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Bone morphogenetic protein 1 cleaves the linker region between ligand-binding repeats 4 and 5 of the LDL receptor and makes the LDL receptor non-functional.

Strøm TB, Bjune K, Leren TP.

Hum Mol Genet. 2019 Oct 10. pii: ddz238. doi: 10.1093/hmg/ddz238. [Epub ahead of print]


Lysosomal acid lipase does not have a propeptide and should not be considered being a proprotein.

Strøm TB, Vinje T, Bjune K, da Costa LT, Laerdahl JK, Leren TP.

Proteins. 2019 Oct 6. doi: 10.1002/prot.25821. [Epub ahead of print]


Strategies to prevent cleavage of the linker region between ligand-binding repeats 4 and 5 of the LDL receptor.

Strøm TB, Bjune K, da Costa LT, Leren TP.

Hum Mol Genet. 2019 Jul 23. pii: ddz164. doi: 10.1093/hmg/ddz164. [Epub ahead of print]


Characterization of the mechanisms by which missense mutations in the lysosomal acid lipase gene disrupt enzymatic activity.

Vinje T, Laerdahl JK, Bjune K, Leren TP, Strøm TB.

Hum Mol Genet. 2019 Sep 15;28(18):3043-3052. doi: 10.1093/hmg/ddz114.


Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and longitudinal samples.

Christakoudi S, Runglall M, Mobillo P, Tsui TL, Duff C, Domingo-Vila C, Kamra Y, Delaney F, Montero R, Spiridou A, Kassimatis T, Phin-Kon S, Tucker B, Farmer C, Strom TB, Lord GM, Rebollo-Mesa I, Stahl D, Sacks S, Hernandez-Fuentes MP, Chowdhury P.

EBioMedicine. 2019 Mar;41:571-583. doi: 10.1016/j.ebiom.2019.01.060. Epub 2019 Mar 2.


Hematopoietic Stem/Progenitor Cell Dependent Participation of Innate Lymphoid Cells in Low-Intensity Sterile Inflammation.

Korniotis S, Thornley TB, Kyriazis P, Theodorou E, Ma L, Li LS, Kokkotou E, Strom TB, Koulmanda M.

Front Immunol. 2018 Sep 5;9:2007. doi: 10.3389/fimmu.2018.02007. eCollection 2018.


Alpha-1 antitrypsin treatment of new-onset type 1 diabetes: An open-label, phase I clinical trial (RETAIN) to assess safety and pharmacokinetics.

Weir GC, Ehlers MR, Harris KM, Kanaparthi S, Long A, Phippard D, Weiner LJ, Jepson B, McNamara JG, Koulmanda M, Strom TB; ITN RETAIN Study Team.

Pediatr Diabetes. 2018 Aug;19(5):945-954. doi: 10.1111/pedi.12660. Epub 2018 May 7.


Prevalence of cholesteryl ester storage disease among hypercholesterolemic subjects and functional characterization of mutations in the lysosomal acid lipase gene.

Vinje T, Wierød L, Leren TP, Strøm TB.

Mol Genet Metab. 2018 Feb;123(2):169-176. doi: 10.1016/j.ymgme.2017.11.008. Epub 2017 Nov 23.


Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ.

Uehara M, McGrath MM, Ohori S, Solhjou Z, Banouni N, Routray S, Evans C, DiNitto JP, Elkhal A, Turka LA, Strom TB, Tullius SG, Winkler DG, Azzi J, Abdi R.

Nat Commun. 2017 Oct 16;8(1):951. doi: 10.1038/s41467-017-00982-x.


Mutations affecting the transmembrane domain of the LDL receptor: impact of charged residues on the membrane insertion.

Strøm TB, Laerdahl JK, Leren TP.

Hum Mol Genet. 2017 May 1;26(9):1634-1642. doi: 10.1093/hmg/ddx068.


Variable phenotypic expression of nonsense mutation p.Thr5* in the APOE gene.

Leren TP, Strøm TB, Berge KE.

Mol Genet Metab Rep. 2016 Oct 25;9:67-70. eCollection 2016 Dec.


Contrasting Roles of Islet Resident Immunoregulatory Macrophages and Dendritic Cells in Experimental Autoimmune Type 1 Diabetes.

