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Publisher Correction: Claudin-3-deficient C57BL/6J mice display intact brain barriers.

Dias MC, Coisne C, Lazarevic I, Baden P, Hata M, Iwamoto N, Francisco DMF, Vanlandewijck M, He L, Baier FA, Stroka D, Bruggmann R, Lyck R, Enzmann G, Deutsch U, Betsholtz C, Furuse M, Tsukita S, Engelhardt B.

Sci Rep. 2019 Jul 18;9(1):10702. doi: 10.1038/s41598-019-43511-0.


Placental secretion of apolipoprotein A1 and E: the anti-atherogenic impact of the placenta.

Melhem H, Kallol S, Huang X, Lüthi M, Ontsouka CE, Keogh A, Stroka D, Thormann W, Schneider H, Albrecht C.

Sci Rep. 2019 Apr 17;9(1):6225. doi: 10.1038/s41598-019-42522-1.


Connexin-43-dependent ATP release mediates macrophage activation during sepsis.

Dosch M, Zindel J, Jebbawi F, Melin N, Sanchez-Taltavull D, Stroka D, Candinas D, Beldi G.

Elife. 2019 Feb 8;8. pii: e42670. doi: 10.7554/eLife.42670.


Claudin-3-deficient C57BL/6J mice display intact brain barriers.

Castro Dias M, Coisne C, Lazarevic I, Baden P, Hata M, Iwamoto N, Francisco DMF, Vanlandewijck M, He L, Baier FA, Stroka D, Bruggmann R, Lyck R, Enzmann G, Deutsch U, Betsholtz C, Furuse M, Tsukita S, Engelhardt B.

Sci Rep. 2019 Jan 18;9(1):203. doi: 10.1038/s41598-018-36731-3. Erratum in: Sci Rep. 2019 Jul 18;9(1):10702.


Autologous transplantation of adipose-derived stem cells improves functional recovery of skeletal muscle without direct participation in new myofiber formation.

Gorecka A, Salemi S, Haralampieva D, Moalli F, Stroka D, Candinas D, Eberli D, Brügger L.

Stem Cell Res Ther. 2018 Jul 17;9(1):195. doi: 10.1186/s13287-018-0922-1.


Identification of a MET-eIF4G1 translational regulation axis that controls HIF-1α levels under hypoxia.

Glück AA, Orlando E, Leiser D, Poliaková M, Nisa L, Quintin A, Gavini J, Stroka DM, Berezowska S, Bubendorf L, Blaukat A, Aebersold DM, Medová M, Zimmer Y.

Oncogene. 2018 Jul;37(30):4181-4196. doi: 10.1038/s41388-018-0256-6. Epub 2018 May 2.


CRIPTO promotes an aggressive tumour phenotype and resistance to treatment in hepatocellular carcinoma.

Karkampouna S, van der Helm D, Gray PC, Chen L, Klima I, Grosjean J, Burgmans MC, Farina-Sarasqueta A, Snaar-Jagalska EB, Stroka DM, Terracciano L, van Hoek B, Schaapherder AF, Osanto S, Thalmann GN, Verspaget HW, Coenraad MJ, Kruithof-de Julio M.

J Pathol. 2018 Jul;245(3):297-310. doi: 10.1002/path.5083. Epub 2018 May 9.


BOK promotes chemical-induced hepatocarcinogenesis in mice.

Rabachini T, Fernandez-Marrero Y, Montani M, Loforese G, Sladky V, He Z, Bachmann D, Wicki S, Villunger A, Stroka D, Kaufmann T.

Cell Death Differ. 2018 Mar;25(4):708-720. doi: 10.1038/s41418-017-0008-0. Epub 2017 Dec 11.


Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2.

Loforese G, Malinka T, Keogh A, Baier F, Simillion C, Montani M, Halazonetis TD, Candinas D, Stroka D.

EMBO Mol Med. 2017 Jan;9(1):46-60. doi: 10.15252/emmm.201506089.


Depletion of FOXM1 via MET Targeting Underlies Establishment of a DNA Damage-Induced Senescence Program in Gastric Cancer.

Francica P, Nisa L, Aebersold DM, Langer R, Bladt F, Blaukat A, Stroka D, Martínez MR, Zimmer Y, Medová M.

Clin Cancer Res. 2016 Nov 1;22(21):5322-5336. Epub 2016 May 16.


R-spondin 1 and noggin facilitate expansion of resident stem cells from non-damaged gallbladders.

Lugli N, Kamileri I, Keogh A, Malinka T, Sarris ME, Talianidis I, Schaad O, Candinas D, Stroka D, Halazonetis TD.

EMBO Rep. 2016 May;17(5):769-79. doi: 10.15252/embr.201642169. Epub 2016 Mar 18.


