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Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial.

van Dyck CH, Nygaard HB, Chen K, Donohue MC, Raman R, Rissman RA, Brewer JB, Koeppe RA, Chow TW, Rafii MS, Gessert D, Choi J, Turner RS, Kaye JA, Gale SA, Reiman EM, Aisen PS, Strittmatter SM.

JAMA Neurol. 2019 Jul 22. doi: 10.1001/jamaneurol.2019.2050. [Epub ahead of print]


In vivo synaptic density imaging with 11C-UCB-J detects treatment effects of saracatinib (AZD0530) in a mouse model of Alzheimer's disease.

Toyonaga T, Smith LM, Finnema SJ, Gallezot JD, Naganawa M, Bini J, Mulnix T, Cai Z, Ropchan J, Huang Y, Strittmatter SM, Carson RE.

J Nucl Med. 2019 May 17. pii: jnumed.118.223867. doi: 10.2967/jnumed.118.223867. [Epub ahead of print]


Limiting Neuronal Nogo Receptor 1 Signaling during Experimental Autoimmune Encephalomyelitis Preserves Axonal Transport and Abrogates Inflammatory Demyelination.

Lee JY, Kim MJ, Thomas S, Oorschot V, Ramm G, Aui PM, Sekine Y, Deliyanti D, Wilkinson-Berka J, Niego B, Harvey AR, Theotokis P, McLean C, Strittmatter SM, Petratos S.

J Neurosci. 2019 Jul 10;39(28):5562-5580. doi: 10.1523/JNEUROSCI.1760-18.2019. Epub 2019 May 6.


Anti-PrPC antibody rescues cognition and synapses in transgenic alzheimer mice.

Cox TO, Gunther EC, Brody AH, Chiasseu MT, Stoner A, Smith LM, Haas LT, Hammersley J, Rees G, Dosanjh B, Groves M, Gardener M, Dobson C, Vaughan T, Chessell I, Billinton A, Strittmatter SM.

Ann Clin Transl Neurol. 2019 Feb 27;6(3):554-574. doi: 10.1002/acn3.730. eCollection 2019 Mar.


Plexina2 and CRMP2 Signaling Complex Is Activated by Nogo-A-Liganded Ngr1 to Restrict Corticospinal Axon Sprouting after Trauma.

Sekine Y, Algarate PT, Cafferty WBJ, Strittmatter SM.

J Neurosci. 2019 Apr 24;39(17):3204-3216. doi: 10.1523/JNEUROSCI.2996-18.2019. Epub 2019 Feb 25.


Systematic and standardized comparison of reported amyloid-β receptors for sufficiency, affinity, and Alzheimer's disease relevance.

Smith LM, Kostylev MA, Lee S, Strittmatter SM.

J Biol Chem. 2019 Apr 12;294(15):6042-6053. doi: 10.1074/jbc.RA118.006252. Epub 2019 Feb 20.


Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists.

Gunther EC, Smith LM, Kostylev MA, Cox TO, Kaufman AC, Lee S, Folta-Stogniew E, Maynard GD, Um JW, Stagi M, Heiss JK, Stoner A, Noble GP, Takahashi H, Haas LT, Schneekloth JS, Merkel J, Teran C, Naderi ZK, Supattapone S, Strittmatter SM.

Cell Rep. 2019 Jan 29;26(5):1368. doi: 10.1016/j.celrep.2019.01.064. No abstract available.


Pyk2 Signaling through Graf1 and RhoA GTPase Is Required for Amyloid-β Oligomer-Triggered Synapse Loss.

Lee S, Salazar SV, Cox TO, Strittmatter SM.

J Neurosci. 2019 Mar 6;39(10):1910-1929. doi: 10.1523/JNEUROSCI.2983-18.2018. Epub 2019 Jan 9.


Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists.

Gunther EC, Smith LM, Kostylev MA, Cox TO, Kaufman AC, Lee S, Folta-Stogniew E, Maynard GD, Um JW, Stagi M, Heiss JK, Stoner A, Noble GP, Takahashi H, Haas LT, Schneekloth JS, Merkel J, Teran C, Naderi ZK, Supattapone S, Strittmatter SM.

Cell Rep. 2019 Jan 2;26(1):145-158.e8. doi: 10.1016/j.celrep.2018.12.021. Erratum in: Cell Rep. 2019 Jan 29;26(5):1368.


Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss.

Salazar SV, Cox TO, Lee S, Brody AH, Chyung AS, Haas LT, Strittmatter SM.

J Neurosci. 2019 Jan 23;39(4):758-772. doi: 10.1523/JNEUROSCI.1873-18.2018. Epub 2018 Dec 5.


