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Items: 1 to 50 of 118

1.

CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation.

Deng J, Wang ES, Jenkins RW, Li S, Dries R, Yates K, Chhabra S, Huang W, Liu H, Aref AR, Ivanova E, Paweletz CP, Bowden M, Zhou CW, Herter-Sprie GS, Sorrentino JA, Bisi JE, Lizotte PH, Merlino AA, Quinn MM, Bufe LE, Yang A, Zhang Y, Zhang H, Gao P, Chen T, Cavanaugh ME, Rode AJ, Haines E, Roberts PJ, Strum JC, Richards WG, Lorch JH, Parangi S, Gunda V, Boland GM, Bueno R, Palakurthi S, Freeman GJ, Ritz J, Haining WN, Sharpless NE, Arthanari H, Shapiro GI, Barbie DA, Gray NS, Wong KK.

Cancer Discov. 2018 Feb;8(2):216-233. doi: 10.1158/2159-8290.CD-17-0915. Epub 2017 Nov 3.

2.

Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion.

He S, Roberts PJ, Sorrentino JA, Bisi JE, Storrie-White H, Tiessen RG, Makhuli KM, Wargin WA, Tadema H, van Hoogdalem EJ, Strum JC, Malik R, Sharpless NE.

Sci Transl Med. 2017 Apr 26;9(387). pii: eaal3986. doi: 10.1126/scitranslmed.aal3986.

3.

Preclinical development of G1T38: A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors.

Bisi JE, Sorrentino JA, Jordan JL, Darr DD, Roberts PJ, Tavares FX, Strum JC.

Oncotarget. 2017 Jun 27;8(26):42343-42358. doi: 10.18632/oncotarget.16216.

4.

CDK4/6 Therapeutic Intervention and Viable Alternative to Taxanes in CRPC.

Stice JP, Wardell SE, Norris JD, Yllanes AP, Alley HM, Haney VO, White HS, Safi R, Winter PS, Cocce KJ, Kishton RJ, Lawrence SA, Strum JC, McDonnell DP.

Mol Cancer Res. 2017 Jun;15(6):660-669. doi: 10.1158/1541-7786.MCR-17-0028. Epub 2017 Feb 16.

5.

Preclinical Characterization of G1T28: A Novel CDK4/6 Inhibitor for Reduction of Chemotherapy-Induced Myelosuppression.

Bisi JE, Sorrentino JA, Roberts PJ, Tavares FX, Strum JC.

Mol Cancer Ther. 2016 May;15(5):783-93. doi: 10.1158/1535-7163.MCT-15-0775. Epub 2016 Jan 29.

6.

Site-specific glycosylation of secretory immunoglobulin A from human colostrum.

Huang J, Guerrero A, Parker E, Strum JS, Smilowitz JT, German JB, Lebrilla CB.

J Proteome Res. 2015 Mar 6;14(3):1335-49. doi: 10.1021/pr500826q. Epub 2015 Feb 11.

7.

Human milk glycomics and gut microbial genomics in infant feces show a correlation between human milk oligosaccharides and gut microbiota: a proof-of-concept study.

De Leoz ML, Kalanetra KM, Bokulich NA, Strum JS, Underwood MA, German JB, Mills DA, Lebrilla CB.

J Proteome Res. 2015 Jan 2;14(1):491-502. doi: 10.1021/pr500759e. Epub 2014 Oct 28.

8.

CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury.

DiRocco DP, Bisi J, Roberts P, Strum J, Wong KK, Sharpless N, Humphreys BD.

Am J Physiol Renal Physiol. 2014 Feb 15;306(4):F379-88. doi: 10.1152/ajprenal.00475.2013. Epub 2013 Dec 11.

9.

Automated assignments of N- and O-site specific glycosylation with extensive glycan heterogeneity of glycoprotein mixtures.

Strum JS, Nwosu CC, Hua S, Kronewitter SR, Seipert RR, Bachelor RJ, An HJ, Lebrilla CB.

Anal Chem. 2013 Jun 18;85(12):5666-75. doi: 10.1021/ac4006556. Epub 2013 May 24.

10.

A quantitative and comprehensive method to analyze human milk oligosaccharide structures in the urine and feces of infants.

De Leoz ML, Wu S, Strum JS, Niñonuevo MR, Gaerlan SC, Mirmiran M, German JB, Mills DA, Lebrilla CB, Underwood MA.

