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Three Types of Functional Regulatory T Cells Control T Cell Responses at the Human Maternal-Fetal Interface.

Salvany-Celades M, van der Zwan A, Benner M, Setrajcic-Dragos V, Bougleux Gomes HA, Iyer V, Norwitz ER, Strominger JL, Tilburgs T.

Cell Rep. 2019 May 28;27(9):2537-2547.e5. doi: 10.1016/j.celrep.2019.04.109.


Generation of hypoimmunogenic human pluripotent stem cells.

Han X, Wang M, Duan S, Franco PJ, Kenty JH, Hedrick P, Xia Y, Allen A, Ferreira LMR, Strominger JL, Melton DA, Meissner TB, Cowan CA.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10441-10446. doi: 10.1073/pnas.1902566116. Epub 2019 Apr 30.


Genetically modified hematopoietic stem/progenitor cells that produce IL-10-secreting regulatory T cells.

Ng SL, Leno-Duran E, Samanta D, Almo SC, Strominger JL.

Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2634-2639. doi: 10.1073/pnas.1811984116. Epub 2019 Jan 25.


Pillars Article: Three-Dimensional Structure of a Human Class II Histocompatibility Molecule Complexed with Superantigen. Nature. 1994. 368: 711-718.

Jardetzky TS, Brown JH, Gorga JC, Stern LJ, Urban RG, Chi YI, Stauffacher C, Strominger JL, Wiley DC.

J Immunol. 2018 Oct 1;201(7):1819-1826. No abstract available.


Mixed signature of activation and dysfunction allows human decidual CD8+ T cells to provide both tolerance and immunity.

van der Zwan A, Bi K, Norwitz ER, Crespo ÂC, Claas FHJ, Strominger JL, Tilburgs T.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):385-390. doi: 10.1073/pnas.1713957115. Epub 2017 Dec 19.


Transcriptome analysis reveals similarities between human blood CD3- CD56bright cells and mouse CD127+ innate lymphoid cells.

Allan DSJ, Cerdeira AS, Ranjan A, Kirkham CL, Aguilar OA, Tanaka M, Childs RW, Dunbar CE, Strominger JL, Kopcow HD, Carlyle JR.

Sci Rep. 2017 Jun 14;7(1):3501. doi: 10.1038/s41598-017-03256-0.


NLRP2 is a suppressor of NF-ƙB signaling and HLA-C expression in human trophoblasts†,‡.

Tilburgs T, Meissner TB, Ferreira LMR, Mulder A, Musunuru K, Ye J, Strominger JL.

Biol Reprod. 2017 Apr 1;96(4):831-842. doi: 10.1093/biolre/iox009.


HLA-G: At the Interface of Maternal-Fetal Tolerance.

Ferreira LMR, Meissner TB, Tilburgs T, Strominger JL.

Trends Immunol. 2017 Apr;38(4):272-286. doi: 10.1016/ Epub 2017 Mar 6. Review.


Expression of KIR2DS1 by decidual natural killer cells increases their ability to control placental HCMV infection.

Crespo ÂC, Strominger JL, Tilburgs T.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):15072-15077. doi: 10.1073/pnas.1617927114. Epub 2016 Dec 12.


Cytotoxic potential of decidual NK cells and CD8+ T cells awakened by infections.

Crespo ÂC, van der Zwan A, Ramalho-Santos J, Strominger JL, Tilburgs T.

J Reprod Immunol. 2017 Feb;119:85-90. doi: 10.1016/j.jri.2016.08.001. Epub 2016 Aug 2. Review.


Pillars Article: Identification of a Putative Second T-cell Receptor. Nature. 1986. 322: 145-149.

Brenner MB, McLean J, Dialynas DP, Strominger JL, Smith JA, Owen FL, Seidman JG, Ip S, Rosen F, Krangel MS.

J Immunol. 2016 May 1;196(9):3509-13. Epub 2016 Apr 18. No abstract available.


A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface.

