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Dapagliflozin Versus Placebo on Left Ventricular Remodeling in Patients With Diabetes and Heart Failure: The REFORM Trial.

Singh JSS, Mordi IR, Vickneson K, Fathi A, Donnan PT, Mohan M, Choy AMJ, Gandy S, George J, Khan F, Pearson ER, Houston JG, Struthers AD, Lang CC.

Diabetes Care. 2020 Apr 3. pii: dc192187. doi: 10.2337/dc19-2187. [Epub ahead of print]



Gingles CR, Symon R, Gandy SJ, Struthers AD, Houston G, MacDonald TM, Lang CC, Donnan PT, George J.

J Hypertens. 2020 Jan;38(1):177-178. doi: 10.1097/HJH.0000000000002219. No abstract available.


Cardiovascular Effects of Switching From Tobacco Cigarettes to Electronic Cigarettes.

George J, Hussain M, Vadiveloo T, Ireland S, Hopkinson P, Struthers AD, Donnan PT, Khan F, Lang CC.

J Am Coll Cardiol. 2019 Dec 24;74(25):3112-3120. doi: 10.1016/j.jacc.2019.09.067. Epub 2019 Nov 15.


Primary care renewal strategies in Manitoba: Family physicians' perceptions.

Struthers A, Metge C, Charette C, Harlos K, Bapuji SB, Beaudin P, Botting I, Katz A, Kreindler S.

Can Fam Physician. 2019 Sep;65(9):e397-e404.


Understanding the Particularities of an Unconditional Prenatal Cash Benefit for Low-Income Women: A Case Study Approach.

Struthers A, Metge C, Charette C, Enns JE, Nickel NC, Chateau D, Chartier M, Burland E, Katz A, Brownell M.

Inquiry. 2019 Jan-Dec;56:46958019870967. doi: 10.1177/0046958019870967.


Allopurinol treatment adversely impacts left ventricular mass regression in patients with well-controlled hypertension.

Gingles CR, Symon R, Gandy SJ, Struthers AD, Houston G, MacDonald TM, Lang CC, Donnan PT, George J.

J Hypertens. 2019 Dec;37(12):2481-2489. doi: 10.1097/HJH.0000000000002189.


A randomized controlled trial of metformin on left ventricular hypertrophy in patients with coronary artery disease without diabetes: the MET-REMODEL trial.

Mohan M, Al-Talabany S, McKinnie A, Mordi IR, Singh JSS, Gandy SJ, Baig F, Hussain MS, Bhalraam U, Khan F, Choy AM, Matthew S, Houston JG, Struthers AD, George J, Lang CC.

Eur Heart J. 2019 Nov 1;40(41):3409-3417. doi: 10.1093/eurheartj/ehz203.


Primary care reform in Manitoba, Canada, 2011-15: Balancing accountability and acceptability.

Kreindler SA, Metge C, Struthers A, Harlos K, Charette C, Bapuji S, Beaudin P, Botting I, Katz A, Zinnick S.

Health Policy. 2019 Jun;123(6):532-537. doi: 10.1016/j.healthpol.2019.03.014. Epub 2019 Mar 27.


Pushing for partnership: physician engagement and resistance in primary care renewal.

Kreindler SA, Struthers A, Metge CJ, Charette C, Harlos K, Beaudin P, Bapuji SB, Botting I, Francois J.

J Health Organ Manag. 2019 Mar 28;33(2):126-140. doi: 10.1108/JHOM-05-2018-0141. Epub 2019 Feb 7.


Health buzz at school: Evaluations of a statewide teen health campaign.

Wang M, Struthers A.

Health Mark Q. 2018 Apr-Jun;35(2):151-166. doi: 10.1080/07359683.2018.1490544. Epub 2018 Oct 15.


Xanthine oxidase inhibition for the improvement of long-term outcomes following ischaemic stroke and transient ischaemic attack (XILO-FIST) - Protocol for a randomised double blind placebo-controlled clinical trial.

Dawson J, Broomfield N, Dani K, Dickie DA, Doney A, Forbes K, Houston G, Kean S, Lees K, McConnachie A, Muir KW, Quinn T, Struthers A, Walters M.

