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Items: 1 to 50 of 190

1.

Guide to the Assessment of Mature Liver Gene Expression in Stem Cell-Derived Hepatocytes.

Zabulica M, Srinivasan RC, Vosough M, Hammarstedt C, Wu T, Gramignoli R, Ellis E, Kannisto K, Collin de l'Hortet A, Takeishi K, Soto-Gutierrez A, Strom SC.

Stem Cells Dev. 2019 Jul 15;28(14):907-919. doi: 10.1089/scd.2019.0064.

2.

Applying hydrodynamic pressure to efficiently generate induced pluripotent stem cells via reprogramming of centenarian skin fibroblasts.

Vosough M, Ravaioli F, Zabulica M, Capri M, Garagnani P, Franceschi C, Piccand J, Kraus MR, Kannisto K, Gramignoli R, Strom SC.

PLoS One. 2019 Apr 25;14(4):e0215490. doi: 10.1371/journal.pone.0215490. eCollection 2019.

3.

A liver-humanized mouse model of carbamoyl phosphate synthetase 1-deficiency.

Srinivasan RC, Zabulica M, Hammarstedt C, Wu T, Gramignoli R, Kannisto K, Ellis E, Karadagi A, Fingerhut R, Allegri G, Rüfenacht V, Thöny B, Häberle J, Nuoffer JM, Strom SC.

J Inherit Metab Dis. 2019 Mar 6. doi: 10.1002/jimd.12067. [Epub ahead of print]

PMID:
30843237
4.

Ectonucleotidase Expression on Human Amnion Epithelial Cells: Adenosinergic Pathways and Dichotomic Effects on Immune Effector Cell Populations.

Morandi F, Horenstein AL, Quarona V, Faini AC, Castella B, Srinivasan RC, Strom SC, Malavasi F, Gramignoli R.

J Immunol. 2019 Feb 1;202(3):724-735. doi: 10.4049/jimmunol.1800432. Epub 2018 Dec 26.

PMID:
30587530
5.

Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma.

Augello G, Emma MR, Cusimano A, Azzolina A, Mongiovì S, Puleio R, Cassata G, Gulino A, Belmonte B, Gramignoli R, Strom SC, McCubrey JA, Montalto G, Cervello M.

Int J Cancer. 2019 May 15;144(10):2613-2624. doi: 10.1002/ijc.31963. Epub 2018 Dec 24.

PMID:
30488605
6.

Evaluation of different routes of administration and biodistribution of human amnion epithelial cells in mice.

Srinivasan RC, Kannisto K, Strom SC, Gramignoli R.

Cytotherapy. 2019 Jan;21(1):113-124. doi: 10.1016/j.jcyt.2018.10.007. Epub 2018 Nov 5.

PMID:
30409699
7.

Clinical Hepatocyte Transplantation: What Is Next?

Squires JE, Soltys KA, McKiernan P, Squires RH, Strom SC, Fox IJ, Soto-Gutierrez A.

Curr Transplant Rep. 2017 Dec;4(4):280-289. doi: 10.1007/s40472-017-0165-6. Epub 2017 Oct 14.

8.

Oleocanthal exerts antitumor effects on human liver and colon cancer cells through ROS generation.

Cusimano A, Balasus D, Azzolina A, Augello G, Emma MR, Di Sano C, Gramignoli R, Strom SC, McCubrey JA, Montalto G, Cervello M.

Int J Oncol. 2017 Aug;51(2):533-544. doi: 10.3892/ijo.2017.4049. Epub 2017 Jun 21.

PMID:
28656311
9.

Differentiation of amniotic epithelial cells into various liver cell types and potential therapeutic applications.

Fanti M, Gramignoli R, Serra M, Cadoni E, Strom SC, Marongiu F.

Placenta. 2017 Nov;59:139-145. doi: 10.1016/j.placenta.2017.03.020. Epub 2017 Mar 30. Review.

PMID:
28411944
10.

Host conditioning and rejection monitoring in hepatocyte transplantation in humans.

