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Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through extracellular vesicles.

Parimon T, Yao C, Habiel DM, Ge L, Bora SA, Brauer R, Evans CM, Xie T, Alonso-Valenteen F, Medina-Kauwe LK, Jiang D, Noble PW, Hogaboam CM, Deng N, Burgy O, Antes TJ, Königshoff M, Stripp BR, Gharib SA, Chen P.

JCI Insight. 2019 Aug 8;5. pii: 129359. doi: 10.1172/jci.insight.129359.


FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury.

Yuan T, Volckaert T, Redente EF, Hopkins S, Klinkhammer K, Wasnick R, Chao CM, Yuan J, Zhang JS, Yao C, Majka S, Stripp BR, Günther A, Riches DWH, Bellusci S, Thannickal VJ, De Langhe SP.

Stem Cell Reports. 2019 May 14;12(5):1041-1055. doi: 10.1016/j.stemcr.2019.04.003. Epub 2019 May 2.


XBP1S Regulates MUC5B in a Promoter Variant-Dependent Pathway in Idiopathic Pulmonary Fibrosis Airway Epithelia.

Chen G, Ribeiro CMP, Sun L, Okuda K, Kato T, Gilmore RC, Martino MB, Dang H, Abzhanova A, Lin JM, Hull-Ryde EA, Volmer AS, Randell SH, Livraghi-Butrico A, Deng Y, Scherer PE, Stripp BR, O'Neal WK, Boucher RC.

Am J Respir Crit Care Med. 2019 Jul 15;200(2):220-234. doi: 10.1164/rccm.201810-1972OC. Erratum in: Am J Respir Crit Care Med. 2019 Oct 15;200(8):1074.


Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium.

McCauley KB, Alysandratos KD, Jacob A, Hawkins F, Caballero IS, Vedaie M, Yang W, Slovik KJ, Morley M, Carraro G, Kook S, Guttentag SH, Stripp BR, Morrisey EE, Kotton DN.

Stem Cell Reports. 2018 May 8;10(5):1579-1595. doi: 10.1016/j.stemcr.2018.03.013. Epub 2018 Apr 12.


Active epithelial Hippo signaling in idiopathic pulmonary fibrosis.

Gokey JJ, Sridharan A, Xu Y, Green J, Carraro G, Stripp BR, Perl AT, Whitsett JA.

JCI Insight. 2018 Mar 22;3(6). pii: 98738. doi: 10.1172/jci.insight.98738.


Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis.

Zhou B, Flodby P, Luo J, Castillo DR, Liu Y, Yu FX, McConnell A, Varghese B, Li G, Chimge NO, Sunohara M, Koss MN, Elatre W, Conti P, Liebler JM, Yang C, Marconett CN, Laird-Offringa IA, Minoo P, Guan K, Stripp BR, Crandall ED, Borok Z.

J Clin Invest. 2018 Mar 1;128(3):970-984. doi: 10.1172/JCI90429. Epub 2018 Feb 5.


The Impact of Allograft CXCL9 during Respiratory Infection on the Risk of Chronic Lung Allograft Dysfunction.

Shino MY, DerHovanessian A, Sayah DM, Saggar R, Ying Xue Y, Ardehali A, Stripp BR, Ross DJ, Lynch JP 3rd, Elashoff RM, Weigt SS, Belperio JA.

OBM Transplant. 2018;2(4). pii: 029. doi: 10.21926/obm.transplant.1804029. Epub 2018 Nov 30.


Sin3a regulates epithelial progenitor cell fate during lung development.

Yao C, Carraro G, Konda B, Guan X, Mizuno T, Chiba N, Kostelny M, Kurkciyan A, David G, McQualter JL, Stripp BR.

Development. 2017 Jul 15;144(14):2618-2628. doi: 10.1242/dev.149708. Epub 2017 Jun 15.


Roles for Myoepithelial Cells in the Formation and Maintenance of Submucosal Glands.

Carraro G, Stripp BR.

Am J Respir Cell Mol Biol. 2017 Jun;56(6):685-686. doi: 10.1165/rcmb.2017-0044ED. No abstract available.


Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis.

Xu Y, Mizuno T, Sridharan A, Du Y, Guo M, Tang J, Wikenheiser-Brokamp KA, Perl AT, Funari VA, Gokey JJ, Stripp BR, Whitsett JA.

JCI Insight. 2016 Dec 8;1(20):e90558. doi: 10.1172/jci.insight.90558.


miR-323a-3p regulates lung fibrosis by targeting multiple profibrotic pathways.