P2X1-regulated IL-22 secretion by innate lymphoid cells is required for efficient liver regeneration.

Kudira R, Malinka T, Kohler A, Dosch M, de Agüero MG, Melin N, Haegele S, Starlinger P, Maharjan N, Saxena S, Keogh A, Stroka D, Candinas D, Beldi G.

Hepatology. 2016 Jun;63(6):2004-17. doi: 10.1002/hep.28492. Epub 2016 Mar 17.


Significant lethality following liver resection in A20 heterozygous knockout mice uncovers a key role for A20 in liver regeneration.

Studer P, da Silva CG, Revuelta Cervantes JM, Mele A, Csizmadia E, Siracuse JJ, Damrauer SM, Peterson CR, Candinas D, Stroka DM, Ma A, Bhasin M, Ferran C.

Cell Death Differ. 2015 Dec;22(12):2068-77. doi: 10.1038/cdd.2015.52. Epub 2015 May 15.


KRAS and HRAS mutations confer resistance to MET targeting in preclinical models of MET-expressing tumor cells.

Leiser D, Medová M, Mikami K, Nisa L, Stroka D, Blaukat A, Bladt F, Aebersold DM, Zimmer Y.

Mol Oncol. 2015 Aug;9(7):1434-46. doi: 10.1016/j.molonc.2015.04.001. Epub 2015 Apr 14.


Nuclear Factor I-C acts as a regulator of hepatocyte proliferation at the onset of liver regeneration.

Edelmann S, Fahrner R, Malinka T, Song BH, Stroka D, Mermod N.

Liver Int. 2015 Apr;35(4):1185-94. doi: 10.1111/liv.12697. Epub 2014 Oct 25.


In vitro rescue of FGA deletion by lentiviral transduction of an afibrinogenemic patient's hepatocytes.

Stroka D, Keogh A, Vu D, Fort A, Stoffel MH, Kühni-Boghenbor K, Furer C, Banz V, Demarmels Biasiutti F, Lämmle B, Candinas D, Neerman-Arbez M.

J Thromb Haemost. 2014 Nov;12(11):1874-9. doi: 10.1111/jth.12714. Epub 2014 Oct 1.


The silencing of N-myc downstream-regulated gene-1 in an orthotopic pancreatic cancer model leads to more aggressive tumor growth and metastases.

Kim-Fuchs C, Winterhalder S, Winter A, Malinka T, Born D, Schäfer S, Stroka D, Gloor B, Candinas D, Angst E.

Dig Surg. 2014;31(2):135-42. doi: 10.1159/000363065. Epub 2014 Jun 20.


The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiota.

Balmer ML, Slack E, de Gottardi A, Lawson MA, Hapfelmeier S, Miele L, Grieco A, Van Vlierberghe H, Fahrner R, Patuto N, Bernsmeier C, Ronchi F, Wyss M, Stroka D, Dickgreber N, Heim MH, McCoy KD, Macpherson AJ.

Sci Transl Med. 2014 May 21;6(237):237ra66. doi: 10.1126/scitranslmed.3008618.


Tumor necrosis factor-related apoptosis-inducing ligand on NK cells protects from hepatic ischemia-reperfusion injury.

Fahrner R, Trochsler M, Corazza N, Graubardt N, Keogh A, Candinas D, Brunner T, Stroka D, Beldi G.

Transplantation. 2014 Jun 15;97(11):1102-9. doi: 10.1097/TP.0000000000000101.


Elevated liver regeneration in response to pharmacological reduction of elevated portal venous pressure by terlipressin after partial hepatectomy.

Fahrner R, Patsenker E, de Gottardi A, Stickel F, Montani M, Stroka D, Candinas D, Beldi G.

Transplantation. 2014 May 15;97(9):892-900. doi: 10.1097/TP.0000000000000045.


The novel ATP-competitive inhibitor of the MET hepatocyte growth factor receptor EMD1214063 displays inhibitory activity against selected MET-mutated variants.

Medová M, Pochon B, Streit B, Blank-Liss W, Francica P, Stroka D, Keogh A, Aebersold DM, Blaukat A, Bladt F, Zimmer Y.

Mol Cancer Ther. 2013 Nov;12(11):2415-24. doi: 10.1158/1535-7163.MCT-13-0151. Epub 2013 Sep 23.


Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo.

Portmann S, Fahrner R, Lechleiter A, Keogh A, Overney S, Laemmle A, Mikami K, Montani M, Tschan MP, Candinas D, Stroka D.

Mol Cancer Ther. 2013 Apr;12(4):499-508. doi: 10.1158/1535-7163.MCT-12-0700. Epub 2013 Jan 21.


