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Items: 1 to 50 of 77

1.

A method for the long-term cultivation of mammalian cells in the absence of oxygen: Characterization of cell replication, hypoxia-inducible factor expression and reactive oxygen species production.

Plotkin BJ, Davis JW, Strizzi L, Lee P, Christoffersen-Cebi J, Kacmar J, Rivero OJ, Elsayed N, Zanghi N, Ito B, Sigar IM.

Tissue Cell. 2018 Feb;50:59-68. doi: 10.1016/j.tice.2017.12.004. Epub 2017 Dec 15.

PMID:
29429519
2.

Targeting melanoma with front-line therapy does not abrogate Nodal-expressing tumor cells.

Hendrix MJ, Kandela I, Mazar AP, Seftor EA, Seftor RE, Margaryan NV, Strizzi L, Murphy GF, Long GV, Scolyer RA.

Lab Invest. 2017 Feb;97(2):176-186. doi: 10.1038/labinvest.2016.107. Epub 2016 Oct 24.

3.

Translational significance of Nodal, Cripto-1 and Notch4 in adult nevi.

Strizzi L, Margaryan NV, Gerami P, Haghighat Z, Harms PW, Madonna G, Botti G, Ascierto PA, Hendrix MJ.

Oncol Lett. 2016 Aug;12(2):1349-1354. Epub 2016 Jun 21.

4.

Melanocytes Affect Nodal Expression and Signaling in Melanoma Cells: A Lesson from Pediatric Large Congenital Melanocytic Nevi.

Margaryan NV, Gilgur A, Seftor EA, Purnell C, Arva NC, Gosain AK, Hendrix MJ, Strizzi L.

Int J Mol Sci. 2016 Mar 22;17(3):418. doi: 10.3390/ijms17030418.

5.

Nodal expression in triple-negative breast cancer: Cellular effects of its inhibition following doxorubicin treatment.

Bodenstine TM, Chandler GS, Reed DW, Margaryan NV, Gilgur A, Atkinson J, Ahmed N, Hyser M, Seftor EA, Strizzi L, Hendrix MJ.

Cell Cycle. 2016 May 2;15(9):1295-302. doi: 10.1080/15384101.2016.1160981.

6.

Effects of a novel Nodal-targeting monoclonal antibody in melanoma.

Strizzi L, Sandomenico A, Margaryan NV, Focà A, Sanguigno L, Bodenstine TM, Chandler GS, Reed DW, Gilgur A, Seftor EA, Seftor RE, Khalkhali-Ellis Z, Leonardi A, Ruvo M, Hendrix MJ.

Oncotarget. 2015 Oct 27;6(33):34071-86. doi: 10.18632/oncotarget.6049.

7.

New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding.

Focà A, Sanguigno L, Focà G, Strizzi L, Iannitti R, Palumbo R, Hendrix MJ, Leonardi A, Ruvo M, Sandomenico A.

Int J Mol Sci. 2015 Sep 7;16(9):21342-62. doi: 10.3390/ijms160921342.

8.

Cripto-1: an extracellular protein - connecting the sequestered biological dots.

Klauzinska M, Bertolette D, Tippireddy S, Strizzi L, Gray PC, Gonzales M, Duroux M, Ruvo M, Wechselberger C, Castro NP, Rangel MC, Focà A, Sandomenico A, Hendrix MJ, Salomon D, Cuttitta F.

Connect Tissue Res. 2015;56(5):364-80. doi: 10.3109/03008207.2015.1077239. Epub 2015 Sep 1.

PMID:
26327334
9.

Targeting nodal in conjunction with dacarbazine induces synergistic anticancer effects in metastatic melanoma.

Hardy KM, Strizzi L, Margaryan NV, Gupta K, Murphy GF, Scolyer RA, Hendrix MJ.

Mol Cancer Res. 2015 Apr;13(4):670-80. doi: 10.1158/1541-7786.MCR-14-0077. Epub 2015 Mar 12.

10.

Nodal signaling promotes a tumorigenic phenotype in human breast cancer.

Kirsammer G, Strizzi L, Margaryan NV, Gilgur A, Hyser M, Atkinson J, Kirschmann DA, Seftor EA, Hendrix MJ.

Semin Cancer Biol. 2014 Dec;29:40-50. doi: 10.1016/j.semcancer.2014.07.007. Epub 2014 Jul 26. Review.

11.

Characterization of cancer stem-like cells derived from mouse induced pluripotent stem cells transformed by tumor-derived extracellular vesicles.

Yan T, Mizutani A, Chen L, Takaki M, Hiramoto Y, Matsuda S, Shigehiro T, Kasai T, Kudoh T, Murakami H, Masuda J, Hendrix MJ, Strizzi L, Salomon DS, Fu L, Seno M.

