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Items: 1 to 50 of 61

1.

Genetic association analysis with pedigrees: Direct inference using the composite likelihood ratio.

Baskurt Z, Strug LJ.

Genet Epidemiol. 2018 Sep 17. doi: 10.1002/gepi.22153. [Epub ahead of print]

PMID:
30221395
2.

Visceral fat-related systemic inflammation and the adolescent brain: a mediating role of circulating glycerophosphocholines.

Syme C, Pelletier S, Shin J, Abrahamowicz M, Leonard G, Perron M, Richer L, Veillette S, Gaudet D, Pike B, Strug LJ, Wang Y, Xu H, Taylor G, Bennett S, Paus T, Pausova Z.

Int J Obes (Lond). 2018 Sep 11. doi: 10.1038/s41366-018-0202-2. [Epub ahead of print]

PMID:
30206338
3.

SLC26A9 Gene Is Associated With Lung Function Response to Ivacaftor in Patients With Cystic Fibrosis.

Corvol H, Mésinèle J, Douksieh IH, Strug LJ, Boëlle PY, Guillot L.

Front Pharmacol. 2018 Jul 26;9:828. doi: 10.3389/fphar.2018.00828. eCollection 2018.

4.

The evidential statistical paradigm in genetics.

Strug LJ.

Genet Epidemiol. 2018 Aug 18. doi: 10.1002/gepi.22151. [Epub ahead of print] Review.

PMID:
30120797
5.

Recent advances in developing therapeutics for cystic fibrosis.

Strug LJ, Stephenson AL, Panjwani N, Harris A.

Hum Mol Genet. 2018 Aug 1;27(R2):R173-R186. doi: 10.1093/hmg/ddy188.

PMID:
30060192
6.

AGTR2 absence or antagonism prevents cystic fibrosis pulmonary manifestations.

Darrah RJ, Jacono FJ, Joshi N, Mitchell AL, Sattar A, Campanaro CK, Litman P, Frey J, Nethery DE, Barbato ES, Hodges CA, Corvol H, Cutting GR, Knowles MR, Strug LJ, Drumm ML.

J Cyst Fibros. 2018 Jun 21. pii: S1569-1993(18)30618-0. doi: 10.1016/j.jcf.2018.05.013. [Epub ahead of print]

7.

Testing Calibration of Cox Survival Models at Extremes of Event Risk.

Soave DM, Strug LJ.

Front Genet. 2018 May 22;9:177. doi: 10.3389/fgene.2018.00177. eCollection 2018.

8.

The CF Canada-Sick Kids Program in individual CF therapy: A resource for the advancement of personalized medicine in CF.

Eckford PDW, McCormack J, Munsie L, He G, Stanojevic S, Pereira SL, Ho K, Avolio J, Bartlett C, Yang JY, Wong AP, Wellhauser L, Huan LJ, Jiang JX, Ouyang H, Du K, Klingel M, Kyriakopoulou L, Gonska T, Moraes TJ, Strug LJ, Rossant J, Ratjen F, Bear CE.

J Cyst Fibros. 2018 Apr 20. pii: S1569-1993(18)30086-9. doi: 10.1016/j.jcf.2018.03.013. [Epub ahead of print]

PMID:
29685812
9.

Improving imputation in disease-relevant regions: lessons from cystic fibrosis.

Panjwani N, Xiao B, Xu L, Gong J, Keenan K, Lin F, He G, Baskurt Z, Kim S, Zhang L, Esmaeili M, Blackman S, Scherer SW, Corvol H, Drumm M, Knowles M, Cutting G, Rommens JM, Sun L, Strug LJ.

NPJ Genom Med. 2018 Mar 20;3:8. doi: 10.1038/s41525-018-0047-6. eCollection 2018.

10.

Reference percentiles of FEV1 for the Canadian cystic fibrosis population: comparisons across time and countries.

Kim SO, Corey M, Stephenson AL, Strug LJ.

Thorax. 2018 May;73(5):446-450. doi: 10.1136/thoraxjnl-2017-210899. Epub 2018 Feb 6.

PMID:
29434047
11.

The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants.