Thornley TB, Agarwal KA, Kyriazis P, Ma L, Chipashvili V, Aker JE, Korniotis S, Csizmadia E, Strom TB, Koulmanda M.

PLoS One. 2016 Mar 4;11(3):e0150792. doi: 10.1371/journal.pone.0150792. eCollection 2016.


Codominant Role of Interferon-γ- and Interleukin-17-Producing T Cells During Rejection in Full Facial Transplant Recipients.

Borges TJ, O'Malley JT, Wo L, Murakami N, Smith B, Azzi J, Tripathi S, Lane JD, Bueno EM, Clark RA, Tullius SG, Chandraker A, Lian CG, Murphy GF, Strom TB, Pomahac B, Najafian N, Riella LV.

Am J Transplant. 2016 Jul;16(7):2158-71. doi: 10.1111/ajt.13705. Epub 2016 Apr 7.


Multicenter Analysis of Immune Biomarkers and Heart Transplant Outcomes: Results of the Clinical Trials in Organ Transplantation-05 Study.

Starling RC, Stehlik J, Baran DA, Armstrong B, Stone JR, Ikle D, Morrison Y, Bridges ND, Putheti P, Strom TB, Bhasin M, Guleria I, Chandraker A, Sayegh M, Daly KP, Briscoe DM, Heeger PS; CTOT-05 consortium.

Am J Transplant. 2016 Jan;16(1):121-36. doi: 10.1111/ajt.13422. Epub 2015 Aug 10.


Mutation p.L799R in the LDLR, which affects the transmembrane domain of the LDLR, prevents membrane insertion and causes secretion of the mutant LDLR.

Strøm TB, Laerdahl JK, Leren TP.

Hum Mol Genet. 2015 Oct 15;24(20):5836-44. doi: 10.1093/hmg/ddv304. Epub 2015 Jul 28.


Firmly tilting the balance of clinical transplant immunity toward tolerance.

Thornley TB, Strom TB.

Am J Transplant. 2015 Mar;15(3):583-4. doi: 10.1111/ajt.13094. No abstract available.


Innate immunity for better or worse govern the allograft response.

Otterbein LE, Fan Z, Koulmanda M, Thronley T, Strom TB.

Curr Opin Organ Transplant. 2015 Feb;20(1):8-12. doi: 10.1097/MOT.0000000000000152. Review.


Multiple Sclerosis and the LIF/IL-6 Axis: Use of Nanotechnology to Harness the Tolerogenic and Reparative Properties of LIF.

Metcalfe SM, Strom TB, Williams A, Fahmy TM.

Nanobiomedicine (Rij). 2015 Jan 1;2:5. doi: 10.5772/60622. eCollection 2015 Jan-Dec. Review.


Bone marrow-derived hematopoietic stem and progenitor cells infiltrate allogeneic and syngeneic transplants.

Fan Z, Enjoji K, Tigges JC, Toxavidis V, Tchipashivili V, Gong W, Strom TB, Koulmanda M.

Am J Transplant. 2014 Dec;14(12):2869-73. doi: 10.1111/ajt.12931. Epub 2014 Nov 11.


Hand transplants and the mandate for tolerance.

Koulmanda M, Pomahac B, Fan Z, Murphy GF, Strom TB.

Curr Opin Organ Transplant. 2014 Dec;19(6):545-51. doi: 10.1097/MOT.0000000000000138. Review.


Acute rejection in vascularized composite allotransplantation.

Fischer S, Lian CG, Kueckelhaus M, Strom TB, Edelman ER, Clark RA, Murphy GF, Chandraker AK, Riella LV, Tullius SG, Pomahac B.

Curr Opin Organ Transplant. 2014 Dec;19(6):531-44. doi: 10.1097/MOT.0000000000000140. Review.


A20--a biomarker of allograft outcome: a showcase in kidney transplantation.

Bodonyi-Kovacs G, Strom TB, Putheti P.

Adv Exp Med Biol. 2014;809:103-16. Review.


Fragile TIM-4-expressing tissue resident macrophages are migratory and immunoregulatory.

Thornley TB, Fang Z, Balasubramanian S, Larocca RA, Gong W, Gupta S, Csizmadia E, Degauque N, Kim BS, Koulmanda M, Kuchroo VK, Strom TB.