Liquid and Hydrogel Phases of PrPC Linked to Conformation Shifts and Triggered by Alzheimer's Amyloid-β Oligomers.

Kostylev MA, Tuttle MD, Lee S, Klein LE, Takahashi H, Cox TO, Gunther EC, Zilm KW, Strittmatter SM.

Mol Cell. 2018 Nov 1;72(3):426-443.e12. doi: 10.1016/j.molcel.2018.10.009. Epub 2018 Oct 25.


Diltiazem Promotes Regenerative Axon Growth.

Huebner EA, Budel S, Jiang Z, Omura T, Ho TS, Barrett L, Merkel JS, Pereira LM, Andrews NA, Wang X, Singh B, Kapur K, Costigan M, Strittmatter SM, Woolf CJ.

Mol Neurobiol. 2019 Jun;56(6):3948-3957. doi: 10.1007/s12035-018-1349-5. Epub 2018 Sep 19.


Human neuroepithelial stem cell regional specificity enables spinal cord repair through a relay circuit.

Dell'Anno MT, Wang X, Onorati M, Li M, Talpo F, Sekine Y, Ma S, Liu F, Cafferty WBJ, Sestan N, Strittmatter SM.

Nat Commun. 2018 Aug 24;9(1):3419. doi: 10.1038/s41467-018-05844-8.


Sleep and EEG Power Spectral Analysis in Three Transgenic Mouse Models of Alzheimer's Disease: APP/PS1, 3xTgAD, and Tg2576.

Kent BA, Strittmatter SM, Nygaard HB.

J Alzheimers Dis. 2018;64(4):1325-1336. doi: 10.3233/JAD-180260.


Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration.

Sekine Y, Lin-Moore A, Chenette DM, Wang X, Jiang Z, Cafferty WB, Hammarlund M, Strittmatter SM.

Cell Rep. 2018 Jul 3;24(1):269. doi: 10.1016/j.celrep.2018.06.079. No abstract available.


Whole Exome Sequencing of an Exceptional Longevity Cohort.

Nygaard HB, Erson-Omay EZ, Wu X, Kent BA, Bernales CQ, Evans DM, Farrer MJ, Vilariño-Güell C, Strittmatter SM.

J Gerontol A Biol Sci Med Sci. 2018 May 10. doi: 10.1093/gerona/gly098. [Epub ahead of print]


Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration.

Sekine Y, Lin-Moore A, Chenette DM, Wang X, Jiang Z, Cafferty WB, Hammarlund M, Strittmatter SM.

Cell Rep. 2018 Apr 10;23(2):415-428. doi: 10.1016/j.celrep.2018.03.058. Erratum in: Cell Rep. 2018 Jul 3;24(1):269.


The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury.

Sekine Y, Siegel CS, Sekine-Konno T, Cafferty WBJ, Strittmatter SM.

Sci Signal. 2018 Apr 3;11(524). pii: eaao4180. doi: 10.1126/scisignal.aao4180.


Synaptotoxic Signaling by Amyloid Beta Oligomers in Alzheimer's Disease Through Prion Protein and mGluR5.

Brody AH, Strittmatter SM.

Adv Pharmacol. 2018;82:293-323. doi: 10.1016/bs.apha.2017.09.007. Epub 2017 Oct 25. Review.


Emerging Mechanisms in Alzheimer's Disease and Their Therapeutic Implications.

Strittmatter SM.

Biol Psychiatry. 2018 Feb 15;83(4):298-299. doi: 10.1016/j.biopsych.2017.12.002. No abstract available.


Disease-modifying benefit of Fyn blockade persists after washout in mouse Alzheimer's model.

Smith LM, Zhu R, Strittmatter SM.

Neuropharmacology. 2018 Mar 1;130:54-61. doi: 10.1016/j.neuropharm.2017.11.042. Epub 2017 Nov 27.


Regulation of axonal regeneration by the level of function of the endogenous Nogo receptor antagonist LOTUS.

Hirokawa T, Zou Y, Kurihara Y, Jiang Z, Sakakibara Y, Ito H, Funakoshi K, Kawahara N, Goshima Y, Strittmatter SM, Takei K.

Sci Rep. 2017 Sep 21;7(1):12119. doi: 10.1038/s41598-017-12449-6.


Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease.

Salazar SV, Gallardo C, Kaufman AC, Herber CS, Haas LT, Robinson S, Manson JC, Lee MK, Strittmatter SM.

J Neurosci. 2017 Sep 20;37(38):9207-9221. doi: 10.1523/JNEUROSCI.0722-17.2017. Epub 2017 Aug 21.


Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.

