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Items: 1 to 50 of 79

1.

Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain.

Burke JR, Cheng L, Gillooly KM, Strnad J, Zupa-Fernandez A, Catlett IM, Zhang Y, Heimrich EM, McIntyre KW, Cunningham MD, Carman JA, Zhou X, Banas D, Chaudhry C, Li S, D'Arienzo C, Chimalakonda A, Yang X, Xie JH, Pang J, Zhao Q, Rose SM, Huang J, Moslin RM, Wrobleski ST, Weinstein DS, Salter-Cid LM.

Sci Transl Med. 2019 Jul 24;11(502). pii: eaaw1736. doi: 10.1126/scitranslmed.aaw1736.

PMID:
31341059
2.

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.

Wrobleski ST, Moslin R, Lin S, Zhang Y, Spergel S, Kempson J, Tokarski JS, Strnad J, Zupa-Fernandez A, Cheng L, Shuster D, Gillooly K, Yang X, Heimrich E, McIntyre KW, Chaudhry C, Khan J, Ruzanov M, Tredup J, Mulligan D, Xie D, Sun H, Huang C, D'Arienzo C, Aranibar N, Chiney M, Chimalakonda A, Pitts WJ, Lombardo L, Carter PH, Burke JR, Weinstein DS.

J Med Chem. 2019 Jul 18. doi: 10.1021/acs.jmedchem.9b00444. [Epub ahead of print]

PMID:
31318208
3.

Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).

Moslin R, Zhang Y, Wrobleski ST, Lin S, Mertzman M, Spergel S, Tokarski JS, Strnad J, Gillooly K, McIntyre KW, Zupa-Fernandez A, Cheng L, Sun H, Chaudhry C, Huang C, D'Arienzo C, Heimrich E, Yang X, Muckelbauer JK, Chang C, Tredup J, Mulligan D, Xie D, Aranibar N, Chiney M, Burke JR, Lombardo L, Carter PH, Weinstein DS.

J Med Chem. 2019 Jul 17. doi: 10.1021/acs.jmedchem.9b00443. [Epub ahead of print]

PMID:
31314518
4.

Marginal bone response of submerged and non-submerged osteoconductive alkali-etched implants in thick and thin biotypes: A 2-year clinical follow-up study.

Novák Z, Strnad J, Nesvadba R, Kamprle J, Strnad Z.

Int J Oral Maxillofac Implants. 2019 September/October;34(5):1184–1194. doi: 10.11607/jomi.7399. Epub 2019 Apr 1.

PMID:
30934033
5.

Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors.

Liu C, Lin J, Moslin R, Tokarski JS, Muckelbauer J, Chang C, Tredup J, Xie D, Park H, Li P, Wu DR, Strnad J, Zupa-Fernandez A, Cheng L, Chaudhry C, Chen J, Chen C, Sun H, Elzinga P, D'arienzo C, Gillooly K, Taylor TL, McIntyre KW, Salter-Cid L, Lombardo LJ, Carter PH, Aranibar N, Burke JR, Weinstein DS.

ACS Med Chem Lett. 2019 Feb 21;10(3):383-388. doi: 10.1021/acsmedchemlett.9b00035. eCollection 2019 Mar 14.

PMID:
30891145
6.

Chronological Age as Factor Influencing the Dental Implant Osseointegration in the Jaw Bone.

Papež J, Dostálová T, Chleborád K, Kříž P, Strnad J.

Prague Med Rep. 2018;119(1):43-51. doi: 10.14712/23362936.2018.4.

7.

In Vitro Bioactivity Test of Real Dental Implants According to ISO 23317.

Kolafová M, Šťovíček J, Strnad J, Zemek J, Dybal J.

Int J Oral Maxillofac Implants. 2017 Nov/Dec;32(6):1221-1230. doi: 10.11607/jomi.5132.

PMID:
29140368
8.

Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling.

Moslin R, Gardner D, Santella J, Zhang Y, Duncia JV, Liu C, Lin J, Tokarski JS, Strnad J, Pedicord D, Chen J, Blat Y, Zupa-Fernandez A, Cheng L, Sun H, Chaudhry C, Huang C, D'Arienzo C, Sack JS, Muckelbauer JK, Chang C, Tredup J, Xie D, Aranibar N, Burke JR, Carter PH, Weinstein DS.

