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Items: 50

1.

The POU4F2/Brn-3b transcription factor is required for the hypertrophic response to angiotensin II in the heart.

Mele L, Maskell LJ, Stuckey DJ, Clark JE, Heads RJ, Budhram-Mahadeo VS.

Cell Death Dis. 2019 Aug 14;10(8):621. doi: 10.1038/s41419-019-1848-y.

2.

In Utero Gene Therapy (IUGT) Using GLOBE Lentiviral Vector Phenotypically Corrects the Heterozygous Humanised Mouse Model and Its Progress Can Be Monitored Using MRI Techniques.

Shangaris P, Loukogeorgakis SP, Subramaniam S, Flouri C, Jackson LH, Wang W, Blundell MP, Liu S, Eaton S, Bakhamis N, Ramachandra DL, Maghsoudlou P, Urbani L, Waddington SN, Eddaoudi A, Archer J, Antoniou MN, Stuckey DJ, Schmidt M, Thrasher AJ, Ryan TM, Coppi P, David AL.

Sci Rep. 2019 Aug 12;9(1):11592. doi: 10.1038/s41598-019-48078-4.

3.

MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo.

Fiedler LR, Chapman K, Xie M, Maifoshie E, Jenkins M, Golforoush PA, Bellahcene M, Noseda M, Faust D, Jarvis A, Newton G, Paiva MA, Harada M, Stuckey DJ, Song W, Habib J, Narasimham P, Aqil R, Sanmugalingam D, Yan R, Pavanello L, Sano M, Wang SC, Sampson RD, Kanayaganam S, Taffet GE, Michael LH, Entman ML, Tan TH, Harding SE, Low CMR, Tralau-Stewart C, Perrior T, Schneider MD.

Cell Stem Cell. 2019 Apr 4;24(4):579-591.e12. doi: 10.1016/j.stem.2019.01.013. Epub 2019 Mar 7.

4.

Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function.

Dupays L, Towers N, Wood S, David A, Stuckey DJ, Mohun T.

PLoS One. 2019 Mar 6;14(3):e0212992. doi: 10.1371/journal.pone.0212992. eCollection 2019.

5.

Complex Congenital Heart Disease Associated With Disordered Myocardial Architecture in a Midtrimester Human Fetus.

Garcia-Canadilla P, Dejea H, Bonnin A, Balicevic V, Loncaric S, Zhang C, Butakoff C, Aguado-Sierra J, Vázquez M, Jackson LH, Stuckey DJ, Rau C, Stampanoni M, Bijnens B, Cook AC.

Circ Cardiovasc Imaging. 2018 Oct;11(10):e007753. doi: 10.1161/CIRCIMAGING.118.007753.

PMID:
30354476
6.

Auxetic Cardiac Patches with Tunable Mechanical and Conductive Properties toward Treating Myocardial Infarction.

Kapnisi M, Mansfield C, Marijon C, Guex AG, Perbellini F, Bardi I, Humphrey EJ, Puetzer JL, Mawad D, Koutsogeorgis DC, Stuckey DJ, Terracciano CM, Harding SE, Stevens MM.

Adv Funct Mater. 2018 May 24;28(21):1800618. doi: 10.1002/adfm.201800618.

7.

Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor.

Wang Z, Stuckey DJ, Murdoch CE, Camelliti P, Lip GYH, Griffin M.

Cell Death Dis. 2018 Apr 27;9(6):613. doi: 10.1038/s41419-018-0573-2.

8.

Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Encapsulating Bioactive Hydrogels Improve Rat Heart Function Post Myocardial Infarction.

Chow A, Stuckey DJ, Kidher E, Rocco M, Jabbour RJ, Mansfield CA, Darzi A, Harding SE, Stevens MM, Athanasiou T.

Stem Cell Reports. 2017 Nov 14;9(5):1415-1422. doi: 10.1016/j.stemcr.2017.09.003. Epub 2017 Oct 5.

9.

Direct comparison of high-temporal-resolution CINE MRI with Doppler ultrasound for assessment of diastolic dysfunction in mice.

Roberts TA, Price AN, Jackson LH, Taylor V, David AL, Lythgoe MF, Stuckey DJ.

NMR Biomed. 2017 Oct;30(10). doi: 10.1002/nbm.3763. Epub 2017 Jun 23.

10.

Multimodal Hydrogel-Based Platform To Deliver and Monitor Cardiac Progenitor/Stem Cell Engraftment.