Klein ZA, Takahashi H, Ma M, Stagi M, Zhou M, Lam TT, Strittmatter SM.

Neuron. 2017 Jul 19;95(2):281-296.e6. doi: 10.1016/j.neuron.2017.06.026.


Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes.

Haas LT, Salazar SV, Smith LM, Zhao HR, Cox TO, Herber CS, Degnan AP, Balakrishnan A, Macor JE, Albright CF, Strittmatter SM.

Cell Rep. 2017 Jul 5;20(1):76-88. doi: 10.1016/j.celrep.2017.06.023.


Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.

Nakamura F, Okada T, Shishikura M, Uetani N, Taniguchi M, Yagi T, Iwakura Y, Ohshima T, Goshima Y, Strittmatter SM.

J Neurosci. 2017 Jul 26;37(30):7125-7139. doi: 10.1523/JNEUROSCI.2519-16.2017. Epub 2017 Jun 21.


Identification of Intrinsic Axon Growth Modulators for Intact CNS Neurons after Injury.

Fink KL, López-Giráldez F, Kim IJ, Strittmatter SM, Cafferty WBJ.

Cell Rep. 2017 Mar 14;18(11):2687-2701. doi: 10.1016/j.celrep.2017.02.058.


Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.

Takahashi H, Klein ZA, Bhagat SM, Kaufman AC, Kostylev MA, Ikezu T, Strittmatter SM; Alzheimer’s Disease Neuroimaging Initiative.

Acta Neuropathol. 2017 May;133(5):785-807. doi: 10.1007/s00401-017-1668-z. Epub 2017 Jan 9.


Inhibition of Poly-ADP-Ribosylation Fails to Increase Axonal Regeneration or Improve Functional Recovery after Adult Mammalian CNS Injury.

Wang X, Sekine Y, Byrne AB, Cafferty WB, Hammarlund M, Strittmatter SM.

eNeuro. 2016 Dec 26;3(6). pii: ENEURO.0270-16.2016. doi: 10.1523/ENEURO.0270-16.2016. eCollection 2016 Nov-Dec.


Rewiring the spinal cord: Direct and indirect strategies.

Dell'Anno MT, Strittmatter SM.

Neurosci Lett. 2017 Jun 23;652:25-34. doi: 10.1016/j.neulet.2016.12.002. Epub 2016 Dec 19. Review.


Axonal branching in lateral olfactory tract is promoted by Nogo signaling.

Iketani M, Yokoyama T, Kurihara Y, Strittmatter SM, Goshima Y, Kawahara N, Takei K.

Sci Rep. 2016 Dec 21;6:39586. doi: 10.1038/srep39586.


Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity.

Smith LM, Strittmatter SM.

Cold Spring Harb Perspect Med. 2017 May 1;7(5). pii: a024075. doi: 10.1101/cshperspect.a024075. Review.


Inhibiting poly(ADP-ribosylation) improves axon regeneration.

Byrne AB, McWhirter RD, Sekine Y, Strittmatter SM, Miller DM, Hammarlund M.

Elife. 2016 Oct 4;5. pii: e12734. doi: 10.7554/eLife.12734.


Cellular prion protein as a receptor for amyloid-β oligomers in Alzheimer's disease.

Salazar SV, Strittmatter SM.

Biochem Biophys Res Commun. 2017 Feb 19;483(4):1143-1147. doi: 10.1016/j.bbrc.2016.09.062. Epub 2016 Sep 14. Review.


Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia.

Onorati M, Li Z, Liu F, Sousa AMM, Nakagawa N, Li M, Dell'Anno MT, Gulden FO, Pochareddy S, Tebbenkamp ATN, Han W, Pletikos M, Gao T, Zhu Y, Bichsel C, Varela L, Szigeti-Buck K, Lisgo S, Zhang Y, Testen A, Gao XB, Mlakar J, Popovic M, Flamand M, Strittmatter SM, Kaczmarek LK, Anton ES, Horvath TL, Lindenbach BD, Sestan N.

Cell Rep. 2016 Sep 6;16(10):2576-2592. doi: 10.1016/j.celrep.2016.08.038. Epub 2016 Aug 24.


SCISSOR-Spinal Cord Injury Study on Small molecule-derived Rho inhibition: a clinical study protocol.

Kopp MA, Liebscher T, Watzlawick R, Martus P, Laufer S, Blex C, Schindler R, Jungehulsing GJ, Knüppel S, Kreutzträger M, Ekkernkamp A, Dirnagl U, Strittmatter SM, Niedeggen A, Schwab JM.

BMJ Open. 2016 Jul 26;6(7):e010651. doi: 10.1136/bmjopen-2015-010651.