Reuter MS, Walker S, Thiruvahindrapuram B, Whitney J, Cohn I, Sondheimer N, Yuen RKC, Trost B, Paton TA, Pereira SL, Herbrick JA, Wintle RF, Merico D, Howe J, MacDonald JR, Lu C, Nalpathamkalam T, Sung WWL, Wang Z, Patel RV, Pellecchia G, Wei J, Strug LJ, Bell S, Kellam B, Mahtani MM, Bassett AS, Bombard Y, Weksberg R, Shuman C, Cohn RD, Stavropoulos DJ, Bowdin S, Hildebrandt MR, Wei W, Romm A, Pasceri P, Ellis J, Ray P, Meyn MS, Monfared N, Hosseini SM, Joseph-George AM, Keeley FW, Cook RA, Fiume M, Lee HC, Marshall CR, Davies J, Hazell A, Buchanan JA, Szego MJ, Scherer SW.

CMAJ. 2018 Feb 5;190(5):E126-E136. doi: 10.1503/cmaj.171151.

12.

Translational research to enable personalized treatment of cystic fibrosis.

Hagemeijer MC, Siegwart DJ, Strug LJ, Cebotaru L, Torres MJ, Sofoluwe A, Beekman JM.

J Cyst Fibros. 2018 Mar;17(2S):S46-S51. doi: 10.1016/j.jcf.2017.10.017. Epub 2017 Dec 21. Review.

PMID:
29275953
13.

Airway Mucosal Host Defense Is Key to Genomic Regulation of Cystic Fibrosis Lung Disease Severity.

Polineni D, Dang H, Gallins PJ, Jones LC, Pace RG, Stonebraker JR, Commander LA, Krenicky JE, Zhou YH, Corvol H, Cutting GR, Drumm ML, Strug LJ, Boyle MP, Durie PR, Chmiel JF, Zou F, Wright FA, O'Neal WK, Knowles MR.

Am J Respir Crit Care Med. 2018 Jan 1;197(1):79-93. doi: 10.1164/rccm.201701-0134OC.

PMID:
28853905
14.

Corrigendum: Novel variation at chr11p13 associated with cystic fibrosis lung disease severity.

Dang H, Gallins PJ, Pace RG, Guo XL, Stonebraker JR, Corvol H, Cutting GR, Drumm ML, Strug LJ, Knowles MR, O'Neal WK.

Hum Genome Var. 2017 May 25;4:17016. doi: 10.1038/hgv.2017.16. eCollection 2017.

15.

Reply to: Is a microRNA-328 binding site in PAX6 associated with Rolandic epilepsy?

Strug LJ, Pal DK.

Ann Clin Transl Neurol. 2017 Mar 23;4(4):278-280. doi: 10.1002/acn3.403. eCollection 2017 Apr. No abstract available.

16.

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.

C Yuen RK, Merico D, Bookman M, L Howe J, Thiruvahindrapuram B, Patel RV, Whitney J, Deflaux N, Bingham J, Wang Z, Pellecchia G, Buchanan JA, Walker S, Marshall CR, Uddin M, Zarrei M, Deneault E, D'Abate L, Chan AJ, Koyanagi S, Paton T, Pereira SL, Hoang N, Engchuan W, Higginbotham EJ, Ho K, Lamoureux S, Li W, MacDonald JR, Nalpathamkalam T, Sung WW, Tsoi FJ, Wei J, Xu L, Tasse AM, Kirby E, Van Etten W, Twigger S, Roberts W, Drmic I, Jilderda S, Modi BM, Kellam B, Szego M, Cytrynbaum C, Weksberg R, Zwaigenbaum L, Woodbury-Smith M, Brian J, Senman L, Iaboni A, Doyle-Thomas K, Thompson A, Chrysler C, Leef J, Savion-Lemieux T, Smith IM, Liu X, Nicolson R, Seifer V, Fedele A, Cook EH, Dager S, Estes A, Gallagher L, Malow BA, Parr JR, Spence SJ, Vorstman J, Frey BJ, Robinson JT, Strug LJ, Fernandez BA, Elsabbagh M, Carter MT, Hallmayer J, Knoppers BM, Anagnostou E, Szatmari P, Ring RH, Glazer D, Pletcher MT, Scherer SW.

