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Disruption of histidine and energy homeostasis in chronic obstructive pulmonary disease.

Diao W, Labaki WW, Han MK, Yeomans L, Sun Y, Smiley Z, Kim JH, McHugh C, Xiang P, Shen N, Sun X, Guo C, Lu M, Standiford TJ, He B, Stringer KA.

Int J Chron Obstruct Pulmon Dis. 2019 Sep 3;14:2015-2025. doi: 10.2147/COPD.S210598. eCollection 2019.


Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study.

Labaki WW, Gu T, Murray S, Curtis JL, Yeomans L, Bowler RP, Barr RG, Comellas AP, Hansel NN, Cooper CB, Barjaktarevic I, Kanner RE, Paine R 3rd, McDonald MN, Krishnan JA, Peters SP, Woodruff PG, O'Neal WK, Diao W, He B, Martinez FJ, Standiford TJ, Stringer KA, Han MK.

Sci Rep. 2019 Aug 6;9(1):11367. doi: 10.1038/s41598-019-47761-w.


Bronchoalveolar Lavage Fluid from COPD Patients Reveals More Compounds Associated with Disease than Matched Plasma.

Halper-Stromberg E, Gillenwater L, Cruickshank-Quinn C, O'Neal WK, Reisdorph N, Petrache I, Zhuang Y, Labaki WW, Curtis JL, Wells J, Rennard S, Pratte KA, Woodruff P, Stringer KA, Kechris K, Bowler RP.

Metabolites. 2019 Jul 25;9(8). pii: E157. doi: 10.3390/metabo9080157.


Inkjet-printed micro-calibration standards for ultraquantitative Raman spectral cytometry.

LaLone V, Fawaz MV, Morales-Mercado J, Mourão MA, Snyder CS, Kim SY, Lieberman AP, Tuteja A, Mehta G, Standiford TJ, Raghavendran K, Shedden K, Schwendeman A, Stringer KA, Rosania GR.

Analyst. 2019 Jun 21;144(12):3790-3799. doi: 10.1039/c9an00500e. Epub 2019 May 22.


Untargeted Metabolomics Differentiates l-Carnitine Treated Septic Shock 1-Year Survivors and Nonsurvivors.

Evans CR, Karnovsky A, Puskarich MA, Michailidis G, Jones AE, Stringer KA.

J Proteome Res. 2019 May 3;18(5):2004-2011. doi: 10.1021/acs.jproteome.8b00774. Epub 2019 Apr 1.


Rapid, Reproducible, Quantifiable NMR Metabolomics: Methanol and Methanol: Chloroform Precipitation for Removal of Macromolecules in Serum and Whole Blood.

McHugh CE, Flott TL, Schooff CR, Smiley Z, Puskarich MA, Myers DD, Younger JG, Jones AE, Stringer KA.

Metabolites. 2018 Dec 14;8(4). pii: E93. doi: 10.3390/metabo8040093.


Synthesis and Characterization of a Biomimetic Formulation of Clofazimine Hydrochloride Microcrystals for Parenteral Administration.

Murashov MD, Diaz-Espinosa J, LaLone V, Tan JWY, Laza R, Wang X, Stringer KA, Rosania GR.

Pharmaceutics. 2018 Nov 17;10(4). pii: E238. doi: 10.3390/pharmaceutics10040238.


An Expandable Mechanopharmaceutical Device (1): Measuring the Cargo Capacity of Macrophages in a Living Organism.

Rzeczycki P, Woldemichael T, Willmer A, Murashov MD, Baik J, Keswani R, Yoon GS, Stringer KA, Rodriguez-Hornedo N, Rosania GR.

Pharm Res. 2018 Nov 12;36(1):12. doi: 10.1007/s11095-018-2539-6.


An Expandable Mechanopharmaceutical Device (2): Drug Induced Granulomas Maximize the Cargo Sequestering Capacity of Macrophages in the Liver.

Rzeczycki P, Yoon GS, Keswani RK, Sud S, Baik J, Murashov MD, Bergin IL, Stringer KA, Rosania GR.

Pharm Res. 2018 Nov 7;36(1):3. doi: 10.1007/s11095-018-2541-z.


