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Items: 1 to 50 of 89

1.

Biosynthesis of a Tricyclo[6.2.2.02,7]dodecane System by a Berberine Bridge Enzyme-like Intramolecular Aldolase.

Li H, Hu J, Wei H, Solomon PS, Stubbs KA, Chooi YH.

Chemistry. 2019 Sep 25. doi: 10.1002/chem.201904360. [Epub ahead of print]

PMID:
31553484
2.

Heterologous biosynthesis of elsinochrome A sheds light on the formation of the photosensitive perylenequinone system.

Hu J, Sarrami F, Li H, Zhang G, Stubbs KA, Lacey E, Stewart SG, Karton A, Piggott AM, Chooi YH.

Chem Sci. 2018 Nov 22;10(5):1457-1465. doi: 10.1039/c8sc02870b. eCollection 2019 Feb 7.

3.

Synthetic and Crystallographic Insight into Exploiting sp2 Hybridization in the Development of α-l-Fucosidase Inhibitors.

Coyle T, Wu L, Debowski AW, Davies GJ, Stubbs KA.

Chembiochem. 2019 Jun 3;20(11):1365-1368. doi: 10.1002/cbic.201800710. Epub 2019 Mar 18.

4.

Integrating thin film microfluidics in developing a concise synthesis of DGJNAc: A potent inhibitor of α-N-acetylgalctosaminidases.

Wills SS, Raston CL, Stubbs KA.

Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3748-3751. doi: 10.1016/j.bmcl.2018.10.015. Epub 2018 Oct 11.

PMID:
30366618
5.

Chemical Ecogenomics-Guided Discovery of Phytotoxic α-Pyrones from the Fungal Wheat Pathogen Parastagonospora nodorum.

Li H, Hu J, Wei H, Solomon PS, Vuong D, Lacey E, Stubbs KA, Piggott AM, Chooi YH.

Org Lett. 2018 Oct 5;20(19):6148-6152. doi: 10.1021/acs.orglett.8b02617. Epub 2018 Sep 18.

PMID:
30226784
6.

Enzyme targets for drug design of new anti-virulence therapeutics.

Kahler CM, Sarkar-Tyson M, Kibble EA, Stubbs KA, Vrielink A.

Curr Opin Struct Biol. 2018 Dec;53:140-150. doi: 10.1016/j.sbi.2018.08.010. Epub 2018 Sep 14. Review.

PMID:
30223251
7.

Lipopolysaccharide Structural Differences between Western and Asian Helicobacter pylori Strains.

Li H, Tang H, Debowski AW, Stubbs KA, Marshall BJ, Benghezal M.

Toxins (Basel). 2018 Sep 8;10(9). pii: E364. doi: 10.3390/toxins10090364. Review.

8.

A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa.

Ho LA, Winogrodzki JL, Debowski AW, Madden Z, Vocadlo DJ, Mark BL, Stubbs KA.

Chem Commun (Camb). 2018 Sep 25;54(75):10630-10633. doi: 10.1039/c8cc05281f. Epub 2018 Sep 4.

PMID:
30178799
9.

Structure of a Talaromyces pinophilus GH62 arabinofuranosidase in complex with AraDNJ at 1.25 Å resolution.

Moroz OV, Sobala LF, Blagova E, Coyle T, Peng W, Mørkeberg Krogh KBR, Stubbs KA, Wilson KS, Davies GJ.

Acta Crystallogr F Struct Biol Commun. 2018 Aug 1;74(Pt 8):490-495. doi: 10.1107/S2053230X18000250. Epub 2018 Jul 26.

10.

Targeting plant DIHYDROFOLATE REDUCTASE with antifolates and mechanisms for genetic resistance.

Corral MG, Haywood J, Stehl LH, Stubbs KA, Murcha MW, Mylne JS.

Plant J. 2018 Jun 7. doi: 10.1111/tpj.13983. [Epub ahead of print]

11.

Potent inhibition of a GH20 exo-β-N-acetylglucosaminidase from marine Vibrio bacteria by reaction intermediate analogues.

Meekrathok P, Stubbs KA, Suginta W.

Int J Biol Macromol. 2018 Aug;115:1165-1173. doi: 10.1016/j.ijbiomac.2018.04.193. Epub 2018 May 3.

PMID:
29730005
12.

Angled Vortex Fluidic Mediated Multicomponent Photocatalytic and Transition Metal-Catalyzed Reactions.

Ho LA, Raston CL, Stubbs KA.

Chemistry. 2018 Jun 21;24(35):8869-8874. doi: 10.1002/chem.201801109. Epub 2018 Jun 1.

PMID:
29645306
13.

Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action.

Wallace MD, Waraich NF, Debowski AW, Corral MG, Maxwell A, Mylne JS, Stubbs KA.