Soltys KA, Setoyama K, Tafaleng EN, Soto Gutiérrez A, Fong J, Fukumitsu K, Nishikawa T, Nagaya M, Sada R, Haberman K, Gramignoli R, Dorko K, Tahan V, Dreyzin A, Baskin K, Crowley JJ, Quader MA, Deutsch M, Ashokkumar C, Shneider BL, Squires RH, Ranganathan S, Reyes-Mugica M, Dobrowolski SF, Mazariegos G, Elango R, Stolz DB, Strom SC, Vockley G, Roy-Chowdhury J, Cascalho M, Guha C, Sindhi R, Platt JL, Fox IJ.

J Hepatol. 2017 May;66(5):987-1000. doi: 10.1016/j.jhep.2016.12.017. Epub 2016 Dec 24.

11.
12.

Addition of Dexamethasone Alters the Bile Acid Composition by Inducing CYP8B1 in Primary Cultures of Human Hepatocytes.

Mörk LM, Strom SC, Mode A, Ellis EC.

J Clin Exp Hepatol. 2016 Jun;6(2):87-93. doi: 10.1016/j.jceh.2016.01.007. Epub 2016 Feb 10.

13.

Human amnion epithelial cells expressing HLA-G as novel cell-based treatment for liver disease.

Strom SC, Gramignoli R.

Hum Immunol. 2016 Sep;77(9):734-9. doi: 10.1016/j.humimm.2016.07.002. Epub 2016 Jul 27. Review.

PMID:
27476049
14.

Isolation of Human Amnion Epithelial Cells According to Current Good Manufacturing Procedures.

Gramignoli R, Srinivasan RC, Kannisto K, Strom SC.

Curr Protoc Stem Cell Biol. 2016 May 12;37:1E.10.1-1E.10.13. doi: 10.1002/cpsc.2.

PMID:
27171794
15.

Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny.

Giebel NL, Shadley JD, McCarver DG, Dorko K, Gramignoli R, Strom SC, Yan K, Simpson PM, Hines RN.

Drug Metab Dispos. 2016 Jul;44(7):1027-37. doi: 10.1124/dmd.116.069344. Epub 2016 Feb 26.

16.

The Use of Induced Pluripotent Stem Cells for the Study and Treatment of Liver Diseases.

Hansel MC, Davila JC, Vosough M, Gramignoli R, Skvorak KJ, Dorko K, Marongiu F, Blake W, Strom SC.

Curr Protoc Toxicol. 2016 Feb 1;67:14.13.1-14.13.27. doi: 10.1002/0471140856.tx1413s67. Review.

17.

The proteome of methylmalonic acidemia (MMA): the elucidation of altered pathways in patient livers.

Caterino M, Chandler RJ, Sloan JL, Dorko K, Cusmano-Ozog K, Ingenito L, Strom SC, Imperlini E, Scolamiero E, Venditti CP, Ruoppolo M.

Mol Biosyst. 2016 Feb;12(2):566-74. doi: 10.1039/c5mb00736d.

18.

Induced pluripotent stem cells model personalized variations in liver disease resulting from α1-antitrypsin deficiency.

Tafaleng EN, Chakraborty S, Han B, Hale P, Wu W, Soto-Gutierrez A, Feghali-Bostwick CA, Wilson AA, Kotton DN, Nagaya M, Strom SC, Roy-Chowdhury J, Stolz DB, Perlmutter DH, Fox IJ.

Hepatology. 2015 Jul;62(1):147-57. doi: 10.1002/hep.27753. Epub 2015 Apr 13.

19.

Rat-derived amniotic epithelial cells differentiate into mature hepatocytes in vivo with no evidence of cell fusion.

Marongiu M, Serra MP, Contini A, Sini M, Strom SC, Laconi E, Marongiu F.

Stem Cells Dev. 2015 Jun 15;24(12):1429-35. doi: 10.1089/scd.2014.0532. Epub 2015 Mar 6.

20.

Clinical hepatocyte transplantation: practical limits and possible solutions.

Gramignoli R, Vosough M, Kannisto K, Srinivasan RC, Strom SC.

Eur Surg Res. 2015;54(3-4):162-77. doi: 10.1159/000369552. Epub 2015 Jan 23. Review.

PMID:
25633583
21.

