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Nephrotic syndrome is associated with increased plasma K+ concentration, intestinal K+ losses and attenuated urinary K+ excretion - studies in rats and humans.

Ydegaard R, Svenningsen P, Bistrup C, Andersen RF, Stubbe J, Buhl KB, Marcussen N, Hinrichs GR, Iraqi H, Zamani R, Dimke H, Jensen BL.

Am J Physiol Renal Physiol. 2019 Sep 30. doi: 10.1152/ajprenal.00179.2019. [Epub ahead of print]


TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex.

Yli-Karjanmaa M, Larsen KS, Fenger CD, Kristensen LK, Martin NA, Jensen PT, Breton A, Nathanson L, Nielsen PV, Lund MC, Carlsen SL, Gramsbergen JB, Finsen B, Stubbe J, Frich LH, Stolp H, Brambilla R, Anthony DC, Meyer M, Lambertsen KL.

Brain Behav Immun. 2019 Nov;82:279-297. doi: 10.1016/j.bbi.2019.08.195. Epub 2019 Sep 7.


Convergent allostery in ribonucleotide reductase.

Thomas WC, Brooks FP 3rd, Burnim AA, Bacik JP, Stubbe J, Kaelber JT, Chen JZ, Ando N.

Nat Commun. 2019 Jun 14;10(1):2653. doi: 10.1038/s41467-019-10568-4.


Effect of spironolactone for 1 yr on endothelial function and vascular inflammation biomarkers in renal transplant recipients.

Mortensen LA, Bistrup C, Stubbe J, Carlström M, Checa A, Wheelock CE, Palarasah Y, Bladbjerg EM, Thiesson HC, Jensen BL.

Am J Physiol Renal Physiol. 2019 Sep 1;317(3):F529-F539. doi: 10.1152/ajprenal.00025.2019. Epub 2019 Jun 5.


Injury incidence and risk factors: a cohort study of 706 8-km or 16-km recreational runners.

Dallinga J, Van Rijn R, Stubbe J, Deutekom M.

BMJ Open Sport Exerc Med. 2019 Mar 7;5(1):e000489. doi: 10.1136/bmjsem-2018-000489. eCollection 2019.


Detailed injury epidemiology in contemporary dance: a 1-year prospective study of 134 students.

van Winden DPAM, Van Rijn RM, Richardson A, Savelsbergh GJP, Oudejans RRD, Stubbe JH.

BMJ Open Sport Exerc Med. 2019 Feb 8;5(1):e000453. doi: 10.1136/bmjsem-2018-000453. eCollection 2019.


Discovery of a New Class I Ribonucleotide Reductase with an Essential DOPA Radical and NO Metal as an Initiator of Long-Range Radical Transfer.

Stubbe J, Seyedsayamdost MR.

Biochemistry. 2019 Feb 12;58(6):435-437. doi: 10.1021/acs.biochem.8b01238. Epub 2018 Dec 26. No abstract available.


"Leave It All Behind": The Role of Mental Demands and Mental Detachment in Relation to Dance Students' Health and Well-Being.

Balk YA, de Jonge J, van Rijn R, Stubbe J.

Med Probl Perform Art. 2018 Dec;33(4):258-264. doi: 10.21091/mppa.2018.4038.


Incidence and risk factors of medial tibial stress syndrome: a prospective study in Physical Education Teacher Education students.

Bliekendaal S, Moen M, Fokker Y, Stubbe JH, Twisk J, Verhagen E.

BMJ Open Sport Exerc Med. 2018 Oct 16;4(1):e000421. doi: 10.1136/bmjsem-2018-000421. eCollection 2018.


Photochemical Rescue of a Conformationally Inactivated Ribonucleotide Reductase.

Greene BL, Stubbe J, Nocera DG.

J Am Chem Soc. 2018 Nov 21;140(46):15744-15752. doi: 10.1021/jacs.8b07902. Epub 2018 Nov 12.


Manual therapy and early return to sport in football players with adductor-related groin pain: A prospective case series.

Tak I PhD, MScPT, Langhout R MMT PT, Bertrand B MScPT, Barendrecht M MPTS, Stubbe J PhD, Kerkhoffs G PhD, MD, Weir A PhD, MBBS.

Physiother Theory Pract. 2018 Oct 11:1-10. doi: 10.1080/09593985.2018.1531096. [Epub ahead of print]


Experimental comparative study of thrombogenicity of two differently luminal heparinized ePTFE vascular prosthetics.

Liisberg M, Stenger M, Behr-Rasmussen C, Stubbe J, Lindholt JS.

Ann Med Surg (Lond). 2018 Sep 27;35:76-81. doi: 10.1016/j.amsu.2018.09.037. eCollection 2018 Nov.


Prospective cohort study on injuries and health problems among circus arts students.

