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Items: 9


pH-dependent gating mechanism of the Helicobacter pylori urea channel revealed by cryo-EM.

Cui Y, Zhou K, Strugatsky D, Wen Y, Sachs G, Zhou ZH, Munson K.

Sci Adv. 2019 Mar 20;5(3):eaav8423. doi: 10.1126/sciadv.aav8423. eCollection 2019 Mar.


Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.

Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Ferng A, Lee R, Ford DA, Young SG, Ikonen E, Schwabe JWR, Tontonoz P.

Cell. 2018 Oct 4;175(2):514-529.e20. doi: 10.1016/j.cell.2018.08.033. Epub 2018 Sep 13.


Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori.

Strugatsky D, McNulty R, Munson K, Chen CK, Soltis SM, Sachs G, Luecke H.

Nature. 2013 Jan 10;493(7431):255-8. doi: 10.1038/nature11684. Epub 2012 Dec 9.


Characterization of a novel potassium-competitive acid blocker of the gastric H,K-ATPase, 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438).

Shin JM, Inatomi N, Munson K, Strugatsky D, Tokhtaeva E, Vagin O, Sachs G.

J Pharmacol Exp Ther. 2011 Nov;339(2):412-20. doi: 10.1124/jpet.111.185314. Epub 2011 Aug 9.


D443 of the N domain of Na+,K+-ATPase interacts with the ATP-Mg2+ complex, possibly via a second Mg2+ ion.

Strugatsky D, Gottschalk KE, Goldshleger R, Karlish SJ.

Biochemistry. 2005 Dec 13;44(49):15961-9.


Genetic polymorphism and expression of a highly potent scorpion depressant toxin enable refinement of the effects on insect Na channels and illuminate the key role of Asn-58.

Strugatsky D, Zilberberg N, Stankiewicz M, Ilan N, Turkov M, Cohen L, Pelhate M, Gilles N, Gordon D, Gurevitz M.

Biochemistry. 2005 Jun 28;44(25):9179-87.


Expression of Na+,K+-ATPase in Pichia pastoris: analysis of wild type and D369N mutant proteins by Fe2+-catalyzed oxidative cleavage and molecular modeling.

Strugatsky D, Gottschalk KE, Goldshleger R, Bibi E, Karlish SJ.

J Biol Chem. 2003 Nov 14;278(46):46064-73. Epub 2003 Aug 29.


Expression of Na,K-ATPase in P. pastoris: Fe2+-catalyzed cleavage of the recombinant enzyme.

Strugatsky D, Goldshleger R, Bibi E, Karlish SJ.

Ann N Y Acad Sci. 2003 Apr;986:247-8. No abstract available.


Sodium channel modifiers from scorpion venom: structure-activity relationship, mode of action and application.

Gurevitz M, Froy O, Zilberberg N, Turkov M, Strugatsky D, Gershburg E, Lee D, Adams ME, Tugarinov V, Anglister J, Shaanan B, Loret E, Stankiewicz M, Pelhate M, Gordon D, Chejanovsky N.

Toxicon. 1998 Nov;36(11):1671-82. No abstract available.


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