Anal Bioanal Chem. 2013 May;405(12):4089-105. doi: 10.1007/s00216-013-6817-1. Epub 2013 Mar 7.

11.

In-gel nonspecific proteolysis for elucidating glycoproteins: a method for targeted protein-specific glycosylation analysis in complex protein mixtures.

Nwosu CC, Huang J, Aldredge DL, Strum JS, Hua S, Seipert RR, Lebrilla CB.

Anal Chem. 2013 Jan 15;85(2):956-63. doi: 10.1021/ac302574f. Epub 2012 Dec 28.

12.

The glycolyzer: automated glycan annotation software for high performance mass spectrometry and its application to ovarian cancer glycan biomarker discovery.

Kronewitter SR, De Leoz ML, Strum JS, An HJ, Dimapasoc LM, Guerrero A, Miyamoto S, Lebrilla CB, Leiserowitz GS.

Proteomics. 2012 Aug;12(15-16):2523-38. doi: 10.1002/pmic.201100273.

13.

Lacto-N-tetraose, fucosylation, and secretor status are highly variable in human milk oligosaccharides from women delivering preterm.

De Leoz ML, Gaerlan SC, Strum JS, Dimapasoc LM, Mirmiran M, Tancredi DJ, Smilowitz JT, Kalanetra KM, Mills DA, German JB, Lebrilla CB, Underwood MA.

J Proteome Res. 2012 Sep 7;11(9):4662-72. doi: 10.1021/pr3004979. Epub 2012 Aug 28.

14.

Identification and accurate quantitation of biological oligosaccharide mixtures.

Strum JS, Kim J, Wu S, De Leoz ML, Peacock K, Grimm R, German JB, Mills DA, Lebrilla CB.

Anal Chem. 2012 Sep 18;84(18):7793-801. doi: 10.1021/ac301128s. Epub 2012 Aug 29.

15.

Coupling flash liquid chromatography with mass spectrometry for enrichment and isolation of milk oligosaccharides for functional studies.

Strum JS, Aldredge D, Barile D, Lebrilla CB.

Anal Biochem. 2012 May 15;424(2):87-96. doi: 10.1016/j.ab.2012.02.012. Epub 2012 Feb 25.

16.

Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy.

Roberts PJ, Bisi JE, Strum JC, Combest AJ, Darr DB, Usary JE, Zamboni WC, Wong KK, Perou CM, Sharpless NE.

J Natl Cancer Inst. 2012 Mar 21;104(6):476-87. doi: 10.1093/jnci/djs002. Epub 2012 Feb 1.

17.

Rosiglitazone Induces Mitochondrial Biogenesis in Differentiated Murine 3T3-L1 and C3H/10T1/2 Adipocytes.

Rong JX, Klein JL, Qiu Y, Xie M, Johnson JH, Waters KM, Zhang V, Kashatus JA, Remlinger KS, Bing N, Crosby RM, Jackson TK, Witherspoon SM, Moore JT, Ryan TE, Neill SD, Strum JC.

PPAR Res. 2011;2011:179454. doi: 10.1155/2011/179454. Epub 2011 Oct 15.

18.

Site-specific protein glycosylation analysis with glycan isomer differentiation.

Hua S, Nwosu CC, Strum JS, Seipert RR, An HJ, Zivkovic AM, German JB, Lebrilla CB.

Anal Bioanal Chem. 2012 May;403(5):1291-302. doi: 10.1007/s00216-011-5109-x. Epub 2011 Jun 8.

PMID:
21647803
19.

Simultaneous and extensive site-specific N- and O-glycosylation analysis in protein mixtures.

Nwosu CC, Seipert RR, Strum JS, Hua SS, An HJ, Zivkovic AM, German BJ, Lebrilla CB.

J Proteome Res. 2011 May 6;10(5):2612-24. doi: 10.1021/pr2001429. Epub 2011 Apr 21.

20.

N-linked glycan profiling of mature human milk by high-performance microfluidic chip liquid chromatography time-of-flight tandem mass spectrometry.

Dallas DC, Martin WF, Strum JS, Zivkovic AM, Smilowitz JT, Underwood MA, Affolter M, Lebrilla CB, German JB.

J Agric Food Chem. 2011 Apr 27;59(8):4255-63. doi: 10.1021/jf104681p. Epub 2011 Mar 18.

21.

Enhanced detection and identification of glycopeptides in negative ion mode mass spectrometry.

Nwosu CC, Strum JS, An HJ, Lebrilla CB.