An Expandable Mechanopharmaceutical Device (3): a Versatile Raman Spectral Cytometry Approach to Study the Drug Cargo Capacity of Individual Macrophages.

LaLone V, Mourão MA, Standiford TJ, Raghavendran K, Shedden K, Stringer KA, Rosania GR.

Pharm Res. 2018 Nov 6;36(1):2. doi: 10.1007/s11095-018-2540-0.


Pharmacometabolomics reveals a role for histidine, phenylalanine, and threonine in the development of paclitaxel-induced peripheral neuropathy.

Sun Y, Kim JH, Vangipuram K, Hayes DF, Smith EML, Yeomans L, Henry NL, Stringer KA, Hertz DL.

Breast Cancer Res Treat. 2018 Oct;171(3):657-666. doi: 10.1007/s10549-018-4862-3. Epub 2018 Jun 26.


Atypical Antipsychotic Exposure May Not Differentiate Metabolic Phenotypes of Patients with Schizophrenia.

Ward KM, Yeoman L, McHugh C, Kraal AZ, Flowers SA, Rothberg AE, Karnovsky A, Das AK, Ellingrod VL, Stringer KA.

Pharmacotherapy. 2018 Jun;38(6):638-650. doi: 10.1002/phar.2119.


Associations of the plasma lipidome with mortality in the acute respiratory distress syndrome: a longitudinal cohort study.

Maile MD, Standiford TJ, Engoren MC, Stringer KA, Jewell ES, Rajendiran TM, Soni T, Burant CF.

Respir Res. 2018 Apr 10;19(1):60. doi: 10.1186/s12931-018-0758-3.


Reverse Engineering the Intracellular Self-Assembly of a Functional Mechanopharmaceutical Device.

Woldemichael T, Keswani RK, Rzeczycki PM, Murashov MD, LaLone V, Gregorka B, Swanson JA, Stringer KA, Rosania GR.

Sci Rep. 2018 Feb 13;8(1):2934. doi: 10.1038/s41598-018-21271-7.


Septic Shock Nonsurvivors Have Persistently Elevated Acylcarnitines Following Carnitine Supplementation.

Puskarich MA, Evans CR, Karnovsky A, Das AK, Jones AE, Stringer KA.

Shock. 2018 Apr;49(4):412-419. doi: 10.1097/SHK.0000000000000997.


New Strategies and Challenges in Lung Proteomics and Metabolomics. An Official American Thoracic Society Workshop Report.

Bowler RP, Wendt CH, Fessler MB, Foster MW, Kelly RS, Lasky-Su J, Rogers AJ, Stringer KA, Winston BW; American Thoracic Society Workgroup on Metabolomics and Proteomics.

Ann Am Thorac Soc. 2017 Dec;14(12):1721-1743. doi: 10.1513/AnnalsATS.201710-770WS.


The Physicochemical Basis of Clofazimine-Induced Skin Pigmentation.

Murashov MD, LaLone V, Rzeczycki PM, Keswani RK, Yoon GS, Sud S, Rajeswaran W, Larsen S, Stringer KA, Rosania GR.

J Invest Dermatol. 2018 Mar;138(3):697-703. doi: 10.1016/j.jid.2017.09.031. Epub 2017 Oct 16.


Emerging Biomarkers of Illness Severity: Urinary Metabolites Associated with Sepsis and Necrotizing Methicillin-Resistant Staphylococcus aureus Pneumonia.

Ambroggio L, Florin TA, Shah SS, Ruddy R, Yeomans L, Trexel J, Stringer KA.

Pharmacotherapy. 2017 Sep;37(9):1033-1042. doi: 10.1002/phar.1973. Epub 2017 Jul 28.


Metabolomics as a Driver in Advancing Precision Medicine in Sepsis.

Eckerle M, Ambroggio L, Puskarich MA, Winston B, Jones AE, Standiford TJ, Stringer KA.

Pharmacotherapy. 2017 Sep;37(9):1023-1032. doi: 10.1002/phar.1974. Epub 2017 Jul 31. Review.