Promotion of liver regeneration by natural killer cells in a murine model is dependent on extracellular adenosine triphosphate phosphohydrolysis.

Graubardt N, Fahrner R, Trochsler M, Keogh A, Breu K, Furer C, Stroka D, Robson SC, Slack E, Candinas D, Beldi G.

Hepatology. 2013 May;57(5):1969-79. doi: 10.1002/hep.26008. Epub 2013 Jan 25.


Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions.

Laemmle A, Lechleiter A, Roh V, Schwarz C, Portmann S, Furer C, Keogh A, Tschan MP, Candinas D, Vorburger SA, Stroka D.

PLoS One. 2012;7(3):e33433. doi: 10.1371/journal.pone.0033433. Epub 2012 Mar 30.


N-myc downstream regulated gene-1 expression correlates with reduced pancreatic cancer growth and increased apoptosis in vitro and in vivo.

Angst E, Dawson DW, Stroka D, Gloor B, Park J, Candinas D, Reber HA, Hines OJ, Eibl G.

Surgery. 2011 May;149(5):614-24. doi: 10.1016/j.surg.2010.11.002. Epub 2011 Jan 14.


The alphavbeta6 integrin is a highly specific immunohistochemical marker for cholangiocarcinoma.

Patsenker E, Wilkens L, Banz V, Osterreicher CH, Weimann R, Eisele S, Keogh A, Stroka D, Zimmermann A, Stickel F.

J Hepatol. 2010 Mar;52(3):362-9. doi: 10.1016/j.jhep.2009.12.006. Epub 2010 Jan 13.


Hypoxia aggravates non-alcoholic steatohepatitis in mice lacking hepatocellular PTEN.

Piguet AC, Stroka D, Zimmermann A, Dufour JF.

Clin Sci (Lond). 2009 Dec 14;118(6):401-10. doi: 10.1042/CS20090313.


NDRG1/2 expression is inhibited in primary acute myeloid leukemia.

Tschan MP, Shan D, Laedrach J, Eyholzer M, Leibundgut EO, Baerlocher GM, Tobler A, Stroka D, Fey MF.

Leuk Res. 2010 Mar;34(3):393-8. doi: 10.1016/j.leukres.2009.08.037. Epub 2009 Sep 22.


Hsp90 transcriptionally and post-translationally regulates the expression of NDRG1 and maintains the stability of its modifying kinase GSK3beta.

Banz VM, Medová M, Keogh A, Furer C, Zimmer Y, Candinas D, Stroka D.

Biochim Biophys Acta. 2009 Oct;1793(10):1597-603. doi: 10.1016/j.bbamcr.2009.08.002. Epub 2009 Aug 12.


Effective treatment of advanced colorectal cancer by rapamycin and 5-FU/oxaliplatin monitored by TIMP-1.

Wagner M, Roh V, Strehlen M, Laemmle A, Stroka D, Egger B, Trochsler M, Hunt KK, Candinas D, Vorburger SA.

J Gastrointest Surg. 2009 Oct;13(10):1781-90. doi: 10.1007/s11605-009-0948-x. Epub 2009 Jun 30.


SIRT1 is downregulated during neutrophil differentiation of acute promyelocytic leukaemia cells.

Wampfler J, Tschan MP, Shan D, Laemmle A, Leibundgut EO, Baerlocher GM, Stroka D, Fey MF, Britschgi C.

Br J Haematol. 2009 Aug;146(3):337-41. doi: 10.1111/j.1365-2141.2009.07749.x. Epub 2009 May 19. No abstract available.


Multiparameter flow cytometry characterization of MHC class I negative mouse bone marrow cells.

Quarta M, Stroka D, Keogh A, Sidler D, Avital I, Gloor B, Muraca M, Candinas D, Inderbitzin D.

Med Sci Monit. 2008 Dec;14(12):BR286-93.


Dual induction of PKR with E2F-1 and IFN-alpha to enhance gene therapy against hepatocellular carcinoma.

Roh V, Laemmle A, Von Holzen U, Stroka D, Dufour JF, Hunt KK, Candinas D, Vorburger SA.

Cancer Gene Ther. 2008 Oct;15(10):636-44. doi: 10.1038/cgt.2008.34. Epub 2008 Jun 6.


Inhibition of mTOR in combination with doxorubicin in an experimental model of hepatocellular carcinoma.

Piguet AC, Semela D, Keogh A, Wilkens L, Stroka D, Stoupis C, St-Pierre MV, Dufour JF.

J Hepatol. 2008 Jul;49(1):78-87. doi: 10.1016/j.jhep.2008.03.024. Epub 2008 Apr 28.


Regulation of human liver delta-aminolevulinic acid synthase by bile acids.