Chem Commun (Camb). 2018 Feb 15;54(15):1869-1872. doi: 10.1039/c7cc09518j.

PMID:
29388638
14.

A herbicide structure-activity analysis of the antimalarial lead compound MMV007978 against Arabidopsis thaliana.

Corral MG, Leroux J, Tresch S, Newton T, Stubbs KA, Mylne JS.

Pest Manag Sci. 2018 Jul;74(7):1558-1563. doi: 10.1002/ps.4872. Epub 2018 Mar 5.

PMID:
29377434
15.

Carrageenan catabolism is encoded by a complex regulon in marine heterotrophic bacteria.

Ficko-Blean E, Préchoux A, Thomas F, Rochat T, Larocque R, Zhu Y, Stam M, Génicot S, Jam M, Calteau A, Viart B, Ropartz D, Pérez-Pascual D, Correc G, Matard-Mann M, Stubbs KA, Rogniaux H, Jeudy A, Barbeyron T, Médigue C, Czjzek M, Vallenet D, McBride MJ, Duchaud E, Michel G.

Nat Commun. 2017 Nov 22;8(1):1685. doi: 10.1038/s41467-017-01832-6.

16.

Insights from the redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains.

Li H, Yang T, Liao T, Debowski AW, Nilsson HO, Haslam SM, Dell A, Stubbs KA, Marshall BJ, Benghezal M.

Microb Cell. 2017 Apr 25;4(5):175-178. doi: 10.15698/mic2017.05.574.

17.

Exploiting the Evolutionary Relationship between Malarial Parasites and Plants To Develop New Herbicides.

Corral MG, Leroux J, Tresch S, Newton T, Stubbs KA, Mylne JS.

Angew Chem Int Ed Engl. 2017 Aug 7;56(33):9881-9885. doi: 10.1002/anie.201705400. Epub 2017 Jul 12.

PMID:
28654179
18.

Helicobacter pylori gene silencing in vivo demonstrates urease is essential for chronic infection.

Debowski AW, Walton SM, Chua EG, Tay AC, Liao T, Lamichhane B, Himbeck R, Stubbs KA, Marshall BJ, Fulurija A, Benghezal M.

PLoS Pathog. 2017 Jun 23;13(6):e1006464. doi: 10.1371/journal.ppat.1006464. eCollection 2017 Jun.

19.

Heterologous expression of cytotoxic sesquiterpenoids from the medicinal mushroom Lignosus rhinocerotis in yeast.

Yap HY, Muria-Gonzalez MJ, Kong BH, Stubbs KA, Tan CS, Ng ST, Tan NH, Solomon PS, Fung SY, Chooi YH.

Microb Cell Fact. 2017 Jun 12;16(1):103. doi: 10.1186/s12934-017-0713-x.

20.

Vortex Fluidic Chemical Transformations.

Britton J, Stubbs KA, Weiss GA, Raston CL.

Chemistry. 2017 Sep 27;23(54):13270-13278. doi: 10.1002/chem.201700888. Epub 2017 Aug 16. Review.

21.

The first crystal structure of a family 129 glycoside hydrolase from a probiotic bacterium reveals critical residues and metal cofactors.

Sato M, Liebschner D, Yamada Y, Matsugaki N, Arakawa T, Wills SS, Hattie M, Stubbs KA, Ito T, Senda T, Ashida H, Fushinobu S.

J Biol Chem. 2017 Jul 21;292(29):12126-12138. doi: 10.1074/jbc.M117.777391. Epub 2017 May 25.

22.

Molecular Insight into Evolution of Symbiosis between Breast-Fed Infants and a Member of the Human Gut Microbiome Bifidobacterium longum.

Yamada C, Gotoh A, Sakanaka M, Hattie M, Stubbs KA, Katayama-Ikegami A, Hirose J, Kurihara S, Arakawa T, Kitaoka M, Okuda S, Katayama T, Fushinobu S.

Cell Chem Biol. 2017 Apr 20;24(4):515-524.e5. doi: 10.1016/j.chembiol.2017.03.012. Epub 2017 Apr 6.

23.

Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance.

Vadlamani G, Stubbs KA, Désiré J, Blériot Y, Vocadlo DJ, Mark BL.

Protein Sci. 2017 Jun;26(6):1161-1170. doi: 10.1002/pro.3166. Epub 2017 Apr 7.

24.

Herbicidal properties of antimalarial drugs.

Corral MG, Leroux J, Stubbs KA, Mylne JS.

Sci Rep. 2017 Mar 31;7:45871. doi: 10.1038/srep45871.

25.

The redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains.

