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Items: 1 to 50 of 103

1.

The multidrug-resistance transporter MdfA from Escherichia coli: crystallization and X-ray diffraction analysis.

Nagarathinam K, Jaenecke F, Nakada-Nakura Y, Hotta Y, Liu K, Iwata S, Stubbs MT, Nomura N, Tanabe M.

Acta Crystallogr F Struct Biol Commun. 2017 Jul 1;73(Pt 7):423-430. doi: 10.1107/S2053230X17008500. Epub 2017 Jun 20.

PMID:
28695852
2.

Structural and functional analyses of pyroglutamate-amyloid-β-specific antibodies as a basis for Alzheimer immunotherapy.

Piechotta A, Parthier C, Kleinschmidt M, Gnoth K, Pillot T, Lues I, Demuth HU, Schilling S, Rahfeld JU, Stubbs MT.

J Biol Chem. 2017 Jul 28;292(30):12713-12724. doi: 10.1074/jbc.M117.777839. Epub 2017 Jun 16.

PMID:
28623233
3.

Nociceptive-Evoked Potentials Are Sensitive to Behaviorally Relevant Stimulus Displacements in Egocentric Coordinates.

Moayedi M, Di Stefano G, Stubbs MT, Djeugam B, Liang M, Iannetti GD.

eNeuro. 2016 Jul 11;3(3). pii: ENEURO.0151-15.2016. doi: 10.1523/ENEURO.0151-15.2016. eCollection 2016 May-Jun.

4.

Membrane composition influences the activity of in vitro refolded human vitamin K epoxide reductase.

Jaenecke F, Friedrich-Epler B, Parthier C, Stubbs MT.

Biochemistry. 2015 Oct 27;54(42):6454-61. doi: 10.1021/acs.biochem.5b00716. Epub 2015 Oct 9.

PMID:
26435421
5.

PspF-binding domain PspA1-144 and the PspA·F complex: New insights into the coiled-coil-dependent regulation of AAA+ proteins.

Osadnik H, Schöpfel M, Heidrich E, Mehner D, Lilie H, Parthier C, Risselada HJ, Grubmüller H, Stubbs MT, Brüser T.

Mol Microbiol. 2015 Nov;98(4):743-59. doi: 10.1111/mmi.13154. Epub 2015 Sep 10.

6.

High-resolution structures of the D-alanyl carrier protein (Dcp) DltC from Bacillus subtilis reveal equivalent conformations of apo- and holo-forms.

Zimmermann S, Pfennig S, Neumann P, Yonus H, Weininger U, Kovermann M, Balbach J, Stubbs MT.

FEBS Lett. 2015 Aug 19;589(18):2283-9. doi: 10.1016/j.febslet.2015.07.008. Epub 2015 Jul 17.

7.

Thermodynamic signatures in macromolecular interactions involving conformational flexibility.

Menzel A, Neumann P, Schwieger C, Stubbs MT.

Biol Chem. 2014 Jul;395(7-8):905-11. doi: 10.1515/hsz-2014-0177.

PMID:
25003391
8.

Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues.

Tziridis A, Rauh D, Neumann P, Kolenko P, Menzel A, Bräuer U, Ursel C, Steinmetzer P, Stürzebecher J, Schweinitz A, Steinmetzer T, Stubbs MT.

Biol Chem. 2014 Jul;395(7-8):891-903. doi: 10.1515/hsz-2014-0158.

PMID:
25003390
9.

Highlight: Conformational transitions in macromolecular interactions.

Stubbs MT.

Biol Chem. 2014 Jul;395(7-8):685-7. doi: 10.1515/hsz-2014-0208. No abstract available.

PMID:
25003380
10.

Deadenylation-a piece of PANcake.

Stubbs MT, Wahle E.

EMBO J. 2014 Jul 17;33(14):1503-5. doi: 10.15252/embj.201489136. Epub 2014 Jun 23. No abstract available.

11.

Structure of the Toll-Spatzle complex, a molecular hub in Drosophila development and innate immunity.

Parthier C, Stelter M, Ursel C, Fandrich U, Lilie H, Breithaupt C, Stubbs MT.

Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6281-6. doi: 10.1073/pnas.1320678111. Epub 2014 Apr 14.

12.

Disulfide linkage and structure of highly stable yeast-derived virus-like particles of murine polyomavirus.

Simon C, Klose T, Herbst S, Han BG, Sinz A, Glaeser RM, Stubbs MT, Lilie H.

J Biol Chem. 2014 Apr 11;289(15):10411-8. doi: 10.1074/jbc.M113.484162. Epub 2014 Feb 24.

13.

N-terminal protein modification by substrate-activated reverse proteolysis.

