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Items: 1 to 50 of 177

1.

The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.

Inda MC, Joshi S, Wang T, Bolaender A, Gandu S, Koren Iii J, Che AY, Taldone T, Yan P, Sun W, Uddin M, Panchal P, Riolo M, Shah S, Barlas A, Xu K, Chan LYL, Gruzinova A, Kishinevsky S, Studer L, Fossati V, Noggle SA, White JR, de Stanchina E, Sequeira S, Anthoney KH, Steele JW, Manova-Todorova K, Patil S, Dunphy MP, Pillarsetty N, Pereira AC, Erdjument-Bromage H, Neubert TA, Rodina A, Ginsberg SD, De Marco Garcia N, Luo W, Chiosis G.

Nat Commun. 2020 Jan 16;11(1):319. doi: 10.1038/s41467-019-14082-5.

2.

Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis.

Lafaille FG, Harschnitz O, Lee YS, Zhang P, Hasek ML, Kerner G, Itan Y, Ewaleifoh O, Rapaport F, Carlile TM, Carter-Timofte ME, Paquet D, Dobbs K, Zimmer B, Gao D, Rojas-Duran MF, Kwart D, Rattina V, Ciancanelli MJ, McAlpine JL, Lorenzo L, Boucherit S, Rozenberg F, Halwani R, Henry B, Amenzoui N, Alsum Z, Marques L, Church JA, Al-Muhsen S, Tardieu M, Bousfiha AA, Paludan SR, Mogensen TH, Quintana-Murci L, Tessier-Lavigne M, Smith GA, Notarangelo LD, Studer L, Gilbert W, Abel L, Casanova JL, Zhang SY.

Nat Med. 2019 Dec;25(12):1873-1884. doi: 10.1038/s41591-019-0672-3. Epub 2019 Dec 5.

PMID:
31806906
3.

Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons.

Riessland M, Kolisnyk B, Kim TW, Cheng J, Ni J, Pearson JA, Park EJ, Dam K, Acehan D, Ramos-Espiritu LS, Wang W, Zhang J, Shim JW, Ciceri G, Brichta L, Studer L, Greengard P.

Cell Stem Cell. 2019 Oct 3;25(4):514-530.e8. doi: 10.1016/j.stem.2019.08.013. Epub 2019 Sep 19.

PMID:
31543366
4.

Corrigendum: TCF3 alternative splicing controlled by hnRNP H/F regulates E-cadherin expression and hESC pluripotency.

Yamazaki T, Liu L, Lazarev D, Al-Zain A, Fomin V, Yeung PL, Chambers SM, Lu CW, Studer L, Manley JL.

Genes Dev. 2019 Jun 1;33(11-12):733-736. doi: 10.1101/gad.326983.119. No abstract available.

5.

Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs.

Cornacchia D, Zhang C, Zimmer B, Chung SY, Fan Y, Soliman MA, Tchieu J, Chambers SM, Shah H, Paull D, Konrad C, Vincendeau M, Noggle SA, Manfredi G, Finley LWS, Cross JR, Betel D, Studer L.

Cell Stem Cell. 2019 Jul 3;25(1):120-136.e10. doi: 10.1016/j.stem.2019.05.001. Epub 2019 May 30.

PMID:
31155483
6.

Does trumpet playing affect lung function?-A case-control study.

Studer L, Schumann DM, Stalder-Siebeneichler A, Tamm M, Stolz D.

PLoS One. 2019 May 2;14(5):e0215781. doi: 10.1371/journal.pone.0215781. eCollection 2019.

7.

Comparison of three congruent patient-specific cell types for the modelling of a human genetic Schwann-cell disorder.

Mukherjee-Clavin B, Mi R, Kern B, Choi IY, Lim H, Oh Y, Lannon B, Kim KJ, Bell S, Hur JK, Hwang W, Che YH, Habib O, Baloh RH, Eggan K, Brandacher G, Hoke A, Studer L, Kim YJ, Lee G.

Nat Biomed Eng. 2019 Jul;3(7):571-582. doi: 10.1038/s41551-019-0381-8. Epub 2019 Apr 8.

8.

Specification of positional identity in forebrain organoids.