J Cancer. 2014 Jul 5;5(7):572-84. doi: 10.7150/jca.8865. eCollection 2014.

12.

Age-Dependent Association between Protein Expression of the Embryonic Stem Cell Marker Cripto-1 and Survival of Glioblastoma Patients.

Tysnes BB, Satran HA, Mork SJ, Margaryan NV, Eide GE, Petersen K, Strizzi L, Hendrix MJ.

Transl Oncol. 2013 Dec 1;6(6):732-41. eCollection 2013 Dec 1.

13.

Neuroblastoma cells injected into experimental mature teratoma reveal a tropism for embryonic loose mesenchyme.

Jamil S, Cedervall J, Hultman I, Ali R, Margaryan NV, Rasmuson A, Johnsen JI, Sveinbjörnsson B, Dalianis T, Kanter L, Orrego A, Strizzi L, Hendrix MJ, Sandstedt B, Kogner P, Ahrlund-Richter L.

Int J Oncol. 2013 Sep;43(3):831-8. doi: 10.3892/ijo.2013.2014. Epub 2013 Jul 12.

PMID:
23857308
14.

The significance of a Cripto-1 positive subpopulation of human melanoma cells exhibiting stem cell-like characteristics.

Strizzi L, Margaryan NV, Gilgur A, Hardy KM, Normanno N, Salomon DS, Hendrix MJ.

Cell Cycle. 2013 May 1;12(9):1450-6. doi: 10.4161/cc.24601. Epub 2013 Apr 10.

15.

Regulation of human Cripto-1 expression by nuclear receptors and DNA promoter methylation in human embryonal and breast cancer cells.

Bianco C, Castro NP, Baraty C, Rollman K, Held N, Rangel MC, Karasawa H, Gonzales M, Strizzi L, Salomon DS.

J Cell Physiol. 2013 Jun;228(6):1174-88. doi: 10.1002/jcp.24271.

16.

Effects of age and parity on mammary gland lesions and progenitor cells in the FVB/N-RC mice.

Raafat A, Strizzi L, Lashin K, Ginsburg E, McCurdy D, Salomon D, Smith GH, Medina D, Callahan R.

PLoS One. 2012;7(8):e43624. doi: 10.1371/journal.pone.0043624. Epub 2012 Aug 30.

17.

Potential for the embryonic morphogen Nodal as a prognostic and predictive biomarker in breast cancer.

Strizzi L, Hardy KM, Margaryan NV, Hillman DW, Seftor EA, Chen B, Geiger XJ, Thompson EA, Lingle WL, Andorfer CA, Perez EA, Hendrix MJ.

Breast Cancer Res. 2012 May 11;14(3):R75.

18.

Nodal expression and detection in cancer: experience and challenges.

Strizzi L, Hardy KM, Kirschmann DA, Ahrlund-Richter L, Hendrix MJ.

Cancer Res. 2012 Apr 15;72(8):1915-20. doi: 10.1158/0008-5472.CAN-11-3419. Review.

19.

Expression and functional role of CRIPTO-1 in cutaneous melanoma.

De Luca A, Lamura L, Strizzi L, Roma C, D'Antonio A, Margaryan N, Pirozzi G, Hsu MY, Botti G, Mari E, Hendrix MJ, Salomon DS, Normanno N.

Br J Cancer. 2011 Sep 27;105(7):1030-8. doi: 10.1038/bjc.2011.324. Epub 2011 Aug 23.

20.

Rspo2/Int7 regulates invasiveness and tumorigenic properties of mammary epithelial cells.

Klauzinska M, Baljinnyam B, Raafat A, Rodriguez-Canales J, Strizzi L, Greer YE, Rubin JS, Callahan R.

J Cell Physiol. 2012 May;227(5):1960-71. doi: 10.1002/jcp.22924.

PMID:
21732367
21.

Embryonic signaling in melanoma: potential for diagnosis and therapy.

Strizzi L, Hardy KM, Kirsammer GT, Gerami P, Hendrix MJ.

Lab Invest. 2011 Jun;91(6):819-24. doi: 10.1038/labinvest.2011.63. Epub 2011 Apr 4.

22.

Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype.

Hardy KM, Kirschmann DA, Seftor EA, Margaryan NV, Postovit LM, Strizzi L, Hendrix MJ.

Cancer Res. 2010 Dec 15;70(24):10340-50. doi: 10.1158/0008-5472.CAN-10-0705.

23.

Cripto-1 is a cell surface marker for a tumorigenic, undifferentiated subpopulation in human embryonal carcinoma cells.

Watanabe K, Meyer MJ, Strizzi L, Lee JM, Gonzales M, Bianco C, Nagaoka T, Farid SS, Margaryan N, Hendrix MJ, Vonderhaar BK, Salomon DS.