Liebscher S, Schöpfel M, Aumüller T, Sharkhuukhen A, Pech A, Höss E, Parthier C, Jahreis G, Stubbs MT, Bordusa F.

Angew Chem Int Ed Engl. 2014 Mar 10;53(11):3024-8. doi: 10.1002/anie.201307736. Epub 2014 Feb 12.

PMID:
24520050
14.

In vitro maturation of Drosophila melanogaster Spätzle protein with refolded Easter reveals a novel cleavage site within the prodomain.

Ursel C, Fandrich U, Hoffmann A, Sieg T, Ihling C, Stubbs MT.

Biol Chem. 2013 Aug;394(8):1069-75. doi: 10.1515/hsz-2013-0131.

PMID:
23729565
15.

High level expression of the Drosophila Toll receptor ectodomain and crystallization of its complex with the morphogen Spätzle.

Stelter M, Fandrich U, Franzke K, Schierhorn A, Breithaupt C, Parthier C, Stubbs MT.

Biol Chem. 2013 Aug;394(8):1091-6. doi: 10.1515/hsz-2013-0136.

PMID:
23729564
16.

Structure of glutaminyl cyclase from Drosophila melanogaster in space group I4.

Kolenko P, Koch B, Rahfeld JU, Schilling S, Demuth HU, Stubbs MT.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Apr 1;69(Pt 4):358-61. doi: 10.1107/S1744309113005575. Epub 2013 Mar 28.

17.

Peptide binding by catalytic domains of the protein disulfide isomerase-related protein ERp46.

Funkner A, Parthier C, Schutkowski M, Zerweck J, Lilie H, Gyrych N, Fischer G, Stubbs MT, Ferrari DM.

J Mol Biol. 2013 Apr 26;425(8):1340-62. doi: 10.1016/j.jmb.2013.01.029. Epub 2013 Jan 30.

PMID:
23376096
18.

No end in sight: the development of protein crystallography in Martinsried.

Stubbs MT, Baumann U.

Biol Chem. 2012 Oct;393(10):1025-6. doi: 10.1515/hsz-2012-0272. No abstract available.

PMID:
23089608
19.

Crystal structures of glutaminyl cyclases (QCs) from Drosophila melanogaster reveal active site conservation between insect and mammalian QCs.

Koch B, Kolenko P, Buchholz M, Carrillo DR, Parthier C, Wermann M, Rahfeld JU, Reuter G, Schilling S, Stubbs MT, Demuth HU.

Biochemistry. 2012 Sep 18;51(37):7383-92. doi: 10.1021/bi300687g. Epub 2012 Sep 5.

PMID:
22897232
20.

Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment.

Morgado I, Wieligmann K, Bereza M, Rönicke R, Meinhardt K, Annamalai K, Baumann M, Wacker J, Hortschansky P, Malešević M, Parthier C, Mawrin C, Schiene-Fischer C, Reymann KG, Stubbs MT, Balbach J, Görlach M, Horn U, Fändrich M.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12503-8. doi: 10.1073/pnas.1206433109. Epub 2012 Jul 18.

21.

Electron microscopy of biotinylated protein complexes bound to streptavidin monolayer crystals.

Han BG, Walton RW, Song A, Hwu P, Stubbs MT, Yannone SM, Arbeláez P, Dong M, Glaeser RM.

J Struct Biol. 2012 Oct;180(1):249-53. doi: 10.1016/j.jsb.2012.04.025. Epub 2012 May 11.

PMID:
22584152
22.

The O-carbamoyltransferase TobZ catalyzes an ancient enzymatic reaction.

Parthier C, Görlich S, Jaenecke F, Breithaupt C, Bräuer U, Fandrich U, Clausnitzer D, Wehmeier UF, Böttcher C, Scheel D, Stubbs MT.

Angew Chem Int Ed Engl. 2012 Apr 23;51(17):4046-52. doi: 10.1002/anie.201108896. Epub 2012 Mar 1. Review. No abstract available.

PMID:
22383337
23.

Flexing and stretching in nonribosomal Peptide synthetases.

Pfennig S, Stubbs MT.

Chem Biol. 2012 Feb 24;19(2):167-9. doi: 10.1016/j.chembiol.2012.02.002.

24.

Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center.

Ruiz-Carrillo D, Koch B, Parthier C, Wermann M, Dambe T, Buchholz M, Ludwig HH, Heiser U, Rahfeld JU, Stubbs MT, Schilling S, Demuth HU.

Biochemistry. 2011 Jul 19;50(28):6280-8. doi: 10.1021/bi200249h. Epub 2011 Jun 27.

PMID:
21671571
25.