Ferreira LM, Meissner TB, Mikkelsen TS, Mallard W, O'Donnell CW, Tilburgs T, Gomes HA, Camahort R, Sherwood RI, Gifford DK, Rinn JL, Cowan CA, Strominger JL.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):5364-9. doi: 10.1073/pnas.1602886113. Epub 2016 Apr 13.


Decidual endothelium, Notch1 and TGFβ, gatekeepers for Treg accumulation at the maternal-fetal interface.

Tilburgs T, Strominger JL.

Immunol Cell Biol. 2016 May;94(5):419-20. doi: 10.1038/icb.2016.23. Epub 2016 Mar 29. No abstract available.


The HLA-G cycle provides for both NK tolerance and immunity at the maternal-fetal interface.

Tilburgs T, Evans JH, Crespo ÂC, Strominger JL.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13312-7. doi: 10.1073/pnas.1517724112. Epub 2015 Oct 12.


Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes.

Tilburgs T, Crespo ÂC, van der Zwan A, Rybalov B, Raj T, Stranger B, Gardner L, Moffett A, Strominger JL.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7219-24. doi: 10.1073/pnas.1507977112. Epub 2015 May 26.


CD1 Antigen Presentation and Autoreactivity in the Pregnant Human Uterus.

Guerin L, Wu V, Houser B, Tilburgs T, de Jong A, Moody DB, Strominger JL.

Am J Reprod Immunol. 2015 Aug;74(2):126-35. doi: 10.1111/aji.12375. Epub 2015 Mar 4.


Pillars article: three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature. 1993. 364: 33-39.

Brown JH, Jardetzky TS, Gorga JC, Stern LJ, Urban RG, Strominger JL, Wiley DC.

J Immunol. 2015 Jan 1;194(1):5-11. No abstract available.


Dysfunction of dendritic cells in aged C57BL/6 mice leads to failure of natural killer cell activation and of tumor eradication.

Guo Z, Tilburgs T, Wong B, Strominger JL.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14199-204. doi: 10.1073/pnas.1414780111. Epub 2014 Sep 15.


Self-specific memory regulatory T cells protect embryos at implantation in mice.

Chen T, Darrasse-Jèze G, Bergot AS, Courau T, Churlaud G, Valdivia K, Strominger JL, Ruocco MG, Chaouat G, Klatzmann D.

J Immunol. 2013 Sep 1;191(5):2273-81. doi: 10.4049/jimmunol.1202413. Epub 2013 Aug 2.


Amino acid copolymers that alleviate experimental autoimmune encephalomyelitis in vivo interact with heparan sulfates and glycoprotein 96 in APCs.

Koenig PA, Spooner E, Kawamoto N, Strominger JL, Ploegh HL.

J Immunol. 2013 Jul 1;191(1):208-16. doi: 10.4049/jimmunol.1300345. Epub 2013 Jun 5.


CD8+ effector T cells at the fetal-maternal interface, balancing fetal tolerance and antiviral immunity.

Tilburgs T, Strominger JL.

Am J Reprod Immunol. 2013 Apr;69(4):395-407. doi: 10.1111/aji.12094. Epub 2013 Feb 23. Review.


The role of dendritic cells in the generation of CD4(+) CD25(HI) Foxp3(+) T cells induced by amino acid copolymers.

Kawamoto N, Ohnishi H, Kondo N, Strominger JL.

Int Immunol. 2013 Jan;25(1):53-65. doi: 10.1093/intimm/dxs087. Epub 2012 Sep 11.


Macrophage-specific chemokines induced via innate immunity by amino acid copolymers and their role in EAE.

Kovalchin J, Krieger J, Genova M, Kawamoto N, Augustyniak M, Collins K, Bloom T, Masci A, Hittinger T, Dufour I, Strominger JL, Zanelli E.

PLoS One. 2011;6(12):e26274. doi: 10.1371/journal.pone.0026274. Epub 2011 Dec 15.


VAMP4- and VAMP7-expressing vesicles are both required for cytotoxic granule exocytosis in NK cells.

Krzewski K, Gil-Krzewska A, Watts J, Stern JN, Strominger JL.

