Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 75


Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex.

Gerondopoulos A, Strutt H, Stevenson NL, Sobajima T, Levine TP, Stephens DJ, Strutt D, Barr FA.

Curr Biol. 2019 Oct 7;29(19):3323-3330.e8. doi: 10.1016/j.cub.2019.07.090. Epub 2019 Sep 26.


Robust Wnt signaling is maintained by a Wg protein gradient and Fz2 receptor activity in the developing Drosophila wing.

Chaudhary V, Hingole S, Frei J, Port F, Strutt D, Boutros M.

Development. 2019 Aug 9;146(15). pii: dev174789. doi: 10.1242/dev.174789.


Experimental and Theoretical Evidence for Bidirectional Signaling via Core Planar Polarity Protein Complexes in Drosophila.

Fisher KH, Strutt D, Fletcher AG.

iScience. 2019 Jul 26;17:49-66. doi: 10.1016/j.isci.2019.06.021. Epub 2019 Jun 18.


Reciprocal action of Casein Kinase Iε on core planar polarity proteins regulates clustering and asymmetric localisation.

Strutt H, Gamage J, Strutt D.

Elife. 2019 May 15;8. pii: e45107. doi: 10.7554/eLife.45107.


A theoretical framework for planar polarity establishment through interpretation of graded cues by molecular bridges.

Fisher KH, Strutt D.

Development. 2019 Feb 1;146(3). pii: dev168955. doi: 10.1242/dev.168955. Review.


Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions.

Strutt H, Langton PF, Pearson N, McMillan KJ, Strutt D, Cullen PJ.

Curr Biol. 2019 Feb 4;29(3):484-491.e6. doi: 10.1016/j.cub.2018.12.027. Epub 2019 Jan 17.


Rapid Disruption of Dishevelled Activity Uncovers an Intercellular Role in Maintenance of Prickle in Core Planar Polarity Protein Complexes.

Ressurreição M, Warrington S, Strutt D.

Cell Rep. 2018 Nov 6;25(6):1415-1424.e6. doi: 10.1016/j.celrep.2018.10.039.


A Dual Function for Prickle in Regulating Frizzled Stability during Feedback-Dependent Amplification of Planar Polarity.

Warrington SJ, Strutt H, Fisher KH, Strutt D.

Curr Biol. 2017 Sep 25;27(18):2784-2797.e3. doi: 10.1016/j.cub.2017.08.016. Epub 2017 Sep 14.


Adhesion GPCRs Govern Polarity of Epithelia and Cell Migration.

Strutt D, Schnabel R, Fiedler F, Prömel S.

Handb Exp Pharmacol. 2016;234:249-274. Review.


Planar cell polarity: the Dachsous/Fat system contributes differently to the embryonic and larval stages of Drosophila.

Saavedra P, Brittle A, Palacios IM, Strutt D, Casal J, Lawrence PA.

Biol Open. 2016 Apr 15;5(4):397-408. doi: 10.1242/bio.017152.


Determination of an optimal dosing schedule for combining Irinophore C™ and temozolomide in an orthotopic model of glioblastoma.

Verreault M, Wehbe M, Strutt D, Masin D, Anantha M, Walker D, Chu F, Backstrom I, Kalra J, Waterhouse D, Yapp DT, Bally MB.

J Control Release. 2015 Dec 28;220(Pt A):348-357. doi: 10.1016/j.jconrel.2015.10.053. Epub 2015 Nov 1.


Planar polarity: forcing cells into line.

Strutt H, Strutt D.

Curr Biol. 2015 Nov 2;25(21):R1032-R1034. doi: 10.1016/j.cub.2015.09.042.


Conservation of Planar Polarity Pathway Function Across the Animal Kingdom.

Hale R, Strutt D.

Annu Rev Genet. 2015;49:529-51. doi: 10.1146/annurev-genet-112414-055224. Epub 2015 Sep 10. Review.


Cellular interpretation of the long-range gradient of Four-jointed activity in the Drosophila wing.

Hale R, Brittle AL, Fisher KH, Monk NA, Strutt D.

Elife. 2015 Feb 24;4. doi: 10.7554/eLife.05789.


Irinophore C™, a lipid nanoparticulate formulation of irinotecan, improves vascular function, increases the delivery of sequentially administered 5-FU in HT-29 tumors, and controls tumor growth in patient derived xenografts of colon cancer.

Neijzen R, Wong MQ, Gill N, Wang H, Karim T, Anantha M, Strutt D, Waterhouse D, Bally MB, Tai IT, Ng SS, Yapp DT.

J Control Release. 2015 Feb 10;199:72-83. doi: 10.1016/j.jconrel.2014.11.031. Epub 2014 Dec 8.


Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities.

Waterhouse DN, Sutherland BW, Santos ND, Masin D, Osooly M, Strutt D, Ostlund C, Anantha M, Harasym N, Manisali I, Wehbe M, Bally MB, Webb MS.

Invest New Drugs. 2014 Dec;32(6):1071-82. doi: 10.1007/s10637-014-0138-x. Epub 2014 Jul 27.


Rabaptin-5 and Rabex-5 are neoplastic tumour suppressor genes that interact to modulate Rab5 dynamics in Drosophila melanogaster.

Thomas C, Strutt D.

Dev Biol. 2014 Jan 1;385(1):107-21. doi: 10.1016/j.ydbio.2013.09.029. Epub 2013 Oct 5.


Control of tissue morphology by Fasciclin III-mediated intercellular adhesion.

Wells RE, Barry JD, Warrington SJ, Cuhlmann S, Evans P, Huber W, Strutt D, Zeidler MP.

Development. 2013 Sep;140(18):3858-68. doi: 10.1242/dev.096214. Epub 2013 Aug 14.


Strabismus promotes recruitment and degradation of farnesylated prickle in Drosophila melanogaster planar polarity specification.

Strutt H, Thomas-MacArthur V, Strutt D.

PLoS Genet. 2013;9(7):e1003654. doi: 10.1371/journal.pgen.1003654. Epub 2013 Jul 18.


Localised JAK/STAT pathway activation is required for Drosophila wing hinge development.

Johnstone K, Wells RE, Strutt D, Zeidler MP.

PLoS One. 2013 May 31;8(5):e65076. doi: 10.1371/journal.pone.0065076. Print 2013.


An intracellular partitioning-based framework for tissue cell polarity in plants and animals.

Abley K, De Reuille PB, Strutt D, Bangham A, Prusinkiewicz P, Marée AF, Grieneisen VA, Coen E.

Development. 2013 May;140(10):2061-74. doi: 10.1242/dev.062984.


Combined RNAi-mediated suppression of Rictor and EGFR resulted in complete tumor regression in an orthotopic glioblastoma tumor model.

Verreault M, Weppler SA, Stegeman A, Warburton C, Strutt D, Masin D, Bally MB.

PLoS One. 2013;8(3):e59597. doi: 10.1371/journal.pone.0059597. Epub 2013 Mar 15.


A Cul-3-BTB ubiquitylation pathway regulates junctional levels and asymmetry of core planar polarity proteins.

Strutt H, Searle E, Thomas-Macarthur V, Brookfield R, Strutt D.

Development. 2013 Apr;140(8):1693-702. doi: 10.1242/dev.089656. Epub 2013 Mar 13.


The Frizzled-dependent planar polarity pathway locally promotes E-cadherin turnover via recruitment of RhoGEF2.

Warrington SJ, Strutt H, Strutt D.

Development. 2013 Mar;140(5):1045-54. doi: 10.1242/dev.088724. Epub 2013 Jan 30.


Characterization of long-circulating cationic nanoparticle formulations consisting of a two-stage PEGylation step for the delivery of siRNA in a breast cancer tumor model.

Ho EA, Osooly M, Strutt D, Masin D, Yang Y, Yan H, Bally M.

J Pharm Sci. 2013 Jan;102(1):227-36. doi: 10.1002/jps.23351. Epub 2012 Nov 6.


Structure-function dissection of the frizzled receptor in Drosophila melanogaster suggests different mechanisms of action in planar polarity and canonical Wnt signaling.

Strutt D, Madder D, Chaudhary V, Artymiuk PJ.

Genetics. 2012 Dec;192(4):1295-313. doi: 10.1534/genetics.112.144592. Epub 2012 Sep 28.


Topophore C: a liposomal nanoparticle formulation of topotecan for treatment of ovarian cancer.

Patankar NA, Waterhouse D, Strutt D, Anantha M, Bally MB.

Invest New Drugs. 2013 Feb;31(1):46-58. doi: 10.1007/s10637-012-9832-8. Epub 2012 May 22.


Planar polarity specification through asymmetric subcellular localization of Fat and Dachsous.

Brittle A, Thomas C, Strutt D.

Curr Biol. 2012 May 22;22(10):907-14. doi: 10.1016/j.cub.2012.03.053. Epub 2012 Apr 12.


Irinophore C™, a lipid-based nanoparticulate formulation of irinotecan, is more effective than free irinotecan when used to treat an orthotopic glioblastoma model.

Verreault M, Strutt D, Masin D, Anantha M, Waterhouse D, Yapp DT, Bally MB.

J Control Release. 2012 Feb 28;158(1):34-43. doi: 10.1016/j.jconrel.2011.09.095. Epub 2011 Oct 5.