Medchemcomm. 2016 Dec 15;8(4):700-712. doi: 10.1039/c6md00560h. eCollection 2017 Apr 1.

9.

Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases.

Shi Q, Tebben A, Dyckman AJ, Li H, Liu C, Lin J, Spergel S, Burke JR, McIntyre KW, Olini GC, Strnad J, Surti N, Muckelbauer JK, Chang C, An Y, Cheng L, Ruan Q, Leftheris K, Carter PH, Tino J, De Lucca GV.

Bioorg Med Chem Lett. 2014 May 1;24(9):2206-11. doi: 10.1016/j.bmcl.2014.02.075. Epub 2014 Mar 13.

PMID:
24685542
10.

Antibacterial, cytotoxicity and physical properties of laser--silver doped hydroxyapatite layers.

Jelinek M, Kocourek T, Remsa J, Weiserová M, Jurek K, Mikšovský J, Strnad J, Galandáková A, Ulrichová J.

Mater Sci Eng C Mater Biol Appl. 2013 Apr 1;33(3):1242-6. doi: 10.1016/j.msec.2012.12.018. Epub 2012 Dec 9.

PMID:
23827567
11.

A screening technique useful for testing the effectiveness of novel "self-cleaning" photocatalytic surfaces.

Finn ST, Strnad JA, Barreto PD, Fox ME, Torres J, Sweeney JD, Barreto JC.

Photochem Photobiol. 2011 Sep-Oct;87(5):1184-8. doi: 10.1111/j.1751-1097.2011.00953.x. Epub 2011 Aug 16.

PMID:
21668868
12.

Optimal process mode selection for clone screening.

Strnad J, Spudić V, Brinc M, Pungerčar JR, Kravanja Z.

Acta Chim Slov. 2011 Jun;58(2):333-41.

PMID:
24062044
13.

Changes in stability after healing of immediately loaded dental implants.

Simunek A, Strnad J, Kopecka D, Brazda T, Pilathadka S, Chauhan R, Slezak R, Capek L.

Int J Oral Maxillofac Implants. 2010 Nov-Dec;25(6):1085-92.

PMID:
21197483
14.

18 months of experiences with the biotitanium replacement (Implaspin) used in treatment of degenerative lumbar spine diseases.

Filip M, Linzer P, Sámal F, Kremr J, Strnad Z, Strnad J.

Chir Narzadow Ruchu Ortop Pol. 2010 Mar-Apr;75(2):131-5.

PMID:
20695188
15.

Optimization of cultivation conditions in spin tubes for Chinese hamster ovary cells producing erythropoietin and the comparison of glycosylation patterns in different cultivation vessels.

Strnad J, Brinc M, Spudić V, Jelnikar N, Mirnik L, Carman B, Kravanja Z.

Biotechnol Prog. 2010 May-Jun;26(3):653-63. doi: 10.1002/btpr.390.

PMID:
20544713
16.

Bioactive titan cage Implaspin in treatment of degenerative disease of the cervcal spine--the results from 2007 till 2008.

Filip M, Linzer P, Sámal F, Jurek P, Strnad Z, Strnad J.

Chir Narzadow Ruchu Ortop Pol. 2010 Jan-Feb;75(1):69-73.

PMID:
20496781
17.

Nasal prosthesis supported with self-tapping implants with bioactive surface--a case report.

Dostalova T, Holakovsky J, Polinsky D, Strnad J, Seydlova M, Lonska J.

Acta Chir Plast. 2009;51(2):53-6.

PMID:
20050423
18.

Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis.

Gillooly KM, Pattoli MA, Taylor TL, Chen L, Cheng L, Gregor KR, Whitney GS, Susulic V, Watterson SH, Kempson J, Pitts WJ, Booth-Lute H, Yang G, Davies P, Kukral DW, Strnad J, McIntyre KW, Darienzo CJ, Salter-Cid L, Yang Z, Wang-Iverson DB, Burke JR.