Stubbe JH, Richardson A, van Rijn RM.

BMJ Open Sport Exerc Med. 2018 Jun 26;4(1):e000327. doi: 10.1136/bmjsem-2017-000327. eCollection 2018.


Abdominal Aortic Aneurysms Growth Is Associated With High Concentrations of Plasma Proteins in the Intraluminal Thrombus and Diseased Arterial Tissue.

Behr Andersen C, Lindholt JS, Urbonavicius S, Halekoh U, Jensen PS, Stubbe J, Rasmussen LM, Beck HC.

Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2254-2267. doi: 10.1161/ATVBAHA.117.310126.


Basis of dATP inhibition of RNRs.

Greene BL, Nocera DG, Stubbe J.

J Biol Chem. 2018 Jun 29;293(26):10413-10414. doi: 10.1074/jbc.H118.003717.


Influence of Movement Quality on Heart Rate While Performing the Dance-Specific Aerobic Fitness Test (DAFT) in Preprofessional Contemporary Dancers.

Tiemens A, van Rijn RM, Wyon MA, Redding E, Stubbe JH.

Med Probl Perform Art. 2018 Jun;33(2):77-81. doi: 10.21091/mppa.2018.2012.


Hip and groin injury is the most common non-time-loss injury in female amateur football.

Langhout R, Weir A, Litjes W, Gozeling M, Stubbe JH, Kerkhoffs G, Tak I.

Knee Surg Sports Traumatol Arthrosc. 2019 Oct;27(10):3133-3141. doi: 10.1007/s00167-018-4996-1. Epub 2018 Jun 2.


Risk Factors for Groin Injury and Groin Symptoms in Elite-Level Soccer Players: A Cohort Study in the Dutch Professional Leagues.

Langhout R, Tak I, van Beijsterveldt AM, Ricken M, Weir A, Barendrecht M, Kerkhoffs G, Stubbe J.

J Orthop Sports Phys Ther. 2018 Sep;48(9):704-712. doi: 10.2519/jospt.2018.7990. Epub 2018 May 23.


An endogenous dAMP ligand in Bacillus subtilis class Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP.

Parker MJ, Maggiolo AO, Thomas WC, Kim A, Meisburger SP, Ando N, Boal AK, Stubbe J.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4594-E4603. doi: 10.1073/pnas.1800356115. Epub 2018 Apr 30.


Properties of Site-Specifically Incorporated 3-Aminotyrosine in Proteins To Study Redox-Active Tyrosines: Escherichia coli Ribonucleotide Reductase as a Paradigm.

Lee W, Kasanmascheff M, Huynh M, Quartararo A, Costentin C, Bejenke I, Nocera DG, Bennati M, Tommos C, Stubbe J.

Biochemistry. 2018 Jun 19;57(24):3402-3415. doi: 10.1021/acs.biochem.8b00160. Epub 2018 Apr 17.


The Dutch Hip and Groin Outcome Score: Cross-cultural Adaptation and Validation According to the COSMIN Checklist.

Tak I, Tijssen M, Schamp T, Sierevelt I, Thorborg K, Kerkhoffs G, Stubbe J, van Beijsterveldt AM, Haverkamp D.

J Orthop Sports Phys Ther. 2018 Apr;48(4):299-306. doi: 10.2519/jospt.2018.7883.


Translation, Cross-cultural Adaptation, and Validation of the Dutch International Hip Outcome Tool-33 (iHOT-33 NL) in Young, Physically Active Individuals With Symptomatic Hip Joint Pathology.

Tijssen M, Tak I, Stubbe J, Haverkamp D, de Visser E, Nijhuis-van der Sanden M, van Cingel R.

J Orthop Sports Phys Ther. 2018 Apr;48(4):289-298. doi: 10.2519/jospt.2018.7610. Epub 2018 Mar 16.


3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound.

Brignole EJ, Tsai KL, Chittuluru J, Li H, Aye Y, Penczek PA, Stubbe J, Drennan CL, Asturias F.

Elife. 2018 Feb 20;7. pii: e31502. doi: 10.7554/eLife.31502.


Infographic. Is lower hip range of motion a risk factor for groin pain in athletes? A systematic review with clinical applications.

Tak I, Pope D, Engelaar L, Gouttebarge V, Barendrecht M, Van den Heuvel S, Kerkhoffs G, Langhout R, Stubbe J, Weir A.

Br J Sports Med. 2018 Aug;52(16):1022-1023. doi: 10.1136/bjsports-2017-098535. Epub 2018 Feb 15. No abstract available.


Identification of differential gene expression patterns in human arteries from patients with chronic kidney disease.

Stubbe J, Skov V, Thiesson HC, Larsen KE, Hansen ML, Jensen BL, Jespersen B, Rasmussen LM.