Cederquist GY, Asciolla JJ, Tchieu J, Walsh RM, Cornacchia D, Resh MD, Studer L.

Nat Biotechnol. 2019 Apr;37(4):436-444. doi: 10.1038/s41587-019-0085-3. Epub 2019 Apr 1.

9.

Derivation of enteric neuron lineages from human pluripotent stem cells.

Barber K, Studer L, Fattahi F.

Nat Protoc. 2019 Apr;14(4):1261-1279. doi: 10.1038/s41596-019-0141-y. Epub 2019 Mar 25.

10.

NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells.

Tchieu J, Calder EL, Guttikonda SR, Gutzwiller EM, Aromolaran KA, Steinbeck JA, Goldstein PA, Studer L.

Nat Biotechnol. 2019 Mar;37(3):267-275. doi: 10.1038/s41587-019-0035-0. Epub 2019 Feb 25.

11.

A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival.

Zhou T, Kim TW, Chong CN, Tan L, Amin S, Sadat Badieyan Z, Mukherjee S, Ghazizadeh Z, Zeng H, Guo M, Crespo M, Zhang T, Kenyon R, Robinson CL, Apostolou E, Wang H, Xiang JZ, Evans T, Studer L, Chen S.

Nat Commun. 2018 Nov 16;9(1):4815. doi: 10.1038/s41467-018-07201-1.

12.

HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons.

Kishinevsky S, Wang T, Rodina A, Chung SY, Xu C, Philip J, Taldone T, Joshi S, Alpaugh ML, Bolaender A, Gutbier S, Sandhu D, Fattahi F, Zimmer B, Shah SK, Chang E, Inda C, Koren J 3rd, Saurat NG, Leist M, Gross SS, Seshan VE, Klein C, Tomishima MJ, Erdjument-Bromage H, Neubert TA, Henrickson RC, Chiosis G, Studer L.

Nat Commun. 2018 Oct 19;9(1):4345. doi: 10.1038/s41467-018-06486-6.

13.

Human iPSC-derived trigeminal neurons lack constitutive TLR3-dependent immunity that protects cortical neurons from HSV-1 infection.

Zimmer B, Ewaleifoh O, Harschnitz O, Lee YS, Peneau C, McAlpine JL, Liu B, Tchieu J, Steinbeck JA, Lafaille F, Volpi S, Notarangelo LD, Casanova JL, Zhang SY, Smith GA, Studer L.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8775-E8782. doi: 10.1073/pnas.1809853115. Epub 2018 Aug 28.

14.

TCF3 alternative splicing controlled by hnRNP H/F regulates E-cadherin expression and hESC pluripotency.

Yamazaki T, Liu L, Lazarev D, Al-Zain A, Fomin V, Yeung PL, Chambers SM, Lu CW, Studer L, Manley JL.

Genes Dev. 2018 Sep 1;32(17-18):1161-1174. doi: 10.1101/gad.316984.118. Epub 2018 Aug 16. Erratum in: Genes Dev. 2019 Jun 1;33(11-12):733-736.

15.

Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ).

Callahan SJ, Tepan S, Zhang YM, Lindsay H, Burger A, Campbell NR, Kim IS, Hollmann TJ, Studer L, Mosimann C, White RM.

Dis Model Mech. 2018 Sep 27;11(9). pii: dmm034561. doi: 10.1242/dmm.034561.

16.

Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells.

Xue X, Sun Y, Resto-Irizarry AM, Yuan Y, Aw Yong KM, Zheng Y, Weng S, Shao Y, Chai Y, Studer L, Fu J.

Nat Mater. 2018 Jul;17(7):633-641. doi: 10.1038/s41563-018-0082-9. Epub 2018 May 21.

17.

Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection.

Zhang SY, Clark NE, Freije CA, Pauwels E, Taggart AJ, Okada S, Mandel H, Garcia P, Ciancanelli MJ, Biran A, Lafaille FG, Tsumura M, Cobat A, Luo J, Volpi S, Zimmer B, Sakata S, Dinis A, Ohara O, Garcia Reino EJ, Dobbs K, Hasek M, Holloway SP, McCammon K, Hussong SA, DeRosa N, Van Skike CE, Katolik A, Lorenzo L, Hyodo M, Faria E, Halwani R, Fukuhara R, Smith GA, Galvan V, Damha MJ, Al-Muhsen S, Itan Y, Boeke JD, Notarangelo LD, Studer L, Kobayashi M, Diogo L, Fairbrother WG, Abel L, Rosenberg BR, Hart PJ, Etzioni A, Casanova JL.

