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Items: 1 to 50 of 152

1.

Fos-Zippered GH Receptor Cytosolic Tails Act as Jak2 Substrates and Signal Transducers.

Nespital T, van der Velden LM, Mensinga A, van der Vaart ED, Strous GJ.

Mol Endocrinol. 2016 Mar;30(3):290-301. doi: 10.1210/me.2015-1315. Epub 2016 Feb 9.

2.

Automation of a phospho-STAT5 staining procedure for flow cytometry for application in drug discovery.

Malergue F, van Agthoven A, Scifo C, Egan D, Strous GJ.

J Biomol Screen. 2015 Mar;20(3):416-21. doi: 10.1177/1087057114555477. Epub 2014 Oct 16.

PMID:
25325258
3.

Multimeric growth hormone receptor complexes serve as signaling platforms.

Sedek M, van der Velden LM, Strous GJ.

J Biol Chem. 2014 Jan 3;289(1):65-73. doi: 10.1074/jbc.M113.523373. Epub 2013 Nov 26.

4.

βTrCP interacts with the ubiquitin-dependent endocytosis motif of the GH receptor in an unconventional manner.

da Silva Almeida AC, Hocking HG, Boelens R, Strous GJ, van Rossum AG.

Biochem J. 2013 Jul 15;453(2):291-301. doi: 10.1042/BJ20121843.

PMID:
23607312
5.

SUMOylation is a regulator of the translocation of Jak2 between nucleus and cytosol.

Sedek M, Strous GJ.

Biochem J. 2013 Jul 15;453(2):231-9. doi: 10.1042/BJ20121375.

PMID:
23581279
6.

Identification of the ubiquitin ligase Triad1 as a regulator of endosomal transport.

Hassink G, Slotman J, Oorschot V, Van Der Reijden BA, Monteferrario D, Noordermeer SM, Van Kerkhof P, Klumperman J, Strous GJ.

Biol Open. 2012 Jun 15;1(6):607-14. doi: 10.1242/bio.2012778. Epub 2012 May 9.

7.

The Jak/STAT signaling pathway is downregulated at febrile temperatures.

Nespital T, Strous GJ.

PLoS One. 2012;7(11):e49374. doi: 10.1371/journal.pone.0049374. Epub 2012 Nov 14.

8.

Ubc13 and COOH terminus of Hsp70-interacting protein (CHIP) are required for growth hormone receptor endocytosis.

Slotman JA, da Silva Almeida AC, Hassink GC, van de Ven RH, van Kerkhof P, Kuiken HJ, Strous GJ.

J Biol Chem. 2012 May 4;287(19):15533-43. doi: 10.1074/jbc.M111.302521. Epub 2012 Mar 20.

9.

βTrCP controls GH receptor degradation via two different motifs.

da Silva Almeida AC, Strous GJ, van Rossum AG.

Mol Endocrinol. 2012 Jan;26(1):165-77. doi: 10.1210/me.2011-1211. Epub 2011 Oct 27.

10.

Jak2 is a negative regulator of ubiquitin-dependent endocytosis of the growth hormone receptor.

Putters J, da Silva Almeida AC, van Kerkhof P, van Rossum AG, Gracanin A, Strous GJ.

PLoS One. 2011 Feb 9;6(2):e14676. doi: 10.1371/journal.pone.0014676.

11.

SCF(TrCP) acts in endosomal sorting of the GH receptor.

van Kerkhof P, Westgeest M, Hassink G, Strous GJ.

Exp Cell Res. 2011 Apr 15;317(7):1071-82. doi: 10.1016/j.yexcr.2010.12.020. Epub 2010 Dec 30.

12.

Specificity, location and function of βTrCP isoforms and their splice variants.

Putters J, Slotman JA, Gerlach JP, Strous GJ.

Cell Signal. 2011 Apr;23(4):641-7. doi: 10.1016/j.cellsig.2010.11.015. Epub 2010 Dec 5.

13.

Autocrine growth hormone: effects on growth hormone receptor trafficking and signaling.

van den Eijnden MJ, Strous GJ.