Speidel AT, Stuckey DJ, Chow LW, Jackson LH, Noseda M, Abreu Paiva M, Schneider MD, Stevens MM.

ACS Cent Sci. 2017 Apr 26;3(4):338-348. doi: 10.1021/acscentsci.7b00039. Epub 2017 Mar 30.

11.

Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease.

Hasham MG, Baxan N, Stuckey DJ, Branca J, Perkins B, Dent O, Duffy T, Hameed TS, Stella SE, Bellahcene M, Schneider MD, Harding SE, Rosenthal N, Sattler S.

Dis Model Mech. 2017 Mar 1;10(3):259-270. doi: 10.1242/dmm.027409.

12.

Non-invasive MRI biomarkers for the early assessment of iron overload in a humanized mouse model of β-thalassemia.

Jackson LH, Vlachodimitropoulou E, Shangaris P, Roberts TA, Ryan TM, Campbell-Washburn AE, David AL, Porter JB, Lythgoe MF, Stuckey DJ.

Sci Rep. 2017 Feb 27;7:43439. doi: 10.1038/srep43439.

13.

Use of high-frequency ultrasound to study the prenatal development of cranial neural tube defects and hydrocephalus in Gldc-deficient mice.

Autuori MC, Pai YJ, Stuckey DJ, Savery D, Marconi AM, Massa V, Lythgoe MF, Copp AJ, David AL, Greene ND.

Prenat Diagn. 2017 Mar;37(3):273-281. doi: 10.1002/pd.5004. Epub 2017 Feb 17.

14.

Monitoring the Growth of an Orthotopic Tumour Xenograft Model: Multi-Modal Imaging Assessment with Benchtop MRI (1T), High-Field MRI (9.4T), Ultrasound and Bioluminescence.

Ramasawmy R, Johnson SP, Roberts TA, Stuckey DJ, David AL, Pedley RB, Lythgoe MF, Siow B, Walker-Samuel S.

PLoS One. 2016 May 25;11(5):e0156162. doi: 10.1371/journal.pone.0156162. eCollection 2016.

15.

On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury.

Cole MA, Abd Jamil AH, Heather LC, Murray AJ, Sutton ER, Slingo M, Sebag-Montefiore L, Tan SC, Aksentijević D, Gildea OS, Stuckey DJ, Yeoh KK, Carr CA, Evans RD, Aasum E, Schofield CJ, Ratcliffe PJ, Neubauer S, Robbins PA, Clarke K.

FASEB J. 2016 Aug;30(8):2684-97. doi: 10.1096/fj.201500094R. Epub 2016 Apr 21.

16.

Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.

Castillo SD, Tzouanacou E, Zaw-Thin M, Berenjeno IM, Parker VE, Chivite I, Milà-Guasch M, Pearce W, Solomon I, Angulo-Urarte A, Figueiredo AM, Dewhurst RE, Knox RG, Clark GR, Scudamore CL, Badar A, Kalber TL, Foster J, Stuckey DJ, David AL, Phillips WA, Lythgoe MF, Wilson V, Semple RK, Sebire NJ, Kinsler VA, Graupera M, Vanhaesebroeck B.

Sci Transl Med. 2016 Mar 30;8(332):332ra43. doi: 10.1126/scitranslmed.aad9982.

17.

Origins of the vagal drive controlling left ventricular contractility.

Machhada A, Marina N, Korsak A, Stuckey DJ, Lythgoe MF, Gourine AV.

J Physiol. 2016 Jul 15;594(14):4017-30. doi: 10.1113/JP270984. Epub 2016 Apr 28.

18.

PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium.

Noseda M, Harada M, McSweeney S, Leja T, Belian E, Stuckey DJ, Abreu Paiva MS, Habib J, Macaulay I, de Smith AJ, al-Beidh F, Sampson R, Lumbers RT, Rao P, Harding SE, Blakemore AI, Jacobsen SE, Barahona M, Schneider MD.

Nat Commun. 2015 May 18;6:6930. doi: 10.1038/ncomms7930.

19.

Computational modeling of Takotsubo cardiomyopathy: effect of spatially varying β-adrenergic stimulation in the rat left ventricle.

Land S, Niederer SA, Louch WE, Røe ÅT, Aronsen JM, Stuckey DJ, Sikkel MB, Tranter MH, Lyon AR, Harding SE, Smith NP.