J Pharmacol Exp Ther. 2009 Nov;331(2):349-60. doi: 10.1124/jpet.109.156018. Epub 2009 Aug 3.

PMID:
19652024
19.

Secondary stability assessment of titanium implants with an alkali-etched surface: a resonance frequency analysis study in beagle dogs.

Strnad J, Urban K, Povysil C, Strnad Z.

Int J Oral Maxillofac Implants. 2008 May-Jun;23(3):502-12.

PMID:
18700375
20.

Effect of chemically modified titanium surfaces on protein adsorption and osteoblast precursor cell behavior.

Protivínský J, Appleford M, Strnad J, Helebrant A, Ong JL.

Int J Oral Maxillofac Implants. 2007 Jul-Aug;22(4):542-50.

PMID:
17929514
21.

A randomized, controlled trial to assess the efficacy and safety of a transdermal delivery system of nicotine/mecamylamine in cigarette smokers.

Glover ED, Laflin MT, Schuh KJ, Schuh LM, Nides M, Christen AG, Glover PN, Strnad JV.

Addiction. 2007 May;102(5):795-802.

PMID:
17506156
22.

Sensitivity and specificity of a reagent-impregnated test strip in identifying smokeless tobacco users.

Glover ED, Glover PN, Laflin MT, Nochur SV, Strnad JV.

Nicotine Tob Res. 2007 Apr;9(4):499-503.

PMID:
17454705
23.

IkappaB kinase inhibitors for treating autoimmune and inflammatory disorders: potential and challenges.

Strnad J, Burke JR.

Trends Pharmacol Sci. 2007 Mar;28(3):142-8. Epub 2007 Feb 6. Review.

PMID:
17287032
24.

NEMO binding domain of IKK-2 encompasses amino acids 735-745.

Strnad J, McDonnell PA, Riexinger DJ, Mapelli C, Cheng L, Gray H, Ryseck RP, Burke JR.

J Mol Recognit. 2006 May-Jun;19(3):227-33.

PMID:
16583354
25.

[Demographic aging, mental health and geriatric psychiatry education].

de Mendonça Lima CA, Benalia T, Bovier P, Budry P, Justiniano I, Renard J, Strnad J.

Rev Med Suisse Romande. 2004 Oct;124(10):649-53. Review. French. No abstract available.

PMID:
15573513
26.

Biomimetic apatite formation on chemically treated titanium.

Jonásová L, Müller FA, Helebrant A, Strnad J, Greil P.

Biomaterials. 2004 Mar-Apr;25(7-8):1187-94.

PMID:
14643592
27.

Major depressive disorder in the general hospital: adaptation of clinical practice guidelines.

Voellinger R, Berney A, Baumann P, Annoni JM, Bryois C, Buclin T, Büla C, Camus V, Christin L, Cornuz J, de Goumoëns P, Lamy O, Strnad J, Burnand B, Stiefel F.

Gen Hosp Psychiatry. 2003 May-Jun;25(3):185-93. Review.

PMID:
12748031
28.

BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice.

Burke JR, Pattoli MA, Gregor KR, Brassil PJ, MacMaster JF, McIntyre KW, Yang X, Iotzova VS, Clarke W, Strnad J, Qiu Y, Zusi FC.

J Biol Chem. 2003 Jan 17;278(3):1450-6. Epub 2002 Oct 25.

29.

Hydroxyapatite formation on alkali-treated titanium with different content of Na+ in the surface layer.

Jonásová L, Müller FA, Helebrant A, Strnad J, Greil P.

Biomaterials. 2002 Aug;23(15):3095-101.

PMID:
12102180
30.
31.

Effect of plasma-sprayed hydroxyapatite coating on the osteoconductivity of commercially pure titanium implants.

Strnad Z, Strnad J, Povýsil C, Urban K.

Int J Oral Maxillofac Implants. 2000 Jul-Aug;15(4):483-90.

PMID:
10960980
32.

[The pharmacotherapy of the cognitive disorders in Alzheimer's disease. Guidelines for rational drug use--a review].