Towards a restriction proteinase: construction of a self-activating enzyme.

Schöpfel M, Tziridis A, Arnold U, Stubbs MT.

Chembiochem. 2011 Jul 4;12(10):1523-7. doi: 10.1002/cbic.201000787. Epub 2011 Mar 8. No abstract available.

PMID:
21387509
26.

Amyloid fibril recognition with the conformational B10 antibody fragment depends on electrostatic interactions.

Haupt C, Morgado I, Kumar ST, Parthier C, Bereza M, Hortschansky P, Stubbs MT, Horn U, Fändrich M.

J Mol Biol. 2011 Jan 14;405(2):341-8. doi: 10.1016/j.jmb.2010.10.059. Epub 2010 Nov 6.

PMID:
21059358
27.

Kinetic and structural characterization of bacterial glutaminyl cyclases from Zymomonas mobilis and Myxococcus xanthus.

Carrillo DR, Parthier C, Jänckel N, Grandke J, Stelter M, Schilling S, Boehme M, Neumann P, Wolf R, Demuth HU, Stubbs MT, Rahfeld JU.

Biol Chem. 2010 Dec;391(12):1419-28. doi: 10.1515/BC.2010.130.

PMID:
20868223
28.

Impact of the C-terminal disulfide bond on the folding and stability of onconase.

Schulenburg C, Weininger U, Neumann P, Meiselbach H, Stubbs MT, Sticht H, Balbach J, Ulbrich-Hofmann R, Arnold U.

Chembiochem. 2010 May 3;11(7):978-86. doi: 10.1002/cbic.200900773.

PMID:
20349493
29.

Crystal structure determination and functional characterization of the metallochaperone SlyD from Thermus thermophilus.

Löw C, Neumann P, Tidow H, Weininger U, Haupt C, Friedrich-Epler B, Scholz C, Stubbs MT, Balbach J.

J Mol Biol. 2010 May 7;398(3):375-90. doi: 10.1016/j.jmb.2010.03.014. Epub 2010 Mar 15.

PMID:
20230833
30.

A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding.

Maestre-Martínez M, Haupt K, Edlich F, Neumann P, Parthier C, Stubbs MT, Fischer G, Lücke C.

J Mol Recognit. 2011 Jan-Feb;24(1):23-34. doi: 10.1002/jmr.1020.

PMID:
20140889
31.

Structure-based stability analysis of an extremely stable dimeric DNA binding protein from Sulfolobus islandicus.

Weininger U, Zeeb M, Neumann P, Löw C, Stubbs MT, Lipps G, Balbach J.

Biochemistry. 2009 Oct 27;48(42):10030-7. doi: 10.1021/bi900760n.

PMID:
19788170
32.

Sinapoyltransferases in the light of molecular evolution.

Stehle F, Brandt W, Stubbs MT, Milkowski C, Strack D.

Phytochemistry. 2009 Oct-Nov;70(15-16):1652-62. doi: 10.1016/j.phytochem.2009.07.023. Epub 2009 Aug 18. Review.

PMID:
19695650
33.

Passing the baton in class B GPCRs: peptide hormone activation via helix induction?

Parthier C, Reedtz-Runge S, Rudolph R, Stubbs MT.

Trends Biochem Sci. 2009 Jun;34(6):303-10. doi: 10.1016/j.tibs.2009.02.004. Epub 2009 May 14. Review.

PMID:
19446460
34.

Crystal structure of the Borna disease virus matrix protein (BDV-M) reveals ssRNA binding properties.

Neumann P, Lieber D, Meyer S, Dautel P, Kerth A, Kraus I, Garten W, Stubbs MT.

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3710-5. doi: 10.1073/pnas.0808101106. Epub 2009 Feb 23.

35.

Crystal structure and functional analysis of the protein disulfide isomerase-related protein ERp29.

Barak NN, Neumann P, Sevvana M, Schutkowski M, Naumann K, Malesević M, Reichardt H, Fischer G, Stubbs MT, Ferrari DM.

J Mol Biol. 2009 Feb 6;385(5):1630-42. doi: 10.1016/j.jmb.2008.11.052. Epub 2008 Dec 3.

PMID:
19084538
36.

Structural basis for membrane binding and catalytic activation of the peripheral membrane enzyme pyruvate oxidase from Escherichia coli.

Neumann P, Weidner A, Pech A, Stubbs MT, Tittmann K.

Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17390-5. doi: 10.1073/pnas.0805027105. Epub 2008 Nov 6.

37.

Biophysical characterization of refolded Drosophila Spätzle, a cystine knot protein, reveals distinct properties of three isoforms.

