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Items: 1 to 50 of 284

1.

Genetic Identification of Two Novel Loci Associated with Steroid-Sensitive Nephrotic Syndrome.

Dufek S, Cheshire C, Levine AP, Trompeter RS, Issler N, Stubbs M, Mozere M, Gupta S, Klootwijk E, Patel V, Hothi D, Waters A, Webb H, Tullus K, Jenkins L, Godinho L, Levtchenko E, Wetzels J, Knoers N, Teeninga N, Nauta J, Shalaby M, Eldesoky S, Kari JA, Thalgahagoda S, Ranawaka R, Abeyagunawardena A, Adeyemo A, Kristiansen M, Gbadegesin R, Webb NJ, Gale DP, Stanescu HC, Kleta R, Bockenhauer D.

J Am Soc Nephrol. 2019 Jul 1. pii: ASN.2018101054. doi: 10.1681/ASN.2018101054. [Epub ahead of print]

PMID:
31263063
2.

Germline mutations in the transcription factor IKZF5 cause thrombocytopenia.

Lentaigne C, Greene D, Sivapalaratnam S, Favier R, Seyres D, Thys C, Grassi L, Mangles S, Sibson K, Stubbs MJ, Burden F, Bordet JC, Armari-Alla C, Erber W, Farrow S, Gleadall N, Gomez K, Megy K, Papadia S, Penkett CJ, Sims MC, Stefanucci L, Stephens JC, Read RJ, Stirrups KE, Ouwehand WH, Laffan MA, Frontini M, Freson K, Turro E.

Blood. 2019 Jun 19. pii: blood.2019000782. doi: 10.1182/blood.2019000782. [Epub ahead of print]

PMID:
31217188
3.

Comparison of Rituximab originator (MabThera) to biosimilar (Truxima) in patients with immune-mediated thrombotic thrombocytopenic purpura.

Stubbs MJ, Low R, McGuckin S, Newton R, Thomas M, Westwood JP, Shah R, Cheesman S, Scully MA.

Br J Haematol. 2019 Jun;185(5):912-917. doi: 10.1111/bjh.15874. Epub 2019 Mar 28.

PMID:
30919938
4.

Administration of immunoglobulin G-degrading enzyme of Streptococcus pyogenes (IdeS) for persistent anti-ADAMTS13 antibodies in patients with thrombotic thrombocytopenic purpura in clinical remission.

Stubbs MJ, Thomas M, Vendramin C, Sonesson E, Kjellman C, Järnum S, Stenberg Y, Elfving C, Scully M.

Br J Haematol. 2019 Jul;186(1):137-140. doi: 10.1111/bjh.15706. Epub 2018 Nov 29. No abstract available.

PMID:
30488420
5.

Outward open conformation of a Major Facilitator Superfamily multidrug/H+ antiporter provides insights into switching mechanism.

Nagarathinam K, Nakada-Nakura Y, Parthier C, Terada T, Juge N, Jaenecke F, Liu K, Hotta Y, Miyaji T, Omote H, Iwata S, Nomura N, Stubbs MT, Tanabe M.

Nat Commun. 2018 Oct 1;9(1):4005. doi: 10.1038/s41467-018-06306-x.

6.

The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies.

Stubbs MC, Burn TC, Sparks R, Maduskuie T, Diamond S, Rupar M, Wen X, Volgina A, Zolotarjova N, Waeltz P, Favata M, Jalluri R, Liu H, Liu XM, Li J, Collins R, Falahatpisheh N, Polam P, DiMatteo D, Feldman P, Dostalik V, Thekkat P, Gardiner C, He X, Li Y, Covington M, Wynn R, Ruggeri B, Yeleswaram S, Xue CB, Yao W, Combs AP, Huber R, Hollis G, Scherle P, Liu PCC.

Clin Cancer Res. 2019 Jan 1;25(1):300-311. doi: 10.1158/1078-0432.CCR-18-0098. Epub 2018 Sep 11.

PMID:
30206163
7.

Patellar tendon properties distinguish elite from non-elite soccer players and are related to peak horizontal but not vertical power.

Murtagh CF, Stubbs M, Vanrenterghem J, O'Boyle A, Morgans R, Drust B, Erskine RM.

Eur J Appl Physiol. 2018 Aug;118(8):1737-1749. doi: 10.1007/s00421-018-3905-0. Epub 2018 Jun 2.

8.

A case series of outcomes in isolated subsegmental pulmonary embolism on ventilation-perfusion imaging.

