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Items: 1 to 50 of 67

1.

Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis.

Liao L, Schneider KM, Galvez EJC, Frissen M, Marschall HU, Su H, Hatting M, Wahlström A, Haybaeck J, Puchas P, Mohs A, Peng J, Bergheim I, Nier A, Hennings J, Reißing J, Zimmermann HW, Longerich T, Strowig T, Liedtke C, Cubero FJ, Trautwein C.

Gut. 2019 Mar 14. pii: gutjnl-2018-316670. doi: 10.1136/gutjnl-2018-316670. [Epub ahead of print]

PMID:
30872395
2.

Performance, Fermentation Characteristics and Composition of the Microbiome in the Digest of Piglets Kept on a Feed With Humic Acid-Rich Peat.

Visscher C, Hankel J, Nies A, Keller B, Galvez E, Strowig T, Keller C, Breves G.

Front Vet Sci. 2019 Feb 12;6:29. doi: 10.3389/fvets.2019.00029. eCollection 2019.

3.

Epithelium-specific MyD88 signaling, but not DCs or macrophages, control acute intestinal infection with Clostridium difficile.

Mamareli P, Kruse F, Friedrich C, Smit N, Strowig T, Sparwasser T, Lochner M.

Eur J Immunol. 2019 May;49(5):747-757. doi: 10.1002/eji.201848022. Epub 2019 Mar 10.

PMID:
30802297
4.

Sequence and cultivation study of Muribaculaceae reveals novel species, host preference, and functional potential of this yet undescribed family.

Lagkouvardos I, Lesker TR, Hitch TCA, Gálvez EJC, Smit N, Neuhaus K, Wang J, Baines JF, Abt B, Stecher B, Overmann J, Strowig T, Clavel T.

Microbiome. 2019 Feb 19;7(1):28. doi: 10.1186/s40168-019-0637-2.

5.

c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host-microbiota homeostasis.

Neumann C, Blume J, Roy U, Teh PP, Vasanthakumar A, Beller A, Liao Y, Heinrich F, Arenzana TL, Hackney JA, Eidenschenk C, Gálvez EJC, Stehle C, Heinz GA, Maschmeyer P, Sidwell T, Hu Y, Amsen D, Romagnani C, Chang HD, Kruglov A, Mashreghi MF, Shi W, Strowig T, Rutz S, Kallies A, Scheffold A.

Nat Immunol. 2019 Apr;20(4):471-481. doi: 10.1038/s41590-019-0316-2. Epub 2019 Feb 18.

PMID:
30778241
6.

Prevotella copri in individuals at risk for rheumatoid arthritis.

Alpizar-Rodriguez D, Lesker TR, Gronow A, Gilbert B, Raemy E, Lamacchia C, Gabay C, Finckh A, Strowig T.

Ann Rheum Dis. 2019 May;78(5):590-593. doi: 10.1136/annrheumdis-2018-214514. Epub 2019 Feb 13.

PMID:
30760471
7.

PrsA2 (CD630_35000) of Clostridioides difficile Is an Active Parvulin-Type PPIase and a Virulence Modulator.

Ünal CM, Berges M, Smit N, Schiene-Fischer C, Priebe C, Strowig T, Jahn D, Steinert M.

Front Microbiol. 2018 Dec 4;9:2913. doi: 10.3389/fmicb.2018.02913. eCollection 2018.

8.

Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3+ Regulatory T Cells.

Mathies F, Steffens N, Kleinschmidt D, Stuhlmann F, Huber FJ, Roy U, Meyer T, Luetgehetmann M, von Petersdorff M, Seiz O, Herkel J, Schramm C, Flavell RA, Gagliani N, Krebs C, Panzer U, Abdullah Z, Strowig T, Bedke T, Huber S.

J Immunol. 2018 Dec 15;201(12):3558-3568. doi: 10.4049/jimmunol.1800711. Epub 2018 Nov 16.

PMID:
30446566
9.

Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes.

Pezoldt J, Pasztoi M, Zou M, Wiechers C, Beckstette M, Thierry GR, Vafadarnejad E, Floess S, Arampatzi P, Buettner M, Schweer J, Fleissner D, Vital M, Pieper DH, Basic M, Dersch P, Strowig T, Hornef M, Bleich A, Bode U, Pabst O, Bajénoff M, Saliba AE, Huehn J.

Nat Commun. 2018 Sep 25;9(1):3903. doi: 10.1038/s41467-018-06423-7.

10.

The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice.

Kindt A, Liebisch G, Clavel T, Haller D, Hörmannsperger G, Yoon H, Kolmeder D, Sigruener A, Krautbauer S, Seeliger C, Ganzha A, Schweizer S, Morisset R, Strowig T, Daniel H, Helm D, Küster B, Krumsiek J, Ecker J.

Nat Commun. 2018 Sep 14;9(1):3760. doi: 10.1038/s41467-018-05767-4.

11.

Chronic d-serine supplementation impairs insulin secretion.

Suwandhi L, Hausmann S, Braun A, Gruber T, Heinzmann SS, Gálvez EJC, Buck A, Legutko B, Israel A, Feuchtinger A, Haythorne E, Staiger H, Heni M, Häring HU, Schmitt-Kopplin P, Walch A, Cáceres CG, Tschöp MH, Rutter GA, Strowig T, Elsner M, Ussar S.

Mol Metab. 2018 Oct;16:191-202. doi: 10.1016/j.molmet.2018.07.002. Epub 2018 Jul 25.

12.

The gut microbiota drives the impact of bile acids and fat source in diet on mouse metabolism.

Just S, Mondot S, Ecker J, Wegner K, Rath E, Gau L, Streidl T, Hery-Arnaud G, Schmidt S, Lesker TR, Bieth V, Dunkel A, Strowig T, Hofmann T, Haller D, Liebisch G, Gérard P, Rohn S, Lepage P, Clavel T.

Microbiome. 2018 Aug 2;6(1):134. doi: 10.1186/s40168-018-0510-8.

13.

NLRP6 and Dysbiosis: Avoiding the Luring Attraction of Over-Simplification.

Elinav E, Henao-Mejia J, Strowig T, Flavell R.

Immunity. 2018 Apr 17;48(4):603-604. doi: 10.1016/j.immuni.2018.04.002. No abstract available.

14.

Successful Fecal Microbiota Transplantation in a Patient with Severe Complicated Clostridium difficile Infection after Liver Transplantation.

Schneider KM, Wirtz TH, Kroy D, Albers S, Neumann UP, Strowig T, Sellge G, Trautwein C.

Case Rep Gastroenterol. 2018 Feb 21;12(1):76-84. doi: 10.1159/000481937. eCollection 2018 Jan-Apr. Review.

15.

Loss of CNFY toxin-induced inflammation drives Yersinia pseudotuberculosis into persistency.

Heine W, Beckstette M, Heroven AK, Thiemann S, Heise U, Nuss AM, Pisano F, Strowig T, Dersch P.

PLoS Pathog. 2018 Feb 1;14(2):e1006858. doi: 10.1371/journal.ppat.1006858. eCollection 2018 Feb.

16.

Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss.

Lucas S, Omata Y, Hofmann J, Böttcher M, Iljazovic A, Sarter K, Albrecht O, Schulz O, Krishnacoumar B, Krönke G, Herrmann M, Mougiakakos D, Strowig T, Schett G, Zaiss MM.

Nat Commun. 2018 Jan 4;9(1):55. doi: 10.1038/s41467-017-02490-4.

17.

Shaping of Intestinal Microbiota in Nlrp6- and Rag2-Deficient Mice Depends on Community Structure.

Gálvez EJC, Iljazovic A, Gronow A, Flavell R, Strowig T.