Anal Chem. 2010 Dec 1;82(23):9654-62. doi: 10.1021/ac101856r. Epub 2010 Nov 4.

22.

MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1.

Strum JC, Johnson JH, Ward J, Xie H, Feild J, Hester A, Alford A, Waters KM.

Mol Endocrinol. 2009 Nov;23(11):1876-84. doi: 10.1210/me.2009-0117. Epub 2009 Oct 9.

23.

GSK983: a novel compound with broad-spectrum antiviral activity.

Harvey R, Brown K, Zhang Q, Gartland M, Walton L, Talarico C, Lawrence W, Selleseth D, Coffield N, Leary J, Moniri K, Singer S, Strum J, Gudmundsson K, Biron K, Romines KR, Sethna P.

Antiviral Res. 2009 Apr;82(1):1-11. doi: 10.1016/j.antiviral.2008.12.015. Epub 2009 Jan 31.

PMID:
19187793
24.

Screening phosphatidylcholine biomarkers in mouse liver extracts from a hypercholesterolemia study using ESI-MS and chemometrics.

Yang L, Bennett R, Strum J, Ellsworth BB, Hamilton D, Tomlinson M, Wolf RW, Housley M, Roberts BA, Welsh J, Jackson BJ, Wood SG, Banka CL, Thulin CD, Linford MR.

Anal Bioanal Chem. 2009 Jan;393(2):643-54. doi: 10.1007/s00216-008-2504-z. Epub 2008 Nov 23.

PMID:
19030846
25.

Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.

Risérus U, Sprecher D, Johnson T, Olson E, Hirschberg S, Liu A, Fang Z, Hegde P, Richards D, Sarov-Blat L, Strum JC, Basu S, Cheeseman J, Fielding BA, Humphreys SM, Danoff T, Moore NR, Murgatroyd P, O'Rahilly S, Sutton P, Willson T, Hassall D, Frayn KN, Karpe F.

Diabetes. 2008 Feb;57(2):332-9. Epub 2007 Nov 16.

26.

Delineation of molecular mechanisms of sensitivity to lapatinib in breast cancer cell lines using global gene expression profiles.

Hegde PS, Rusnak D, Bertiaux M, Alligood K, Strum J, Gagnon R, Gilmer TM.

Mol Cancer Ther. 2007 May;6(5):1629-40.

27.

Adipose mitochondrial biogenesis is suppressed in db/db and high-fat diet-fed mice and improved by rosiglitazone.

Rong JX, Qiu Y, Hansen MK, Zhu L, Zhang V, Xie M, Okamoto Y, Mattie MD, Higashiyama H, Asano S, Strum JC, Ryan TE.

Diabetes. 2007 Jul;56(7):1751-60. Epub 2007 Apr 24.

28.

Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia.

Robbins MJ, Starr KR, Honey A, Soffin EM, Rourke C, Jones GA, Kelly FM, Strum J, Melarange RA, Harris AJ, Rocheville M, Rupniak T, Murdock PR, Jones DN, Kew JN, Maycox PR.

Brain Res. 2007 Jun 4;1152:215-27. Epub 2007 Mar 15.

PMID:
17434465
29.

Automated solutions for total RNA isolation from diverse sample types.

Selley P, Bruner J, Kelly F, Maurio F, Waters M, Strum J.

Clin Lab Med. 2007 Mar;27(1):155-61.

PMID:
17416308
30.

Rosiglitazone induces mitochondrial biogenesis in mouse brain.

Strum JC, Shehee R, Virley D, Richardson J, Mattie M, Selley P, Ghosh S, Nock C, Saunders A, Roses A.

J Alzheimers Dis. 2007 Mar;11(1):45-51.

PMID:
17361034
31.

Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease).

Roses AD, Saunders AM, Huang Y, Strum J, Weisgraber KH, Mahley RW.

Pharmacogenomics J. 2007 Feb;7(1):10-28. Epub 2006 Jun 13. Review.

PMID:
16770341
32.

A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer.

Xia W, Bacus S, Hegde P, Husain I, Strum J, Liu L, Paulazzo G, Lyass L, Trusk P, Hill J, Harris J, Spector NL.

Proc Natl Acad Sci U S A. 2006 May 16;103(20):7795-800. Epub 2006 May 8.

33.

Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers.

Xia W, Bisi J, Strum J, Liu L, Carrick K, Graham KM, Treece AL, Hardwicke MA, Dush M, Liao Q, Westlund RE, Zhao S, Bacus S, Spector NL.