Mallorie A, Chan K, Ioannidis S, Stubbs M, Navalkissoor S, Wagner T.

Nucl Med Commun. 2018 Jul;39(7):618-620. doi: 10.1097/MNM.0000000000000866.

PMID:
29846298
9.

The BET inhibitor INCB054329 reduces homologous recombination efficiency and augments PARP inhibitor activity in ovarian cancer.

Wilson AJ, Stubbs M, Liu P, Ruggeri B, Khabele D.

Gynecol Oncol. 2018 Jun;149(3):575-584. doi: 10.1016/j.ygyno.2018.03.049. Epub 2018 Mar 20.

10.

Deep vein thrombosis.

Stubbs MJ, Mouyis M, Thomas M.

BMJ. 2018 Feb 22;360:k351. doi: 10.1136/bmj.k351. Review. No abstract available. Erratum in: BMJ. 2018 Mar 21;360:k1335.

PMID:
29472180
11.

Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).

Chessum NEA, Sharp SY, Caldwell JJ, Pasqua AE, Wilding B, Colombano G, Collins I, Ozer B, Richards M, Rowlands M, Stubbs M, Burke R, McAndrew PC, Clarke PA, Workman P, Cheeseman MD, Jones K.

J Med Chem. 2018 Feb 8;61(3):918-933. doi: 10.1021/acs.jmedchem.7b01406. Epub 2018 Jan 5.

12.

MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma.

Lampis A, Carotenuto P, Vlachogiannis G, Cascione L, Hedayat S, Burke R, Clarke P, Bosma E, Simbolo M, Scarpa A, Yu S, Cole R, Smyth E, Mateos JF, Begum R, Hezelova B, Eltahir Z, Wotherspoon A, Fotiadis N, Bali MA, Nepal C, Khan K, Stubbs M, Hahne JC, Gasparini P, Guzzardo V, Croce CM, Eccles S, Fassan M, Cunningham D, Andersen JB, Workman P, Valeri N, Braconi C.

Gastroenterology. 2018 Mar;154(4):1066-1079.e5. doi: 10.1053/j.gastro.2017.10.043. Epub 2017 Nov 4.

13.

Murine Retrovirally-Transduced Bone Marrow Engraftment Models of MLL-Fusion-Driven Acute Myelogenous Leukemias (AML).

Stubbs MC, Krivtsov AV.

Curr Protoc Pharmacol. 2017 Sep 11;78:14.42.1-14.42.19. doi: 10.1002/cpph.28.

14.

The multidrug-resistance transporter MdfA from Escherichia coli: crystallization and X-ray diffraction analysis.

Nagarathinam K, Jaenecke F, Nakada-Nakura Y, Hotta Y, Liu K, Iwata S, Stubbs MT, Nomura N, Tanabe M.

Acta Crystallogr F Struct Biol Commun. 2017 Jul 1;73(Pt 7):423-430. doi: 10.1107/S2053230X17008500. Epub 2017 Jun 20.

15.

Structural and functional analyses of pyroglutamate-amyloid-β-specific antibodies as a basis for Alzheimer immunotherapy.

Piechotta A, Parthier C, Kleinschmidt M, Gnoth K, Pillot T, Lues I, Demuth HU, Schilling S, Rahfeld JU, Stubbs MT.

J Biol Chem. 2017 Jul 28;292(30):12713-12724. doi: 10.1074/jbc.M117.777839. Epub 2017 Jun 16.

16.

The action of β-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours: evidence of a β-hydroxybutyrate paradox.

Rodrigues LM, Uribe-Lewis S, Madhu B, Honess DJ, Stubbs M, Griffiths JR.

Cancer Metab. 2017 Feb 28;5:4. doi: 10.1186/s40170-017-0166-z. eCollection 2017.

17.

Incidence of a single subsegmental mismatched perfusion defect in single-photon emission computed tomography and planar ventilation/perfusion scans.

Stubbs M, Chan K, McMeekin H, Navalkissoor S, Wagner T.

Nucl Med Commun. 2017 Feb;38(2):135-140. doi: 10.1097/MNM.0000000000000632.

PMID:
27977536
18.

Assessment of Cardiac Troponin I Responses in Nonhuman Primates during Restraint, Blood Collection, and Dosing in Preclinical Safety Studies.

Reagan WJ, Barnes R, Harris P, Summers S, Lopes S, Stubbs M, Blackwell D, Steidl-Nichols J.