Detecting ordered small molecule drug aggregates in live macrophages: a multi-parameter microscope image data acquisition and analysis strategy.

Rzeczycki P, Yoon GS, Keswani RK, Sud S, Stringer KA, Rosania GR.

Biomed Opt Express. 2017 Jan 13;8(2):860-872. doi: 10.1364/BOE.8.000860. eCollection 2017 Feb 1.


Macrophage-Mediated Clofazimine Sequestration Is Accompanied by a Shift in Host Energy Metabolism.

Trexel J, Yoon GS, Keswani RK, McHugh C, Yeomans L, Vitvitsky V, Banerjee R, Sud S, Sun Y, Rosania GR, Stringer KA.

J Pharm Sci. 2017 Apr;106(4):1162-1174. doi: 10.1016/j.xphs.2016.12.009. Epub 2016 Dec 20.


Clofazimine Biocrystal Accumulation in Macrophages Upregulates Interleukin 1 Receptor Antagonist Production To Induce a Systemic Anti-Inflammatory State.

Yoon GS, Keswani RK, Sud S, Rzeczycki PM, Murashov MD, Koehn TA, Standiford TJ, Stringer KA, Rosania GR.

Antimicrob Agents Chemother. 2016 May 23;60(6):3470-9. doi: 10.1128/AAC.00265-16. Print 2016 Jun.


1D-¹H-nuclear magnetic resonance metabolomics reveals age-related changes in metabolites associated with experimental venous thrombosis.

Obi AT, Stringer KA, Diaz JA, Finkel MA, Farris DM, Yeomans L, Wakefield T, Myers DD Jr.

J Vasc Surg Venous Lymphat Disord. 2016 Apr;4(2):221-30. doi: 10.1016/j.jvsv.2015.09.010. Epub 2015 Nov 24.


Metabolomics and Its Application to Acute Lung Diseases.

Stringer KA, McKay RT, Karnovsky A, Quémerais B, Lacy P.

Front Immunol. 2016 Feb 29;7:44. doi: 10.3389/fimmu.2016.00044. eCollection 2016. Review.


Massive Bioaccumulation and Self-Assembly of Phenazine Compounds in Live Cells.

Min KA, Rajeswaran WG, Oldenbourg R, Harris G, Keswani RK, Chiang M, Rzeczycki P, Talattof A, Hafeez M, Horobin RW, Larsen SD, Stringer KA, Rosania GR.

Adv Sci (Weinh). 2015 Aug;2(8). pii: 1500025.


A Role for Low Density Lipoprotein Receptor-Related Protein 1 in the Cellular Uptake of Tissue Plasminogen Activator in the Lungs.

Lin S, Racz J, Tai MF, Brooks KM, Rzeczycki P, Heath LJ, Newstead MW, Standiford TJ, Rosania GR, Stringer KA.

Pharm Res. 2016 Jan;33(1):72-82. doi: 10.1007/s11095-015-1763-6. Epub 2015 Aug 1.


A far-red fluorescent probe for flow cytometry and image-based functional studies of xenobiotic sequestering macrophages.

Keswani RK, Yoon GS, Sud S, Stringer KA, Rosania GR.

Cytometry A. 2015 Sep;87(9):855-67. doi: 10.1002/cyto.a.22706. Epub 2015 Jun 24.


Whole Blood Reveals More Metabolic Detail of the Human Metabolome than Serum as Measured by 1H-NMR Spectroscopy: Implications for Sepsis Metabolomics.

Stringer KA, Younger JG, McHugh C, Yeomans L, Finkel MA, Puskarich MA, Jones AE, Trexel J, Karnovsky A.

Shock. 2015 Sep;44(3):200-8. doi: 10.1097/SHK.0000000000000406.


Immune Abnormalities in Fontan Protein-Losing Enteropathy: A Case-Control Study.

Magdo HS, Stillwell TL, Greenhawt MJ, Stringer KA, Yu S, Fifer CG, Russell MW, Schumacher KR.

J Pediatr. 2015 Aug;167(2):331-7. doi: 10.1016/j.jpeds.2015.04.061. Epub 2015 May 23.