Cell Rep. 2017 Dec 26;21(13):3914-3926. doi: 10.1016/j.celrep.2017.12.027.

18.

Corrigendum: Development and function of human innate immune cells in a humanized mouse model.

Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA.

Nat Biotechnol. 2017 Dec 8;35(12):1211. doi: 10.1038/nbt1217-1211c. No abstract available.

PMID:
29220023
19.

Humanized mouse model supports development, function, and tissue residency of human natural killer cells.

Herndler-Brandstetter D, Shan L, Yao Y, Stecher C, Plajer V, Lietzenmayer M, Strowig T, de Zoete MR, Palm NW, Chen J, Blish CA, Frleta D, Gurer C, Macdonald LE, Murphy AJ, Yancopoulos GD, Montgomery RR, Flavell RA.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9626-E9634. doi: 10.1073/pnas.1705301114. Epub 2017 Oct 25.

20.

Distinct Microbial Communities Trigger Colitis Development upon Intestinal Barrier Damage via Innate or Adaptive Immune Cells.

Roy U, Gálvez EJC, Iljazovic A, Lesker TR, Błażejewski AJ, Pils MC, Heise U, Huber S, Flavell RA, Strowig T.

Cell Rep. 2017 Oct 24;21(4):994-1008. doi: 10.1016/j.celrep.2017.09.097.

21.

A flagellum-specific chaperone facilitates assembly of the core type III export apparatus of the bacterial flagellum.

Fabiani FD, Renault TT, Peters B, Dietsche T, Gálvez EJC, Guse A, Freier K, Charpentier E, Strowig T, Franz-Wachtel M, Macek B, Wagner S, Hensel M, Erhardt M.

PLoS Biol. 2017 Aug 3;15(8):e2002267. doi: 10.1371/journal.pbio.2002267. eCollection 2017 Aug.

22.

Enhancement of IFNγ Production by Distinct Commensals Ameliorates Salmonella-Induced Disease.

Thiemann S, Smit N, Roy U, Lesker TR, Gálvez EJC, Helmecke J, Basic M, Bleich A, Goodman AL, Kalinke U, Flavell RA, Erhardt M, Strowig T.

Cell Host Microbe. 2017 Jun 14;21(6):682-694.e5. doi: 10.1016/j.chom.2017.05.005.

23.

Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation.

Błażejewski AJ, Thiemann S, Schenk A, Pils MC, Gálvez EJC, Roy U, Heise U, de Zoete MR, Flavell RA, Strowig T.

Cell Rep. 2017 Jun 13;19(11):2319-2330. doi: 10.1016/j.celrep.2017.05.058.

24.

MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.

Friedrich C, Mamareli P, Thiemann S, Kruse F, Wang Z, Holzmann B, Strowig T, Sparwasser T, Lochner M.

PLoS Pathog. 2017 May 16;13(5):e1006357. doi: 10.1371/journal.ppat.1006357. eCollection 2017 May.

25.

Cyclic dinucleotides modulate induced type I IFN responses in innate immune cells by degradation of STING.

Rueckert C, Rand U, Roy U, Kasmapour B, Strowig T, Guzmán CA.

FASEB J. 2017 Jul;31(7):3107-3115. doi: 10.1096/fj.201601093R. Epub 2017 Apr 10.

PMID:
28396343
26.

Flagellin phase-dependent swimming on epithelial cell surfaces contributes to productive Salmonella gut colonisation.

Horstmann JA, Zschieschang E, Truschel T, de Diego J, Lunelli M, Rohde M, May T, Strowig T, Stradal T, Kolbe M, Erhardt M.

Cell Microbiol. 2017 Aug;19(8). doi: 10.1111/cmi.12739. Epub 2017 Apr 18.

PMID:
28295924
27.

A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production.

Yu H, Borsotti C, Schickel JN, Zhu S, Strowig T, Eynon EE, Frleta D, Gurer C, Murphy AJ, Yancopoulos GD, Meffre E, Manz MG, Flavell RA.