Toxicol Pathol. 2017 Feb;45(2):335-343. doi: 10.1177/0192623316663865. Epub 2016 Aug 20.

PMID:
27543323
19.

Nociceptive-Evoked Potentials Are Sensitive to Behaviorally Relevant Stimulus Displacements in Egocentric Coordinates.

Moayedi M, Di Stefano G, Stubbs MT, Djeugam B, Liang M, Iannetti GD.

eNeuro. 2016 Jul 11;3(3). pii: ENEURO.0151-15.2016. doi: 10.1523/ENEURO.0151-15.2016. eCollection 2016 May-Jun.

20.

2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19.

Mallinger A, Schiemann K, Rink C, Sejberg J, Honey MA, Czodrowski P, Stubbs M, Poeschke O, Busch M, Schneider R, Schwarz D, Musil D, Burke R, Urbahns K, Workman P, Wienke D, Clarke PA, Raynaud FI, Eccles SA, Esdar C, Rohdich F, Blagg J.

ACS Med Chem Lett. 2016 Mar 28;7(6):573-8. doi: 10.1021/acsmedchemlett.6b00022. eCollection 2016 Jun 9.

21.

Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19.

Mallinger A, Schiemann K, Rink C, Stieber F, Calderini M, Crumpler S, Stubbs M, Adeniji-Popoola O, Poeschke O, Busch M, Czodrowski P, Musil D, Schwarz D, Ortiz-Ruiz MJ, Schneider R, Thai C, Valenti M, de Haven Brandon A, Burke R, Workman P, Dale T, Wienke D, Clarke PA, Esdar C, Raynaud FI, Eccles SA, Rohdich F, Blagg J.

J Med Chem. 2016 Feb 11;59(3):1078-101. doi: 10.1021/acs.jmedchem.5b01685. Epub 2016 Jan 21.

22.

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.

Dale T, Clarke PA, Esdar C, Waalboer D, Adeniji-Popoola O, Ortiz-Ruiz MJ, Mallinger A, Samant RS, Czodrowski P, Musil D, Schwarz D, Schneider K, Stubbs M, Ewan K, Fraser E, TePoele R, Court W, Box G, Valenti M, de Haven Brandon A, Gowan S, Rohdich F, Raynaud F, Schneider R, Poeschke O, Blaukat A, Workman P, Schiemann K, Eccles SA, Wienke D, Blagg J.

Nat Chem Biol. 2015 Dec;11(12):973-980. doi: 10.1038/nchembio.1952. Epub 2015 Oct 26.

23.

Metabolomic changes during cellular transformation monitored by metabolite-metabolite correlation analysis and correlated with gene expression.

Madhu B, Narita M, Jauhiainen A, Menon S, Stubbs M, Tavaré S, Narita M, Griffiths JR.

Metabolomics. 2015;11(6):1848-1863. Epub 2015 Aug 11.

24.

Membrane composition influences the activity of in vitro refolded human vitamin K epoxide reductase.

Jaenecke F, Friedrich-Epler B, Parthier C, Stubbs MT.

Biochemistry. 2015 Oct 27;54(42):6454-61. doi: 10.1021/acs.biochem.5b00716. Epub 2015 Oct 9.

PMID:
26435421
25.

PspF-binding domain PspA1-144 and the PspA·F complex: New insights into the coiled-coil-dependent regulation of AAA+ proteins.

Osadnik H, Schöpfel M, Heidrich E, Mehner D, Lilie H, Parthier C, Risselada HJ, Grubmüller H, Stubbs MT, Brüser T.

Mol Microbiol. 2015 Nov;98(4):743-59. doi: 10.1111/mmi.13154. Epub 2015 Sep 10.

26.

High-resolution structures of the D-alanyl carrier protein (Dcp) DltC from Bacillus subtilis reveal equivalent conformations of apo- and holo-forms.

Zimmermann S, Pfennig S, Neumann P, Yonus H, Weininger U, Kovermann M, Balbach J, Stubbs MT.

FEBS Lett. 2015 Aug 19;589(18):2283-9. doi: 10.1016/j.febslet.2015.07.008. Epub 2015 Jul 17.

27.

Molecular mechanisms of human IRE1 activation through dimerization and ligand binding.

Joshi A, Newbatt Y, McAndrew PC, Stubbs M, Burke R, Richards MW, Bhatia C, Caldwell JJ, McHardy T, Collins I, Bayliss R.

Oncotarget. 2015 May 30;6(15):13019-35.