Am J Physiol Heart Circ Physiol. 2014 Nov 15;307(10):H1487-96. doi: 10.1152/ajpheart.00443.2014. Epub 2014 Sep 19.

20.

Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy.

Dodd MS, Atherton HJ, Carr CA, Stuckey DJ, West JA, Griffin JL, Radda GK, Clarke K, Heather LC, Tyler DJ.

Circ Cardiovasc Imaging. 2014 Nov;7(6):895-904. doi: 10.1161/CIRCIMAGING.114.001857. Epub 2014 Sep 8.

21.

T₁ mapping detects pharmacological retardation of diffuse cardiac fibrosis in mouse pressure-overload hypertrophy.

Stuckey DJ, McSweeney SJ, Thin MZ, Habib J, Price AN, Fiedler LR, Gsell W, Prasad SK, Schneider MD.

Circ Cardiovasc Imaging. 2014 Mar;7(2):240-9. doi: 10.1161/CIRCIMAGING.113.000993. Epub 2014 Jan 14.

PMID:
24425501
22.

Rearrangement of atrial bundle architecture and consequent changes in anisotropy of conduction constitute the 3-dimensional substrate for atrial fibrillation.

Maesen B, Zeemering S, Afonso C, Eckstein J, Burton RA, van Hunnik A, Stuckey DJ, Tyler D, Maessen J, Grau V, Verheule S, Kohl P, Schotten U.

Circ Arrhythm Electrophysiol. 2013 Oct;6(5):967-75. doi: 10.1161/CIRCEP.113.000050. Epub 2013 Aug 22.

PMID:
23969531
23.

Metabolic imaging of acute and chronic infarction in the perfused rat heart using hyperpolarised [1-13C]pyruvate.

Ball DR, Cruickshank R, Carr CA, Stuckey DJ, Lee P, Clarke K, Tyler DJ.

NMR Biomed. 2013 Nov;26(11):1441-50. doi: 10.1002/nbm.2972. Epub 2013 Jun 14.

PMID:
23775685
24.

MEN1 gene replacement therapy reduces proliferation rates in a mouse model of pituitary adenomas.

Walls GV, Lemos MC, Javid M, Bazan-Peregrino M, Jeyabalan J, Reed AA, Harding B, Tyler DJ, Stuckey DJ, Piret S, Christie PT, Ansorge O, Clarke K, Seymour L, Thakker RV.

Cancer Res. 2012 Oct 1;72(19):5060-8. doi: 10.1158/0008-5472.CAN-12-1821. Epub 2012 Aug 21.

25.

Human cardiosphere-derived cells from patients with chronic ischaemic heart disease can be routinely expanded from atrial but not epicardial ventricular biopsies.

Chan HH, Meher Homji Z, Gomes RS, Sweeney D, Thomas GN, Tan JJ, Zhang H, Perbellini F, Stuckey DJ, Watt SM, Taggart D, Clarke K, Martin-Rendon E, Carr CA.

J Cardiovasc Transl Res. 2012 Oct;5(5):678-87. Epub 2012 Jul 3. Erratum in: J Cardiovasc Transl Res. 2012 Oct;5(5):688.

26.

High levels of circulating epinephrine trigger apical cardiodepression in a β2-adrenergic receptor/Gi-dependent manner: a new model of Takotsubo cardiomyopathy.

Paur H, Wright PT, Sikkel MB, Tranter MH, Mansfield C, O'Gara P, Stuckey DJ, Nikolaev VO, Diakonov I, Pannell L, Gong H, Sun H, Peters NS, Petrou M, Zheng Z, Gorelik J, Lyon AR, Harding SE.

Circulation. 2012 Aug 7;126(6):697-706. doi: 10.1161/CIRCULATIONAHA.112.111591. Epub 2012 Jun 25.

27.

Mice expressing a human K(ATP) channel mutation have altered channel ATP sensitivity but no cardiac abnormalities.

Clark R, Männikkö R, Stuckey DJ, Iberl M, Clarke K, Ashcroft FM.

Diabetologia. 2012 Apr;55(4):1195-204. doi: 10.1007/s00125-011-2428-6. Epub 2012 Jan 18.

28.

In vivo MRI characterization of progressive cardiac dysfunction in the mdx mouse model of muscular dystrophy.

Stuckey DJ, Carr CA, Camelliti P, Tyler DJ, Davies KE, Clarke K.