Cancer Res. 2006 Feb 1;66(3):1640-7.

34.

Changes of skeletal muscle adiponectin content in diet-induced insulin resistant rats.

Yang B, Chen L, Qian Y, Triantafillou JA, McNulty JA, Carrick K, Clifton LG, Han B, Geske R, Strum J, Brown KK, Stimpson SA, Pahel G.

Biochem Biophys Res Commun. 2006 Mar 3;341(1):209-17. Epub 2006 Jan 9.

PMID:
16414018
35.

PPARgamma agonists diminish serum VEGF elevation in diet-induced insulin resistant SD rats and ZDF rats.

Yang B, Lin P, Carrick KM, McNulty JA, Clifton LG, Winegar DA, Strum JC, Stimpson SA, Pahel GL.

Biochem Biophys Res Commun. 2005 Aug 19;334(1):176-82.

PMID:
15993383
36.

Serum adiponectin as a biomarker for in vivo PPARgamma activation and PPARgamma agonist-induced efficacy on insulin sensitization/lipid lowering in rats.

Yang B, Brown KK, Chen L, Carrick KM, Clifton LG, McNulty JA, Winegar DA, Strum JC, Stimpson SA, Pahel GL.

BMC Pharmacol. 2004 Oct 18;4:23.

37.

GI262570, a peroxisome proliferator-activated receptor {gamma} agonist, changes electrolytes and water reabsorption from the distal nephron in rats.

Chen L, Yang B, McNulty JA, Clifton LG, Binz JG, Grimes AM, Strum JC, Harrington WW, Chen Z, Balon TW, Stimpson SA, Brown KK.

J Pharmacol Exp Ther. 2005 Feb;312(2):718-25. Epub 2004 Oct 8.

PMID:
15475592
38.

The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.

Briscoe CP, Tadayyon M, Andrews JL, Benson WG, Chambers JK, Eilert MM, Ellis C, Elshourbagy NA, Goetz AS, Minnick DT, Murdock PR, Sauls HR Jr, Shabon U, Spinage LD, Strum JC, Szekeres PG, Tan KB, Way JM, Ignar DM, Wilson S, Muir AI.

J Biol Chem. 2003 Mar 28;278(13):11303-11. Epub 2002 Dec 19.

39.

The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.

Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, Muir AI, Wigglesworth MJ, Kinghorn I, Fraser NJ, Pike NB, Strum JC, Steplewski KM, Murdock PR, Holder JC, Marshall FH, Szekeres PG, Wilson S, Ignar DM, Foord SM, Wise A, Dowell SJ.

J Biol Chem. 2003 Mar 28;278(13):11312-9. Epub 2002 Dec 19.

40.

Tissue expression profiling using real-time PCR.

Strum JC, Carrick KM, Stuart JS, Martensen SA.

Curr Protoc Pharmacol. 2002 Nov;Chapter 6:Unit 6.9. doi: 10.1002/0471141755.ph0609s18.

PMID:
22294081
41.

Recovery and expression of messenger RNA from postmortem human brain tissue.

Cummings TJ, Strum JC, Yoon LW, Szymanski MH, Hulette CM.

Mod Pathol. 2001 Nov;14(11):1157-61.

42.

Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA.

Lai WS, Carballo E, Strum JR, Kennington EA, Phillips RS, Blackshear PJ.

Mol Cell Biol. 1999 Jun;19(6):4311-23.

43.

Cellular mechanisms of altered contractility in the hypertrophied heart: big hearts, big sparks.

Shorofsky SR, Aggarwal R, Corretti M, Baffa JM, Strum JM, Al-Seikhan BA, Kobayashi YM, Jones LR, Wier WG, Balke CW.

Circ Res. 1999 Mar 5;84(4):424-34.

PMID:
10066677
46.

[The Baerveldt implant in refractory glaucoma: clinial results].

Strum J, Postelmans L, Deflorenne C, Huyghe P, Libert J.

Bull Soc Belge Ophtalmol. 1997;267:169-74. French.

PMID:
9745827
47.

Lipid second messengers. A role in cell growth regulation and cell cycle progression.

Strum JC, Ghosh S, Bell RM.

Adv Exp Med Biol. 1997;407:421-31. Review. No abstract available.

PMID:
9321986
48.

Lipid biochemistry: functions of glycerolipids and sphingolipids in cellular signaling.

Ghosh S, Strum JC, Bell RM.

FASEB J. 1997 Jan;11(1):45-50. Review.

PMID:
9034165
50.

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