Li H, Yang T, Liao T, Debowski AW, Nilsson HO, Fulurija A, Haslam SM, Mulloy B, Dell A, Stubbs KA, Marshall BJ, Benghezal M.

PLoS Pathog. 2017 Mar 17;13(3):e1006280. doi: 10.1371/journal.ppat.1006280. eCollection 2017 Mar.

26.

Acquisition of the capsule locus by horizontal gene transfer in Neisseria meningitidis is often accompanied by the loss of UDP-GalNAc synthesis.

Bartley SN, Mowlaboccus S, Mullally CA, Stubbs KA, Vrielink A, Maiden MC, Harrison OB, Perkins TT, Kahler CM.

Sci Rep. 2017 Mar 14;7:44442. doi: 10.1038/srep44442.

27.

Exploiting sp2 -Hybridisation in the Development of Potent 1,5-α-l-Arabinanase Inhibitors.

Coyle T, Debowski AW, Varrot A, Stubbs KA.

Chembiochem. 2017 Jun 1;18(11):974-978. doi: 10.1002/cbic.201700073. Epub 2017 Apr 20.

PMID:
28266777
28.

Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding.

Anandan A, Evans GL, Condic-Jurkic K, O'Mara ML, John CM, Phillips NJ, Jarvis GA, Wills SS, Stubbs KA, Moraes I, Kahler CM, Vrielink A.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2218-2223. doi: 10.1073/pnas.1612927114. Epub 2017 Feb 13.

29.

Synergistic activity of fosfomycin, β-lactams and peptidoglycan recycling inhibition against Pseudomonas aeruginosa.

Hamou-Segarra M, Zamorano L, Vadlamani G, Chu M, Sanchez-Diener I, Juan C, Blazquez J, Hattie M, Stubbs KA, Mark BL, Oliver A.

J Antimicrob Chemother. 2017 Feb;72(2):448-454. doi: 10.1093/jac/dkw456. Epub 2016 Dec 20.

PMID:
27999022
30.

Understanding protein glycosylation pathways in bacteria.

Li H, Debowski AW, Liao T, Tang H, Nilsson HO, Marshall BJ, Stubbs KA, Benghezal M.

Future Microbiol. 2017 Jan;12:59-72. doi: 10.2217/fmb-2016-0166. Epub 2016 Sep 30. Review.

31.

Structural dissection of a complex Bacteroides ovatus gene locus conferring xyloglucan metabolism in the human gut.

Hemsworth GR, Thompson AJ, Stepper J, Sobala ŁF, Coyle T, Larsbrink J, Spadiut O, Goddard-Borger ED, Stubbs KA, Brumer H, Davies GJ.

Open Biol. 2016 Jul;6(7). pii: 160142. doi: 10.1098/rsob.160142.

32.

A Fluorescent Transport Assay Enables Studying AmpG Permeases Involved in Peptidoglycan Recycling and Antibiotic Resistance.

Perley-Robertson GE, Yadav AK, Winogrodzki JL, Stubbs KA, Mark BL, Vocadlo DJ.

ACS Chem Biol. 2016 Sep 16;11(9):2626-35. doi: 10.1021/acschembio.6b00552. Epub 2016 Aug 5.

33.

Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human O-GlcNAcase.

Cekic N, Heinonen JE, Stubbs KA, Roth C, He Y, Bennet AJ, McEachern EJ, Davies GJ, Vocadlo DJ.

Chem Sci. 2016 Jun 1;7(6):3742-3750. doi: 10.1039/c6sc00370b. Epub 2016 Feb 15.

34.

Lipopolysaccharide Structure and Biosynthesis in Helicobacter pylori.

Li H, Liao T, Debowski AW, Tang H, Nilsson HO, Stubbs KA, Marshall BJ, Benghezal M.

Helicobacter. 2016 Dec;21(6):445-461. doi: 10.1111/hel.12301. Epub 2016 Mar 2. Review.

35.

Modifying the phenyl group of PUGNAc: reactivity tuning to deliver selective inhibitors for N-acetyl-D-glucosaminidases.

Hattie M, Cekic N, Debowski AW, Vocadlo DJ, Stubbs KA.

Org Biomol Chem. 2016 Mar 28;14(12):3193-7. doi: 10.1039/c6ob00297h.

36.

Glycosylation-related Diagnostic and Therapeutic Drug Target Markers in Hepatocellular Carcinoma.

Watson ME, Diepeveen LA, Stubbs KA, Yeoh GC.

J Gastrointestin Liver Dis. 2015 Sep;24(3):349-57. doi: 10.15403/jgld.2014.1121.243.mew. Review.

37.

Expansion of the tetracycline-dependent regulation toolbox for Helicobacter pylori.

Debowski AW, Sehnal M, Liao T, Stubbs KA, Marshall BJ, Benghezal M.