Chemical Analysis of Drug Biocrystals: A Role for Counterion Transport Pathways in Intracellular Drug Disposition.

Keswani RK, Baik J, Yeomans L, Hitzman C, Johnson AM, Pawate AS, Kenis PJ, Rodriguez-Hornedo N, Stringer KA, Rosania GR.

Mol Pharm. 2015 Jul 6;12(7):2528-36. doi: 10.1021/acs.molpharmaceut.5b00032. Epub 2015 Jun 5.


Phagocytosed Clofazimine Biocrystals Can Modulate Innate Immune Signaling by Inhibiting TNFα and Boosting IL-1RA Secretion.

Yoon GS, Sud S, Keswani RK, Baik J, Standiford TJ, Stringer KA, Rosania GR.

Mol Pharm. 2015 Jul 6;12(7):2517-27. doi: 10.1021/acs.molpharmaceut.5b00035. Epub 2015 Jun 5.


Microarray analysis identifies IL-1 receptor type 2 as a novel candidate biomarker in patients with acute respiratory distress syndrome.

Kovach MA, Stringer KA, Bunting R, Wu X, San Mateo L, Newstead MW, Paine R, Standiford TJ.

Respir Res. 2015 Feb 21;16:29. doi: 10.1186/s12931-015-0190-x.


Fontan-associated protein-losing enteropathy and plastic bronchitis.

Schumacher KR, Stringer KA, Donohue JE, Yu S, Shaver A, Caruthers RL, Zikmund-Fisher BJ, Fifer C, Goldberg C, Russell MW.

J Pediatr. 2015 Apr;166(4):970-7. doi: 10.1016/j.jpeds.2014.12.068. Epub 2015 Feb 4.


Pharmacometabolomics of l-carnitine treatment response phenotypes in patients with septic shock.

Puskarich MA, Finkel MA, Karnovsky A, Jones AE, Trexel J, Harris BN, Stringer KA.

Ann Am Thorac Soc. 2015 Jan;12(1):46-56. doi: 10.1513/AnnalsATS.201409-415OC.


Social media methods for studying rare diseases.

Schumacher KR, Stringer KA, Donohue JE, Yu S, Shaver A, Caruthers RL, Zikmund-Fisher BJ, Fifer C, Goldberg C, Russell MW.

Pediatrics. 2014 May;133(5):e1345-53. doi: 10.1542/peds.2013-2966. Epub 2014 Apr 14.


Signal intensities derived from different NMR probes and parameters contribute to variations in quantification of metabolites.

Lacy P, McKay RT, Finkel M, Karnovsky A, Woehler S, Lewis MJ, Chang D, Stringer KA.

PLoS One. 2014 Jan 21;9(1):e85732. doi: 10.1371/journal.pone.0085732. eCollection 2014. Erratum in: PLoS One. 2014;9(7):e102929.


Untargeted LC-MS metabolomics of bronchoalveolar lavage fluid differentiates acute respiratory distress syndrome from health.

Evans CR, Karnovsky A, Kovach MA, Standiford TJ, Burant CF, Stringer KA.

J Proteome Res. 2014 Feb 7;13(2):640-9. doi: 10.1021/pr4007624. Epub 2013 Dec 9.


The extracellular microenvironment explains variations in passive drug transport across different airway epithelial cell types.

Min KA, Talattof A, Tsume Y, Stringer KA, Yu JY, Lim DH, Rosania GR.

Pharm Res. 2013 Aug;30(8):2118-32. doi: 10.1007/s11095-013-1069-5. Epub 2013 May 25.


Pharmacotherapy challenges of Fontan-associated plastic bronchitis: a rare pediatric disease.

Brooks K, Caruthers RL, Schumacher KR, Stringer KA.

Pharmacotherapy. 2013 Sep;33(9):922-34. doi: 10.1002/phar.1290. Epub 2013 May 17.


Immunophenotyping and protein profiling of Fontan-associated plastic bronchitis airway casts.

Racz J, Mane G, Ford M, Schmidt L, Myers J, Standiford TJ, Schumacher KR, Fifer C, Russell MW, Stringer KA.