Peyer AK, Jung D, Beer M, Gnerre C, Keogh A, Stroka D, Zavolan M, Meyer UA.

Hepatology. 2007 Dec;46(6):1960-70.


Annexins sense changes in intracellular pH during hypoxia.

Monastyrskaya K, Tschumi F, Babiychuk EB, Stroka D, Draeger A.

Biochem J. 2008 Jan 1;409(1):65-75.


Activation of non-ischemic, hypoxia-inducible signalling pathways up-regulate cytoprotective genes in the murine liver.

Plock J, Frese S, Keogh A, Bisch-Knaden S, Ayuni E, Corazza N, Weikert C, Jakob S, Erni D, Dufour JF, Brunner T, Candinas D, Stroka D.

J Hepatol. 2007 Oct;47(4):538-45. Epub 2007 Jun 4.


Hypoxia increases cytoplasmic expression of NDRG1, but is insufficient for its membrane localization in human hepatocellular carcinoma.

Sibold S, Roh V, Keogh A, Studer P, Tiffon C, Angst E, Vorburger SA, Weimann R, Candinas D, Stroka D.

FEBS Lett. 2007 Mar 6;581(5):989-94. Epub 2007 Feb 7.


Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver.

Rencurel F, Foretz M, Kaufmann MR, Stroka D, Looser R, Leclerc I, da Silva Xavier G, Rutter GA, Viollet B, Meyer UA.

Mol Pharmacol. 2006 Dec;70(6):1925-34. Epub 2006 Sep 20.


TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality.

Corazza N, Jakob S, Schaer C, Frese S, Keogh A, Stroka D, Kassahn D, Torgler R, Mueller C, Schneider P, Brunner T.

J Clin Invest. 2006 Sep;116(9):2493-9.


Cellular differentiation determines the expression of the hypoxia-inducible protein NDRG1 in pancreatic cancer.

Angst E, Sibold S, Tiffon C, Weimann R, Gloor B, Candinas D, Stroka D.

Br J Cancer. 2006 Aug 7;95(3):307-13. Epub 2006 Jul 11.


Interferon-inducible expression of APOBEC3 editing enzymes in human hepatocytes and inhibition of hepatitis B virus replication.

Bonvin M, Achermann F, Greeve I, Stroka D, Keogh A, Inderbitzin D, Candinas D, Sommer P, Wain-Hobson S, Vartanian JP, Greeve J.

Hepatology. 2006 Jun;43(6):1364-74.


The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants.

Berthou S, Aebersold DM, Schmidt LS, Stroka D, Heigl C, Streit B, Stalder D, Gruber G, Liang C, Howlett AR, Candinas D, Greiner RH, Lipson KE, Zimmer Y.

Oncogene. 2004 Jul 8;23(31):5387-93.


Sinomenine blocks tissue remodeling in a rat model of chronic cardiac allograft rejection.

Mark W, Schneeberger S, Seiler R, Stroka DM, Amberger A, Offner F, Candinas D, Margreiter R.

Transplantation. 2003 Apr 15;75(7):940-5.


Apoptosis in hypoxic human pancreatic islets correlates with HIF-1alpha expression.

Moritz W, Meier F, Stroka DM, Giuliani M, Kugelmeier P, Nett PC, Lehmann R, Candinas D, Gassmann M, Weber M.

FASEB J. 2002 May;16(7):745-7. Epub 2002 Mar 26.


Attenuation of HIF-1 DNA-binding activity limits hypoxia-inducible endothelin-1 expression.

Camenisch G, Stroka DM, Gassmann M, Wenger RH.

Pflugers Arch. 2001 Nov;443(2):240-9.


HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia.

Stroka DM, Burkhardt T, Desbaillets I, Wenger RH, Neil DA, Bauer C, Gassmann M, Candinas D.

FASEB J. 2001 Nov;15(13):2445-53.


The BH4 domain of A1, an anti-apoptotic bcl family gene, is necessary and sufficient for its antiinflammatory function in endothelial cells.

Rocha E, Mahiou J, Badrichani AZ, Stroka DM, Ferran C.

Transplant Proc. 2001 Feb-Mar;33(1-2):314. No abstract available.


Epolones induce erythropoietin expression via hypoxia-inducible factor-1 alpha activation.

Wanner RM, Spielmann P, Stroka DM, Camenisch G, Camenisch I, Scheid A, Houck DR, Bauer C, Gassmann M, Wenger RH.

Blood. 2000 Aug 15;96(4):1558-65.


Overexpression of A1, an NF-kappaB-inducible anti-apoptotic bcl gene, inhibits endothelial cell activation.

Stroka DM, Badrichani AZ, Bach FH, Ferran C.

Blood. 1999 Jun 1;93(11):3803-10.

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