Xu W, Mavrakis DA, Janocha AJ, Comhair SA, Haque MM, Stuehr DJ, Yu J, Polgar P, Naga Prasad SV, Erzurum SC.

Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1199-205. doi: 10.1152/ajplung.00092.2016. Epub 2016 Apr 29.

19.

Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma.

Ghosh A, Koziol-White CJ, Asosingh K, Cheng G, Ruple L, Groneberg D, Friebe A, Comhair SA, Stasch JP, Panettieri RA Jr, Aronica MA, Erzurum SC, Stuehr DJ.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):E2355-62. doi: 10.1073/pnas.1524398113. Epub 2016 Apr 11.

20.

Engineering nitric oxide synthase chimeras to function as NO dioxygenases.

Wang ZQ, Haque MM, Binder K, Sharma M, Wei CC, Stuehr DJ.

J Inorg Biochem. 2016 May;158:122-130. doi: 10.1016/j.jinorgbio.2016.03.002. Epub 2016 Mar 15.

PMID:
27013266
21.

Regulation of sGC via hsp90, Cellular Heme, sGC Agonists, and NO: New Pathways and Clinical Perspectives.

Ghosh A, Stuehr DJ.

Antioxid Redox Signal. 2017 Feb 1;26(4):182-190. doi: 10.1089/ars.2016.6690. Epub 2016 May 2.

22.

Occurrence, structure, and evolution of nitric oxide synthase-like proteins in the plant kingdom.

Jeandroz S, Wipf D, Stuehr DJ, Lamattina L, Melkonian M, Tian Z, Zhu Y, Carpenter EJ, Wong GK, Wendehenne D.

Sci Signal. 2016 Mar 1;9(417):re2. doi: 10.1126/scisignal.aad4403. Review.

PMID:
26933064
23.

Single-molecule spectroscopy reveals how calmodulin activates NO synthase by controlling its conformational fluctuation dynamics.

He Y, Haque MM, Stuehr DJ, Lu HP.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11835-40. doi: 10.1073/pnas.1508829112. Epub 2015 Aug 26.

24.

Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase: IMplications for Enzyme Maturation.

Sarkar A, Dai Y, Haque MM, Seeger F, Ghosh A, Garcin ED, Montfort WR, Hazen SL, Misra S, Stuehr DJ.

J Biol Chem. 2015 Aug 28;290(35):21615-28. doi: 10.1074/jbc.M115.645515. Epub 2015 Jul 1.

25.
26.

A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteins.

Zhang H, Amick J, Chakravarti R, Santarriaga S, Schlanger S, McGlone C, Dare M, Nix JC, Scaglione KM, Stuehr DJ, Misra S, Page RC.

Structure. 2015 Mar 3;23(3):472-482. doi: 10.1016/j.str.2015.01.003. Epub 2015 Feb 12.

27.

Novel insights in mammalian catalase heme maturation: effect of NO and thioredoxin-1.

Chakravarti R, Gupta K, Majors A, Ruple L, Aronica M, Stuehr DJ.

Free Radic Biol Med. 2015 May;82:105-13. doi: 10.1016/j.freeradbiomed.2015.01.030. Epub 2015 Feb 4.

28.

Dissecting structural and electronic effects in inducible nitric oxide synthase.

Hannibal L, Page RC, Haque MM, Bolisetty K, Yu Z, Misra S, Stuehr DJ.

Biochem J. 2015 Apr 1;467(1):153-65. doi: 10.1042/BJ20141319.

29.
30.

Hydrogen sulfide and nitric oxide metabolites in the blood of free-ranging brown bears and their potential roles in hibernation.

Revsbech IG, Shen X, Chakravarti R, Jensen FB, Thiel B, Evans AL, Kindberg J, Fröbert O, Stuehr DJ, Kevil CG, Fago A.

Free Radic Biol Med. 2014 Aug;73:349-57. doi: 10.1016/j.freeradbiomed.2014.05.025. Epub 2014 Jun 5.

31.

Nitric oxide and heat shock protein 90 activate soluble guanylate cyclase by driving rapid change in its subunit interactions and heme content.

Ghosh A, Stasch JP, Papapetropoulos A, Stuehr DJ.

J Biol Chem. 2014 May 30;289(22):15259-71. doi: 10.1074/jbc.M114.559393. Epub 2014 Apr 14.

32.

A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerization.

Benson MA, Batchelor H, Chuaiphichai S, Bailey J, Zhu H, Stuehr DJ, Bhattacharya S, Channon KM, Crabtree MJ.

J Biol Chem. 2013 Oct 11;288(41):29836-45. doi: 10.1074/jbc.M113.493023. Epub 2013 Aug 21.

33.

Thermodynamic characterization of five key kinetic parameters that define neuronal nitric oxide synthase catalysis.

Haque MM, Tejero J, Bayachou M, Wang ZQ, Fadlalla M, Stuehr DJ.

FEBS J. 2013 Sep;280(18):4439-53. doi: 10.1111/febs.12404. Epub 2013 Jul 15.

34.

Mechanism of inducible nitric-oxide synthase dimerization inhibition by novel pyrimidine imidazoles.

Nagpal L, Haque MM, Saha A, Mukherjee N, Ghosh A, Ranu BC, Stuehr DJ, Panda K.