Hoffmann A, Funkner A, Neumann P, Juhnke S, Walther M, Schierhorn A, Weininger U, Balbach J, Reuter G, Stubbs MT.

J Biol Chem. 2008 Nov 21;283(47):32598-609. doi: 10.1074/jbc.M801815200. Epub 2008 Sep 12.

38.

Crystal structure of DltA. Implications for the reaction mechanism of non-ribosomal peptide synthetase adenylation domains.

Yonus H, Neumann P, Zimmermann S, May JJ, Marahiel MA, Stubbs MT.

J Biol Chem. 2008 Nov 21;283(47):32484-91. doi: 10.1074/jbc.M800557200. Epub 2008 Sep 10.

39.

Crystallization of Spätzle, a cystine-knot protein involved in embryonic development and innate immunity in Drosophila melanogaster.

Hoffmann A, Neumann P, Schierhorn A, Stubbs MT.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Aug 1;64(Pt 8):707-10. doi: 10.1107/S1744309108018812. Epub 2008 Jul 5.

40.

Functional and structural characterization of a cation-dependent O-methyltransferase from the cyanobacterium Synechocystis sp. strain PCC 6803.

Kopycki JG, Stubbs MT, Brandt W, Hagemann M, Porzel A, Schmidt J, Schliemann W, Zenk MH, Vogt T.

J Biol Chem. 2008 Jul 25;283(30):20888-96. doi: 10.1074/jbc.M801943200. Epub 2008 May 23.

41.

Biochemical and structural analysis of substrate promiscuity in plant Mg2+-dependent O-methyltransferases.

Kopycki JG, Rauh D, Chumanevich AA, Neumann P, Vogt T, Stubbs MT.

J Mol Biol. 2008 Apr 18;378(1):154-64. doi: 10.1016/j.jmb.2008.02.019. Epub 2008 Feb 20.

PMID:
18342334
42.

Crystallization and preliminary X-ray diffraction analysis of full-length and proteolytically activated pyruvate oxidase from Escherichia coli.

Weidner A, Neumann P, Wille G, Stubbs MT, Tittmann K.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Mar 1;64(Pt 3):179-81. doi: 10.1107/S1744309108003473. Epub 2008 Feb 23.

43.

Structural insights into an equilibrium folding intermediate of an archaeal ankyrin repeat protein.

Löw C, Weininger U, Neumann P, Klepsch M, Lilie H, Stubbs MT, Balbach J.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3779-84. doi: 10.1073/pnas.0710657105. Epub 2008 Feb 27.

44.

Heterologous expression of a serine carboxypeptidase-like acyltransferase and characterization of the kinetic mechanism.

Stehle F, Stubbs MT, Strack D, Milkowski C.

FEBS J. 2008 Feb;275(4):775-87. doi: 10.1111/j.1742-4658.2007.06244.x. Epub 2008 Jan 11.

45.

Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor.

Parthier C, Kleinschmidt M, Neumann P, Rudolph R, Manhart S, Schlenzig D, Fanghänel J, Rahfeld JU, Demuth HU, Stubbs MT.

Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):13942-7. Epub 2007 Aug 21.

46.

Affilin-novel binding molecules based on human gamma-B-crystallin, an all beta-sheet protein.

Ebersbach H, Fiedler E, Scheuermann T, Fiedler M, Stubbs MT, Reimann C, Proetzel G, Rudolph R, Fiedler U.

J Mol Biol. 2007 Sep 7;372(1):172-85. Epub 2007 Jun 22.

PMID:
17628592
47.

Aminoacyl-coenzyme A synthesis catalyzed by adenylation domains.

Linne U, Schäfer A, Stubbs MT, Marahiel MA.

FEBS Lett. 2007 Mar 6;581(5):905-10. Epub 2007 Feb 7.

48.

The crystal structure of Plasmodium falciparum glutamate dehydrogenase, a putative target for novel antimalarial drugs.

Werner C, Stubbs MT, Krauth-Siegel RL, Klebe G.

J Mol Biol. 2005 Jun 10;349(3):597-607. Epub 2005 Apr 12.

PMID:
15878595
49.

Crystallographic study of inhibitors of tRNA-guanine transglycosylase suggests a new structure-based pharmacophore for virtual screening.

Brenk R, Meyer EA, Reuter K, Stubbs MT, Garcia GA, Diederich F, Klebe G.

J Mol Biol. 2004 Apr 16;338(1):55-75.

PMID:
15050823
50.

Understanding protein-ligand interactions: the price of protein flexibility.

Rauh D, Klebe G, Stubbs MT.

J Mol Biol. 2004 Jan 30;335(5):1325-41.

PMID:
14729347

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