Cell. 2018 Feb 22;172(5):952-965.e18. doi: 10.1016/j.cell.2018.02.019.

18.

Hepatic Epithelioid Hemangioendothelioma.

Studer LL, Selby DM.

Arch Pathol Lab Med. 2018 Feb;142(2):263-267. doi: 10.5858/arpa.2016-0171-RS. Review.

PMID:
29372848
19.

DNA replication timing alterations identify common markers between distinct progeroid diseases.

Rivera-Mulia JC, Desprat R, Trevilla-Garcia C, Cornacchia D, Schwerer H, Sasaki T, Sima J, Fells T, Studer L, Lemaitre JM, Gilbert DM.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10972-E10980. doi: 10.1073/pnas.1711613114. Epub 2017 Dec 1.

20.

Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era.

Barker RA, Parmar M, Studer L, Takahashi J.

Cell Stem Cell. 2017 Nov 2;21(5):569-573. doi: 10.1016/j.stem.2017.09.014.

21.

A Modular Platform for Differentiation of Human PSCs into All Major Ectodermal Lineages.

Tchieu J, Zimmer B, Fattahi F, Amin S, Zeltner N, Chen S, Studer L.

Cell Stem Cell. 2017 Sep 7;21(3):399-410.e7. doi: 10.1016/j.stem.2017.08.015.

22.

High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain.

Zhou T, Tan L, Cederquist GY, Fan Y, Hartley BJ, Mukherjee S, Tomishima M, Brennand KJ, Zhang Q, Schwartz RE, Evans T, Studer L, Chen S.

Cell Stem Cell. 2017 Aug 3;21(2):274-283.e5. doi: 10.1016/j.stem.2017.06.017. Epub 2017 Jul 20.

23.

Human Pluripotent-Derived Lineages for Repairing Hypopituitarism.

Studer L, Tabar V.

In: Pfaff D, Christen Y, editors. Stem Cells in Neuroendocrinology [Internet]. Cham (CH): Springer; 2016.
2016 Jul 27.

24.

Strategies for bringing stem cell-derived dopamine neurons to the clinic-The NYSTEM trial.

Studer L.

Prog Brain Res. 2017;230:191-212. doi: 10.1016/bs.pbr.2017.02.008. Epub 2017 Mar 21.

PMID:
28552229
25.

Pluripotent stem cells in neuropsychiatric disorders.

Soliman MA, Aboharb F, Zeltner N, Studer L.

Mol Psychiatry. 2017 Sep;22(9):1241-1249. doi: 10.1038/mp.2017.40. Epub 2017 Mar 21. Review.

26.

Lessons Learned from Pioneering Neural Stem Cell Studies.

Temple S, Studer L.

Stem Cell Reports. 2017 Feb 14;8(2):191-193. doi: 10.1016/j.stemcr.2017.01.024.

27.

Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells.

Qi Y, Zhang XJ, Renier N, Wu Z, Atkin T, Sun Z, Ozair MZ, Tchieu J, Zimmer B, Fattahi F, Ganat Y, Azevedo R, Zeltner N, Brivanlou AH, Karayiorgou M, Gogos J, Tomishima M, Tessier-Lavigne M, Shi SH, Studer L.

Nat Biotechnol. 2017 Feb;35(2):154-163. doi: 10.1038/nbt.3777. Epub 2017 Jan 23.

28.

Systematic Literature Review of General Health Care Interventions Within Programs of Assertive Community Treatment.

Vanderlip ER, Henwood BF, Hrouda DR, Meyer PS, Monroe-DeVita M, Studer LM, Schweikhard AJ, Moser LL.

Psychiatr Serv. 2017 Mar 1;68(3):218-224. doi: 10.1176/appi.ps.201600100. Epub 2016 Dec 1. Review.