Early Activation of Experience-Independent Dendritic Spine Turnover in a Mouse Model of Alzheimer's Disease.

Heiss JK, Barrett J, Yu Z, Haas LT, Kostylev MA, Strittmatter SM.

Cereb Cortex. 2017 Jul 1;27(7):3660-3674. doi: 10.1093/cercor/bhw188.


Oligomers of Amyloid β Prevent Physiological Activation of the Cellular Prion Protein-Metabotropic Glutamate Receptor 5 Complex by Glutamate in Alzheimer Disease.

Haas LT, Strittmatter SM.

J Biol Chem. 2016 Aug 12;291(33):17112-21. doi: 10.1074/jbc.M116.720664. Epub 2016 Jun 20.


Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles.

Han L, Cai Q, Tian D, Kong DK, Gou X, Chen Z, Strittmatter SM, Wang Z, Sheth KN, Zhou J.

Nanomedicine. 2016 Oct;12(7):1833-1842. doi: 10.1016/j.nano.2016.03.005. Epub 2016 Mar 30.


Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease.

Haas LT, Salazar SV, Kostylev MA, Um JW, Kaufman AC, Strittmatter SM.

Brain. 2016 Feb;139(Pt 2):526-46. doi: 10.1093/brain/awv356. Epub 2015 Dec 14.


Erasure of fear memories is prevented by Nogo Receptor 1 in adulthood.

Bhagat SM, Butler SS, Taylor JR, McEwen BS, Strittmatter SM.

Mol Psychiatry. 2016 Sep;21(9):1281-9. doi: 10.1038/mp.2015.179. Epub 2015 Dec 1.


Comprehensive Corticospinal Labeling with mu-crystallin Transgene Reveals Axon Regeneration after Spinal Cord Trauma in ngr1-/- Mice.

Fink KL, Strittmatter SM, Cafferty WB.

J Neurosci. 2015 Nov 18;35(46):15403-18. doi: 10.1523/JNEUROSCI.3165-15.2015.


Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury.

Zou Y, Stagi M, Wang X, Yigitkanli K, Siegel CS, Nakatsu F, Cafferty WB, Strittmatter SM.

J Neurosci. 2015 Jul 22;35(29):10429-39. doi: 10.1523/JNEUROSCI.1718-15.2015.


Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models.

Kostylev MA, Kaufman AC, Nygaard HB, Patel P, Haas LT, Gunther EC, Vortmeyer A, Strittmatter SM.

J Biol Chem. 2015 Jul 10;290(28):17415-38. doi: 10.1074/jbc.M115.643577. Epub 2015 May 27.


Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer's disease mouse model.

Nygaard HB, Kaufman AC, Sekine-Konno T, Huh LL, Going H, Feldman SJ, Kostylev MA, Strittmatter SM.

Alzheimers Res Ther. 2015 May 5;7(1):25. doi: 10.1186/s13195-015-0110-9. eCollection 2015.


A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease.

Nygaard HB, Wagner AF, Bowen GS, Good SP, MacAvoy MG, Strittmatter KA, Kaufman AC, Rosenberg BJ, Sekine-Konno T, Varma P, Chen K, Koleske AJ, Reiman EM, Strittmatter SM, van Dyck CH.

Alzheimers Res Ther. 2015 Apr 14;7(1):35. doi: 10.1186/s13195-015-0119-0. eCollection 2015.


Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.

Nakatsu F, Messa M, Nández R, Czapla H, Zou Y, Strittmatter SM, De Camilli P.

J Cell Biol. 2015 Apr 13;209(1):85-95. doi: 10.1083/jcb.201409064.


Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.

Kaufman AC, Salazar SV, Haas LT, Yang J, Kostylev MA, Jeng AT, Robinson SA, Gunther EC, van Dyck CH, Nygaard HB, Strittmatter SM.

Ann Neurol. 2015 Jun;77(6):953-71. doi: 10.1002/ana.24394. Epub 2015 Mar 21.


Intravitreal delivery of human NgR-Fc decoy protein regenerates axons after optic nerve crush and protects ganglion cells in glaucoma models.

Wang X, Lin J, Arzeno A, Choi JY, Boccio J, Frieden E, Bhargava A, Maynard G, Tsai JC, Strittmatter SM.

Invest Ophthalmol Vis Sci. 2015 Feb 5;56(2):1357-66. doi: 10.1167/iovs.14-15472.


Plasticity of intact rubral projections mediates spontaneous recovery of function after corticospinal tract injury.

Siegel CS, Fink KL, Strittmatter SM, Cafferty WB.

J Neurosci. 2015 Jan 28;35(4):1443-57. doi: 10.1523/JNEUROSCI.3713-14.2015.

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