Strnad J, Bahro M.

Dtsch Med Wochenschr. 2000 Jul 7;125(27):835-9. Review. German. No abstract available.

PMID:
10929539
33.

Oestrogens and Alzheimer's disease.

Birkhäuser MH, Strnad J, Kämpf C, Bahro M.

Int J Geriatr Psychiatry. 2000 Jul;15(7):600-9. Review.

PMID:
10918340
34.

[Psychiatric complications of pharmacotherapy--a review].

Strnad J, Schäfer S, Bahro M.

Wien Med Wochenschr. 2000;150(6):115-9. Review. German.

PMID:
10893761
35.
36.

[Diagnosis and therapy of alcohol-withdrawal symptoms in the elderly: a case report].

Missler G, Strnad J, Bahro M.

Praxis (Bern 1994). 1999 Aug 19;88(34):1343-6. German.

PMID:
10484880
37.

[Depression in old age].

Strnad J, Bahro M.

Schweiz Med Wochenschr. 1999 Aug 21;129(33):1162-70. Review. German.

PMID:
10483669
38.

[Suicide of psychiatric inpatients assisted by euthanasia advocacy groups. Cases of assisted suicide?].

Strnad J, Grosjean S, Schüpbach B, Bahro M.

Nervenarzt. 1999 Jul;70(7):645-9. German.

PMID:
10434264
39.

Catatonia under medication with risperidone in a 61-year-old patient.

Bahro M, Kämpf C, Strnad J.

Acta Psychiatr Scand. 1999 Mar;99(3):223-4; discussion 224-6.

PMID:
10100918
40.

Apnea syndrome in a patient with Alzheimer dementia under chlormethiazole treatment: a clinical experience report.

Kaldune A, Strnad J, Cornu C, Bahro M.

Acta Psychiatr Scand. 1999 Jan;99(1):79-81.

PMID:
10066011
41.

[Treatment of anxiety and panic attacks in geriatric psychiatry].

Madarasz K, Strnad J, Bahro M.

Praxis (Bern 1994). 1998 Sep 23;87(39):1252-4. German.

PMID:
9793416
42.

[Diagnostic and therapeutic procedures in intraabdominal injuries.].

Vyhnánek F, Novák L, Strnad J.

Acta Chir Orthop Traumatol Cech. 1997;64(5):292-5. Czech.

PMID:
20470635
43.
44.

Identification and characterization of novel somatostatin antagonists.

Bass RT, Buckwalter BL, Patel BP, Pausch MH, Price LA, Strnad J, Hadcock JR.

Mol Pharmacol. 1996 Oct;50(4):709-15. Erratum in: Mol Pharmacol 1997 Jan;51(1):170.

PMID:
8863814
46.

Rat somatostatin receptor type 1 couples to G proteins and inhibition of cyclic AMP accumulation.

Hadcock JR, Strnad J, Eppler CM.

Mol Pharmacol. 1994 Mar;45(3):410-6.

PMID:
8145728
47.

[Stab and gunshot thoracoabdominal injuries].

Vyhnánek F, Strnad J, Vojtísek O, Pelák Z.

Rozhl Chir. 1993 Sep;72(6):242-5. Czech.

PMID:
8256148
48.

The rat SSTR2 somatostatin receptor subtype is coupled to inhibition of cyclic AMP accumulation.

Strnad J, Eppler CM, Corbett M, Hadcock JR.

Biochem Biophys Res Commun. 1993 Mar 31;191(3):968-76.

PMID:
8096694
49.

[Catheterization of the central venous system by way of the cubital veins].

Strnad J, Honců E, Kunásek J.

Rozhl Chir. 1990 Dec;69(12):803-9. Czech.

PMID:
2089652
50.

In vivo selection of human tumor cells resistant to monoclonal antibody-Vinca alkaloid immunoconjugates.

Starling JJ, Maciak RS, Hinson NA, Hoskins J, Laguzza BC, Gadski RA, Strnad J, Rittmann-Grauer L, DeHerdt SV, Bumol TF, et al.

Cancer Res. 1990 Dec 1;50(23):7634-40.

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