28.

Dengue fever in returning travellers.

Bain BJ, Stubbs MJ.

Am J Hematol. 2015 Mar;90(3):263. No abstract available.

PMID:
25839074
29.

Selective Inhibition of HDAC1 and HDAC2 as a Potential Therapeutic Option for B-ALL.

Stubbs MC, Kim W, Bariteau M, Davis T, Vempati S, Minehart J, Witkin M, Qi J, Krivtsov AV, Bradner JE, Kung AL, Armstrong SA.

Clin Cancer Res. 2015 May 15;21(10):2348-58. doi: 10.1158/1078-0432.CCR-14-1290. Epub 2015 Feb 16.

30.

Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.

Mallinger A, Crumpler S, Pichowicz M, Waalboer D, Stubbs M, Adeniji-Popoola O, Wood B, Smith E, Thai C, Henley AT, Georgi K, Court W, Hobbs S, Box G, Ortiz-Ruiz MJ, Valenti M, De Haven Brandon A, TePoele R, Leuthner B, Workman P, Aherne W, Poeschke O, Dale T, Wienke D, Esdar C, Rohdich F, Raynaud F, Clarke PA, Eccles SA, Stieber F, Schiemann K, Blagg J.

J Med Chem. 2015 Feb 26;58(4):1717-35. doi: 10.1021/jm501436m. Epub 2015 Feb 13.

31.

RAS mutation status and bortezomib therapy for relapsed multiple myeloma.

Smith D, Armenteros E, Percy L, Kumar M, Lach A, Herledan G, Stubbs M, Downward J, Yong K.

Br J Haematol. 2015 Jun;169(6):905-8. doi: 10.1111/bjh.13258. Epub 2015 Jan 12. No abstract available.

PMID:
25580780
32.

Thermodynamic signatures in macromolecular interactions involving conformational flexibility.

Menzel A, Neumann P, Schwieger C, Stubbs MT.

Biol Chem. 2014 Jul;395(7-8):905-11. doi: 10.1515/hsz-2014-0177.

PMID:
25003391
33.

Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues.

Tziridis A, Rauh D, Neumann P, Kolenko P, Menzel A, Bräuer U, Ursel C, Steinmetzer P, Stürzebecher J, Schweinitz A, Steinmetzer T, Stubbs MT.

Biol Chem. 2014 Jul;395(7-8):891-903. doi: 10.1515/hsz-2014-0158.

PMID:
25003390
34.

Highlight: Conformational transitions in macromolecular interactions.

Stubbs MT.

Biol Chem. 2014 Jul;395(7-8):685-7. doi: 10.1515/hsz-2014-0208. No abstract available.

PMID:
25003380
35.

Deadenylation-a piece of PANcake.

Stubbs MT, Wahle E.

EMBO J. 2014 Jul 17;33(14):1503-5. doi: 10.15252/embj.201489136. Epub 2014 Jun 23. No abstract available.

36.

Access to primary care physicians differs by health insurance coverage in Mississippi.

Cossman RE, Cossman JS, Rogers S, McBride D, Song X, Sutton L, Stubbs M.

South Med J. 2014 Feb;107(2):87-90. doi: 10.1097/SMJ.0000000000000057.

PMID:
24926673
37.

Structure of the Toll-Spatzle complex, a molecular hub in Drosophila development and innate immunity.

Parthier C, Stelter M, Ursel C, Fandrich U, Lilie H, Breithaupt C, Stubbs MT.

Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6281-6. doi: 10.1073/pnas.1320678111. Epub 2014 Apr 14.

38.

Disulfide linkage and structure of highly stable yeast-derived virus-like particles of murine polyomavirus.

Simon C, Klose T, Herbst S, Han BG, Sinz A, Glaeser RM, Stubbs MT, Lilie H.

J Biol Chem. 2014 Apr 11;289(15):10411-8. doi: 10.1074/jbc.M113.484162. Epub 2014 Feb 24.

39.

N-terminal protein modification by substrate-activated reverse proteolysis.

Liebscher S, Schöpfel M, Aumüller T, Sharkhuukhen A, Pech A, Höss E, Parthier C, Jahreis G, Stubbs MT, Bordusa F.

Angew Chem Int Ed Engl. 2014 Mar 10;53(11):3024-8. doi: 10.1002/anie.201307736. Epub 2014 Feb 12.

PMID:
24520050
40.