Stem Cells. 2010 Aug;28(8):1303-14. doi: 10.1002/stem.463.

24.

Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment.

Costa FF, Seftor EA, Bischof JM, Kirschmann DA, Strizzi L, Arndt K, Bonaldo Mde F, Soares MB, Hendrix MJ.

Epigenomics. 2009 Dec;1(2):387-98. doi: 10.2217/epi.09.25.

25.

ErbB/EGF signaling and EMT in mammary development and breast cancer.

Hardy KM, Booth BW, Hendrix MJ, Salomon DS, Strizzi L.

J Mammary Gland Biol Neoplasia. 2010 Jun;15(2):191-9. doi: 10.1007/s10911-010-9172-2. Epub 2010 Apr 6. Review.

26.

Nodal as a biomarker for melanoma progression and a new therapeutic target for clinical intervention.

Strizzi L, Postovit LM, Margaryan NV, Lipavsky A, Gadiot J, Blank C, Seftor RE, Seftor EA, Hendrix MJ.

Expert Rev Dermatol. 2009;4(1):67-78.

27.

Cripto-1 is required for hypoxia to induce cardiac differentiation of mouse embryonic stem cells.

Bianco C, Cotten C, Lonardo E, Strizzi L, Baraty C, Mancino M, Gonzales M, Watanabe K, Nagaoka T, Berry C, Arai AE, Minchiotti G, Salomon DS.

Am J Pathol. 2009 Nov;175(5):2146-58. doi: 10.2353/ajpath.2009.090218. Epub 2009 Oct 15.

28.

Development and cancer: at the crossroads of Nodal and Notch signaling.

Strizzi L, Hardy KM, Seftor EA, Costa FF, Kirschmann DA, Seftor RE, Postovit LM, Hendrix MJ.

Cancer Res. 2009 Sep 15;69(18):7131-4. doi: 10.1158/0008-5472.CAN-09-1199. Epub 2009 Sep 8. Review.

29.

EphA2 as a promoter of melanoma tumorigenicity.

Margaryan NV, Strizzi L, Abbott DE, Seftor EA, Rao MS, Hendrix MJ, Hess AR.

Cancer Biol Ther. 2009 Feb;8(3):279-88. Epub 2009 Feb 21.

30.

Neuronal guidance protein Netrin-1 induces differentiation in human embryonal carcinoma cells.

Mancino M, Esposito C, Watanabe K, Nagaoka T, Gonzales M, Bianco C, Normanno N, Salomon DS, Strizzi L.

Cancer Res. 2009 Mar 1;69(5):1717-21. doi: 10.1158/0008-5472.CAN-08-2985. Epub 2009 Feb 17.

31.

Msx2 induces epithelial-mesenchymal transition in mouse mammary epithelial cells through upregulation of Cripto-1.

di Bari MG, Ginsburg E, Plant J, Strizzi L, Salomon DS, Vonderhaar BK.

J Cell Physiol. 2009 Jun;219(3):659-66. doi: 10.1002/jcp.21712.

32.

Emerging roles of nodal and Cripto-1: from embryogenesis to breast cancer progression.

Strizzi L, Postovit LM, Margaryan NV, Seftor EA, Abbott DE, Seftor RE, Salomon DS, Hendrix MJ.

Breast Dis. 2008;29:91-103.

33.

Characterization of the glycosylphosphatidylinositol-anchor signal sequence of human Cryptic with a hydrophilic extension.

Watanabe K, Nagaoka T, Strizzi L, Mancino M, Gonzales M, Bianco C, Salomon DS.

Biochim Biophys Acta. 2008 Dec;1778(12):2671-81. doi: 10.1016/j.bbamem.2008.09.011. Epub 2008 Oct 1.

34.

Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis.

Raafat A, Lawson S, Bargo S, Klauzinska M, Strizzi L, Goldhar AS, Buono K, Salomon D, Vonderhaar BK, Callahan R.

Oncogene. 2009 Jan 15;28(2):219-30. doi: 10.1038/onc.2008.379. Epub 2008 Oct 6.

35.

Potential for cripto-1 in defining stem cell-like characteristics in human malignant melanoma.

Strizzi L, Abbott DE, Salomon DS, Hendrix MJ.

Cell Cycle. 2008 Jul 1;7(13):1931-5. Epub 2008 May 5.

36.

Smad2 functions as a co-activator of canonical Wnt/beta-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300.

Hirota M, Watanabe K, Hamada S, Sun Y, Strizzi L, Mancino M, Nagaoka T, Gonzales M, Seno M, Bianco C, Salomon DS.

Cell Signal. 2008 Sep;20(9):1632-41. doi: 10.1016/j.cellsig.2008.05.003. Epub 2008 May 18.

37.

Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland.

