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Items: 1 to 50 of 171


Zika Virus: Origins, Pathological Action, and Treatment Strategies.

Gorshkov K, Shiryaev SA, Fertel S, Lin YW, Huang CT, Pinto A, Farhy C, Strongin AY, Zheng W, Terskikh AV.

Front Microbiol. 2019 Jan 7;9:3252. doi: 10.3389/fmicb.2018.03252. eCollection 2018. Review.


Characterization and regulation of MT1-MMP cell surface-associated activity.

Pahwa S, Bhowmick M, Amar S, Cao J, Strongin AY, Fridman R, Weiss SJ, Fields GB.

Chem Biol Drug Des. 2019 Jun;93(6):1251-1264. doi: 10.1111/cbdd.13450. Epub 2018 Dec 19.


Coordinated histone modifications and chromatin reorganization in a single cell revealed by FRET biosensors.

Peng Q, Lu S, Shi Y, Pan Y, Limsakul P, Chernov AV, Qiu J, Chai X, Shi Y, Wang P, Ji Y, Li YJ, Strongin AY, Verkhusha VV, Izpisua Belmonte JC, Ren B, Wang Y, Chien S, Wang Y.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11681-E11690. doi: 10.1073/pnas.1811818115. Epub 2018 Nov 26.


Structural homology of myelin basic protein and muscarinic acetylcholine receptor: Significance in the pathogenesis of complex regional pain syndrome.

Shubayev VI, Strongin AY, Yaksh TL.

Mol Pain. 2018 Jan-Dec;14:1744806918815005. doi: 10.1177/1744806918815005. Epub 2018 Nov 5. Review.


Tissue inhibitors of metalloproteases strike a nerve.

Shubayev VI, Strongin AY.

Neural Regen Res. 2018 Nov;13(11):1890-1892. doi: 10.4103/1673-5374.239437. No abstract available.


Amino acid sequence conservation of the algesic fragment of myelin basic protein is required for its interaction with CDK5 and function in pain.

Chernov AV, Remacle AG, Hullugundi SK, Cieplak P, Angert M, Dolkas J, Shubayev VI, Strongin AY.

FEBS J. 2018 Sep;285(18):3485-3502. doi: 10.1111/febs.14623. Epub 2018 Aug 27.


Interaction of the cryptic fragment of myelin basic protein with mitochondrial voltage-dependent anion-selective channel-1 affects cell energy metabolism.

Remacle AG, Hullugundi SK, Dolkas J, Angert M, Cieplak P, Scott D, Chernov AV, Shubayev VI, Strongin AY.

Biochem J. 2018 Jul 31;475(14):2355-2376. doi: 10.1042/BCJ20180137.


Acute- and late-phase matrix metalloproteinase (MMP)-9 activity is comparable in female and male rats after peripheral nerve injury.

Remacle AG, Hullugundi SK, Dolkas J, Angert M, Chernov AV, Strongin AY, Shubayev VI.

J Neuroinflammation. 2018 Mar 20;15(1):89. doi: 10.1186/s12974-018-1123-7.


A sensitive and selective ELISA methodology quantifies a demyelination marker in experimental and clinical samples.

Remacle AG, Dolkas J, Angert M, Hullugundi SK, Chernov AV, Jones RCW 3rd, Shubayev VI, Strongin AY.

J Immunol Methods. 2018 Apr;455:80-87. doi: 10.1016/j.jim.2018.02.002. Epub 2018 Feb 8.


Directed Evolution to Engineer Monobody for FRET Biosensor Assembly and Imaging at Live-Cell Surface.

Limsakul P, Peng Q, Wu Y, Allen ME, Liang J, Remacle AG, Lopez T, Ge X, Kay BK, Zhao H, Strongin AY, Yang XL, Lu S, Wang Y.

Cell Chem Biol. 2018 Apr 19;25(4):370-379.e4. doi: 10.1016/j.chembiol.2018.01.002. Epub 2018 Jan 27.


Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis.

Shiryaev SA, Mesci P, Pinto A, Fernandes I, Sheets N, Shresta S, Farhy C, Huang CT, Strongin AY, Muotri AR, Terskikh AV.

Sci Rep. 2017 Nov 17;7(1):15771. doi: 10.1038/s41598-017-15467-6.


Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists.

Shiryaev SA, Farhy C, Pinto A, Huang CT, Simonetti N, Elong Ngono A, Dewing A, Shresta S, Pinkerton AB, Cieplak P, Strongin AY, Terskikh AV.