Am J Physiol Renal Physiol. 2018 Jun 1;314(6):F1117-F1128. doi: 10.1152/ajprenal.00418.2017. Epub 2018 Feb 7.


Capturing effort and recovery: reactive and recuperative cortisol responses to competition in well-trained rowers.

Kallen VL, Stubbe JH, Zwolle HJ, Valk P.

BMJ Open Sport Exerc Med. 2017 Jul 6;3(1):e000235. doi: 10.1136/bmjsem-2017-000235. eCollection 2017.


Highly Electrophilic, Catalytically Active and Redox-Responsive Cobaltoceniumyl and Ferrocenyl Triazolylidene Coinage Metal Complexes.

Vanicek S, Podewitz M, Stubbe J, Schulze D, Kopacka H, Wurst K, Müller T, Lippmann P, Haslinger S, Schottenberger H, Liedl KR, Ott I, Sarkar B, Bildstein B.

Chemistry. 2018 Mar 12;24(15):3742-3753. doi: 10.1002/chem.201705051. Epub 2018 Jan 17.


Conformationally Dynamic Radical Transfer within Ribonucleotide Reductase.

Greene BL, Taguchi AT, Stubbe J, Nocera DG.

J Am Chem Soc. 2017 Nov 22;139(46):16657-16665. doi: 10.1021/jacs.7b08192. Epub 2017 Nov 9.


Risk Factors for Lower-Extremity Injuries Among Contemporary Dance Students.

van Seters C, van Rijn RM, van Middelkoop M, Stubbe JH.

Clin J Sport Med. 2017 Oct 10. doi: 10.1097/JSM.0000000000000533. [Epub ahead of print]


High prevalence of self-reported injuries and illnesses in talented female athletes.

Richardson A, Clarsen B, Verhagen EALM, Stubbe JH.

BMJ Open Sport Exerc Med. 2017 Apr 22;3(1):e000199. doi: 10.1136/bmjsem-2016-000199. eCollection 2017.


Sports injuries and illnesses in first-year physical education teacher education students.

van Beijsterveldt AM, Richardson A, Clarsen B, Stubbe J.

BMJ Open Sport Exerc Med. 2017 Apr 22;3(1):e000189. doi: 10.1136/bmjsem-2016-000189. eCollection 2017.


Induction of autoimmune abdominal aortic aneurysm in pigs - A novel large animal model.

Riber SS, Ali M, Bergseth SH, Stubbe J, Stenger M, Behr-Rasmussen C, Lindholt JS.

Ann Med Surg (Lond). 2017 Jun 15;20:26-31. doi: 10.1016/j.amsu.2017.06.017. eCollection 2017 Aug.


Spectroscopic Evidence for a H Bond Network at Y356 Located at the Subunit Interface of Active E. coli Ribonucleotide Reductase.

Nick TU, Ravichandran KR, Stubbe J, Kasanmascheff M, Bennati M.

Biochemistry. 2017 Jul 18;56(28):3647-3656. doi: 10.1021/acs.biochem.7b00462. Epub 2017 Jul 7.


The diferric-tyrosyl radical cluster of ribonucleotide reductase and cytosolic iron-sulfur clusters have distinct and similar biogenesis requirements.

Li H, Stümpfig M, Zhang C, An X, Stubbe J, Lill R, Huang M.

J Biol Chem. 2017 Jul 7;292(27):11445-11451. doi: 10.1074/jbc.M117.786178. Epub 2017 May 17.


Is lower hip range of motion a risk factor for groin pain in athletes? A systematic review with clinical applications.

Tak I, Engelaar L, Gouttebarge V, Barendrecht M, Van den Heuvel S, Kerkhoffs G, Langhout R, Stubbe J, Weir A.

Br J Sports Med. 2017 Nov;51(22):1611-1621. doi: 10.1136/bjsports-2016-096619. Epub 2017 Apr 21. Review.


Glutamate 52-β at the α/β subunit interface of Escherichia coli class Ia ribonucleotide reductase is essential for conformational gating of radical transfer.

Lin Q, Parker MJ, Taguchi AT, Ravichandran K, Kim A, Kang G, Shao J, Drennan CL, Stubbe J.

J Biol Chem. 2017 Jun 2;292(22):9229-9239. doi: 10.1074/jbc.M117.783092. Epub 2017 Apr 4.


Formal Reduction Potentials of Difluorotyrosine and Trifluorotyrosine Protein Residues: Defining the Thermodynamics of Multistep Radical Transfer.

Ravichandran KR, Zong AB, Taguchi AT, Nocera DG, Stubbe J, Tommos C.

J Am Chem Soc. 2017 Mar 1;139(8):2994-3004. doi: 10.1021/jacs.6b11011. Epub 2017 Feb 21.