Ge L, Habiel DM, Hansbro PM, Kim RY, Gharib SA, Edelman JD, Königshoff M, Parimon T, Brauer R, Huang Y, Allen J, Jiang D, Kurkciyan AA, Mizuno T, Stripp BR, Noble PW, Hogaboam CM, Chen P.

JCI Insight. 2016 Dec 8;1(20):e90301. doi: 10.1172/jci.insight.90301.


p53 Regulates Progenitor Cell Quiescence and Differentiation in the Airway.

McConnell AM, Yao C, Yeckes AR, Wang Y, Selvaggio AS, Tang J, Kirsch DG, Stripp BR.

Cell Rep. 2016 Nov 22;17(9):2173-2182. doi: 10.1016/j.celrep.2016.11.007.


Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice.

Liang J, Zhang Y, Xie T, Liu N, Chen H, Geng Y, Kurkciyan A, Mena JM, Stripp BR, Jiang D, Noble PW.

Nat Med. 2016 Nov;22(11):1285-1293. doi: 10.1038/nm.4192. Epub 2016 Oct 3.


Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection.

Ray S, Chiba N, Yao C, Guan X, McConnell AM, Brockway B, Que L, McQualter JL, Stripp BR.

Stem Cell Reports. 2016 Nov 8;7(5):817-825. doi: 10.1016/j.stemcr.2016.09.010. Epub 2016 Oct 20.


Distal airway epithelial progenitor cells are radiosensitive to High-LET radiation.

McConnell AM, Konda B, Kirsch DG, Stripp BR.

Sci Rep. 2016 Sep 23;6:33455. doi: 10.1038/srep33455.


Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis.

Xie T, Liang J, Liu N, Huan C, Zhang Y, Liu W, Kumar M, Xiao R, D'Armiento J, Metzger D, Chambon P, Papaioannou VE, Stripp BR, Jiang D, Noble PW.

J Clin Invest. 2016 Sep 1;126(9):3626. doi: 10.1172/JCI89968. Epub 2016 Aug 22. No abstract available.


Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis.

Xie T, Liang J, Liu N, Huan C, Zhang Y, Liu W, Kumar M, Xiao R, D'Armiento J, Metzger D, Chambon P, Papaioannou VE, Stripp BR, Jiang D, Noble PW.

J Clin Invest. 2016 Aug 1;126(8):3063-79. doi: 10.1172/JCI85328. Epub 2016 Jul 11. Erratum in: J Clin Invest. 2016 Sep 1;126(9):3626.


A new notch for lung stem cells.

Carraro G, Stripp BR.

Cell Stem Cell. 2015 Feb 5;16(2):107-9. doi: 10.1016/j.stem.2015.01.012.


Low- and high-LET radiation drives clonal expansion of lung progenitor cells in vivo.

Farin AM, Manzo ND, Kirsch DG, Stripp BR.

Radiat Res. 2015 Jan;183(1):124-32. doi: 10.1667/RR13878.1. Epub 2015 Jan 7.


Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung.

Lange AW, Sridharan A, Xu Y, Stripp BR, Perl AK, Whitsett JA.

J Mol Cell Biol. 2015 Feb;7(1):35-47. doi: 10.1093/jmcb/mju046. Epub 2014 Dec 5.


Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.

Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, White ES, Whitsett JA, Morrisey EE.

Cell Stem Cell. 2014 Aug 7;15(2):123-38. doi: 10.1016/j.stem.2014.07.012. Review.


Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis.

Lee JH, Bhang DH, Beede A, Huang TL, Stripp BR, Bloch KD, Wagers AJ, Tseng YH, Ryeom S, Kim CF.

Cell. 2014 Jan 30;156(3):440-55. doi: 10.1016/j.cell.2013.12.039.


Type 2 alveolar cells are stem cells in adult lung.

Barkauskas CE, Cronce MJ, Rackley CR, Bowie EJ, Keene DR, Stripp BR, Randell SH, Noble PW, Hogan BL.

J Clin Invest. 2013 Jul;123(7):3025-36. doi: 10.1172/JCI68782. Epub 2013 Jun 10.


Surfactant protein-C chromatin-bound green fluorescence protein reporter mice reveal heterogeneity of surfactant protein C-expressing lung cells.

Lee JH, Kim J, Gludish D, Roach RR, Saunders AH, Barrios J, Woo AJ, Chen H, Conner DA, Fujiwara Y, Stripp BR, Kim CF.

