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Items: 30

1.

Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling.

Georgieva T, Devanathan S, Stropova D, Park CK, Salamon Z, Tollin G, Hruby VJ, Roeske WR, Yamamura HI, Varga E.

Eur J Pharmacol. 2008 Feb 26;581(1-2):19-29. Epub 2007 Nov 28.

2.

Quantitative evaluation of human delta opioid receptor desensitization using the operational model of drug action.

Navratilova E, Waite S, Stropova D, Eaton MC, Alves ID, Hruby VJ, Roeske WR, Yamamura HI, Varga EV.

Mol Pharmacol. 2007 May;71(5):1416-26. Epub 2007 Feb 22.

PMID:
17322005
3.

Chronic morphine-mediated adenylyl cyclase superactivation is attenuated by the Raf-1 inhibitor, GW5074.

Yue X, Varga EV, Stropova D, Vanderah TW, Yamamura HI, Roeske WR.

Eur J Pharmacol. 2006 Jul 1;540(1-3):57-9. Epub 2006 May 3.

PMID:
16750187
4.

Morphine promotes phosphorylation of the human delta-opioid receptor at serine 363.

Navratilova E, Eaton MC, Stropova D, Varga EV, Vanderah TW, Roeske WR, Yamamura HI.

Eur J Pharmacol. 2005 Sep 20;519(3):212-4.

PMID:
16135360
5.

Agonist-specific regulation of the delta-opioid receptor.

Varga EV, Navratilova E, Stropova D, Jambrosic J, Roeske WR, Yamamura HI.

Life Sci. 2004 Dec 24;76(6):599-612. Review.

PMID:
15567186
6.

Mutation S363A in the human delta-opioid receptor selectively reduces down-regulation by a peptide agonist.

Navratilova E, Varga EV, Stropova D, Jambrosic JC, Roeske WR, Yamamura HI.

Eur J Pharmacol. 2004 Feb 6;485(1-3):341-3.

PMID:
14757159
7.

Molecular mechanisms of excitatory signaling upon chronic opioid agonist treatment.

Varga EV, Yamamura HI, Rubenzik MK, Stropova D, Navratilova E, Roeske WR.

Life Sci. 2003 Dec 5;74(2-3):299-311. Review.

PMID:
14607258
8.

Converging protein kinase pathways mediate adenylyl cyclase superactivation upon chronic delta-opioid agonist treatment.

Varga EV, Rubenzik MK, Stropova D, Sugiyama M, Grife V, Hruby VJ, Rice KC, Roeske WR, Yamamura HI.

J Pharmacol Exp Ther. 2003 Jul;306(1):109-15. Epub 2003 Mar 26.

PMID:
12660310
9.

Involvement of Raf-1 in chronic delta-opioid receptor agonist-mediated adenylyl cyclase superactivation.

Varga EV, Rubenzik M, Grife V, Sugiyama M, Stropova D, Roeske WR, Yamamura HI.

Eur J Pharmacol. 2002 Sep 6;451(1):101-2.

PMID:
12223234
11.

Mutation W284L of the human delta opioid receptor reveals agonist specific receptor conformations for G protein activation.

Hosohata Y, Varga EV, Stropova D, Li X, Knapp RJ, Hruby VJ, Rice KC, Nagase H, Roeske WR, Yamamura HI.

Life Sci. 2001 Apr 6;68(19-20):2233-42.

PMID:
11358332
12.

Improved bioavailability to the brain of glycosylated Met-enkephalin analogs.

Egleton RD, Mitchell SA, Huber JD, Janders J, Stropova D, Polt R, Yamamura HI, Hruby VJ, Davis TP.

Brain Res. 2000 Oct 20;881(1):37-46.

PMID:
11033091
13.

Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays.

Bonner GG, Davis P, Stropova D, Edsall S, Yamamura HI, Porreca F, Hruby VJ.

J Med Chem. 2000 Feb 24;43(4):569-80.

PMID:
10691683
14.

Coupling of human delta-opioid receptor to retinal rod transducin in Chinese hamster ovary cells.

Varga EV, Stropova D, Kim T, Wang M, Roeske WR, Yamamura HI.

J Pharmacol Exp Ther. 2000 Jan;292(1):209-14.

PMID:
10604950
15.

Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin.

Lipkowski AW, Misicka A, Davis P, Stropova D, Janders J, Lachwa M, Porreca F, Yamamura HI, Hruby VJ.

Bioorg Med Chem Lett. 1999 Sep 20;9(18):2763-6.

PMID:
10509931
16.