Strizzi L, Mancino M, Bianco C, Raafat A, Gonzales M, Booth BW, Watanabe K, Nagaoka T, Mack DL, Howard B, Callahan R, Smith GH, Salomon DS.

J Cell Physiol. 2008 Sep;216(3):824-34. doi: 10.1002/jcp.21462.

38.

Regulation of Cripto-1 signaling and biological activity by caveolin-1 in mammary epithelial cells.

Bianco C, Strizzi L, Mancino M, Watanabe K, Gonzales M, Hamada S, Raafat A, Sahlah L, Chang C, Sotgia F, Normanno N, Lisanti M, Salomon DS.

Am J Pathol. 2008 Feb;172(2):345-57. doi: 10.2353/ajpath.2008.070696. Epub 2008 Jan 17.

39.

Regulation of human Cripto-1 gene expression by TGF-beta1 and BMP-4 in embryonal and colon cancer cells.

Mancino M, Strizzi L, Wechselberger C, Watanabe K, Gonzales M, Hamada S, Normanno N, Salomon DS, Bianco C.

J Cell Physiol. 2008 Apr;215(1):192-203.

PMID:
17941089
40.

Requirement of glycosylphosphatidylinositol anchor of Cripto-1 for trans activity as a Nodal co-receptor.

Watanabe K, Hamada S, Bianco C, Mancino M, Nagaoka T, Gonzales M, Bailly V, Strizzi L, Salomon DS.

J Biol Chem. 2007 Dec 7;282(49):35772-86. Epub 2007 Oct 9.

41.

Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration.

Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS.

J Biol Chem. 2007 Oct 26;282(43):31643-55. Epub 2007 Aug 24.

42.

beta-Catenin/TCF/LEF regulate expression of the short form human Cripto-1.

Hamada S, Watanabe K, Hirota M, Bianco C, Strizzi L, Mancino M, Gonzales M, Salomon DS.

Biochem Biophys Res Commun. 2007 Mar 30;355(1):240-4. Epub 2007 Feb 2.

43.

Development of leiomyosarcoma of the uterus in MMTV-CR-1 transgenic mice.

Strizzi L, Bianco C, Hirota M, Watanabe K, Mancino M, Hamada S, Raafat A, Lawson S, Ebert AD, D'Antonio A, Losito S, Normanno N, Salomon DS.

J Pathol. 2007 Jan;211(1):36-44.

PMID:
17072826
44.

Identification of cripto-1 as a novel serologic marker for breast and colon cancer.

Bianco C, Strizzi L, Mancino M, Rehman A, Hamada S, Watanabe K, De Luca A, Jones B, Balogh G, Russo J, Mailo D, Palaia R, D'Aiuto G, Botti G, Perrone F, Salomon DS, Normanno N.

Clin Cancer Res. 2006 Sep 1;12(17):5158-64.

45.

Kit and PDGFR-alpha activities are necessary for Notch4/Int3-induced tumorigenesis.

Raafat A, Zoltan-Jones A, Strizzi L, Bargo S, Kimura K, Salomon D, Callahan R.

Oncogene. 2007 Feb 1;26(5):662-72. Epub 2006 Jul 31.

PMID:
16878155
46.

Epidermal growth factor receptor (EGFR) signaling in cancer.

Normanno N, De Luca A, Bianco C, Strizzi L, Mancino M, Maiello MR, Carotenuto A, De Feo G, Caponigro F, Salomon DS.

Gene. 2006 Jan 17;366(1):2-16. Epub 2005 Dec 27. Review.

PMID:
16377102
47.

Netrin-1 regulates invasion and migration of mouse mammary epithelial cells overexpressing Cripto-1 in vitro and in vivo.

Strizzi L, Bianco C, Raafat A, Abdallah W, Chang C, Raafat D, Hirota M, Hamada S, Sun Y, Normanno N, Callahan R, Hinck L, Salomon D.

J Cell Sci. 2005 Oct 15;118(Pt 20):4633-43. Epub 2005 Sep 21.

48.

Modulation of TGF-beta signaling by EGF-CFC proteins.

Wechselberger C, Bianco C, Strizzi L, Ebert AD, Kenney N, Sun Y, Salomon DS.

Exp Cell Res. 2005 Nov 1;310(2):249-55. Epub 2005 Aug 31. Review.

PMID:
16137677
49.

Cripto-1: a multifunctional modulator during embryogenesis and oncogenesis.

Strizzi L, Bianco C, Normanno N, Salomon D.

Oncogene. 2005 Aug 29;24(37):5731-41. Review.

PMID:
16123806
50.

Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis.

Sun Y, Strizzi L, Raafat A, Hirota M, Bianco C, Feigenbaum L, Kenney N, Wechselberger C, Callahan R, Salomon DS.

Am J Pathol. 2005 Aug;167(2):585-97.

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