The history and use of human hepatocytes for the treatment of liver diseases: the first 100 patients.

Hansel MC, Gramignoli R, Skvorak KJ, Dorko K, Marongiu F, Blake W, Davila J, Strom SC.

Curr Protoc Toxicol. 2014 Nov 6;62:14.12.1-23. doi: 10.1002/0471140856.tx1412s62.

22.

Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures.

Liu J, Lu H, Lu YF, Lei X, Cui JY, Ellis E, Strom SC, Klaassen CD.

Toxicol Sci. 2014 Oct;141(2):538-46. doi: 10.1093/toxsci/kfu151. Epub 2014 Jul 23.

23.

Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase.

Tso SC, Gui WJ, Wu CY, Chuang JL, Qi X, Skvora KJ, Dork K, Wallace AL, Morlock LK, Lee BH, Hutson SM, Strom SC, Williams NS, Tambar UK, Wynn RM, Chuang DT.

J Biol Chem. 2014 Jul 25;289(30):20583-93.

24.

Rapid and sensitive assessment of human hepatocyte functions.

Gramignoli R, Tahan V, Dorko K, Venkataramanan R, Fox IJ, Ellis EC, Vosough M, Strom SC.

Cell Transplant. 2014;23(12):1545-56. doi: 10.3727/096368914X680064. Epub 2014 Apr 4.

PMID:
24702711
25.

Why do most human liver cytosol preparations lack xanthine oxidase activity?

Barr JT, Choughule KV, Nepal S, Wong T, Chaudhry AS, Joswig-Jones CA, Zientek M, Strom SC, Schuetz EG, Thummel KE, Jones JP.

Drug Metab Dispos. 2014 Apr;42(4):695-9. doi: 10.1124/dmd.113.056374. Epub 2014 Jan 15.

26.

Translation of amnion stem cells to the clinic.

Strom SC, Skvorak K, Gramignoli R, Marongiu F, Miki T.

Stem Cells Dev. 2013 Dec;22 Suppl 1:96-102. doi: 10.1089/scd.2013.0391.

PMID:
24304085
27.

Mice with chimeric livers are an improved model for human lipoprotein metabolism.

Ellis EC, Naugler WE, Parini P, Mörk LM, Jorns C, Zemack H, Sandblom AL, Björkhem I, Ericzon BG, Wilson EM, Strom SC, Grompe M.

PLoS One. 2013 Nov 4;8(11):e78550. doi: 10.1371/journal.pone.0078550. eCollection 2013. Erratum in: PLoS One. 2014;9(7):e103870. Nauglers, Scott [corrected to Naugler, Willscott Edward].

28.

Potential barriers to human hepatocyte transplantation in MUP-uPAtg(⁺/⁺)Rag2⁻/⁻γC⁻/⁻ mice.

Komori J, DeWard AD, Gramignoli R, Strom SC, Fontes P, Lagasse E.

Cell Transplant. 2014;23(12):1537-44. doi: 10.3727/096368913X672046. Epub 2013 Aug 30.

PMID:
23998208
29.

Ritonavir and efavirenz significantly alter the metabolism of erlotinib--an observation in primary cultures of human hepatocytes that is relevant to HIV patients with cancer.

Pillai VC, Venkataramanan R, Parise RA, Christner SM, Gramignoli R, Strom SC, Rudek MA, Beumer JH.

Drug Metab Dispos. 2013 Oct;41(10):1843-51. doi: 10.1124/dmd.113.052100. Epub 2013 Aug 2.

30.

Hypothermic storage of human hepatocytes for transplantation.

Gramignoli R, Dorko K, Tahan V, Skvorak KJ, Ellis E, Jorns C, Ericzon BG, Fox IJ, Strom SC.

Cell Transplant. 2014;23(9):1143-51. doi: 10.3727/096368913X668627.

PMID:
23768881
31.

Genetic variation in aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of multiple cytochrome P450s.

Chaudhry AS, Thirumaran RK, Yasuda K, Yang X, Fan Y, Strom SC, Schuetz EG.