Eur Stroke J. 2018 Sep;3(3):281-290. doi: 10.1177/2396987318771426. Epub 2018 Apr 18.


Acceptability and feasibility of magnetic femoral nerve stimulation in older, functionally impaired patients.

Beveridge LA, Price RJG, Burton LA, Witham MD, Struthers AD, Sumukadas D.

BMC Res Notes. 2018 Jun 15;11(1):394. doi: 10.1186/s13104-018-3493-4.


Disconnection of pulmonary and systemic arterial stiffness in COPD.

Weir-McCall JR, Liu-Shiu-Cheong PS, Struthers AD, Lipworth BJ, Houston JG.

Int J Chron Obstruct Pulmon Dis. 2018 May 28;13:1755-1765. doi: 10.2147/COPD.S160077. eCollection 2018.


Effect of Vitamin D Supplementation on Markers of Vascular Function: A Systematic Review and Individual Participant Meta-Analysis.

Beveridge LA, Khan F, Struthers AD, Armitage J, Barchetta I, Bressendorff I, Cavallo MG, Clarke R, Dalan R, Dreyer G, Gepner AD, Forouhi NG, Harris RA, Hitman GA, Larsen T, Khadgawat R, Marckmann P, Mose FH, Pilz S, Scholze A, Shargorodsky M, Sokol SI, Stricker H, Zoccali C, Witham MD.

J Am Heart Assoc. 2018 May 30;7(11). pii: e008273. doi: 10.1161/JAHA.117.008273.


Prevalence and Distribution of Atherosclerosis in a Low- to Intermediate-Risk Population: Assessment with Whole-Body MR Angiography.

Lambert MA, Weir-McCall JR, Salsano M, Gandy SJ, Levin D, Cavin I, Littleford R, MacFarlane JA, Matthew SZ, Nicholas RS, Struthers AD, Sullivan F, Henderson SA, White RD, Belch JJF, Houston JG.

Radiology. 2018 Jun;287(3):795-804. doi: 10.1148/radiol.2018171609. Epub 2018 May 1.


Development and Validation of a Path Length Calculation for Carotid-Femoral Pulse Wave Velocity Measurement: A TASCFORCE, SUMMIT, and Caerphilly Collaborative Venture.

Weir-McCall JR, Brown L, Summersgill J, Talarczyk P, Bonnici-Mallia M, Chin SC, Khan F, Struthers AD, Sullivan F, Colhoun HM, Shore AC, Aizawa K, Groop L, Nilsson J, Cockcroft JR, McEniery CM, Wilkinson IB, Ben-Shlomo Y, Houston JG.

Hypertension. 2018 May;71(5):937-945. doi: 10.1161/HYPERTENSIONAHA.117.10620. Epub 2018 Mar 19.


Pulmonary arterial stiffening in COPD and its implications for right ventricular remodelling.

Weir-McCall JR, Liu-Shiu-Cheong PS, Struthers AD, Lipworth BJ, Houston JG.

Eur Radiol. 2018 Aug;28(8):3464-3472. doi: 10.1007/s00330-018-5346-x. Epub 2018 Feb 27.


Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study.

Weir-McCall JR, Lambert M, Gandy SJ, Belch JJF, Cavin I, Henderson SA, Littleford R, Macfarlane JA, Matthew SZ, Stephen Nicholas R, Struthers AD, Sullivan F, White RD, Graeme Houston J.

J Cardiovasc Magn Reson. 2018 Jan 30;20(1):7. doi: 10.1186/s12968-018-0428-0.


Leucine and ACE inhibitors as therapies for sarcopenia (LACE trial): study protocol for a randomised controlled trial.

Band MM, Sumukadas D, Struthers AD, Avenell A, Donnan PT, Kemp PR, Smith KT, Hume CL, Hapca A, Witham MD.

Trials. 2018 Jan 4;19(1):6. doi: 10.1186/s13063-017-2390-9.


Effects of contrast administration on cardiac MRI volumetric, flow and pulse wave velocity quantification using manual and software-based analysis.