PLoS One. 2012;7(1):e28569. doi: 10.1371/journal.pone.0028569. Epub 2012 Jan 3.

29.

Efficient differentiation of human induced pluripotent stem cells generates cardiac cells that provide protection following myocardial infarction in the rat.

Carpenter L, Carr C, Yang CT, Stuckey DJ, Clarke K, Watt SM.

Stem Cells Dev. 2012 Apr 10;21(6):977-86. doi: 10.1089/scd.2011.0075. Epub 2012 Feb 15.

30.

Igf2 ligand dependency of Pten(+/-) developmental and tumour phenotypes in the mouse.

Church DN, Phillips BR, Stuckey DJ, Barnes DJ, Buffa FM, Manek S, Clarke K, Harris AL, Carter EJ, Hassan AB.

Oncogene. 2012 Aug 2;31(31):3635-46. doi: 10.1038/onc.2011.526. Epub 2011 Nov 28.

31.

Cardiosphere-derived cells improve function in the infarcted rat heart for at least 16 weeks--an MRI study.

Carr CA, Stuckey DJ, Tan JJ, Tan SC, Gomes RS, Camelliti P, Messina E, Giacomello A, Ellison GM, Clarke K.

PLoS One. 2011;6(10):e25669. doi: 10.1371/journal.pone.0025669. Epub 2011 Oct 17.

32.

First-pass perfusion CMR two days after infarction predicts severity of functional impairment six weeks later in the rat heart.

Stuckey DJ, Carr CA, Meader SJ, Tyler DJ, Cole MA, Clarke K.

J Cardiovasc Magn Reson. 2011 Aug 3;13:38. doi: 10.1186/1532-429X-13-38.

33.

Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse.

Song W, Dyer E, Stuckey DJ, Copeland O, Leung MC, Bayliss C, Messer A, Wilkinson R, Tremoleda JL, Schneider MD, Harding SE, Redwood CS, Clarke K, Nowak K, Monserrat L, Wells D, Marston SB.

J Biol Chem. 2011 Aug 5;286(31):27582-93. doi: 10.1074/jbc.M111.252320. Epub 2011 May 26.

34.

Diaphragm rescue alone prevents heart dysfunction in dystrophic mice.

Crisp A, Yin H, Goyenvalle A, Betts C, Moulton HM, Seow Y, Babbs A, Merritt T, Saleh AF, Gait MJ, Stuckey DJ, Clarke K, Davies KE, Wood MJ.

Hum Mol Genet. 2011 Feb 1;20(3):413-21. doi: 10.1093/hmg/ddq477. Epub 2010 Nov 9.

PMID:
21062902
35.

Ongoing dual-angle measurements for the correction of partial saturation in 31P MR spectroscopy.

Tyler DJ, Lopez O, Cole MA, Carr CA, Stuckey DJ, Lakatta E, Clarke K, Spencer RG.

Magn Reson Med. 2010 Oct;64(4):957-66. doi: 10.1002/mrm.22511.

36.

Magnetic resonance imaging evaluation of remodeling by cardiac elastomeric tissue scaffold biomaterials in a rat model of myocardial infarction.

Stuckey DJ, Ishii H, Chen QZ, Boccaccini AR, Hansen U, Carr CA, Roether JA, Jawad H, Tyler DJ, Ali NN, Clarke K, Harding SE.

Tissue Eng Part A. 2010 Nov;16(11):3395-402. doi: 10.1089/ten.TEA.2010.0213. Epub 2010 Jul 20.

PMID:
20528670
37.

Measurement and analysis of sarcomere length in rat cardiomyocytes in situ and in vitro.

Bub G, Camelliti P, Bollensdorff C, Stuckey DJ, Picton G, Burton RA, Clarke K, Kohl P.

Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1616-25. doi: 10.1152/ajpheart.00481.2009. Epub 2010 Mar 12.

38.

Functional and morphological maturation of implanted neonatal cardiomyocytes as a comparator for cell therapy.

Sato M, Carr CA, Stuckey DJ, Ishii H, Kanda GK, Terracciano CM, Siedlecka U, Tatton L, Watt SM, Martin-Rendon E, Clarke K, Harding SE.

Stem Cells Dev. 2010 Jul;19(7):1025-34. doi: 10.1089/scd.2009.0330.

PMID:
20053126
39.