Am J Respir Cell Mol Biol. 2013 Mar;48(3):288-98. doi: 10.1165/rcmb.2011-0403OC. Epub 2012 Nov 29.


Activation of the canonical bone morphogenetic protein (BMP) pathway during lung morphogenesis and adult lung tissue repair.

Sountoulidis A, Stavropoulos A, Giaglis S, Apostolou E, Monteiro R, Chuva de Sousa Lopes SM, Chen H, Stripp BR, Mummery C, Andreakos E, Sideras P.

PLoS One. 2012;7(8):e41460. doi: 10.1371/journal.pone.0041460. Epub 2012 Aug 20.


Epithelial clara cell injury occurs in bronchiolitis obliterans syndrome after human lung transplantation.

Kelly FL, Kennedy VE, Jain R, Sindhwani NS, Finlen Copeland CA, Snyder LD, Eu JP, Meltzer EB, Brockway BL, Pavlisko E, Stripp BR, Palmer SM.

Am J Transplant. 2012 Nov;12(11):3076-84. doi: 10.1111/j.1600-6143.2012.04201.x. Epub 2012 Aug 6.


Building and maintaining the epithelium of the lung.

Rackley CR, Stripp BR.

J Clin Invest. 2012 Aug;122(8):2724-30. doi: 10.1172/JCI60519. Epub 2012 Aug 1. Review.


Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury.

Chen H, Matsumoto K, Brockway BL, Rackley CR, Liang J, Lee JH, Jiang D, Noble PW, Randell SH, Kim CF, Stripp BR.

Stem Cells. 2012 Sep;30(9):1948-60. doi: 10.1002/stem.1150.


Amphiregulin-dependent mucous cell metaplasia in a model of nonallergic lung injury.

Manzo ND, Foster WM, Stripp BR.

Am J Respir Cell Mol Biol. 2012 Sep;47(3):349-57. doi: 10.1165/rcmb.2011-0257OC. Epub 2012 Apr 5.


β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium.

Hashimoto S, Chen H, Que J, Brockway BL, Drake JA, Snyder JC, Randell SH, Stripp BR.

J Cell Sci. 2012 Feb 15;125(Pt 4):932-42. doi: 10.1242/jcs.092734. Epub 2012 Mar 15.


Antimicrobial activity of PLUNC protects against Pseudomonas aeruginosa infection.

Lukinskiene L, Liu Y, Reynolds SD, Steele C, Stripp BR, Leikauf GD, Kolls JK, Di YP.

J Immunol. 2011 Jul 1;187(1):382-90. doi: 10.4049/jimmunol.1001769. Epub 2011 Jun 1.


c-Kit is essential for alveolar maintenance and protection from emphysema-like disease in mice.

Lindsey JY, Ganguly K, Brass DM, Li Z, Potts EN, Degan S, Chen H, Brockway B, Abraham SN, Berndt A, Stripp BR, Foster WM, Leikauf GD, Schulz H, Hollingsworth JW.

Am J Respir Crit Care Med. 2011 Jun 15;183(12):1644-52. doi: 10.1164/rccm.201007-1157OC. Epub 2011 Mar 11.


Functional analysis of two distinct bronchiolar progenitors during lung injury and repair.

Teisanu RM, Chen H, Matsumoto K, McQualter JL, Potts E, Foster WM, Bertoncello I, Stripp BR.

Am J Respir Cell Mol Biol. 2011 Jun;44(6):794-803. doi: 10.1165/rcmb.2010-0098OC. Epub 2010 Jul 23.


Bronchiolar progenitor cells.

Chen H, Matsumoto K, Stripp BR.

Proc Am Thorac Soc. 2009 Dec 1;6(7):602-6. doi: 10.1513/pats.200907-078RM. Review.


Stem cells are dispensable for lung homeostasis but restore airways after injury.

Giangreco A, Arwert EN, Rosewell IR, Snyder J, Watt FM, Stripp BR.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9286-91. doi: 10.1073/pnas.0900668106. Epub 2009 May 28.


Clara cells attenuate the inflammatory response through regulation of macrophage behavior.

Snyder JC, Reynolds SD, Hollingsworth JW, Li Z, Kaminski N, Stripp BR.

Am J Respir Cell Mol Biol. 2010 Feb;42(2):161-71. doi: 10.1165/rcmb.2008-0353OC. Epub 2009 May 7.


beta-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium.