Fathi A, Weir-McCall JR, Struthers AD, Lipworth BJ, Houston G.

Br J Radiol. 2018 Apr;91(1084):20170717. doi: 10.1259/bjr.20170717. Epub 2018 Jan 19.


The APEX trial: Effects of allopurinol on exercise capacity, coronary and peripheral endothelial function, and natriuretic peptides in patients with cardiac syndrome X.

Lim TK, Noman A, Choy AMJ, Khan F, Struthers AD, Lang CC.

Cardiovasc Ther. 2018 Feb;36(1). doi: 10.1111/1755-5922.12311. Epub 2017 Nov 26.


Myocardial changes in incident haemodialysis patients over 6-months: an observational cardiac magnetic resonance imaging study.

Rutherford E, Mangion K, McComb C, Bell E, Cockburn S, Talle M, Roditi G, Welsh P, Woodward R, Radjenovic A, Struthers AD, Jardine AG, Berry C, Patel RK, Mark PB.

Sci Rep. 2017 Oct 25;7(1):13976. doi: 10.1038/s41598-017-14481-y.


The effect of perindopril on postural instability in older people with a history of falls-a randomised controlled trial.

Sumukadas D, Price R, McMurdo MET, Rauchhaus P, Struthers A, McSwiggan S, Arnold G, Abboud R, Witham M.

Age Ageing. 2018 Jan 1;47(1):75-81. doi: 10.1093/ageing/afx127.


Twenty-Year Predictors of Peripheral Arterial Disease Compared With Coronary Heart Disease in the Scottish Heart Health Extended Cohort (SHHEC).

Tunstall-Pedoe H, Peters SAE, Woodward M, Struthers AD, Belch JJF.

J Am Heart Assoc. 2017 Sep 18;6(9). pii: e005967. doi: 10.1161/JAHA.117.005967. Erratum in: J Am Heart Assoc. 2017 Dec 23;6(12):e004215.


Does dapagliflozin regress left ventricular hypertrophy in patients with type 2 diabetes? A prospective, double-blind, randomised, placebo-controlled study.

Brown AJM, Lang C, McCrimmon R, Struthers A.

BMC Cardiovasc Disord. 2017 Aug 23;17(1):229. doi: 10.1186/s12872-017-0663-6.


An Open-Label Dose-Finding Study of Allopurinol to Target Defined Reduction in Urate Levels in Hemodialysis Patients.

Rutherford E, Stewart G, Houston JG, Jardine AG, Mark PB, Struthers AD.

J Clin Pharmacol. 2017 Nov;57(11):1409-1414. doi: 10.1002/jcph.939. Epub 2017 Jun 9. No abstract available.


Reply: The Enigma of Left Ventricular Non-Compaction.

Weir-McCall JR, Yeap PM, Papagiorcopulo C, Fitzgerald K, Gandy SJ, Lambert M, Belch JJF, Cavin I, Littleford R, Macfarlane JA, Matthew SZ, Nicholas RS, Struthers AD, Sullivan F, Henderson SA, White RD, Houston JG.

J Am Coll Cardiol. 2017 May 16;69(19):2470-2471. doi: 10.1016/j.jacc.2017.02.062. No abstract available.


Left Ventricular Noncompaction: Anatomical Phenotype or Distinct Cardiomyopathy?

Weir-McCall JR, Yeap PM, Papagiorcopulo C, Fitzgerald K, Gandy SJ, Lambert M, Belch JJ, Cavin I, Littleford R, Macfarlane JA, Matthew SZ, Nicholas RS, Struthers AD, Sullivan F, Waugh SA, White RD, Houston JG.

J Am Coll Cardiol. 2016 Nov 15;68(20):2157-2165. doi: 10.1016/j.jacc.2016.08.054.


Assessment of proximal pulmonary arterial stiffness using magnetic resonance imaging: effects of technique, age and exercise.

Weir-McCall JR, Kamalasanan A, Cassidy DB, Struthers AD, Lipworth BJ, Houston JG.