The roles of the cadherins Fat and Dachsous in planar polarity specification in Drosophila.

Thomas C, Strutt D.

Dev Dyn. 2012 Jan;241(1):27-39. doi: 10.1002/dvdy.22736. Epub 2011 Sep 14. Review.


Development of glioblastoma cell lines expressing red fluorescence for non-invasive live imaging of intracranial tumors.

Verreault M, Strutt D, Masin D, Fink D, Gill R, Bally MB.

Anticancer Res. 2011 Jun;31(6):2161-71.


Principles of planar polarity in animal development.

Goodrich LV, Strutt D.

Development. 2011 May;138(10):1877-92. doi: 10.1242/dev.054080. Review.


Dynamics of core planar polarity protein turnover and stable assembly into discrete membrane subdomains.

Strutt H, Warrington SJ, Strutt D.

Dev Cell. 2011 Apr 19;20(4):511-25. doi: 10.1016/j.devcel.2011.03.018.


Vascular normalization in orthotopic glioblastoma following intravenous treatment with lipid-based nanoparticulate formulations of irinotecan (Irinophore C™), doxorubicin (Caelyx®) or vincristine.

Verreault M, Strutt D, Masin D, Anantha M, Yung A, Kozlowski P, Waterhouse D, Bally MB, Yapp DT.

BMC Cancer. 2011 Apr 8;11:124. doi: 10.1186/1471-2407-11-124.


Frizzled signaling: Gαo and Rab5 at the crossroads of the canonical and PCP pathways?

Strutt D, Vincent JP.

Sci Signal. 2010 Nov 16;3(148):pe43. doi: 10.1126/scisignal.3148pe43.


Four-jointed modulates growth and planar polarity by reducing the affinity of dachsous for fat.

Brittle AL, Repiso A, Casal J, Lawrence PA, Strutt D.

Curr Biol. 2010 May 11;20(9):803-10. doi: 10.1016/j.cub.2010.03.056. Epub 2010 Apr 29.


Gradients and the specification of planar polarity in the insect cuticle.

Strutt D.

Cold Spring Harb Perspect Biol. 2009 Nov;1(5):a000489. doi: 10.1101/cshperspect.a000489. Review.


Asymmetric localisation of planar polarity proteins: Mechanisms and consequences.

Strutt H, Strutt D.

Semin Cell Dev Biol. 2009 Oct;20(8):957-63. doi: 10.1016/j.semcdb.2009.03.006. Epub 2009 Mar 21. Review.


The planar polarity pathway.

Strutt D.

Curr Biol. 2008 Oct 14;18(19):R898-902. doi: 10.1016/j.cub.2008.07.055. No abstract available.


Differential stability of flamingo protein complexes underlies the establishment of planar polarity.

Strutt H, Strutt D.

Curr Biol. 2008 Oct 28;18(20):1555-64. doi: 10.1016/j.cub.2008.08.063. Epub 2008 Sep 18.


Irinophore C: a liposome formulation of irinotecan with substantially improved therapeutic efficacy against a panel of human xenograft tumors.

Ramsay EC, Anantha M, Zastre J, Meijs M, Zonderhuis J, Strutt D, Webb MS, Waterhouse D, Bally MB.

Clin Cancer Res. 2008 Feb 15;14(4):1208-17. doi: 10.1158/1078-0432.CCR-07-0780.


Microcephalin coordinates mitosis in the syncytial Drosophila embryo.

Brunk K, Vernay B, Griffith E, Reynolds NL, Strutt D, Ingham PW, Jackson AP.

J Cell Sci. 2007 Oct 15;120(Pt 20):3578-88. Epub 2007 Sep 25.


The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis.

Bastock R, Strutt D.

Development. 2007 Sep;134(17):3055-64. Epub 2007 Jul 25.


Differential activities of the core planar polarity proteins during Drosophila wing patterning.

Strutt D, Strutt H.

Dev Biol. 2007 Feb 1;302(1):181-94. Epub 2006 Sep 16.


Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila.

Strutt H, Price MA, Strutt D.

Curr Biol. 2006 Jul 11;16(13):1329-36.


Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium.

Shimada Y, Yonemura S, Ohkura H, Strutt D, Uemura T.

Dev Cell. 2006 Feb;10(2):209-22.


Long-range coordination of planar polarity in Drosophila.

Strutt H, Strutt D.

Bioessays. 2005 Dec;27(12):1218-27. Review.


Organ shape: controlling oriented cell division.

Strutt D.

Curr Biol. 2005 Sep 20;15(18):R758-9. Review.

Supplemental Content

Loading ...
Support Center