Mol Endocrinol. 2007 Nov;21(11):2832-46. Epub 2007 Jul 31.

PMID:
17666586
14.

The ubiquitin ligase SCF(betaTrCP) regulates the degradation of the growth hormone receptor.

van Kerkhof P, Putters J, Strous GJ.

J Biol Chem. 2007 Jul 13;282(28):20475-83. Epub 2007 May 10. Erratum in: J Biol Chem. 2008 Apr 25;283(17):11860.

15.

Disulfide bonds determine growth hormone receptor folding, dimerisation and ligand binding.

van den Eijnden MJ, Lahaye LL, Strous GJ.

J Cell Sci. 2006 Aug 1;119(Pt 15):3078-86. Epub 2006 Jul 4.

16.

Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system.

Comellas AP, Dada LA, Lecuona E, Pesce LM, Chandel NS, Quesada N, Budinger GR, Strous GJ, Ciechanover A, Sznajder JI.

Circ Res. 2006 May 26;98(10):1314-22. Epub 2006 Apr 13.

PMID:
16614303
17.

Sorting nexin 17 facilitates LRP recycling in the early endosome.

van Kerkhof P, Lee J, McCormick L, Tetrault E, Lu W, Schoenfish M, Oorschot V, Strous GJ, Klumperman J, Bu G.

EMBO J. 2005 Aug 17;24(16):2851-61. Epub 2005 Jul 28.

18.

Ubiquitin system-dependent regulation of growth hormone receptor signal transduction.

Strous GJ, dos Santos CA, Gent J, Govers R, Sachse M, Schantl J, van Kerkhof P.

Curr Top Microbiol Immunol. 2004;286:81-118. Review.

PMID:
15645711
19.

ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles.

Sachse M, Strous GJ, Klumperman J.

J Cell Sci. 2004 Apr 1;117(Pt 9):1699-708. Epub 2004 Mar 9.

20.

The growth hormone receptor interacts with its sheddase, the tumour necrosis factor-alpha-converting enzyme (TACE).

Schantl JA, Roza M, Van Kerkhof P, Strous GJ.

Biochem J. 2004 Jan 15;377(Pt 2):379-84.

21.

The UIM domain of Hrs couples receptor sorting to vesicle formation.

Urbé S, Sachse M, Row PE, Preisinger C, Barr FA, Strous G, Klumperman J, Clague MJ.

J Cell Sci. 2003 Oct 15;116(Pt 20):4169-79. Epub 2003 Sep 2.

22.

Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor.

Pasquali C, Curchod ML, Wälchli S, Espanel X, Guerrier M, Arigoni F, Strous G, Hooft van Huijsduijnen R.

Mol Endocrinol. 2003 Nov;17(11):2228-39. Epub 2003 Aug 7.

PMID:
12907755
24.

A method to increase the number of growth hormone receptors at the surface of cells.

van Kerkhof P, Vallon E, Strous GJ.

Mol Cell Endocrinol. 2003 Mar 28;201(1-2):57-62.

PMID:
12706294
25.

Dimerization and signal transduction of the growth hormone receptor.

Gent J, Van Den Eijnden M, Van Kerkhof P, Strous GJ.

Mol Endocrinol. 2003 May;17(5):967-75. Epub 2003 Feb 6.

PMID:
12576487
26.

The ubiquitin-proteasome pathway and the regulation of growth hormone receptor availability.

Strous GJ, van Kerkhof P.

Mol Cell Endocrinol. 2002 Nov 29;197(1-2):143-51. Review.

PMID:
12431807
27.

Multiple internalization motifs differentially used by prolactin receptor isoforms mediate similar endocytic pathways.

Lu JC, Scott P, Strous GJ, Schuler LA.

Mol Endocrinol. 2002 Nov;16(11):2515-27.

PMID:
12403840
28.
29.

Proteasome regulates the delivery of LDL receptor-related protein into the degradation pathway.

Melman L, Geuze HJ, Li Y, McCormick LM, Van Kerkhof P, Strous GJ, Schwartz AL, Bu G.