Eur J Immunol. 2011 Nov;41(11):3323-9. doi: 10.1002/eji.201141582. Epub 2011 Sep 28.


Two unique human decidual macrophage populations.

Houser BL, Tilburgs T, Hill J, Nicotra ML, Strominger JL.

J Immunol. 2011 Feb 15;186(4):2633-42. doi: 10.4049/jimmunol.1003153. Epub 2011 Jan 21.


Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells.

Stern JN, Keskin DB, Kato Z, Waldner H, Schallenberg S, Anderson A, von Boehmer H, Kretschmer K, Strominger JL.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17280-5. doi: 10.1073/pnas.1010263107. Epub 2010 Sep 20.


The autoimmune TCR-Ob.2F3 can bind to MBP85-99/HLA-DR2 having an unconventional mode as in TCR-Ob.1A12.

Kato Z, Stern JN, Nakamura HK, Miyashita N, Kuwata K, Kondo N, Strominger JL.

Mol Immunol. 2010 Nov-Dec;48(1-3):314-20. doi: 10.1016/j.molimm.2010.07.010.


The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation.

Park B, Spooner E, Houser BL, Strominger JL, Ploegh HL.

J Exp Med. 2010 Aug 30;207(9):2033-41. doi: 10.1084/jem.20091793. Epub 2010 Aug 16.


TGF-β affects development and differentiation of human natural killer cell subsets.

Allan DS, Rybalov B, Awong G, Zúñiga-Pflücker JC, Kopcow HD, Carlyle JR, Strominger JL.

Eur J Immunol. 2010 Aug;40(8):2289-95. doi: 10.1002/eji.200939910.


Interaction between CD4 and class II MHC molecules mediates cell adhesion. 1987.

Doyle C, Strominger JL.

J Immunol. 2010 Jun 1;184(11):5935-8. No abstract available.


Nomenclature for factors of the HLA system, 2010.

Marsh SG, Albert ED, Bodmer WF, Bontrop RE, Dupont B, Erlich HA, Fernández-Viña M, Geraghty DE, Holdsworth R, Hurley CK, Lau M, Lee KW, Mach B, Maiers M, Mayr WR, Müller CR, Parham P, Petersdorf EW, Sasazuki T, Strominger JL, Svejgaard A, Terasaki PI, Tiercy JM, Trowsdale J.

Tissue Antigens. 2010 Apr;75(4):291-455. doi: 10.1111/j.1399-0039.2010.01466.x. Review. No abstract available.


An update to HLA nomenclature, 2010.

Marsh SG, Albert ED, Bodmer WF, Bontrop RE, Dupont B, Erlich HA, Fernández-Viña M, Geraghty DE, Holdsworth R, Hurley CK, Lau M, Lee KW, Mach B, Maiers M, Mayr WR, Müller CR, Parham P, Petersdorf EW, Sasazuki T, Strominger JL, Svejgaard A, Terasaki PI, Tiercy JM, Trowsdale J.

Bone Marrow Transplant. 2010 May;45(5):846-8. doi: 10.1038/bmt.2010.79. Epub 2010 Mar 29.


An alternative path for antigen presentation: group 1 CD1 proteins.

Strominger JL.

J Immunol. 2010 Apr 1;184(7):3303-5. doi: 10.4049/jimmunol.1090008. Review. No abstract available.


Human decidual NK cells from gravid uteri and NK cells from cycling endometrium are distinct NK cell subsets.

Kopcow HD, Eriksson M, Mselle TF, Damrauer SM, Wira CR, Sentman CL, Strominger JL.

Placenta. 2010 Apr;31(4):334-8. doi: 10.1016/j.placenta.2010.01.003. Epub 2010 Feb 20.


Inhibition of experimental autoimmune uveitis by amino acid copolymers.

Yin H, Vistica BP, Chan CC, Strominger JL, Gery I.

J Neuroimmunol. 2009 Oct 30;215(1-2):43-8. doi: 10.1016/j.jneuroim.2009.08.002. Epub 2009 Sep 11.


