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Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice.

Grosjean F, Yubero-Serrano EM, Zheng F, Esposito V, Swamy S, Elliot SJ, Cai W, Vlassara H, Salem F, Striker GE.

PLoS One. 2018 Sep 25;13(9):e0204366. doi: 10.1371/journal.pone.0204366. eCollection 2018.


Dietary fat quantity and quality modifies advanced glycation end products metabolism in patients with metabolic syndrome.

Lopez-Moreno J, Quintana-Navarro GM, Camargo A, Jimenez-Lucena R, Delgado-Lista J, Marin C, Tinahones FJ, Striker GE, Roche HM, Perez-Martinez P, Lopez-Miranda J, Yubero-Serrano EM.

Mol Nutr Food Res. 2017 Aug;61(8). doi: 10.1002/mnfr.201601029. Epub 2017 Mar 30.


Oral AGE restriction ameliorates insulin resistance in obese individuals with the metabolic syndrome: a randomised controlled trial.

Vlassara H, Cai W, Tripp E, Pyzik R, Yee K, Goldberg L, Tansman L, Chen X, Mani V, Fayad ZA, Nadkarni GN, Striker GE, He JC, Uribarri J.

Diabetologia. 2016 Oct;59(10):2181-92. doi: 10.1007/s00125-016-4053-x. Epub 2016 Jul 29.


Inhibition of Advanced Glycation End Products (AGEs) Accumulation by Pyridoxamine Modulates Glomerular and Mesangial Cell Estrogen Receptor α Expression in Aged Female Mice.

Pereira-Simon S, Rubio GA, Xia X, Cai W, Choi R, Striker GE, Elliot SJ.

PLoS One. 2016 Jul 18;11(7):e0159666. doi: 10.1371/journal.pone.0159666. eCollection 2016.


Mediterranean Diet Reduces Serum Advanced Glycation End Products and Increases Antioxidant Defenses in Elderly Adults: A Randomized Controlled Trial.

Lopez-Moreno J, Quintana-Navarro GM, Delgado-Lista J, Garcia-Rios A, Delgado-Casado N, Camargo A, Perez-Martinez P, Striker GE, Tinahones FJ, Perez-Jimenez F, Lopez-Miranda J, Yubero-Serrano EM.

J Am Geriatr Soc. 2016 Apr;64(4):901-4. doi: 10.1111/jgs.14062. No abstract available.


Mediterranean Diet Supplemented With Coenzyme Q10 Modulates the Postprandial Metabolism of Advanced Glycation End Products in Elderly Men and Women.

Lopez-Moreno J, Quintana-Navarro GM, Delgado-Lista J, Garcia-Rios A, Alcala-Diaz JF, Gomez-Delgado F, Camargo A, Perez-Martinez P, Tinahones FJ, Striker GE, Perez-Jimenez F, Villalba JM, Lopez-Miranda J, Yubero-Serrano EM.

J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):340-346. doi: 10.1093/gerona/glw214.


Uremic Toxicity of Advanced Glycation End Products in CKD.

Stinghen AE, Massy ZA, Vlassara H, Striker GE, Boullier A.

J Am Soc Nephrol. 2016 Feb;27(2):354-70. doi: 10.1681/ASN.2014101047. Epub 2015 Aug 26. Review.


Effects of sevelamer carbonate on advanced glycation end products and antioxidant/pro-oxidant status in patients with diabetic kidney disease.

Yubero-Serrano EM, Woodward M, Poretsky L, Vlassara H, Striker GE; AGE-less Study Group.

Clin J Am Soc Nephrol. 2015 May 7;10(5):759-66. doi: 10.2215/CJN.07750814. Epub 2015 Feb 20.


Chronic ingestion of advanced glycation end products induces degenerative spinal changes and hypertrophy in aging pre-diabetic mice.

Illien-Jünger S, Lu Y, Qureshi SA, Hecht AC, Cai W, Vlassara H, Striker GE, Iatridis JC.

PLoS One. 2015 Feb 10;10(2):e0116625. doi: 10.1371/journal.pone.0116625. eCollection 2015.


Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans.