Nat Neurosci. 2017 Apr;20(4):602-611. doi: 10.1038/nn.4524. Epub 2017 Mar 6.

17.

Cystic fibrosis gene modifier SLC26A9 modulates airway response to CFTR-directed therapeutics.

Strug LJ, Gonska T, He G, Keenan K, Ip W, Boëlle PY, Lin F, Panjwani N, Gong J, Li W, Soave D, Xiao B, Tullis E, Rabin H, Parkins MD, Price A, Zuberbuhler PC, Corvol H, Ratjen F, Sun L, Bear CE, Rommens JM.

Hum Mol Genet. 2016 Oct 15;25(20):4590-4600. doi: 10.1093/hmg/ddw290.

18.

Endoplasmic Reticulum Stress and Chemokine Production in Cystic Fibrosis Airway Cells: Regulation by STAT3 Modulation.

Tang AC, Saferali A, He G, Sandford AJ, Strug LJ, Turvey SE.

J Infect Dis. 2017 Jan 15;215(2):293-302. doi: 10.1093/infdis/jiw516.

PMID:
27799352
19.

Idiopathic focal epilepsies: the "lost tribe".

Pal DK, Ferrie C, Addis L, Akiyama T, Capovilla G, Caraballo R, de Saint-Martin A, Fejerman N, Guerrini R, Hamandi K, Helbig I, Ioannides AA, Kobayashi K, Lal D, Lesca G, Muhle H, Neubauer BA, Pisano T, Rudolf G, Seegmuller C, Shibata T, Smith A, Striano P, Strug LJ, Szepetowski P, Valeta T, Yoshinaga H, Koutroumanidis M.

Epileptic Disord. 2016 Sep 1;18(3):252-88. doi: 10.1684/epd.2016.0839. Review.

20.

Novel variation at chr11p13 associated with cystic fibrosis lung disease severity.

Dang H, Gallins PJ, Pace RG, Guo XL, Stonebraker JR, Corvol H, Cutting GR, Drumm ML, Strug LJ, Knowles MR, O'Neal WK.

Hum Genome Var. 2016 Jul 7;3:16020. doi: 10.1038/hgv.2016.20. eCollection 2016. Erratum in: Hum Genome Var. 2017 May 25;4:17016.

21.

A microRNA-328 binding site in PAX6 is associated with centrotemporal spikes of rolandic epilepsy.

Panjwani N, Wilson MD, Addis L, Crosbie J, Wirrell E, Auvin S, Caraballo RH, Kinali M, McCormick D, Oren C, Taylor J, Trounce J, Clarke T, Akman CI, Kugler SL, Mandelbaum DE, McGoldrick P, Wolf SM, Arnold P, Schachar R, Pal DK, Strug LJ.

Ann Clin Transl Neurol. 2016 Jun 2;3(7):512-22. doi: 10.1002/acn3.320. eCollection 2016 Jul.

22.

Sources of Variation in Sweat Chloride Measurements in Cystic Fibrosis.

Collaco JM, Blackman SM, Raraigh KS, Corvol H, Rommens JM, Pace RG, Boelle PY, McGready J, Sosnay PR, Strug LJ, Knowles MR, Cutting GR.

Am J Respir Crit Care Med. 2016 Dec 1;194(11):1375-1382.

23.

Risk factors for reading disability in families with rolandic epilepsy.

Vega YH, Smith A, Cockerill H, Tang S, Agirre-Arrizubieta Z, Goyal S, Pina M, Akman CI, Jolleff N, McGinnity C, Gomez K, Gupta R, Hughes E, Jackman J, McCormick D, Oren C, Scott D, Taylor J, Trounce J, Clarke T, Kugler S, Mandelbaum DE, McGoldrick P, Wolf S, Strug LJ, Pal DK.

Epilepsy Behav. 2015 Dec;53:174-9. doi: 10.1016/j.yebeh.2015.10.016. Epub 2015 Nov 12.

24.

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis.