Ann Am Thorac Soc. 2013 Apr;10(2):98-107. doi: 10.1513/AnnalsATS.201209-080OC.


Genetic variations in TGFβ1, tPA, and ACE and radiation-induced thoracic toxicities in patients with non-small-cell lung cancer.

Yuan ST, Ellingrod VL, Schipper M, Stringer KA, Cai X, Hayman JA, Yu J, Lawrence TS, Kong FM.

J Thorac Oncol. 2013 Feb;8(2):208-13. doi: 10.1097/JTO.0b013e318274592e.


Multiscale distribution and bioaccumulation analysis of clofazimine reveals a massive immune system-mediated xenobiotic sequestration response.

Baik J, Stringer KA, Mane G, Rosania GR.

Antimicrob Agents Chemother. 2013 Mar;57(3):1218-30. doi: 10.1128/AAC.01731-12. Epub 2012 Dec 21.


Demographic characteristics and estimated prevalence of Fontan-associated plastic bronchitis.

Caruthers RL, Kempa M, Loo A, Gulbransen E, Kelly E, Erickson SR, Hirsch JC, Schumacher KR, Stringer KA.

Pediatr Cardiol. 2013 Feb;34(2):256-61. doi: 10.1007/s00246-012-0430-5. Epub 2012 Jul 15.


A cell-based computational modeling approach for developing site-directed molecular probes.

Yu JY, Zheng N, Mane G, Min KA, Hinestroza JP, Zhu H, Stringer KA, Rosania GR.

PLoS Comput Biol. 2012;8(2):e1002378. doi: 10.1371/journal.pcbi.1002378. Epub 2012 Feb 23.


Pulmonary administration of a water-soluble curcumin complex reduces severity of acute lung injury.

Suresh MV, Wagner MC, Rosania GR, Stringer KA, Min KA, Risler L, Shen DD, Georges GE, Reddy AT, Parkkinen J, Reddy RC.

Am J Respir Cell Mol Biol. 2012 Sep;47(3):280-7. doi: 10.1165/rcmb.2011-0175OC. Epub 2012 Feb 3.


Metscape 2 bioinformatics tool for the analysis and visualization of metabolomics and gene expression data.

Karnovsky A, Weymouth T, Hull T, Tarcea VG, Scardoni G, Laudanna C, Sartor MA, Stringer KA, Jagadish HV, Burant C, Athey B, Omenn GS.

Bioinformatics. 2012 Feb 1;28(3):373-80. doi: 10.1093/bioinformatics/btr661. Epub 2011 Nov 30.


Prospective, longitudinal study of plastic bronchitis cast pathology and responsiveness to tissue plasminogen activator.

Heath L, Ling S, Racz J, Mane G, Schmidt L, Myers JL, Tsai WC, Caruthers RL, Hirsch JC, Stringer KA.

Pediatr Cardiol. 2011 Dec;32(8):1182-9. doi: 10.1007/s00246-011-0058-x. Epub 2011 Jul 24.


The emerging field of quantitative blood metabolomics for biomarker discovery in critical illnesses.

Serkova NJ, Standiford TJ, Stringer KA.

Am J Respir Crit Care Med. 2011 Sep 15;184(6):647-55. doi: 10.1164/rccm.201103-0474CI. Epub 2011 Jun 16. Review.


Metabolic consequences of sepsis-induced acute lung injury revealed by plasma ¹H-nuclear magnetic resonance quantitative metabolomics and computational analysis.

Stringer KA, Serkova NJ, Karnovsky A, Guire K, Paine R 3rd, Standiford TJ.

Am J Physiol Lung Cell Mol Physiol. 2011 Jan;300(1):L4-L11. doi: 10.1152/ajplung.00231.2010. Epub 2010 Oct 1.


Safety of prolonged, repeated administration of a pulmonary formulation of tissue plasminogen activator in mice.

Lackowski NP, Pitzer JE, Tobias M, Van Rheen Z, Nayar R, Mosharaff M, Stringer KA.

Pulm Pharmacol Ther. 2010 Apr;23(2):107-14. doi: 10.1016/j.pupt.2009.10.009. Epub 2009 Oct 29.

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