Mol Biol Cell. 2002 Sep;13(9):3325-35.

30.

Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis.

Gent J, van Kerkhof P, Roza M, Bu G, Strous GJ.

Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9858-63. Epub 2002 Jul 8.

31.

Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes.

Sachse M, Urbé S, Oorschot V, Strous GJ, Klumperman J.

Mol Biol Cell. 2002 Apr;13(4):1313-28.

32.

Endosomes: multipurpose designs for integrating housekeeping and specialized tasks.

Sachse M, Ramm G, Strous G, Klumperman J.

Histochem Cell Biol. 2002 Feb;117(2):91-104. Epub 2001 Dec 14. Review.

PMID:
11935285
33.

The ubiquitin-proteasome pathway regulates the availability of the GH receptor.

van Kerkhof P, Smeets M, Strous GJ.

Endocrinology. 2002 Apr;143(4):1243-52.

PMID:
11897680
34.

Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin.

Staal FJ, van Noort M, Strous GJ, Clevers HC.

EMBO Rep. 2002 Jan;3(1):63-8. Epub 2001 Dec 19.

35.

Hans Geuze: a career full of fascination for function and beauty of cellular structures.

Strous GJ.

Traffic. 2001 Dec;2(12):921-3. No abstract available.

36.

Beta-arrestin and Mdm2, unsuspected partners in signaling from the cell surface.

Strous GJ, Schantl JA.

Sci STKE. 2001 Nov 27;2001(110):pe41. Review.

PMID:
11724970
38.

Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteins.

van Kerkhof P, Alves dos Santos CM, Sachse M, Klumperman J, Bu G, Strous GJ.

Mol Biol Cell. 2001 Aug;12(8):2556-66.

39.

The ubiquitin-proteasome pathway regulates lysosomal degradation of the growth hormone receptor and its ligand.

van Kerkhof P, Strous GJ.

Biochem Soc Trans. 2001 Aug;29(Pt 4):488-93.

PMID:
11498015
40.

Growth hormone receptor ubiquitination, endocytosis, and degradation are independent of signal transduction via Janus kinase 2.

Alves dos Santos CM, ten Broeke T, Strous GJ.

J Biol Chem. 2001 Aug 31;276(35):32635-41. Epub 2001 Jun 19.

42.

The signal transduction of the growth hormone receptor is regulated by the ubiquitin/proteasome system and continues after endocytosis.

Alves dos Santos CM, van Kerkhof P, Strous GJ.

J Biol Chem. 2001 Apr 6;276(14):10839-46. Epub 2001 Jan 10.

43.

Growth hormone receptor ubiquitination coincides with recruitment to clathrin-coated membrane domains.

van Kerkhof P, Sachse M, Klumperman J, Strous GJ.

J Biol Chem. 2001 Feb 9;276(6):3778-84. Epub 2000 Oct 19.

44.
45.

Endocytosis and degradation of the growth hormone receptor are proteasome-dependent.

van Kerkhof P, Govers R, Alves dos Santos CM, Strous GJ.

J Biol Chem. 2000 Jan 21;275(3):1575-80.

46.

The ubiquitin-proteasome system and endocytosis.

Strous GJ, Govers R.

J Cell Sci. 1999 May;112 ( Pt 10):1417-23. Review.

47.

Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor.

Govers R, ten Broeke T, van Kerkhof P, Schwartz AL, Strous GJ.

EMBO J. 1999 Jan 4;18(1):28-36.

48.
49.

Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif.

van de Bovenkamp JH, Hau CM, Strous GJ, Büller HA, Dekker J, Einerhand AW.

Biochem Biophys Res Commun. 1998 Apr 28;245(3):853-9.

PMID:
9588204
50.

An advanced in vitro model to study hypoxia/low glucose-induced neuronal cell damage and death.

Tabor MP, Van der Worp HB, Sodaar P, Veldman H, Joosten EA, Strous G, Bär PR.

Ann N Y Acad Sci. 1997 Oct 15;825:267-78. No abstract available.

PMID:
9369993

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