Cai W, Uribarri J, Zhu L, Chen X, Swamy S, Zhao Z, Grosjean F, Simonaro C, Kuchel GA, Schnaider-Beeri M, Woodward M, Striker GE, Vlassara H.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4940-5. doi: 10.1073/pnas.1316013111. Epub 2014 Feb 24.


Advanced glycation endproducts in diabetes and diabetic complications.

Vlassara H, Striker GE.

Endocrinol Metab Clin North Am. 2013 Dec;42(4):697-719. doi: 10.1016/j.ecl.2013.07.005. Review.


Combined anti-inflammatory and anti-AGE drug treatments have a protective effect on intervertebral discs in mice with diabetes.

Illien-Junger S, Grosjean F, Laudier DM, Vlassara H, Striker GE, Iatridis JC.

PLoS One. 2013 May 17;8(5):e64302. doi: 10.1371/journal.pone.0064302. Print 2013. Erratum in: PLoS One. 2015;10(3):e0119112.


Suppression of native defense mechanisms, SIRT1 and PPARγ, by dietary glycoxidants precedes disease in adult humans; relevance to lifestyle-engendered chronic diseases.

Uribarri J, Cai W, Pyzik R, Goodman S, Chen X, Zhu L, Ramdas M, Striker GE, Vlassara H.

Amino Acids. 2014 Feb;46(2):301-9. doi: 10.1007/s00726-013-1502-4. Epub 2013 May 1.


Increased circulating advanced glycation endproducts (AGEs) in acute trauma patients.

Schulman CI, Uribarri J, Cai W, Manning R, Landy DC, Gallardo M, Castillo A, Namias N, Striker GE, Livingstone A, Vlassara H.

Clin Chem Lab Med. 2014 Jan 1;52(1):103-8. doi: 10.1515/cclm-2012-0834.


CHOP deficiency results in elevated lipopolysaccharide-induced inflammation and kidney injury.

Esposito V, Grosjean F, Tan J, Huang L, Zhu L, Chen J, Xiong H, Striker GE, Zheng F.

Am J Physiol Renal Physiol. 2013 Feb 15;304(4):F440-50. doi: 10.1152/ajprenal.00487.2011. Epub 2012 Dec 12.


Managing chronic inflammation in the aging diabetic patient with CKD by diet or sevelamer carbonate: a modern paradigm shift.

Vlassara H, Cai W, Chen X, Serrano EJ, Shobha MS, Uribarri J, Woodward M, Striker GE.

J Gerontol A Biol Sci Med Sci. 2012 Dec;67(12):1410-6. doi: 10.1093/gerona/gls195. Epub 2012 Oct 29. Review.


Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1.

Cai W, Ramdas M, Zhu L, Chen X, Striker GE, Vlassara H.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15888-93. Epub 2012 Aug 20.


Effects of sevelamer on HbA1c, inflammation, and advanced glycation end products in diabetic kidney disease.

Vlassara H, Uribarri J, Cai W, Goodman S, Pyzik R, Post J, Grosjean F, Woodward M, Striker GE.

Clin J Am Soc Nephrol. 2012 Jun;7(6):934-42. doi: 10.2215/CJN.12891211. Epub 2012 Mar 29.


Pentosan polysulfate inhibits atherosclerosis in Watanabe heritable hyperlipidemic rabbits: differential modulation of metalloproteinase-2 and -9.

Lupia E, Zheng F, Grosjean F, Tack I, Doublier S, Elliot SJ, Vlassara H, Striker GE.

Lab Invest. 2012 Feb;92(2):236-45. doi: 10.1038/labinvest.2011.154. Epub 2011 Oct 31.


The aging kidney phenotype and systemically derived stem cells.

Striker GE.

J Am Soc Nephrol. 2011 Nov;22(11):1958-60. doi: 10.1681/ASN.2011090946. Epub 2011 Oct 13. No abstract available.


Phosphate and CVD: it's all in what's on the table.

Striker GE, Grosjean F, Vlassara H.

Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):1951-2. doi: 10.1161/ATVBAHA.111.231928. No abstract available.


Inhibition of inflammation by pentosan polysulfate impedes the development and progression of severe diabetic nephropathy in aging C57B6 mice.