Animal antimicrobial peptides: ancient players in innate immunity.

Strominger JL.

J Immunol. 2009 Jun 1;182(11):6633-4. doi: 10.4049/jimmunol.0990038. No abstract available.


HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells.

Li C, Houser BL, Nicotra ML, Strominger JL.

Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5767-72. doi: 10.1073/pnas.0901173106. Epub 2009 Mar 20.


T cell receptors in an IL-10-secreting amino acid copolymer-specific regulatory T cell line that mediates bystander immunosuppression.

Zhang H, Stern JN, Strominger JL.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3336-41. doi: 10.1073/pnas.0813197106. Epub 2009 Feb 9.


T cell apoptosis at the maternal-fetal interface in early human pregnancy, involvement of galectin-1.

Kopcow HD, Rosetti F, Leung Y, Allan DS, Kutok JL, Strominger JL.

Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18472-7. doi: 10.1073/pnas.0809233105. Epub 2008 Nov 14.


Positioning of autoimmune TCR-Ob.2F3 and TCR-Ob.3D1 on the MBP85-99/HLA-DR2 complex.

Kato Z, Stern JN, Nakamura HK, Kuwata K, Kondo N, Strominger JL.

Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15523-8. doi: 10.1073/pnas.0807338105. Epub 2008 Sep 29.


Dendritic cell and natural killer cell cross-talk: a pivotal role of CX3CL1 in NK cytoskeleton organization and activation.

Pallandre JR, Krzewski K, Bedel R, Ryffel B, Caignard A, Rohrlich PS, Pivot X, Tiberghien P, Zitvogel L, Strominger JL, Borg C.

Blood. 2008 Dec 1;112(12):4420-4. doi: 10.1182/blood-2007-12-126888. Epub 2008 Aug 5.


The killer's kiss: the many functions of NK cell immunological synapses.

Krzewski K, Strominger JL.

Curr Opin Cell Biol. 2008 Oct;20(5):597-605. doi: 10.1016/ Epub 2008 Jul 17. Review.


An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells.

Yu MC, Su LL, Zou L, Liu Y, Wu N, Kong L, Zhuang ZH, Sun L, Liu HP, Hu JH, Li D, Strominger JL, Zang JW, Pei G, Ge BX.

Nat Immunol. 2008 Aug;9(8):898-907. doi: 10.1038/ni.1635. Epub 2008 Jul 11.


CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization.

Yang XH, Richardson AL, Torres-Arzayus MI, Zhou P, Sharma C, Kazarov AR, Andzelm MM, Strominger JL, Brown M, Hemler ME.

Cancer Res. 2008 May 1;68(9):3204-13. doi: 10.1158/0008-5472.CAN-07-2949.


Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice.

Stern JN, Keskin DB, Zhang H, Lv H, Kato Z, Strominger JL.

Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5172-6. doi: 10.1073/pnas.0712131105. Epub 2008 Mar 24.


JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity.

Li C, Ge B, Nicotra M, Stern JN, Kopcow HD, Chen X, Strominger JL.

Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3017-22. doi: 10.1073/pnas.0712310105. Epub 2008 Feb 19.


WIP is essential for lytic granule polarization and NK cell cytotoxicity.

Krzewski K, Chen X, Strominger JL.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2568-73. doi: 10.1073/pnas.0711593105. Epub 2008 Feb 7.


Bacterial cell walls, innate immunity and immunoadjuvants.

Strominger JL.

Nat Immunol. 2007 Dec;8(12):1269-71. No abstract available.


Myosin IIA is required for cytolytic granule exocytosis in human NK cells.

Andzelm MM, Chen X, Krzewski K, Orange JS, Strominger JL.

J Exp Med. 2007 Oct 1;204(10):2285-91. Epub 2007 Sep 17.


Many NK cell receptors activate ERK2 and JNK1 to trigger microtubule organizing center and granule polarization and cytotoxicity.

Chen X, Trivedi PP, Ge B, Krzewski K, Strominger JL.

Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6329-34. Epub 2007 Mar 29.

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