J Clin Invest. 2014 Aug;124(8):3443-54. doi: 10.1172/JCI73527. Epub 2014 Jul 1.


Prevention of nonimmunologic loss of transplanted islets in monkeys.

Koulmanda M, Sampathkumar RS, Bhasin M, Qipo A, Fan Z, Singh G, Movahedi B, Duggan M, Chipashvili V, Strom TB.

Am J Transplant. 2014 Jul;14(7):1543-51. doi: 10.1111/ajt.12723. Epub 2014 Jun 9.


Role of myeloid-derived suppressor cells in mouse pre-sensitized cardiac transplant model.

Gong W, Ge F, Liu D, Wu Y, Liu F, Kim BS, Huang T, Koulmanda M, Robson SC, Strom TB.

Clin Immunol. 2014 Jul;153(1):8-16. doi: 10.1016/j.clim.2014.03.013. Epub 2014 Mar 30.


Tolerance--is it worth it?

Finger EB, Strom TB, Matas AJ.

Cold Spring Harb Perspect Med. 2014 Feb 1;4(2). pii: a015594. doi: 10.1101/cshperspect.a015594. Review.


Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells.

Moraes-Vieira PM, Larocca RA, Bassi EJ, Peron JP, Andrade-Oliveira V, Wasinski F, Araujo R, Thornley T, Quintana FJ, Basso AS, Strom TB, Câmara NO.

Eur J Immunol. 2014 Mar;44(3):794-806. doi: 10.1002/eji.201343592. Epub 2014 Jan 13.


PCSK9 acts as a chaperone for the LDL receptor in the endoplasmic reticulum.

Strøm TB, Tveten K, Leren TP.

Biochem J. 2014 Jan 1;457(1):99-105. doi: 10.1042/BJ20130930.


Transplantation: a new molecular approach to the diagnosis of acute rejection.

Chandraker A, Strom TB.

Nat Rev Nephrol. 2013 Nov;9(11):631-2. doi: 10.1038/nrneph.2013.199. Epub 2013 Oct 1.


Tracking single cells in live animals using a photoconvertible near-infrared cell membrane label.

Carlson AL, Fujisaki J, Wu J, Runnels JM, Turcotte R, Spencer JA, Celso CL, Scadden DT, Strom TB, Lin CP.

PLoS One. 2013 Aug 26;8(8):e69257. doi: 10.1371/journal.pone.0069257. eCollection 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/c05446df-ee55-4072-940c-543adff42086. Spencer, Joel A [added].


Multicenter evaluation of a standardized protocol for noninvasive gene expression profiling.

Keslar KS, Lin M, Zmijewska AA, Sigdel TK, Tran TQ, Ma L, Bhasin M, Rao P, Ding R, Iklé DN, Mannon RB, Sarwal MM, Strom TB, Reed EF, Heeger PS, Suthanthiran M, Fairchild RL.

Am J Transplant. 2013 Jul;13(7):1891-7. doi: 10.1111/ajt.12284.


Transplant rejection and paradigms lost.

Strom TB.

J Clin Invest. 2013 Jun;123(6):2360-2. doi: 10.1172/JCI69385. Epub 2013 May 15.


PCSK9-mediated degradation of the LDL receptor generates a 17 kDa C-terminal LDL receptor fragment.

Tveten K, Strøm TB, Berge KE, Leren TP.

J Lipid Res. 2013 Jun;54(6):1560-6. doi: 10.1194/jlr.M034371. Epub 2013 Mar 18.


Molecular characterization and functional activity of an IL-15 antagonist MutIL-15/Fc human fusion protein.

Yang X, Kallarakal A, Saptharishi N, Jiang H, Yang Z, Xie Y, Mitra G, Zheng XX, Strom TB, Soman G.

Mol Pharm. 2013 Feb 4;10(2):717-27. doi: 10.1021/mp300513j. Epub 2013 Jan 22.


TIM family proteins promote the lysosomal degradation of the nuclear receptor NUR77.

Balasubramanian S, Kota SK, Kuchroo VK, Humphreys BD, Strom TB.

Sci Signal. 2012 Dec 11;5(254):ra90. doi: 10.1126/scisignal.2003200.


Mutations in the SORT1 gene are unlikely to cause autosomal dominant hypercholesterolemia.