Corvol H, Blackman SM, Boëlle PY, Gallins PJ, Pace RG, Stonebraker JR, Accurso FJ, Clement A, Collaco JM, Dang H, Dang AT, Franca A, Gong J, Guillot L, Keenan K, Li W, Lin F, Patrone MV, Raraigh KS, Sun L, Zhou YH, O'Neal WK, Sontag MK, Levy H, Durie PR, Rommens JM, Drumm ML, Wright FA, Strug LJ, Cutting GR, Knowles MR.

Nat Commun. 2015 Sep 29;6:8382. doi: 10.1038/ncomms9382.

25.

A Joint Location-Scale Test Improves Power to Detect Associated SNPs, Gene Sets, and Pathways.

Soave D, Corvol H, Panjwani N, Gong J, Li W, Boëlle PY, Durie PR, Paterson AD, Rommens JM, Strug LJ, Sun L.

Am J Hum Genet. 2015 Jul 2;97(1):125-38. doi: 10.1016/j.ajhg.2015.05.015.

26.

Prevalence of meconium ileus marks the severity of mutations of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene.

Dupuis A, Keenan K, Ooi CY, Dorfman R, Sontag MK, Naehrlich L, Castellani C, Strug LJ, Rommens JM, Gonska T.

Genet Med. 2016 Apr;18(4):333-40. doi: 10.1038/gim.2015.79. Epub 2015 Jun 18.

PMID:
26087176
27.

Microdeletions of ELP4 Are Associated with Language Impairment, Autism Spectrum Disorder, and Mental Retardation.

Addis L, Ahn JW, Dobson R, Dixit A, Ogilvie CM, Pinto D, Vaags AK, Coon H, Chaste P, Wilson S, Parr JR, Andrieux J, Lenne B, Tumer Z, Leuzzi V, Aubell K, Koillinen H, Curran S, Marshall CR, Scherer SW, Strug LJ, Collier DA, Pal DK.

Hum Mutat. 2015 Sep;36(9):842-50. doi: 10.1002/humu.22816. Epub 2015 Jun 30.

PMID:
26010655
28.

Variants in Solute Carrier SLC26A9 Modify Prenatal Exocrine Pancreatic Damage in Cystic Fibrosis.

Miller MR, Soave D, Li W, Gong J, Pace RG, Boëlle PY, Cutting GR, Drumm ML, Knowles MR, Sun L, Rommens JM, Accurso F, Durie PR, Corvol H, Levy H, Sontag MK, Strug LJ.

J Pediatr. 2015 May;166(5):1152-1157.e6. doi: 10.1016/j.jpeds.2015.01.044. Epub 2015 Mar 11.

29.

Prioritizing rare variants with conditional likelihood ratios.

Li W, Dobbins S, Tomlinson I, Houlston R, Pal DK, Strug LJ.

Hum Hered. 2015;79(1):5-13. doi: 10.1159/000371579. Epub 2015 Feb 3.

30.

Gene expression in transformed lymphocytes reveals variation in endomembrane and HLA pathways modifying cystic fibrosis pulmonary phenotypes.

O'Neal WK, Gallins P, Pace RG, Dang H, Wolf WE, Jones LC, Guo X, Zhou YH, Madar V, Huang J, Liang L, Moffatt MF, Cutting GR, Drumm ML, Rommens JM, Strug LJ, Sun W, Stonebraker JR, Wright FA, Knowles MR.

Am J Hum Genet. 2015 Feb 5;96(2):318-28. doi: 10.1016/j.ajhg.2014.12.022. Epub 2015 Jan 29.

31.

Polymorphisms associated with expression of BPIFA1/BPIFB1 and lung disease severity in cystic fibrosis.

Saferali A, Obeidat M, Bérubé JC, Lamontagne M, Bossé Y, Laviolette M, Hao K, Nickle DC, Timens W, Sin DD, Postma DS, Strug LJ, Gallins PJ, Paré PD, Bingle CD, Sandford AJ.

Am J Respir Cell Mol Biol. 2015 Nov;53(5):607-14. doi: 10.1165/rcmb.2014-0182OC.

PMID:
25574903
32.

The genetics of common epilepsies: common or distinct?

Pal DK, Strug LJ.

Lancet Neurol. 2014 Sep;13(9):859-60. doi: 10.1016/S1474-4422(14)70124-3. Epub 2014 Jul 30. No abstract available.