Noninvasive phosphorus magnetic resonance spectroscopic imaging predicts outcome to first-line chemotherapy in newly diagnosed patients with diffuse large B-cell lymphoma.

Arias-Mendoza F, Payne GS, Zakian K, Stubbs M, O'Connor OA, Mojahed H, Smith MR, Schwarz AJ, Shukla-Dave A, Howe F, Poptani H, Lee SC, Pettengel R, Schuster SJ, Cunningham D, Heerschap A, Glickson JD, Griffiths JR, Koutcher JA, Leach MO, Brown TR.

Acad Radiol. 2013 Sep;20(9):1122-9. doi: 10.1016/j.acra.2013.04.013.

41.

In vitro maturation of Drosophila melanogaster Spätzle protein with refolded Easter reveals a novel cleavage site within the prodomain.

Ursel C, Fandrich U, Hoffmann A, Sieg T, Ihling C, Stubbs MT.

Biol Chem. 2013 Aug;394(8):1069-75. doi: 10.1515/hsz-2013-0131.

PMID:
23729565
42.

High level expression of the Drosophila Toll receptor ectodomain and crystallization of its complex with the morphogen Spätzle.

Stelter M, Fandrich U, Franzke K, Schierhorn A, Breithaupt C, Parthier C, Stubbs MT.

Biol Chem. 2013 Aug;394(8):1091-6. doi: 10.1515/hsz-2013-0136.

PMID:
23729564
43.

Structure of glutaminyl cyclase from Drosophila melanogaster in space group I4.

Kolenko P, Koch B, Rahfeld JU, Schilling S, Demuth HU, Stubbs MT.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Apr 1;69(Pt 4):358-61. doi: 10.1107/S1744309113005575. Epub 2013 Mar 28.

44.

Peptide binding by catalytic domains of the protein disulfide isomerase-related protein ERp46.

Funkner A, Parthier C, Schutkowski M, Zerweck J, Lilie H, Gyrych N, Fischer G, Stubbs MT, Ferrari DM.

J Mol Biol. 2013 Apr 26;425(8):1340-62. doi: 10.1016/j.jmb.2013.01.029. Epub 2013 Jan 30.

PMID:
23376096
45.

Cell of origin determines clinically relevant subtypes of MLL-rearranged AML.

Krivtsov AV, Figueroa ME, Sinha AU, Stubbs MC, Feng Z, Valk PJ, Delwel R, Döhner K, Bullinger L, Kung AL, Melnick AM, Armstrong SA.

Leukemia. 2013 Apr;27(4):852-60. doi: 10.1038/leu.2012.363. Epub 2012 Dec 13.

46.

No end in sight: the development of protein crystallography in Martinsried.

Stubbs MT, Baumann U.

Biol Chem. 2012 Oct;393(10):1025-6. doi: 10.1515/hsz-2012-0272. No abstract available.

PMID:
23089608
47.

Crystal structures of glutaminyl cyclases (QCs) from Drosophila melanogaster reveal active site conservation between insect and mammalian QCs.

Koch B, Kolenko P, Buchholz M, Carrillo DR, Parthier C, Wermann M, Rahfeld JU, Reuter G, Schilling S, Stubbs MT, Demuth HU.

Biochemistry. 2012 Sep 18;51(37):7383-92. doi: 10.1021/bi300687g. Epub 2012 Sep 5.

PMID:
22897232
48.

Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment.

Morgado I, Wieligmann K, Bereza M, Rönicke R, Meinhardt K, Annamalai K, Baumann M, Wacker J, Hortschansky P, Malešević M, Parthier C, Mawrin C, Schiene-Fischer C, Reymann KG, Stubbs MT, Balbach J, Görlach M, Horn U, Fändrich M.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12503-8. doi: 10.1073/pnas.1206433109. Epub 2012 Jul 18.

49.

Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy.

Rodrigues LM, Chung YL, Al Saffar NM, Sharp SY, Jackson LE, Banerji U, Stubbs M, Leach MO, Griffiths JR, Workman P.

BMC Res Notes. 2012 May 23;5:250. doi: 10.1186/1756-0500-5-250.

50.

Electron microscopy of biotinylated protein complexes bound to streptavidin monolayer crystals.

Han BG, Walton RW, Song A, Hwu P, Stubbs MT, Yannone SM, Arbeláez P, Dong M, Glaeser RM.

J Struct Biol. 2012 Oct;180(1):249-53. doi: 10.1016/j.jsb.2012.04.025. Epub 2012 May 11.

PMID:
22584152

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