Blood. 2017 Feb 23;129(8):959-969. doi: 10.1182/blood-2016-04-709584. Epub 2017 Jan 11.

28.

PTPN22 inhibition resets defective human central B cell tolerance.

Schickel JN, Kuhny M, Baldo A, Bannock JM, Massad C, Wang H, Katz N, Oe T, Menard L, Soulas-Sprauel P, Strowig T, Flavell R, Meffre E.

Sci Immunol. 2016;1(1). pii: aaf7153. Epub 2016 Jul 22.

29.

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury.

Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA.

Science. 2016 Nov 11;354(6313):765-768.

30.

A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease.

Pelczar P, Witkowski M, Perez LG, Kempski J, Hammel AG, Brockmann L, Kleinschmidt D, Wende S, Haueis C, Bedke T, Witkowski M, Krasemann S, Steurer S, Booth CJ, Busch P, König A, Rauch U, Benten D, Izbicki JR, Rösch T, Lohse AW, Strowig T, Gagliani N, Flavell RA, Huber S.

Science. 2016 Oct 21;354(6310):358-362.

PMID:
27846573
31.

Microenvironment-dependent growth of preneoplastic and malignant plasma cells in humanized mice.

Das R, Strowig T, Verma R, Koduru S, Hafemann A, Hopf S, Kocoglu MH, Borsotti C, Zhang L, Branagan A, Eynon E, Manz MG, Flavell RA, Dhodapkar MV.

Nat Med. 2016 Nov;22(11):1351-1357. doi: 10.1038/nm.4202. Epub 2016 Oct 10.

32.

Antibiotics and the Intestinal Microbiome : Individual Responses, Resilience of the Ecosystem, and the Susceptibility to Infections.

Thiemann S, Smit N, Strowig T.

Curr Top Microbiol Immunol. 2016;398:123-146. doi: 10.1007/82_2016_504. Review.

PMID:
27738912
33.

Analysis of factors contributing to variation in the C57BL/6J fecal microbiota across German animal facilities.

Rausch P, Basic M, Batra A, Bischoff SC, Blaut M, Clavel T, Gläsner J, Gopalakrishnan S, Grassl GA, Günther C, Haller D, Hirose M, Ibrahim S, Loh G, Mattner J, Nagel S, Pabst O, Schmidt F, Siegmund B, Strowig T, Volynets V, Wirtz S, Zeissig S, Zeissig Y, Bleich A, Baines JF.

Int J Med Microbiol. 2016 Aug;306(5):343-355. doi: 10.1016/j.ijmm.2016.03.004. Epub 2016 Mar 15.

34.

Corrigendum: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.

Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA.

Nature. 2016 Feb 25;530(7591):504. doi: 10.1038/nature16074. Epub 2015 Nov 25. No abstract available.

PMID:
26605525
35.

Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.

Finethy R, Jorgensen I, Haldar AK, de Zoete MR, Strowig T, Flavell RA, Yamamoto M, Nagarajan UM, Miao EA, Coers J.

Infect Immun. 2015 Dec;83(12):4740-9. doi: 10.1128/IAI.00856-15. Epub 2015 Sep 28.

36.

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations.

Deng K, Pertea M, Rongvaux A, Wang L, Durand CM, Ghiaur G, Lai J, McHugh HL, Hao H, Zhang H, Margolick JB, Gurer C, Murphy AJ, Valenzuela DM, Yancopoulos GD, Deeks SG, Strowig T, Kumar P, Siliciano JD, Salzberg SL, Flavell RA, Shan L, Siliciano RF.

Nature. 2015 Jan 15;517(7534):381-5. doi: 10.1038/nature14053. Epub 2015 Jan 7.

37.

IQGAP1 is important for activation of caspase-1 in macrophages and is targeted by Yersinia pestis type III effector YopM.

Chung LK, Philip NH, Schmidt VA, Koller A, Strowig T, Flavell RA, Brodsky IE, Bliska JB.