BMJ Open Respir Res. 2016 Oct 7;3(1):e000149. eCollection 2016.


Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension.

Barma M, Khan F, Price RJG, Donnan PT, Messow CM, Ford I, McConnachie A, Struthers AD, McMurdo MET, Witham MD.

Aging Clin Exp Res. 2017 Oct;29(5):1055-1059. doi: 10.1007/s40520-016-0636-0. Epub 2016 Oct 12.


Multicentre, prospective, randomised, open-label, blinded end point trial of the efficacy of allopurinol therapy in improving cardiovascular outcomes in patients with ischaemic heart disease: protocol of the ALL-HEART study.

Mackenzie IS, Ford I, Walker A, Hawkey C, Begg A, Avery A, Taggar J, Wei L, Struthers AD, MacDonald TM; ALL-HEART study group.

BMJ Open. 2016 Sep 8;6(9):e013774. doi: 10.1136/bmjopen-2016-013774.


Prevalence of unrecognized myocardial infarction in a low-intermediate risk asymptomatic cohort and its relation to systemic atherosclerosis.

Weir-McCall JR, Fitzgerald K, Papagiorcopulo CJ, Gandy SJ, Lambert M, Belch JJF, Cavin I, Littleford R, Macfarlane JA, Matthew SZ, Nicholas RS, Struthers AD, Sullivan FM, Waugh SA, White RD, Houston JG.

Eur Heart J Cardiovasc Imaging. 2017 Jun 1;18(6):657-662. doi: 10.1093/ehjci/jew155.


Defining myocardial tissue abnormalities in end-stage renal failure with cardiac magnetic resonance imaging using native T1 mapping.

Rutherford E, Talle MA, Mangion K, Bell E, Rauhalammi SM, Roditi G, McComb C, Radjenovic A, Welsh P, Woodward R, Struthers AD, Jardine AG, Patel RK, Berry C, Mark PB.

Kidney Int. 2016 Oct;90(4):845-52. doi: 10.1016/j.kint.2016.06.014. Epub 2016 Aug 5.


Research into the effect Of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and design.

Singh JS, Fathi A, Vickneson K, Mordi I, Mohan M, Houston JG, Pearson ER, Struthers AD, Lang CC.

Cardiovasc Diabetol. 2016 Jul 15;15:97. doi: 10.1186/s12933-016-0419-0.


Whole-body cardiovascular MRI for the comparison of atherosclerotic burden and cardiac remodelling in healthy South Asian and European adults.

Weir-McCall JR, Cassidy DB, Belch JJ, Gandy SJ, Houston JG, Lambert MA, Littleford RC, Rowland J, Struthers AD, Khan F.

Br J Radiol. 2016 Sep;89(1065):20160342. doi: 10.1259/bjr.20160342. Epub 2016 Jun 28.


3T MRI investigation of cardiac left ventricular structure and function in a UK population: The tayside screening for the prevention of cardiac events (TASCFORCE) study.

Gandy SJ, Lambert M, Belch J, Cavin I, Crowe E, Littleford R, MacFarlane JA, Matthew SZ, Martin P, Nicholas RS, Struthers A, Sullivan F, Waugh SA, White RD, Weir-McCall JR, Houston JG.

J Magn Reson Imaging. 2016 Nov;44(5):1186-1196. doi: 10.1002/jmri.25267. Epub 2016 May 3.


Assessing the organizational impact of patient involvement: a first STEPP.

Kreindler SA, Struthers A.

Int J Health Care Qual Assur. 2016 May 9;29(4):441-53. doi: 10.1108/IJHCQA-01-2015-0013.


The Incidence and Risk of Biochemical Recurrence Following Radical Radiotherapy for Prostate Cancer in Men on Angiotensin-Converting Enzyme Inhibitors (ACEIs) or Angiotensin Receptor Blockers (ARBs).

Alashkham A, Paterson C, Windsor P, Struthers A, Rauchhaus P, Nabi G.

Clin Genitourin Cancer. 2016 Oct;14(5):398-405. doi: 10.1016/j.clgc.2016.03.009. Epub 2016 Mar 12.