33.

Association analysis using next-generation sequence data from publicly available control groups: the robust variance score statistic.

Derkach A, Chiang T, Gong J, Addis L, Dobbins S, Tomlinson I, Houlston R, Pal DK, Strug LJ.

Bioinformatics. 2014 Aug 1;30(15):2179-88. doi: 10.1093/bioinformatics/btu196. Epub 2014 Apr 14.

34.

Evidence for a causal relationship between early exocrine pancreatic disease and cystic fibrosis-related diabetes: a Mendelian randomization study.

Soave D, Miller MR, Keenan K, Li W, Gong J, Ip W, Accurso F, Sun L, Rommens JM, Sontag M, Durie PR, Strug LJ.

Diabetes. 2014 Jun;63(6):2114-9. doi: 10.2337/db13-1464. Epub 2014 Feb 18.

35.

Evidence for linkage of migraine in Rolandic epilepsy to known 1q23 FHM2 and novel 17q22 genetic loci.

Addis L, Chiang T, Clarke T, Hardison H, Kugler S, Mandelbaum DE, Novotny E, Wolf S, Strug LJ, Pal DK.

Genes Brain Behav. 2014 Mar;13(3):333-40. doi: 10.1111/gbb.12110. Epub 2013 Dec 26.

36.

Unraveling the complex genetic model for cystic fibrosis: pleiotropic effects of modifier genes on early cystic fibrosis-related morbidities.

Li W, Soave D, Miller MR, Keenan K, Lin F, Gong J, Chiang T, Stephenson AL, Durie P, Rommens J, Sun L, Strug LJ.

Hum Genet. 2014 Feb;133(2):151-61. doi: 10.1007/s00439-013-1363-7. Epub 2013 Sep 22.

PMID:
24057835
37.

Genetic modifiers of cystic fibrosis-related diabetes.

Blackman SM, Commander CW, Watson C, Arcara KM, Strug LJ, Stonebraker JR, Wright FA, Rommens JM, Sun L, Pace RG, Norris SA, Durie PR, Drumm ML, Knowles MR, Cutting GR.

Diabetes. 2013 Oct;62(10):3627-35. doi: 10.2337/db13-0510. Epub 2013 May 13.

38.

Response inhibition and ADHD traits: correlates and heritability in a community sample.

Crosbie J, Arnold P, Paterson A, Swanson J, Dupuis A, Li X, Shan J, Goodale T, Tam C, Strug LJ, Schachar RJ.

J Abnorm Child Psychol. 2013 Apr;41(3):497-507. doi: 10.1007/s10802-012-9693-9.

39.

The genetics of reading disability in an often excluded sample: novel loci suggested for reading disability in Rolandic epilepsy.

Strug LJ, Addis L, Chiang T, Baskurt Z, Li W, Clarke T, Hardison H, Kugler SL, Mandelbaum DE, Novotny EJ, Wolf SM, Pal DK.

PLoS One. 2012;7(7):e40696. doi: 10.1371/journal.pone.0040696. Epub 2012 Jul 18.

40.

Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis.

Sun L, Rommens JM, Corvol H, Li W, Li X, Chiang TA, Lin F, Dorfman R, Busson PF, Parekh RV, Zelenika D, Blackman SM, Corey M, Doshi VK, Henderson L, Naughton KM, O'Neal WK, Pace RG, Stonebraker JR, Wood SD, Wright FA, Zielenski J, Clement A, Drumm ML, Boëlle PY, Cutting GR, Knowles MR, Durie PR, Strug LJ.

Nat Genet. 2012 May;44(5):562-9. doi: 10.1038/ng.2221.

41.

Using parametric multipoint lods and mods for linkage analysis requires a shift in statistical thinking.

Hodge SE, Baskurt Z, Strug LJ.

Hum Hered. 2011;72(4):264-75. doi: 10.1159/000331463. Epub 2011 Dec 23.

42.

Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2.