Drug Metab Dispos. 2013 Aug;41(8):1538-47. doi: 10.1124/dmd.113.051672. Epub 2013 May 23. Erratum in: Drug Metab Dispos. 2014 May;42(5):917.

32.

New potential cell source for hepatocyte transplantation: discarded livers from metabolic disease liver transplants.

Gramignoli R, Tahan V, Dorko K, Skvorak KJ, Hansel MC, Zhao W, Venkataramanan R, Ellis EC, Jorns C, Ericzon BG, Rosenborg S, Kuiper R, Soltys KA, Mazariegos GV, Fox IJ, Wilson EM, Grompe M, Strom SC.

Stem Cell Res. 2013 Jul;11(1):563-73. doi: 10.1016/j.scr.2013.03.002. Epub 2013 Mar 27.

33.

Improved amino acid, bioenergetic metabolite and neurotransmitter profiles following human amnion epithelial cell transplant in intermediate maple syrup urine disease mice.

Skvorak KJ, Dorko K, Marongiu F, Tahan V, Hansel MC, Gramignoli R, Arning E, Bottiglieri T, Gibson KM, Strom SC.

Mol Genet Metab. 2013 Jun;109(2):132-8. doi: 10.1016/j.ymgme.2013.02.011. Epub 2013 Feb 26.

PMID:
23566440
34.

Increased reprogramming of human fetal hepatocytes compared with adult hepatocytes in feeder-free conditions.

Hansel MC, Gramignoli R, Blake W, Davila J, Skvorak K, Dorko K, Tahan V, Lee BR, Tafaleng E, Guzman-Lepe J, Soto-Gutierrez A, Fox IJ, Strom SC.

Cell Transplant. 2014 Jan;23(1):27-38. doi: 10.3727/096368912X662453. Epub 2013 Feb 4.

35.

A sensitive and specific CYP cocktail assay for the simultaneous assessment of human cytochrome P450 activities in primary cultures of human hepatocytes using LC-MS/MS.

Pillai VC, Strom SC, Caritis SN, Venkataramanan R.

J Pharm Biomed Anal. 2013 Feb 23;74:126-32. doi: 10.1016/j.jpba.2012.10.016. Epub 2012 Oct 22.

36.

Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORα and RORγ and its potential relevance to human liver diseases.

Ou Z, Shi X, Gilroy RK, Kirisci L, Romkes M, Lynch C, Wang H, Xu M, Jiang M, Ren S, Gramignoli R, Strom SC, Huang M, Xie W.

Mol Endocrinol. 2013 Jan;27(1):106-15. doi: 10.1210/me.2012-1145. Epub 2012 Dec 4.

37.

Treprostinil Improves Hepatic Cytochrome P450 Activity during Rat Liver Transplantation.

Ghonem N, Yoshida J, Murase N, Strom SC, Venkataramanan R.

J Clin Exp Hepatol. 2012 Dec;2(4):323-32. doi: 10.1016/j.jceh.2012.09.002. Epub 2012 Oct 12.

38.

Placental stem cell correction of murine intermediate maple syrup urine disease.

Skvorak KJ, Dorko K, Marongiu F, Tahan V, Hansel MC, Gramignoli R, Gibson KM, Strom SC.

Hepatology. 2013 Mar;57(3):1017-23. doi: 10.1002/hep.26150. Epub 2013 Feb 15.

39.

Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: a comparison with adult human hepatocytes.

Sharma S, Ellis EC, Gramignoli R, Dorko K, Tahan V, Hansel M, Mattison DR, Caritis SN, Hines RN, Venkataramanan R, Strom SC.

Drug Metab Dispos. 2013 Feb;41(2):296-304. doi: 10.1124/dmd.112.044891. Epub 2012 Nov 5.

40.

The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).

Laurenzana EM, Chen T, Kannuswamy M, Sell BE, Strom SC, Li Y, Omiecinski CJ.

Mol Pharmacol. 2012 Nov;82(5):918-28. doi: 10.1124/mol.112.080721. Epub 2012 Aug 15.

41.

Hepatocyte transplantation for inherited metabolic diseases of the liver.

Jorns C, Ellis EC, Nowak G, Fischler B, Nemeth A, Strom SC, Ericzon BG.