J Biol Chem. 2013 Jul 5;288(27):19685-97. doi: 10.1074/jbc.M112.446542. Epub 2013 May 21.

35.

Charge-pairing interactions control the conformational setpoint and motions of the FMN domain in neuronal nitric oxide synthase.

Haque MM, Bayachou M, Fadlalla MA, Durra D, Stuehr DJ.

Biochem J. 2013 Mar 15;450(3):607-17. doi: 10.1042/BJ20121488.

36.

Catalytic intermediates of inducible nitric-oxide synthase stabilized by the W188H mutation.

Sabat J, Egawa T, Lu C, Stuehr DJ, Gerfen GJ, Rousseau DL, Yeh SR.

J Biol Chem. 2013 Mar 1;288(9):6095-106. doi: 10.1074/jbc.M112.403238. Epub 2012 Dec 26.

37.

Ascorbate in aqueous humor augments nitric oxide production by macrophages.

McKenna KC, Beatty KM, Scherder RC, Li F, Liu H, Chen AF, Ghosh A, Stuehr DJ.

J Immunol. 2013 Jan 15;190(2):556-64. doi: 10.4049/jimmunol.1201754. Epub 2012 Dec 12.

38.

Heme binding properties of glyceraldehyde-3-phosphate dehydrogenase.

Hannibal L, Collins D, Brassard J, Chakravarti R, Vempati R, Dorlet P, Santolini J, Dawson JH, Stuehr DJ.

Biochemistry. 2012 Oct 30;51(43):8514-29. doi: 10.1021/bi300863a. Epub 2012 Oct 15.

39.

Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme.

Ghosh A, Stuehr DJ.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):12998-3003. doi: 10.1073/pnas.1205854109. Epub 2012 Jul 25.

40.

Protection of extraribosomal RPL13a by GAPDH and dysregulation by S-nitrosylation.

Jia J, Arif A, Willard B, Smith JD, Stuehr DJ, Hazen SL, Fox PL.

Mol Cell. 2012 Aug 24;47(4):656-63. doi: 10.1016/j.molcel.2012.06.006. Epub 2012 Jul 5.

41.

Control of electron transfer and catalysis in neuronal nitric-oxide synthase (nNOS) by a hinge connecting its FMN and FAD-NADPH domains.

Haque MM, Fadlalla MA, Aulak KS, Ghosh A, Durra D, Stuehr DJ.

J Biol Chem. 2012 Aug 31;287(36):30105-16. doi: 10.1074/jbc.M112.339697. Epub 2012 Jun 20.

42.

Characterization of the 1st and 2nd EF-hands of NADPH oxidase 5 by fluorescence, isothermal titration calorimetry, and circular dichroism.

Wei CC, Reynolds N, Palka C, Wetherell K, Boyle T, Yang YP, Wang ZQ, Stuehr DJ.

Chem Cent J. 2012 Apr 10;6(1):29. doi: 10.1186/1752-153X-6-29.

43.

Thioredoxin-1 regulates cellular heme insertion by controlling S-nitrosation of glyceraldehyde-3-phosphate dehydrogenase.

Chakravarti R, Stuehr DJ.

J Biol Chem. 2012 May 11;287(20):16179-86. doi: 10.1074/jbc.M112.342758. Epub 2012 Mar 28.

44.

Arg375 tunes tetrahydrobiopterin functions and modulates catalysis by inducible nitric oxide synthase.

Wang ZQ, Tejero J, Wei CC, Haque MM, Santolini J, Fadlalla M, Biswas A, Stuehr DJ.

J Inorg Biochem. 2012 Mar;108:203-15. doi: 10.1016/j.jinorgbio.2011.11.015. Epub 2011 Nov 23.

45.

Influence of heme-thiolate in shaping the catalytic properties of a bacterial nitric-oxide synthase.

Hannibal L, Somasundaram R, Tejero J, Wilson A, Stuehr DJ.

J Biol Chem. 2011 Nov 11;286(45):39224-35. doi: 10.1074/jbc.M111.286351. Epub 2011 Sep 14.

47.

Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process.

Ghosh A, Chawla-Sarkar M, Stuehr DJ.

FASEB J. 2011 Jun;25(6):2049-60. doi: 10.1096/fj.10-180554. Epub 2011 Feb 25.

48.

Mesohaem substitution reveals how haem electronic properties can influence the kinetic and catalytic parameters of neuronal NO synthase.

Tejero J, Biswas A, Haque MM, Wang ZQ, Hemann C, Varnado CL, Novince Z, Hille R, Goodwin DC, Stuehr DJ.

Biochem J. 2011 Jan 1;433(1):163-74. doi: 10.1042/BJ20101353.

PMID:
20950274
49.

GAPDH regulates cellular heme insertion into inducible nitric oxide synthase.

Chakravarti R, Aulak KS, Fox PL, Stuehr DJ.

Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18004-9. doi: 10.1073/pnas.1008133107. Epub 2010 Oct 4.

50.

NO synthase isoforms specifically modify peroxynitrite reactivity.

Maréchal A, Mattioli TA, Stuehr DJ, Santolini J.

FEBS J. 2010 Oct;277(19):3963-73. doi: 10.1111/j.1742-4658.2010.07786.x. Epub 2010 Sep 2.

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