Antiviral Res. 2017 Jul;143:218-229. doi: 10.1016/j.antiviral.2017.04.015. Epub 2017 Apr 29.


Matrix metalloproteinases - From the cleavage data to the prediction tools and beyond.

Cieplak P, Strongin AY.

Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt A):1952-1963. doi: 10.1016/j.bbamcr.2017.03.010. Epub 2017 Mar 24. Review.


Active-site MMP-selective antibody inhibitors discovered from convex paratope synthetic libraries.

Nam DH, Rodriguez C, Remacle AG, Strongin AY, Ge X.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):14970-14975. doi: 10.1073/pnas.1609375114. Epub 2016 Dec 13.


Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis.

Remacle AG, Cieplak P, Nam DH, Shiryaev SA, Ge X, Strongin AY.

Oncotarget. 2017 Jan 10;8(2):2781-2799. doi: 10.18632/oncotarget.13157.


Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain.

Hong S, Remacle AG, Shiryaev SA, Choi W, Hullugundi SK, Dolkas J, Angert M, Nishihara T, Yaksh TL, Strongin AY, Shubayev VI.

Brain Behav Immun. 2017 Feb;60:282-292. doi: 10.1016/j.bbi.2016.11.003. Epub 2016 Nov 7.


Role of myelin auto-antigens in pain: a female connection.

Shubayev VI, Strongin AY, Yaksh TL.

Neural Regen Res. 2016 Jun;11(6):890-1. doi: 10.4103/1673-5374.184452. No abstract available.


Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia.

Ko JS, Eddinger KA, Angert M, Chernov AV, Dolkas J, Strongin AY, Yaksh TL, Shubayev VI.

Brain Behav Immun. 2016 Aug;56:378-89. doi: 10.1016/j.bbi.2016.03.003. Epub 2016 Mar 9.


Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer.

Alonso S, González B, Ruiz-Larroya T, Durán Domínguez M, Kato T, Matsunaga A, Suzuki K, Strongin AY, Gimènez-Bonafé P, Perucho M.

Clin Epigenetics. 2015 Dec 2;7:124. doi: 10.1186/s13148-015-0158-1. eCollection 2015.


Depletion of CG-Specific Methylation in Mycoplasma hyorhinis Genomic DNA after Host Cell Invasion.

Chernov AV, Reyes L, Peterson S, Strongin AY.

PLoS One. 2015 Nov 6;10(11):e0142529. doi: 10.1371/journal.pone.0142529. eCollection 2015.


The alternatively spliced fibronectin CS1 isoform regulates IL-17A levels and mechanical allodynia after peripheral nerve injury.

Liu H, Dolkas J, Hoang K, Angert M, Chernov AV, Remacle AG, Shiryaev SA, Strongin AY, Nishihara T, Shubayev VI.

J Neuroinflammation. 2015 Sep 4;12:158. doi: 10.1186/s12974-015-0377-6.


Matrix Metalloproteinase (MMP) Proteolysis of the Extracellular Loop of Voltage-gated Sodium Channels and Potential Alterations in Pain Signaling.

Remacle AG, Kumar S, Motamedchaboki K, Cieplak P, Hullugundi S, Dolkas J, Shubayev VI, Strongin AY.

J Biol Chem. 2015 Sep 18;290(38):22939-44. doi: 10.1074/jbc.C115.671107. Epub 2015 Aug 17.


High-Throughput Multiplexed Peptide-Centric Profiling Illustrates Both Substrate Cleavage Redundancy and Specificity in the MMP Family.

Kukreja M, Shiryaev SA, Cieplak P, Muranaka N, Routenberg DA, Chernov AV, Kumar S, Remacle AG, Smith JW, Kozlov IA, Strongin AY.

Chem Biol. 2015 Aug 20;22(8):1122-33. doi: 10.1016/j.chembiol.2015.07.008. Epub 2015 Aug 6.


Activatable and Cell-Penetrable Multiplex FRET Nanosensor for Profiling MT1-MMP Activity in Single Cancer Cells.

Chung EY, Ochs CJ, Wang Y, Lei L, Qin Q, Smith AM, Strongin AY, Kamm R, Qi YX, Lu S, Wang Y.

Nano Lett. 2015 Aug 12;15(8):5025-32. doi: 10.1021/acs.nanolett.5b01047. Epub 2015 Jul 27.


Secondary Analysis of the NCI-60 Whole Exome Sequencing Data Indicates Significant Presence of Propionibacterium acnes Genomic Material in Leukemia (RPMI-8226) and Central Nervous System (SF-295, SF-539, and SNB-19) Cell Lines.