PMID:
27903142
29.

Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.

Zeltner N, Fattahi F, Dubois NC, Saurat N, Lafaille F, Shang L, Zimmer B, Tchieu J, Soliman MA, Lee G, Casanova JL, Studer L.

Nat Med. 2016 Dec;22(12):1421-1427. doi: 10.1038/nm.4220. Epub 2016 Nov 14.

30.

Generating Late-Onset Human iPSC-Based Disease Models by Inducing Neuronal Age-Related Phenotypes through Telomerase Manipulation.

Vera E, Bosco N, Studer L.

Cell Rep. 2016 Oct 18;17(4):1184-1192. doi: 10.1016/j.celrep.2016.09.062.

31.

The epichaperome is an integrated chaperome network that facilitates tumour survival.

Rodina A, Wang T, Yan P, Gomes ED, Dunphy MP, Pillarsetty N, Koren J, Gerecitano JF, Taldone T, Zong H, Caldas-Lopes E, Alpaugh M, Corben A, Riolo M, Beattie B, Pressl C, Peter RI, Xu C, Trondl R, Patel HJ, Shimizu F, Bolaender A, Yang C, Panchal P, Farooq MF, Kishinevsky S, Modi S, Lin O, Chu F, Patil S, Erdjument-Bromage H, Zanzonico P, Hudis C, Studer L, Roboz GJ, Cesarman E, Cerchietti L, Levine R, Melnick A, Larson SM, Lewis JS, Guzman ML, Chiosis G.

Nature. 2016 Oct 20;538(7625):397-401. doi: 10.1038/nature19807. Epub 2016 Oct 5.

32.

Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation.

Chung SY, Kishinevsky S, Mazzulli JR, Graziotto J, Mrejeru A, Mosharov EV, Puspita L, Valiulahi P, Sulzer D, Milner TA, Taldone T, Krainc D, Studer L, Shim JW.

Stem Cell Reports. 2016 Oct 11;7(4):664-677. doi: 10.1016/j.stemcr.2016.08.012. Epub 2016 Sep 15.

33.

Même pas mal.

Kapanci L, Langhart J, Lembo AB, Shore C, Steger VJ, Studer LB, Leiba J, Cosson P.

Rev Med Suisse. 2016 Jun 1;12(521):1113. French. No abstract available.

PMID:
27487681
34.

Opportunities for Integrating Physical Health Within Assertive Community Treatment Teams: Results from Practitioner Focus Groups.

Meyer-Kalos PS, Lee MG, Studer LM, Line TA, Fisher CM.

Community Ment Health J. 2017 Apr;53(3):306-315. doi: 10.1007/s10597-016-0043-1. Epub 2016 Jul 11.

PMID:
27401164
35.

Derivation of Diverse Hormone-Releasing Pituitary Cells from Human Pluripotent Stem Cells.

Zimmer B, Piao J, Ramnarine K, Tomishima MJ, Tabar V, Studer L.

Stem Cell Reports. 2016 Jun 14;6(6):858-872. doi: 10.1016/j.stemcr.2016.05.005.

36.

Policy: Global standards for stem-cell research.

Kimmelman J, Hyun I, Benvenisty N, Caulfield T, Heslop HE, Murry CE, Sipp D, Studer L, Sugarman J, Daley GQ.

Nature. 2016 May 19;533(7603):311-3. doi: 10.1038/533311a. No abstract available.

PMID:
27193661
37.

Setting Global Standards for Stem Cell Research and Clinical Translation: The 2016 ISSCR Guidelines.

Daley GQ, Hyun I, Apperley JF, Barker RA, Benvenisty N, Bredenoord AL, Breuer CK, Caulfield T, Cedars MI, Frey-Vasconcells J, Heslop HE, Jin Y, Lee RT, McCabe C, Munsie M, Murry CE, Piantadosi S, Rao M, Rooke HM, Sipp D, Studer L, Sugarman J, Takahashi M, Zimmerman M, Kimmelman J.

Stem Cell Reports. 2016 Jun 14;6(6):787-797. doi: 10.1016/j.stemcr.2016.05.001. Epub 2016 May 12.

38.