J Intern Med. 2012 Sep;272(3):201-23. doi: 10.1111/j.1365-2796.2012.02574.x. Epub 2012 Aug 20. Review.

42.

ChREBP mediates glucose-stimulated pancreatic β-cell proliferation.

Metukuri MR, Zhang P, Basantani MK, Chin C, Stamateris RE, Alonso LC, Takane KK, Gramignoli R, Strom SC, O'Doherty RM, Stewart AF, Vasavada RC, Garcia-Ocaña A, Scott DK.

Diabetes. 2012 Aug;61(8):2004-15. doi: 10.2337/db11-0802. Epub 2012 May 14.

43.

Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes.

Noreault-Conti TL, Fellows A, Jacobs JM, Trask HW, Strom SC, Evans RM, Wrighton SA, Sinclair PR, Sinclair JF, Nichols RC.

Int Immunopharmacol. 2012 Apr;12(4):651-6. doi: 10.1016/j.intimp.2012.01.008. Epub 2012 Feb 4.

44.

Development and application of purified tissue dissociation enzyme mixtures for human hepatocyte isolation.

Gramignoli R, Green ML, Tahan V, Dorko K, Skvorak KJ, Marongiu F, Zao W, Venkataramanan R, Ellis EC, Geller D, Breite AG, Dwulet FE, McCarthy RC, Strom SC.

Cell Transplant. 2012;21(6):1245-60. doi: 10.3727/096368911X600939. Epub 2011 Nov 11.

PMID:
22080793
45.

Frequent aneuploidy among normal human hepatocytes.

Duncan AW, Hanlon Newell AE, Smith L, Wilson EM, Olson SB, Thayer MJ, Strom SC, Grompe M.

Gastroenterology. 2012 Jan;142(1):25-8. doi: 10.1053/j.gastro.2011.10.029. Epub 2011 Nov 2.

46.

Hepatic organic anion transporting polypeptide transporter and thyroid hormone receptor interplay determines cholesterol and glucose homeostasis.

Meyer zu Schwabedissen HE, Ware JA, Finkelstein D, Chaudhry AS, Mansell S, Leon-Ponte M, Strom SC, Zaher H, Schwarz UI, Freeman DJ, Schuetz EG, Tirona RG, Kim RB.

Hepatology. 2011 Aug;54(2):644-54. doi: 10.1002/hep.24391. Epub 2011 Jun 26.

47.

Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London.

Puppi J, Strom SC, Hughes RD, Bansal S, Castell JV, Dagher I, Ellis EC, Nowak G, Ericzon BG, Fox IJ, Gómez-Lechón MJ, Guha C, Gupta S, Mitry RR, Ohashi K, Ott M, Reid LM, Roy-Chowdhury J, Sokal E, Weber A, Dhawan A.

Cell Transplant. 2012;21(1):1-10. doi: 10.3727/096368911X566208.

PMID:
21457616
48.

A whole-organ regenerative medicine approach for liver replacement.

Soto-Gutierrez A, Zhang L, Medberry C, Fukumitsu K, Faulk D, Jiang H, Reing J, Gramignoli R, Komori J, Ross M, Nagaya M, Lagasse E, Stolz D, Strom SC, Fox IJ, Badylak SF.

Tissue Eng Part C Methods. 2011 Jun;17(6):677-86. doi: 10.1089/ten.tec.2010.0698. Epub 2011 Apr 20.

49.

Hepatic differentiation of amniotic epithelial cells.

Marongiu F, Gramignoli R, Dorko K, Miki T, Ranade AR, Paola Serra M, Doratiotto S, Sini M, Sharma S, Mitamura K, Sellaro TL, Tahan V, Skvorak KJ, Ellis EC, Badylak SF, Davila JC, Hines R, Laconi E, Strom SC.

Hepatology. 2011 May;53(5):1719-29. doi: 10.1002/hep.24255.

50.

MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation.

Ou Z, Wada T, Gramignoli R, Li S, Strom SC, Huang M, Xie W.

Mol Endocrinol. 2011 Apr;25(4):584-96. doi: 10.1210/me.2010-0360. Epub 2011 Feb 10.

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