MBio. 2014 Jul 1;5(4):e01402-14. doi: 10.1128/mBio.01402-14.

38.

Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome.

Wynosky-Dolfi MA, Snyder AG, Philip NH, Doonan PJ, Poffenberger MC, Avizonis D, Zwack EE, Riblett AM, Hu B, Strowig T, Flavell RA, Jones RG, Freedman BD, Brodsky IE.

J Exp Med. 2014 Apr 7;211(4):653-68. doi: 10.1084/jem.20130627. Epub 2014 Mar 17.

39.

Development and function of human innate immune cells in a humanized mouse model.

Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA.

Nat Biotechnol. 2014 Apr;32(4):364-72. doi: 10.1038/nbt.2858. Epub 2014 Mar 16. Erratum in: Nat Biotechnol. 2017 Dec 8;35(12 ):1211.

40.

Caspase-11 activation in response to bacterial secretion systems that access the host cytosol.

Casson CN, Copenhaver AM, Zwack EE, Nguyen HT, Strowig T, Javdan B, Bradley WP, Fung TC, Flavell RA, Brodsky IE, Shin S.

PLoS Pathog. 2013;9(6):e1003400. doi: 10.1371/journal.ppat.1003400. Epub 2013 Jun 6.

41.

Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer.

Hu B, Elinav E, Huber S, Strowig T, Hao L, Hafemann A, Jin C, Wunderlich C, Wunderlich T, Eisenbarth SC, Flavell RA.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9862-7. doi: 10.1073/pnas.1307575110. Epub 2013 May 21. Erratum in: Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12852. Wunderlich, Claudia [added]; Wunderlich, Thomas [added].

42.

Microbiota keep the intestinal clock ticking.

Henao-Mejia J, Strowig T, Flavell RA.

Cell. 2013 May 9;153(4):741-3. doi: 10.1016/j.cell.2013.04.043. Erratum in: Cell. 2013 Jun 20;153(7):1612.

43.

Human hemato-lymphoid system mice: current use and future potential for medicine.

Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA, Manz MG.

Annu Rev Immunol. 2013;31:635-674. doi: 10.1146/annurev-immunol-032712-095921. Epub 2013 Jan 16. Review.

44.

Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila.

Case CL, Kohler LJ, Lima JB, Strowig T, de Zoete MR, Flavell RA, Zamboni DS, Roy CR.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1851-6. doi: 10.1073/pnas.1211521110. Epub 2013 Jan 10.

45.

NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.

Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA.

Nature. 2012 Apr 25;484(7395):510-3. doi: 10.1038/nature11012. Erratum in: Nature. 2016 Feb 25;530(7591):504.

46.

Inflammasomes: far beyond inflammation.

Henao-Mejia J, Elinav E, Strowig T, Flavell RA.

Nat Immunol. 2012 Mar 19;13(4):321-4. doi: 10.1038/ni.2257. Review.

PMID:
22430784
47.

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.

Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA.

Nature. 2012 Feb 1;482(7384):179-85. doi: 10.1038/nature10809.

48.

Inflammasomes in health and disease.

Strowig T, Henao-Mejia J, Elinav E, Flavell R.

Nature. 2012 Jan 18;481(7381):278-86. doi: 10.1038/nature10759. Review.

PMID:
22258606
49.

Dendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma.

Koduru S, Wong E, Strowig T, Sundaram R, Zhang L, Strout MP, Flavell RA, Schatz DG, Dhodapkar KM, Dhodapkar MV.

Blood. 2012 Mar 8;119(10):2302-9. doi: 10.1182/blood-2011-08-376236. Epub 2012 Jan 10.

50.

Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.

Strowig T, Rongvaux A, Rathinam C, Takizawa H, Borsotti C, Philbrick W, Eynon EE, Manz MG, Flavell RA.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13218-23. doi: 10.1073/pnas.1109769108. Epub 2011 Jul 25.

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