Tveten K, Strøm TB, Cameron J, Berge KE, Leren TP.

Atherosclerosis. 2012 Dec;225(2):370-5. doi: 10.1016/j.atherosclerosis.2012.10.026. Epub 2012 Oct 11.


Leptin deficiency modulates allograft survival by favoring a Th2 and a regulatory immune profile. [corrected].

Moraes-Vieira PM, Bassi EJ, Larocca RA, Castoldi A, Burghos M, Lepique AP, Quintana FJ, Araujo RC, Basso AS, Strom TB, Câmara NO.

Am J Transplant. 2013 Jan;13(1):36-44. doi: 10.1111/j.1600-6143.2012.04283.x. Epub 2012 Sep 27. Erratum in: Am J Transplant. 2013 Aug;13(8):2231.


Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival.

Koulmanda M, Bhasin M, Fan Z, Hanidziar D, Goel N, Putheti P, Movahedi B, Libermann TA, Strom TB.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15443-8. Epub 2012 Sep 4.


Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs.

Gupta S, Thornley TB, Gao W, Larocca R, Turka LA, Kuchroo VK, Strom TB.

J Clin Invest. 2012 Jul;122(7):2395-404. doi: 10.1172/JCI45138. Epub 2012 Jun 11.


Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells.

Veenstra RG, Taylor PA, Zhou Q, Panoskaltsis-Mortari A, Hirashima M, Flynn R, Liu D, Anderson AC, Strom TB, Kuchroo VK, Blazar BR.

Blood. 2012 Jul 19;120(3):682-90. doi: 10.1182/blood-2011-10-387977. Epub 2012 Jun 7.


The role of TNF-α in mice with type 1- and 2- diabetes.

Koulmanda M, Bhasin M, Awdeh Z, Qipo A, Fan Z, Hanidziar D, Putheti P, Shi H, Csizuadia E, Libermann TA, Strom TB.

PLoS One. 2012;7(5):e33254. doi: 10.1371/journal.pone.0033254. Epub 2012 May 11.


Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term triple therapy.

Koulmanda M, Qipo A, Fan Z, Smith N, Auchincloss H, Zheng XX, Strom TB.

Am J Transplant. 2012 May;12(5):1296-302. doi: 10.1111/j.1600-6143.2012.03973.x. Epub 2012 Mar 5.


Effects of an agonist interleukin-2/Fc fusion protein, a mutant antagonist interleukin-15/Fc fusion protein, and sirolimus on cardiac allograft survival in non-human primates.

Millington T, Koulmanda M, Ng C, Boskovic S, Nadazdin OM, Benichou G, Zheng XX, Strom TB, Madsen JC.

J Heart Lung Transplant. 2012 Apr;31(4):427-35. doi: 10.1016/j.healun.2012.01.864. Epub 2012 Feb 24.


Orphan nuclear receptor Nur77 promotes acute kidney injury and renal epithelial apoptosis.

Balasubramanian S, Jansen M, Valerius MT, Humphreys BD, Strom TB.

J Am Soc Nephrol. 2012 Apr;23(4):674-86. doi: 10.1681/ASN.2011070646. Epub 2012 Feb 16.


Interaction between the ligand-binding domain of the LDL receptor and the C-terminal domain of PCSK9 is required for PCSK9 to remain bound to the LDL receptor during endosomal acidification.

Tveten K, Holla ØL, Cameron J, Strøm TB, Berge KE, Laerdahl JK, Leren TP.

Hum Mol Genet. 2012 Mar 15;21(6):1402-9. doi: 10.1093/hmg/ddr578. Epub 2011 Dec 8.


Characterization of residues in the cytoplasmic domain of the LDL receptor required for exit from the endoplasmic reticulum.

Strøm TB, Tveten K, Holla ØL, Cameron J, Berge KE, Leren TP.

Biochem Biophys Res Commun. 2011 Dec 2;415(4):642-5. doi: 10.1016/j.bbrc.2011.10.127. Epub 2011 Nov 2.


Characterization of a naturally occurring degradation product of the LDL receptor.

Tveten K, Strøm TB, Cameron J, Holla ØL, Berge KE, Leren TP.

Mol Genet Metab. 2012 Jan;105(1):149-54. doi: 10.1016/j.ymgme.2011.10.008. Epub 2011 Oct 24.


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