Isoproterenol induces in vivo functional and metabolic abnormalities: similar to those found in the infarcted rat heart.

Heather LC, Catchpole AF, Stuckey DJ, Cole MA, Carr CA, Clarke K.

J Physiol Pharmacol. 2009 Sep;60(3):31-9.

40.

Critical role of complex III in the early metabolic changes following myocardial infarction.

Heather LC, Carr CA, Stuckey DJ, Pope S, Morten KJ, Carter EE, Edwards LM, Clarke K.

Cardiovasc Res. 2010 Jan 1;85(1):127-36. doi: 10.1093/cvr/cvp276.

PMID:
19666902
41.

Neural stem cell transplantation benefits a monogenic neurometabolic disorder during the symptomatic phase of disease.

Jeyakumar M, Lee JP, Sibson NR, Lowe JP, Stuckey DJ, Tester K, Fu G, Newlin R, Smith DA, Snyder EY, Platt FM.

Stem Cells. 2009 Sep;27(9):2362-70. doi: 10.1002/stem.163.

42.

Abnormal cardiac morphology, function and energy metabolism in the dystrophic mdx mouse: an MRI and MRS study.

Zhang W, ten Hove M, Schneider JE, Stuckey DJ, Sebag-Montefiore L, Bia BL, Radda GK, Davies KE, Neubauer S, Clarke K.

J Mol Cell Cardiol. 2008 Dec;45(6):754-60. doi: 10.1016/j.yjmcc.2008.09.125. Epub 2008 Sep 27.

PMID:
18929569
43.

Novel MRI method to detect altered left ventricular ejection and filling patterns in rodent models of disease.

Stuckey DJ, Carr CA, Tyler DJ, Aasum E, Clarke K.

Magn Reson Med. 2008 Sep;60(3):582-7. doi: 10.1002/mrm.21677.

44.

Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI study.

Carr CA, Stuckey DJ, Tatton L, Tyler DJ, Hale SJ, Sweeney D, Schneider JE, Martin-Rendon E, Radda GK, Harding SE, Watt SM, Clarke K.

Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H533-42. doi: 10.1152/ajpheart.00094.2008. Epub 2008 Jun 6.

45.

Cine-MRI versus two-dimensional echocardiography to measure in vivo left ventricular function in rat heart.

Stuckey DJ, Carr CA, Tyler DJ, Clarke K.

NMR Biomed. 2008 Aug;21(7):765-72. doi: 10.1002/nbm.1268.

PMID:
18457349
46.

Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart.

Murray AJ, Cole MA, Lygate CA, Carr CA, Stuckey DJ, Little SE, Neubauer S, Clarke K.

J Mol Cell Cardiol. 2008 Apr;44(4):694-700. doi: 10.1016/j.yjmcc.2008.01.008. Epub 2008 Feb 9.

PMID:
18328500
47.

Fatty acid transporter levels and palmitate oxidation rate correlate with ejection fraction in the infarcted rat heart.

Heather LC, Cole MA, Lygate CA, Evans RD, Stuckey DJ, Murray AJ, Neubauer S, Clarke K.

Cardiovasc Res. 2006 Dec 1;72(3):430-7. Epub 2006 Sep 1.

PMID:
17034771
48.

Iron particles for noninvasive monitoring of bone marrow stromal cell engraftment into, and isolation of viable engrafted donor cells from, the heart.

Stuckey DJ, Carr CA, Martin-Rendon E, Tyler DJ, Willmott C, Cassidy PJ, Hale SJ, Schneider JE, Tatton L, Harding SE, Radda GK, Watt S, Clarke K.

Stem Cells. 2006 Aug;24(8):1968-75. Epub 2006 Apr 20.

49.

MRS reveals additional hexose N-acetyl resonances in the brain of a mouse model for Sandhoff disease.

Lowe JP, Stuckey DJ, Awan FR, Jeyakumar M, Neville DC, Platt FM, Griffin JL, Styles P, Blamire AM, Sibson NR.

NMR Biomed. 2005 Dec;18(8):517-26.

PMID:
16206131
50.

Detection of the inhibitory neurotransmitter GABA in macrophages by magnetic resonance spectroscopy.

Stuckey DJ, Anthony DC, Lowe JP, Miller J, Palm WM, Styles P, Perry VH, Blamire AM, Sibson NR.

J Leukoc Biol. 2005 Aug;78(2):393-400. Epub 2005 May 20.

PMID:
15908457

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