Research cardiac magnetic resonance imaging in end stage renal disease - incidence, significance and implications of unexpected incidental findings.

Rutherford E, Weir-McCall JR, Patel RK, Houston JG, Roditi G, Struthers AD, Jardine AG, Mark PB.

Eur Radiol. 2017 Jan;27(1):315-324. Epub 2016 Apr 7.


Letter to the editor: Comparing pace and speed in the pulmonary circulation?

Weir-McCall JR, Struthers AD, Lipworth BJ, Houston JG.

Am J Physiol Heart Circ Physiol. 2016 Apr 1;310(7):H949. doi: 10.1152/ajpheart.00065.2016. No abstract available.


Whole body cardiovascular magnetic resonance imaging to stratify symptomatic and asymptomatic atherosclerotic burden in patients with isolated cardiovascular disease.

Weir-McCall JR, Duce SL, Gandy SJ, Matthew SZ, Martin P, Cassidy DB, McCormick L, Belch JJF, Struthers AD, Colhoun HM, Houston JG.

BMC Med Imaging. 2016 Feb 29;16:18. doi: 10.1186/s12880-016-0121-4.


Effect of Vitamin K on Vascular Health and Physical Function in Older People with Vascular Disease--A Randomised Controlled Trial.

Fulton RL, McMurdo ME, Hill A, Abboud RJ, Arnold GP, Struthers AD, Khan F, Vermeer C, Knapen MH, Drummen NE, Witham MD.

J Nutr Health Aging. 2016 Mar;20(3):325-33. doi: 10.1007/s12603-015-0619-4.


MRI of the left atrium at 3T: evaluation of measurement reproducibility in healthy volunteers and patients with cardiovascular disease.

Gandy SJ, Matthew S, Rekhraj S, Szwejkowski B, Crowe E, Struthers AD, Houston JG.

Acta Radiol. 2016 Dec;57(12):1468-1475. doi: 10.1177/0284185115627386. Epub 2016 Jul 19.


Follow-up of atheroma burden with sequential whole body contrast enhanced MR angiography: a feasibility study.

Weir-McCall JR, White RD, Ramkumar PG, Gandy SJ, Khan F, Belch JJ, Struthers AD, Houston JG.

Int J Cardiovasc Imaging. 2016 May;32(5):825-32. doi: 10.1007/s10554-016-0842-z. Epub 2016 Jan 25.


Mean HbA1c and mortality in diabetic individuals with heart failure: a population cohort study.

Elder DH, Singh JS, Levin D, Donnelly LA, Choy AM, George J, Struthers AD, Doney AS, Lang CC.

Eur J Heart Fail. 2016 Jan;18(1):94-102. doi: 10.1002/ejhf.455. Epub 2015 Dec 13.


Ezetimibe plus a Statin after Acute Coronary Syndromes.

Singh JS, Struthers AD, Lang CC.

N Engl J Med. 2015 Oct 8;373(15):1476. doi: 10.1056/NEJMc1509363. No abstract available.


High B-Type Natriuretic Peptide Hypertensives at Target Blood Pressure: Potential Role of β-Blockers to Reduce Their Elevated Risk.

Struthers AD, George J.

Hypertension. 2015 Nov;66(5):927-32. doi: 10.1161/HYPERTENSIONAHA.115.06270. Epub 2015 Sep 21. Review. No abstract available.


Spironolactone for People Age 70 Years and Older With Osteoarthritic Knee Pain: A Proof-of-Concept Trial.

Mcmurdo ME, Sumukadas D, Donnan PT, Cvoro V, Rauchhaus P, Argo I, Waldie H, Littleford R, Struthers AD, Witham MD.

Arthritis Care Res (Hoboken). 2016 May;68(5):716-21. doi: 10.1002/acr.22724.


Older Women Fleeing Violence and Abuse in Canada: Bringing Together Separate Spheres of Practice.

James K, Dickinson R, Struthers A.

J Elder Abuse Negl. 2015;27(4-5):454-69. doi: 10.1080/08946566.2015.1082528. Epub 2015 Sep 11.


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