Rojas M, Golovko G, Khanipov K, Albayrak L, Chumakov S, Pettitt BM, Strongin AY, Fofanov Y.

PLoS One. 2015 Jun 3;10(6):e0127799. doi: 10.1371/journal.pone.0127799. eCollection 2015.


A humanized leucine zipper-TRAIL hybrid induces apoptosis of tumors both in vitro and in vivo.

Rozanov D, Spellman P, Savinov A, Strongin AY.

PLoS One. 2015 Apr 7;10(4):e0122980. doi: 10.1371/journal.pone.0122980. eCollection 2015.


The calcium-binding proteins S100A8 and S100A9 initiate the early inflammatory program in injured peripheral nerves.

Chernov AV, Dolkas J, Hoang K, Angert M, Srikrishna G, Vogl T, Baranovskaya S, Strongin AY, Shubayev VI.

J Biol Chem. 2015 May 1;290(18):11771-84. doi: 10.1074/jbc.M114.622316. Epub 2015 Mar 19.


Mycoplasma CG- and GATC-specific DNA methyltransferases selectively and efficiently methylate the host genome and alter the epigenetic landscape in human cells.

Chernov AV, Reyes L, Xu Z, Gonzalez B, Golovko G, Peterson S, Perucho M, Fofanov Y, Strongin AY.

Epigenetics. 2015;10(4):303-18. doi: 10.1080/15592294.2015.1020000. Epub 2015 Feb 19.


Methylation of MGMT and ADAMTS14 in normal colon mucosa: biomarkers of a field defect for cancerization preferentially targeting elder African-Americans.

Alonso S, Dai Y, Yamashita K, Horiuchi S, Dai T, Matsunaga A, Sánchez-Muñoz R, Bilbao-Sieyro C, Díaz-Chico JC, Chernov AV, Strongin AY, Perucho M.

Oncotarget. 2015 Feb 20;6(5):3420-31.


Matrix metalloproteinase-14 both sheds cell surface neuronal glial antigen 2 (NG2) proteoglycan on macrophages and governs the response to peripheral nerve injury.

Nishihara T, Remacle AG, Angert M, Shubayev I, Shiryaev SA, Liu H, Dolkas J, Chernov AV, Strongin AY, Shubayev VI.

J Biol Chem. 2015 Feb 6;290(6):3693-707. doi: 10.1074/jbc.M114.603431. Epub 2014 Dec 8.


Distinct interactions with cellular E-cadherin of the two virulent metalloproteinases encoded by a Bacteroides fragilis pathogenicity island.

Remacle AG, Shiryaev SA, Strongin AY.

PLoS One. 2014 Nov 20;9(11):e113896. doi: 10.1371/journal.pone.0113896. eCollection 2014.


Identification of Annexin A4 as a hepatopancreas factor involved in liver cell survival.

Zhang D, Golubkov VS, Han W, Correa RG, Zhou Y, Lee S, Strongin AY, Dong PD.

Dev Biol. 2014 Nov 1;395(1):96-110. doi: 10.1016/j.ydbio.2014.08.025. Epub 2014 Aug 29.


Protein-tyrosine pseudokinase 7 (PTK7) directs cancer cell motility and metastasis.

Golubkov VS, Prigozhina NL, Zhang Y, Stoletov K, Lewis JD, Schwartz PE, Hoffman RM, Strongin AY.

J Biol Chem. 2014 Aug 29;289(35):24238-49. doi: 10.1074/jbc.M114.574459. Epub 2014 Jul 8.


Structural and functional diversity of metalloproteinases encoded by the Bacteroides fragilis pathogenicity island.

Shiryaev SA, Aleshin AE, Muranaka N, Kukreja M, Routenberg DA, Remacle AG, Liddington RC, Cieplak P, Kozlov IA, Strongin AY.

FEBS J. 2014 Jun;281(11):2487-502. doi: 10.1111/febs.12804. Epub 2014 Apr 22.


Downstream signaling and genome-wide regulatory effects of PTK7 pseudokinase and its proteolytic fragments in cancer cells.

Golubkov VS, Strongin AY.

Cell Commun Signal. 2014 Mar 11;12:15. doi: 10.1186/1478-811X-12-15.


A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1-MMP.

Shiryaev SA, Remacle AG, Golubkov VS, Ingvarsen S, Porse A, Behrendt N, Cieplak P, Strongin AY.

Oncogenesis. 2013 Dec 2;2:e80. doi: 10.1038/oncsis.2013.44.