Incidence and risk factors of injuries and their impact on academic success: A prospective study in PETE students.

Bliekendaal S, Goossens L, Stubbe JH.

Scand J Med Sci Sports. 2017 Dec;27(12):1978-1985. doi: 10.1111/sms.12838. Epub 2017 Jan 30.


The water channel AQP1 is expressed in human atherosclerotic vascular lesions and AQP1 deficiency augments angiotensin II-induced atherosclerosis in mice.

Wintmo P, Johansen SH, Hansen PBL, Lindholt JS, Urbonavicius S, Rasmussen LM, Bie P, Jensen BL, Stubbe J.

Acta Physiol (Oxf). 2017 Aug;220(4):446-460. doi: 10.1111/apha.12853. Epub 2017 Feb 22.


Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase.

Ravichandran K, Minnihan EC, Lin Q, Yokoyama K, Taguchi AT, Shao J, Nocera DG, Stubbe J.

Biochemistry. 2017 Feb 14;56(6):856-868. doi: 10.1021/acs.biochem.6b01145. Epub 2017 Feb 2.


A >200 meV Uphill Thermodynamic Landscape for Radical Transport in Escherichia coli Ribonucleotide Reductase Determined Using Fluorotyrosine-Substituted Enzymes.

Ravichandran KR, Taguchi AT, Wei Y, Tommos C, Nocera DG, Stubbe J.

J Am Chem Soc. 2016 Oct 19;138(41):13706-13716. Epub 2016 Oct 7.


Structure of the Catalytic Domain of the Class I Polyhydroxybutyrate Synthase from Cupriavidus necator.

Wittenborn EC, Jost M, Wei Y, Stubbe J, Drennan CL.

J Biol Chem. 2016 Nov 25;291(48):25264-25277. Epub 2016 Oct 14.


A new clinical test for measurement of lower limb specific range of motion in football players: Design, reliability and reference findings in non-injured players and those with long-standing adductor-related groin pain.

Tak IJ, Langhout RF, Groters S, Weir A, Stubbe JH, Kerkhoffs GM.

Phys Ther Sport. 2017 Jan;23:67-74. doi: 10.1016/j.ptsp.2016.07.007. Epub 2016 Jul 31.


Animal Models Used to Explore Abdominal Aortic Aneurysms: A Systematic Review.

Lysgaard Poulsen J, Stubbe J, Lindholt JS.

Eur J Vasc Endovasc Surg. 2016 Oct;52(4):487-499. doi: 10.1016/j.ejvs.2016.07.004. Epub 2016 Aug 16. Review.


Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. coli Ribonucleotide Reductase As an Example.

Oyala PH, Ravichandran KR, Funk MA, Stucky PA, Stich TA, Drennan CL, Britt RD, Stubbe J.

J Am Chem Soc. 2016 Jun 29;138(25):7951-64. doi: 10.1021/jacs.6b03605. Epub 2016 Jun 21.


P/Q-type and T-type voltage-gated calcium channels are involved in the contraction of mammary and brain blood vessels from hypertensive patients.

Thuesen AD, Lyngsø KS, Rasmussen L, Stubbe J, Skøtt O, Poulsen FR, Pedersen CB, Rasmussen LM, Hansen PB.

Acta Physiol (Oxf). 2017 Mar;219(3):640-651. doi: 10.1111/apha.12732. Epub 2016 Jun 29.


Photochemical Generation of a Tryptophan Radical within the Subunit Interface of Ribonucleotide Reductase.

Olshansky L, Greene BL, Finkbeiner C, Stubbe J, Nocera DG.

Biochemistry. 2016 Jun 14;55(23):3234-40. doi: 10.1021/acs.biochem.6b00292. Epub 2016 May 31.


Decreased physical activity, reduced QoL and presence of debilitating fatigue in patients with Addison's disease.

van der Valk ES, Smans LC, Hofstetter H, Stubbe JH, de Vries M, Backx FJ, Hermus AR, Zelissen PM.

Clin Endocrinol (Oxf). 2016 Sep;85(3):354-60. doi: 10.1111/cen.13059. Epub 2016 Apr 6.


Radical transfer in E. coli ribonucleotide reductase: a NH2Y731/R411A-α mutant unmasks a new conformation of the pathway residue 731.

Kasanmascheff M, Lee W, Nick TU, Stubbe J, Bennati M.

Chem Sci. 2016 Mar 1;7(3):2170-2178. doi: 10.1039/c5sc03460d. Epub 2015 Dec 9.


Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer.

Ando N, Li H, Brignole EJ, Thompson S, McLaughlin MI, Page JE, Asturias FJ, Stubbe J, Drennan CL.

Biochemistry. 2016 Jan 19;55(2):373-81. doi: 10.1021/acs.biochem.5b01207. Epub 2016 Jan 4.

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