Cyclic enkephalin analogs that are hybrids of DPDPE-related peptides and metenkephalin-Arg-Gly-Leu: prohormone analogs that retain good potency and selectivity for delta opioid receptors.

Bartosz-Bechowski H, Davis P, Slaninova J, Malatynska E, Stropova D, Porreca F, Yamamura HI, Hruby VJ.

J Pept Res. 1999 Mar;53(3):329-36.

PMID:
10231722
17.

Phosphorylation of adenylyl cyclase VI upon chronic delta-opioid receptor stimulation.

Varga EV, Stropova D, Rubenzik M, Waite S, Roeske WR, Yamamura HI.

Eur J Pharmacol. 1999 Jan 8;364(2-3):R1-3.

PMID:
9932732
18.

De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor.

Liao S, Alfaro-Lopez J, Shenderovich MD, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan KA, Porreca F, Yamamura HI, Hruby VJ.

J Med Chem. 1998 Nov 19;41(24):4767-76.

PMID:
9822547
19.

Identification of adenylyl cyclase isoenzymes in CHO and B82 cells.

Varga EV, Stropova D, Rubenzik M, Wang M, Landsman RS, Roeske WR, Yamamura HI.

Eur J Pharmacol. 1998 May 8;348(2-3):R1-2.

PMID:
9652350
20.

The efficacy of delta-opioid receptor-selective drugs.

Burkey TH, Ehlert FJ, Hosohata Y, Quock RM, Cowell S, Hosohata K, Varga E, Stropova D, Li X, Slate C, Nagase H, Porreca F, Hruby VJ, Roeske WR, Yamamura HI.

Life Sci. 1998;62(17-18):1531-6. Review.

PMID:
9585131
21.

Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors.

Hruby VJ, Bartosz-Bechowski H, Davis P, Slaninova J, Zalewska T, Stropova D, Porreca F, Yamamura HI.

J Med Chem. 1997 Nov 21;40(24):3957-62.

PMID:
9397176
22.

Opioid peptides: simultaneous delta agonism and mu antagonism in somatostatin analogues.

Bonner GG, Davis P, Stropova D, Ferguson R, Yamamura HI, Porreca F, Hruby VJ.

Peptides. 1997;18(1):93-100.

PMID:
9114458
23.

The third extracellular loop of the human delta-opioid receptor determines the selectivity of delta-opioid agonists.

Varga EV, Li X, Stropova D, Zalewska T, Landsman RS, Knapp RJ, Malatynska E, Kawai K, Mizusura A, Nagase H, Calderon SN, Rice K, Hruby VJ, Roeske WR, Yamamura HI.

Mol Pharmacol. 1996 Dec;50(6):1619-24. Erratum in: Mol Pharmacol 1997 Aug;52(2):335.

PMID:
8967985
25.

Novel scaffolds for non-peptide mimetics of delta opioid receptor agonists based on peptide leads.

Qian X, Liao S, Stropova D, Yamamura HI, Hruby VJ.

Regul Pept. 1996 Aug 27;65(1):79-82. No abstract available.

PMID:
8876039
26.

delta-Opioid receptor: the third extracellular loop determines naltrindole selectivity.

Li X, Varga EV, Stropova D, Zalewska T, Malatynska E, Knapp RJ, Roeske WR, Yamamura HI.

Eur J Pharmacol. 1996 Apr 4;300(1-2):R1-2.

PMID:
8741185
27.

Design, synthesis, and biological activities of cyclic lactam peptide analogues of dynorphine A(1-11)-NH2.

Lung FD, Collins N, Stropova D, Davis P, Yamamura HI, Porreca F, Hruby VJ.

J Med Chem. 1996 Mar 1;39(5):1136-41.

PMID:
8676350
28.

Synthesis and biological properties of gamma-glutamyl-dermorphin, a prodrug.

Misicka A, Maszczynska I, Lipkowski AW, Stropova D, Yamamura HI, Hruby VJ.

Life Sci. 1996;58(11):905-11.

PMID:
8786696
29.

The role of the Val353 residue in antagonist binding to rat CCK-B receptors.

Malatynska E, Knapp RJ, Stropova D, Varga E, Yamamura HI.

Neuroreport. 1995 Jun 19;6(9):1325-9.

PMID:
7669996
30.

Highly kappa receptor-selective dynorphin A analogues with modifications in position 3 of dynorphin A(1-11)-NH2.

Lung FD, Meyer JP, Li G, Lou BS, Stropova D, Davis P, Yamamura HI, Porreca F, Hruby VJ.

J Med Chem. 1995 Feb 17;38(4):585-6. No abstract available.

PMID:
7861405

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