New ISSCR guidelines: clinical translation of stem cell research.

Kimmelman J, Heslop HE, Sugarman J, Studer L, Benvenisty N, Caulfield T, Hyun I, Murry CE, Sipp D, Daley GQ.

Lancet. 2016 May 14;387(10032):1979-81. No abstract available.

PMID:
27179752
39.

Feeder-free Derivation of Melanocytes from Human Pluripotent Stem Cells.

Callahan SJ, Mica Y, Studer L.

J Vis Exp. 2016 Mar 3;(109):e53806. doi: 10.3791/53806.

40.

Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease.

Fattahi F, Steinbeck JA, Kriks S, Tchieu J, Zimmer B, Kishinevsky S, Zeltner N, Mica Y, El-Nachef W, Zhao H, de Stanchina E, Gershon MD, Grikscheit TC, Chen S, Studer L.

Nature. 2016 Mar 3;531(7592):105-9. doi: 10.1038/nature16951. Epub 2016 Feb 10.

41.

α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models.

Mazzulli JR, Zunke F, Isacson O, Studer L, Krainc D.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1931-6. doi: 10.1073/pnas.1520335113. Epub 2016 Feb 2.

42.

Correction: Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors.

Deng X, Michaelson D, Tchieu J, Cheng J, Rothenstein D, Feldman R, Lee SG, Fuller J, Haimovitz-Friedman A, Studer L, Powell S, Fuks Z, Albert Hubbard EJ, Kolesnick R.

PLoS One. 2016 Jan 22;11(1):e0141673. doi: 10.1371/journal.pone.0141673. eCollection 2016. No abstract available.

43.

Pluripotent stem cell-based disease modeling: current hurdles and future promise.

Zeltner N, Studer L.

Curr Opin Cell Biol. 2015 Dec;37:102-10. doi: 10.1016/j.ceb.2015.10.008. Epub 2015 Nov 27. Review.

PMID:
26629748
44.

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.

Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R.

Stem Cell Reports. 2015 Dec 8;5(6):933-945. doi: 10.1016/j.stemcr.2015.10.011. Epub 2015 Nov 21.

45.

Back and forth in time: Directing age in iPSC-derived lineages.

Cornacchia D, Studer L.

Brain Res. 2017 Feb 1;1656:14-26. doi: 10.1016/j.brainres.2015.11.013. Epub 2015 Nov 17. Review.

46.

Functional Connectivity under Optogenetic Control Allows Modeling of Human Neuromuscular Disease.

Steinbeck JA, Jaiswal MK, Calder EL, Kishinevsky S, Weishaupt A, Toyka KV, Goldstein PA, Studer L.

Cell Stem Cell. 2016 Jan 7;18(1):134-43. doi: 10.1016/j.stem.2015.10.002. Epub 2015 Nov 5.

47.

When rejuvenation is a problem: challenges of modeling late-onset neurodegenerative disease.

Vera E, Studer L.

Development. 2015 Sep 15;142(18):3085-9. doi: 10.1242/dev.120667. Review.

48.

G-Force PD: a global initiative in coordinating stem cell-based dopamine treatments for Parkinson's disease.

Barker RA, Studer L, Cattaneo E, Takahashi J; G-Force PD consortium.

NPJ Parkinsons Dis. 2015 Sep 24;1:15017. doi: 10.1038/npjparkd.2015.17. eCollection 2015.

49.

Neural Crest Cells from Dual SMAD Inhibition.

Fattahi F, Studer L, Tomishima MJ.

Curr Protoc Stem Cell Biol. 2015 May 1;33:1H.9.1-1H.9.9. doi: 10.1002/9780470151808.sc01h09s33.

PMID:
26344232
50.

Retinoic Acid-Mediated Regulation of GLI3 Enables Efficient Motoneuron Derivation from Human ESCs in the Absence of Extrinsic SHH Activation.

Calder EL, Tchieu J, Steinbeck JA, Tu E, Keros S, Ying SW, Jaiswal MK, Cornacchia D, Goldstein PA, Tabar V, Studer L.

J Neurosci. 2015 Aug 19;35(33):11462-81. doi: 10.1523/JNEUROSCI.3046-14.2015.

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