Wu J, Guan TJ, Zheng S, Grosjean F, Liu W, Xiong H, Gordon R, Vlassara H, Striker GE, Zheng F.

Lab Invest. 2011 Oct;91(10):1459-71. doi: 10.1038/labinvest.2011.93. Epub 2011 Aug 1.


Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1.

Uribarri J, Cai W, Ramdas M, Goodman S, Pyzik R, Chen X, Zhu L, Striker GE, Vlassara H.

Diabetes Care. 2011 Jul;34(7):1610-6. doi: 10.2337/dc11-0091.


AGE restriction in diabetes mellitus: a paradigm shift.

Vlassara H, Striker GE.

Nat Rev Endocrinol. 2011 May 24;7(9):526-39. doi: 10.1038/nrendo.2011.74. Review.


Increased susceptibility to acute kidney injury due to endoplasmic reticulum stress in mice lacking tumor necrosis factor-α and its receptor 1.

Huang L, Zhang R, Wu J, Chen J, Grosjean F, Satlin LH, Klein JD, Sands JM, Striker GE, Tan J, Zheng F.

Kidney Int. 2011 Mar;79(6):613-623. doi: 10.1038/ki.2010.469. Epub 2010 Dec 8.


Maternally transmitted and food-derived glycotoxins: a factor preconditioning the young to diabetes?

Mericq V, Piccardo C, Cai W, Chen X, Zhu L, Striker GE, Vlassara H, Uribarri J.

Diabetes Care. 2010 Oct;33(10):2232-7. doi: 10.2337/dc10-1058. Epub 2010 Jul 13.


Advanced glycation end products in foods and a practical guide to their reduction in the diet.

Uribarri J, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R, Yong A, Striker GE, Vlassara H.

J Am Diet Assoc. 2010 Jun;110(6):911-16.e12. doi: 10.1016/j.jada.2010.03.018.


Induction of diabetes in aged C57B6 mice results in severe nephropathy: an association with oxidative stress, endoplasmic reticulum stress, and inflammation.

Wu J, Zhang R, Torreggiani M, Ting A, Xiong H, Striker GE, Vlassara H, Zheng F.

Am J Pathol. 2010 May;176(5):2163-76. doi: 10.2353/ajpath.2010.090386. Epub 2010 Apr 2.


Identifying advanced glycation end products as a major source of oxidants in aging: implications for the management and/or prevention of reduced renal function in elderly persons.

Vlassara H, Uribarri J, Ferrucci L, Cai W, Torreggiani M, Post JB, Zheng F, Striker GE.

Semin Nephrol. 2009 Nov;29(6):594-603. doi: 10.1016/j.semnephrol.2009.07.013.


Aging and the kidney: introduction.

Striker GE, Vlassara H, Ferrucci L.

Semin Nephrol. 2009 Nov;29(6):549-50. doi: 10.1016/j.semnephrol.2009.07.014. No abstract available.


AGER1 regulates endothelial cell NADPH oxidase-dependent oxidant stress via PKC-delta: implications for vascular disease.

Cai W, Torreggiani M, Zhu L, Chen X, He JC, Striker GE, Vlassara H.

Am J Physiol Cell Physiol. 2010 Mar;298(3):C624-34. doi: 10.1152/ajpcell.00463.2009. Epub 2009 Dec 2.


Role of oxidants/inflammation in declining renal function in chronic kidney disease and normal aging.

Vlassara H, Torreggiani M, Post JB, Zheng F, Uribarri J, Striker GE.

Kidney Int Suppl. 2009 Dec;(114):S3-11. doi: 10.1038/ki.2009.401. Review.


Protection against loss of innate defenses in adulthood by low advanced glycation end products (AGE) intake: role of the antiinflammatory AGE receptor-1.

Vlassara H, Cai W, Goodman S, Pyzik R, Yong A, Chen X, Zhu L, Neade T, Beeri M, Silverman JM, Ferrucci L, Tansman L, Striker GE, Uribarri J.

J Clin Endocrinol Metab. 2009 Nov;94(11):4483-91. doi: 10.1210/jc.2009-0089. Epub 2009 Oct 9.


Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells.

Wu J, Mei C, Vlassara H, Striker GE, Zheng F.

Am J Physiol Renal Physiol. 2009 Dec;297(6):F1622-31. doi: 10.1152/ajprenal.00078.2009. Epub 2009 Sep 23.


(Pro)renin receptor is expressed in human retinal pigment epithelium and participates in extracellular matrix remodeling.

Alcazar O, Cousins SW, Striker GE, Marin-Castano ME.

Exp Eye Res. 2009 Nov;89(5):638-47. doi: 10.1016/j.exer.2009.06.014. Epub 2009 Jul 4.


17 beta-estradiol and tamoxifen upregulate estrogen receptor beta expression and control podocyte signaling pathways in a model of type 2 diabetes.

Catanuto P, Doublier S, Lupia E, Fornoni A, Berho M, Karl M, Striker GE, Xia X, Elliot S.

Kidney Int. 2009 Jun;75(11):1194-1201. doi: 10.1038/ki.2009.69. Epub 2009 Mar 11.


Regulation of angiotensin II receptors and extracellular matrix turnover in human retinal pigment epithelium: role of angiotensin II.

Striker GE, Praddaude F, Alcazar O, Cousins SW, Marin-Castaño ME.

Am J Physiol Cell Physiol. 2008 Dec;295(6):C1633-46. doi: 10.1152/ajpcell.00092.2008. Epub 2008 Oct 15.


Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan.

Cai W, He JC, Zhu L, Chen X, Zheng F, Striker GE, Vlassara H.

Am J Pathol. 2008 Aug;173(2):327-36. doi: 10.2353/ajpath.2008.080152. Epub 2008 Jul 3.


AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation.

Cai W, He JC, Zhu L, Chen X, Striker GE, Vlassara H.

Am J Physiol Cell Physiol. 2008 Jan;294(1):C145-52. Epub 2007 Nov 21.


Reduced oxidant stress and extended lifespan in mice exposed to a low glycotoxin diet: association with increased AGER1 expression.

Cai W, He JC, Zhu L, Chen X, Wallenstein S, Striker GE, Vlassara H.

Am J Pathol. 2007 Jun;170(6):1893-902.


Gender-specific effects of endogenous testosterone: female alpha-estrogen receptor-deficient C57Bl/6J mice develop glomerulosclerosis.

Elliot SJ, Berho M, Korach K, Doublier S, Lupia E, Striker GE, Karl M.

Kidney Int. 2007 Aug;72(4):464-72. Epub 2007 May 9.


Smoking induces glomerulosclerosis in aging estrogen-deficient mice through cross-talk between TGF-beta1 and IGF-I signaling pathways.

Elliot SJ, Karl M, Berho M, Xia X, Pereria-Simon S, Espinosa-Heidmann D, Striker GE.

J Am Soc Nephrol. 2006 Dec;17(12):3315-24. Epub 2006 Nov 8.


Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo.

Marin-Castaño ME, Striker GE, Alcazar O, Catanuto P, Espinosa-Heidmann DG, Cousins SW.

Invest Ophthalmol Vis Sci. 2006 Sep;47(9):4098-112.


Reduced acute vascular injury and atherosclerosis in hyperlipidemic mice transgenic for lysozyme.

Liu H, Zheng F, Li Z, Uribarri J, Ren B, Hutter R, Tunstead JR, Badimon J, Striker GE, Vlassara H.

Am J Pathol. 2006 Jul;169(1):303-13.


Combined AGE inhibition and ACEi decreases the progression of established diabetic nephropathy in B6 db/db mice.

Zheng F, Zeng YJ, Plati AR, Elliot SJ, Berho M, Potier M, Striker LJ, Striker GE.

Kidney Int. 2006 Aug;70(3):507-14. Epub 2006 Jun 14.


Glomerular aging in females is a multi-stage reversible process mediated by phenotypic changes in progenitors.

Feng Z, Plati AR, Cheng QL, Berho M, Banerjee A, Potier M, Jy WC, Koff A, Striker LJ, Striker GE.

Am J Pathol. 2005 Aug;167(2):355-63.

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