Substrate cleavage profiling suggests a distinct function of Bacteroides fragilis metalloproteinases (fragilysin and metalloproteinase II) at the microbiome-inflammation-cancer interface.

Shiryaev SA, Remacle AG, Chernov AV, Golubkov VS, Motamedchaboki K, Muranaka N, Dambacher CM, Capek P, Kukreja M, Kozlov IA, Perucho M, Cieplak P, Strongin AY.

J Biol Chem. 2013 Nov 29;288(48):34956-67. doi: 10.1074/jbc.M113.516153. Epub 2013 Oct 21.


Non-destructive and selective imaging of the functionally active, pro-invasive membrane type-1 matrix metalloproteinase (MT1-MMP) enzyme in cancer cells.

Remacle AG, Shiryaev SA, Golubkov VS, Freskos JN, Brown MA, Karwa AS, Naik AD, Howard CP, Sympson CJ, Strongin AY.

J Biol Chem. 2013 Jul 12;288(28):20568-80. doi: 10.1074/jbc.M113.471508. Epub 2013 Jun 3.


Quantitative FRET imaging to visualize the invasiveness of live breast cancer cells.

Lu S, Wang Y, Huang H, Pan Y, Chaney EJ, Boppart SA, Ozer H, Strongin AY, Wang Y.

PLoS One. 2013;8(3):e58569. doi: 10.1371/journal.pone.0058569. Epub 2013 Mar 13.


High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome.

Shiryaev SA, Chernov AV, Golubkov VS, Thomsen ER, Chudin E, Chee MS, Kozlov IA, Strongin AY, Cieplak P.

PLoS One. 2013;8(1):e54290. doi: 10.1371/journal.pone.0054290. Epub 2013 Jan 15.


Insights into ectodomain shedding and processing of protein-tyrosine pseudokinase 7 (PTK7).

Golubkov VS, Strongin AY.

J Biol Chem. 2012 Dec 7;287(50):42009-18. doi: 10.1074/jbc.M112.371153. Epub 2012 Oct 24.


Activity, specificity, and probe design for the smallpox virus protease K7L.

Aleshin AE, Drag M, Gombosuren N, Wei G, Mikolajczyk J, Satterthwait AC, Strongin AY, Liddington RC, Salvesen GS.

J Biol Chem. 2012 Nov 16;287(47):39470-9. doi: 10.1074/jbc.M112.388678. Epub 2012 Sep 25.


Probing of exosites leads to novel inhibitor scaffolds of HCV NS3/4A proteinase.

Shiryaev SA, Cheltsov AV, Strongin AY.

PLoS One. 2012;7(7):e40029. doi: 10.1371/journal.pone.0040029. Epub 2012 Jul 2.


Immunodominant fragments of myelin basic protein initiate T cell-dependent pain.

Liu H, Shiryaev SA, Chernov AV, Kim Y, Shubayev I, Remacle AG, Baranovskaya S, Golubkov VS, Strongin AY, Shubayev VI.

J Neuroinflammation. 2012 Jun 7;9:119. doi: 10.1186/1742-2094-9-119.


New details of HCV NS3/4A proteinase functionality revealed by a high-throughput cleavage assay.

Shiryaev SA, Thomsen ER, Cieplak P, Chudin E, Cheltsov AV, Chee MS, Kozlov IA, Strongin AY.

PLoS One. 2012;7(4):e35759. doi: 10.1371/journal.pone.0035759. Epub 2012 Apr 27.


The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration.

Kim Y, Remacle AG, Chernov AV, Liu H, Shubayev I, Lai C, Dolkas J, Shiryaev SA, Golubkov VS, Mizisin AP, Strongin AY, Shubayev VI.

PLoS One. 2012;7(3):e33664. doi: 10.1371/journal.pone.0033664. Epub 2012 Mar 16.


Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth.

Remacle AG, Golubkov VS, Shiryaev SA, Dahl R, Stebbins JL, Chernov AV, Cheltsov AV, Pellecchia M, Strongin AY.

Cancer Res. 2012 May 1;72(9):2339-49. doi: 10.1158/0008-5472.CAN-11-4149. Epub 2012 Mar 9.


Intradomain cleavage of inhibitory prodomain is essential to protumorigenic function of membrane type-1 matrix metalloproteinase (MT1-MMP) in vivo.

Golubkov VS, Chernov AV, Strongin AY.

J Biol Chem. 2011 Sep 30;286(39):34215-23. doi: 10.1074/jbc.M111.264036. Epub 2011 Aug 8.

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