Appl Environ Microbiol. 2015 Dec;81(23):7969-80. doi: 10.1128/AEM.02191-15. Epub 2015 Sep 11.

38.

Gaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysis.

Hattie M, Ito T, Debowski AW, Arakawa T, Katayama T, Yamamoto K, Fushinobu S, Stubbs KA.

Chem Commun (Camb). 2015 Oct 18;51(81):15008-11. doi: 10.1039/c5cc05494j.

39.

Photoredox catalysis under shear using thin film vortex microfluidics.

Gandy MN, Raston CL, Stubbs KA.

Chem Commun (Camb). 2015 Jul 14;51(55):11041-4. doi: 10.1039/c5cc02153g.

PMID:
26063339
40.

An interactive database to explore herbicide physicochemical properties.

Gandy MN, Corral MG, Mylne JS, Stubbs KA.

Org Biomol Chem. 2015 May 28;13(20):5586-90. doi: 10.1039/c5ob00469a. Epub 2015 Apr 21. Review.

PMID:
25895669
41.

A simple and robust preparation of N-acetylindoxyls: precursors for indigogenic substrates.

Gandy MN, Byrne LT, Stubbs KA.

Org Biomol Chem. 2015 Jan 21;13(3):905-8. doi: 10.1039/c4ob02248c.

PMID:
25407923
42.

The role of oxidoreductases in determining the function of the neisserial lipid A phosphoethanolamine transferase required for resistance to polymyxin.

Piek S, Wang Z, Ganguly J, Lakey AM, Bartley SN, Mowlaboccus S, Anandan A, Stubbs KA, Scanlon MJ, Vrielink A, Azadi P, Carlson RW, Kahler CM.

PLoS One. 2014 Sep 12;9(9):e106513. doi: 10.1371/journal.pone.0106513. eCollection 2014.

43.

Unravelling the multiple functions of the architecturally intricate Streptococcus pneumoniae β-galactosidase, BgaA.

Singh AK, Pluvinage B, Higgins MA, Dalia AB, Woodiga SA, Flynn M, Lloyd AR, Weiser JN, Stubbs KA, Boraston AB, King SJ.

PLoS Pathog. 2014 Sep 11;10(9):e1004364. doi: 10.1371/journal.ppat.1004364. eCollection 2014 Sep.

44.

Towards aryl C-N bond formation in dynamic thin films.

Gandy MN, Raston CL, Stubbs KA.

Org Biomol Chem. 2014 Jul 14;12(26):4594-7. doi: 10.1039/c4ob00926f.

PMID:
24887640
45.

Activity-based proteomics probes for carbohydrate-processing enzymes: current trends and future outlook.

Stubbs KA.

Carbohydr Res. 2014 May 22;390:9-19. doi: 10.1016/j.carres.2014.02.023. Epub 2014 Mar 4. Review.

PMID:
24680833
46.

Structural enzymology of Helicobacter pylori methylthioadenosine nucleosidase in the futalosine pathway.

Kim RQ, Offen WA, Davies GJ, Stubbs KA.

Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):177-85. doi: 10.1107/S1399004713026655. Epub 2013 Dec 31.

PMID:
24419390
47.

Letter to the glycoforum transforming glycoscience: an Australian perspective.

Coombe DR, Davis C, Fincher G, McConville MJ, Packer N, Stubbs KA, Williams SJ, Dell A.

Glycobiology. 2014 Jan;24(1):1-3. doi: 10.1093/glycob/cwt103. No abstract available.

PMID:
24319023
48.

Inhibition of the family 20 glycoside hydrolase catalytic modules in the Streptococcus pneumoniae exo-β-D-N-acetylglucosaminidase, StrH.

Pluvinage B, Stubbs KA, Hattie M, Vocadlo DJ, Boraston AB.

Org Biomol Chem. 2013 Dec 7;11(45):7907-15. doi: 10.1039/c3ob41579a. Epub 2013 Oct 16.

PMID:
24132305
49.

Stereospecific synthesis of resorcin[4]arenes and pyrogallol[4]arenes in dynamic thin films.

Yasmin L, Coyle T, Stubbs KA, Raston CL.

Chem Commun (Camb). 2013 Dec 4;49(93):10932-4. doi: 10.1039/c3cc45176c.

PMID:
24131936
50.

The development of selective inhibitors of NagZ: increased susceptibility of Gram-negative bacteria to β-lactams.

Stubbs KA, Bacik JP, Perley-Robertson GE, Whitworth GE, Gloster TM, Vocadlo DJ, Mark BL.

Chembiochem. 2013 Oct 11;14(15):1973-81. doi: 10.1002/cbic.201300395. Epub 2013 Sep 5.

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