Wright FA, Strug LJ, Doshi VK, Commander CW, Blackman SM, Sun L, Berthiaume Y, Cutler D, Cojocaru A, Collaco JM, Corey M, Dorfman R, Goddard K, Green D, Kent JW Jr, Lange EM, Lee S, Li W, Luo J, Mayhew GM, Naughton KM, Pace RG, Paré P, Rommens JM, Sandford A, Stonebraker JR, Sun W, Taylor C, Vanscoy LL, Zou F, Blangero J, Zielenski J, O'Neal WK, Drumm ML, Durie PR, Knowles MR, Cutting GR.

Nat Genet. 2011 Jun;43(6):539-46. doi: 10.1038/ng.838. Epub 2011 May 22.

43.

A novel lung disease phenotype adjusted for mortality attrition for cystic fibrosis genetic modifier studies.

Taylor C, Commander CW, Collaco JM, Strug LJ, Li W, Wright FA, Webel AD, Pace RG, Stonebraker JR, Naughton K, Dorfman R, Sandford A, Blackman SM, Berthiaume Y, Paré P, Drumm ML, Zielenski J, Durie P, Cutting GR, Knowles MR, Corey M.

Pediatr Pulmonol. 2011 Sep;46(9):857-69. doi: 10.1002/ppul.21456. Epub 2011 Apr 1.

44.

Pleiotropic effects of the 11p13 locus on developmental verbal dyspraxia and EEG centrotemporal sharp waves.

Pal DK, Li W, Clarke T, Lieberman P, Strug LJ.

Genes Brain Behav. 2010 Nov;9(8):1004-12. doi: 10.1111/j.1601-183X.2010.00648.x. Epub 2010 Oct 18.

45.

Understanding the population structure of North American patients with cystic fibrosis.

Li W, Sun L, Corey M, Zou F, Lee S, Cojocaru AL, Taylor C, Blackman SM, Stephenson A, Sandford AJ, Dorfman R, Drumm ML, Cutting GR, Knowles MR, Durie P, Wright FA, Strug LJ.

Clin Genet. 2011 Feb;79(2):136-46. doi: 10.1111/j.1399-0004.2010.01502.x.

46.

A pure likelihood approach to the analysis of genetic association data: an alternative to Bayesian and frequentist analysis.

Strug LJ, Hodge SE, Chiang T, Pal DK, Corey PN, Rohde C.

Eur J Hum Genet. 2010 Aug;18(8):933-41. doi: 10.1038/ejhg.2010.47. Epub 2010 Apr 28.

47.

Evidence of shared genetic risk factors for migraine and rolandic epilepsy.

Clarke T, Baskurt Z, Strug LJ, Pal DK.

Epilepsia. 2009 Nov;50(11):2428-33. doi: 10.1111/j.1528-1167.2009.02240.x. Epub 2009 Aug 8.

48.

Modifier gene study of meconium ileus in cystic fibrosis: statistical considerations and gene mapping results.

Dorfman R, Li W, Sun L, Lin F, Wang Y, Sandford A, Paré PD, McKay K, Kayserova H, Piskackova T, Macek M, Czerska K, Sands D, Tiddens H, Margarit S, Repetto G, Sontag MK, Accurso FJ, Blackman S, Cutting GR, Tsui LC, Corey M, Durie P, Zielenski J, Strug LJ.

Hum Genet. 2009 Dec;126(6):763-78. doi: 10.1007/s00439-009-0724-8.

49.

Centrotemporal sharp wave EEG trait in rolandic epilepsy maps to Elongator Protein Complex 4 (ELP4).

Strug LJ, Clarke T, Chiang T, Chien M, Baskurt Z, Li W, Dorfman R, Bali B, Wirrell E, Kugler SL, Mandelbaum DE, Wolf SM, McGoldrick P, Hardison H, Novotny EJ, Ju J, Greenberg DA, Russo JJ, Pal DK.

Eur J Hum Genet. 2009 Sep;17(9):1171-81. doi: 10.1038/ejhg.2008.267. Epub 2009 Jan 28.

50.

Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR).

Strug LJ, Suresh R, Fyer AJ, Talati A, Adams PB, Li W, Hodge SE, Gilliam TC, Weissman MM.

Mol Psychiatry. 2010 Feb;15(2):166-76. doi: 10.1038/mp.2008.79. Epub 2008 Jul 29.

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