Zemke AC, Teisanu RM, Giangreco A, Drake JA, Brockway BL, Reynolds SD, Stripp BR.

Am J Respir Cell Mol Biol. 2009 Nov;41(5):535-43. doi: 10.1165/rcmb.2008-0407OC. Epub 2009 Feb 12.


Prospective isolation of bronchiolar stem cells based upon immunophenotypic and autofluorescence characteristics.

Teisanu RM, Lagasse E, Whitesides JF, Stripp BR.

Stem Cells. 2009 Mar;27(3):612-22. doi: 10.1634/stemcells.2008-0838.


Endogenous lung stem cells and contribution to disease.

Snyder JC, Teisanu RM, Stripp BR.

J Pathol. 2009 Jan;217(2):254-64. doi: 10.1002/path.2473. Review.


Reparative capacity of airway epithelium impacts deposition and remodeling of extracellular matrix.

Snyder JC, Zemke AC, Stripp BR.

Am J Respir Cell Mol Biol. 2009 Jun;40(6):633-42. doi: 10.1165/rcmb.2008-0334OC. Epub 2008 Oct 31.


Molecular staging of epithelial maturation using secretory cell-specific genes as markers.

Zemke AC, Snyder JC, Brockway BL, Drake JA, Reynolds SD, Kaminski N, Stripp BR.

Am J Respir Cell Mol Biol. 2009 Mar;40(3):340-8. doi: 10.1165/rcmb.2007-0380OC. Epub 2008 Aug 28.


Hierarchical organization of lung progenitor cells: is there an adult lung tissue stem cell?

Stripp BR.

Proc Am Thorac Soc. 2008 Aug 15;5(6):695-8. doi: 10.1513/pats.200801-011AW. Review.


Maintenance and repair of the bronchiolar epithelium.

Stripp BR, Reynolds SD.

Proc Am Thorac Soc. 2008 Apr 15;5(3):328-33. doi: 10.1513/pats.200711-167DR.


Conditional stabilization of beta-catenin expands the pool of lung stem cells.

Reynolds SD, Zemke AC, Giangreco A, Brockway BL, Teisanu RM, Drake JA, Mariani T, Di PY, Taketo MM, Stripp BR.

Stem Cells. 2008 May;26(5):1337-46. doi: 10.1634/stemcells.2008-0053. Epub 2008 Mar 20.


CCSP regulates cross talk between secretory cells and both ciliated cells and macrophages of the conducting airway.

Reynolds SD, Reynolds PR, Snyder JC, Whyte F, Paavola KJ, Stripp BR.

Am J Physiol Lung Cell Mol Physiol. 2007 Jul;293(1):L114-23. Epub 2007 Mar 23.


Molecular and functional properties of lung SP cells.

Reynolds SD, Shen H, Reynolds PR, Betsuyaku T, Pilewski JM, Gambelli F, Di Giuseppe M, Ortiz LA, Stripp BR.

Am J Physiol Lung Cell Mol Physiol. 2007 Apr;292(4):L972-83. Epub 2006 Dec 1. Erratum in: Am J Physiol Lung Cell Mol Physiol. 2007 Apr;292(3):L821. DeGuiseppe, Michelangelo [corrected to Di Giuseppe, Michelangelo].


Stem cells in lung disease, repair, and the potential for therapeutic interventions: State-of-the-art and future challenges.

Stripp BR, Shapiro SD.

Am J Respir Cell Mol Biol. 2006 May;34(5):517-18. No abstract available.


Elevation of susceptibility to ozone-induced acute tracheobronchial injury in transgenic mice deficient in Clara cell secretory protein.

Plopper CG, Mango GW, Hatch GE, Wong VJ, Toskala E, Reynolds SD, Tarkington BK, Stripp BR.

Toxicol Appl Pharmacol. 2006 May 15;213(1):74-85. Epub 2005 Oct 14.


Bioengineered lung epithelium: implications for basic and applied studies in lung tissue regeneration.

Stripp BR, Reynolds SD.

Am J Respir Cell Mol Biol. 2005 Feb;32(2):85-6. No abstract available.


Clara cell secretory protein and phospholipase A2 activity modulate acute ventilator-induced lung injury in mice.

Yoshikawa S, Miyahara T, Reynolds SD, Stripp BR, Anghelescu M, Eyal FG, Parker JC.

J Appl Physiol (1985). 2005 Apr;98(4):1264-71. Epub 2004 Dec 17.

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