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Items: 1 to 50 of 180

1.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview.

Alexander SP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators.

Br J Pharmacol. 2017 Dec;174 Suppl 1:S1-S16. doi: 10.1111/bph.13882.

2.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Voltage-gated ion channels.

Alexander SP, Striessnig J, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators.

Br J Pharmacol. 2017 Dec;174 Suppl 1:S160-S194. doi: 10.1111/bph.13884.

3.

Mechanisms Responsible for ω-Pore Currents in Cav Calcium Channel Voltage-Sensing Domains.

Monteleone S, Lieb A, Pinggera A, Negro G, Fuchs JE, Hofer F, Striessnig J, Tuluc P, Liedl KR.

Biophys J. 2017 Oct 3;113(7):1485-1495. doi: 10.1016/j.bpj.2017.08.010.

4.

CaV1.3 L-type Ca2+ channel contributes to the heartbeat by generating a dihydropyridine-sensitive persistent Na+ current.

Toyoda F, Mesirca P, Dubel S, Ding WG, Striessnig J, Mangoni ME, Matsuura H.

Sci Rep. 2017 Aug 11;7(1):7869. doi: 10.1038/s41598-017-08191-8.

5.

Lower Affinity of Isradipine for L-Type Ca2+ Channels during Substantia Nigra Dopamine Neuron-Like Activity: Implications for Neuroprotection in Parkinson's Disease.

Ortner NJ, Bock G, Dougalis A, Kharitonova M, Duda J, Hess S, Tuluc P, Pomberger T, Stefanova N, Pitterl F, Ciossek T, Oberacher H, Draheim HJ, Kloppenburg P, Liss B, Striessnig J.

J Neurosci. 2017 Jul 12;37(28):6761-6777. doi: 10.1523/JNEUROSCI.2946-16.2017. Epub 2017 Jun 7.

6.

Aldosterone-Producing Adenomas: Histopathology-Genotype Correlation and Identification of a Novel CACNA1D Mutation.

Tan GC, Negro G, Pinggera A, Tizen Laim NMS, Mohamed Rose I, Ceral J, Ryska A, Chin LK, Kamaruddin NA, Mohd Mokhtar N, A Jamal AR, Sukor N, Solar M, Striessnig J, Brown MJ, Azizan EA.

Hypertension. 2017 Jul;70(1):129-136. doi: 10.1161/HYPERTENSIONAHA.117.09057. Epub 2017 Jun 5.

7.

New gain-of-function mutation shows CACNA1D as recurrently mutated gene in autism spectrum disorders and epilepsy.

Pinggera A, Mackenroth L, Rump A, Schallner J, Beleggia F, Wollnik B, Striessnig J.

Hum Mol Genet. 2017 Aug 1;26(15):2923-2932. doi: 10.1093/hmg/ddx175.

8.

Enhancing VTA Cav1.3 L-type Ca2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens.

Martínez-Rivera A, Hao J, Tropea TF, Giordano TP, Kosovsky M, Rice RC, Lee A, Huganir RL, Striessnig J, Addy NA, Han S, Rajadhyaksha AM.

Mol Psychiatry. 2017 Dec;22(12):1735-1745. doi: 10.1038/mp.2017.9. Epub 2017 Feb 14.

9.

Loss of α2δ-1 Calcium Channel Subunit Function Increases the Susceptibility for Diabetes.

Mastrolia V, Flucher SM, Obermair GJ, Drach M, Hofer H, Renström E, Schwartz A, Striessnig J, Flucher BE, Tuluc P.

Diabetes. 2017 Apr;66(4):897-907. doi: 10.2337/db16-0336. Epub 2017 Jan 23.

10.

Enhancing dopaminergic signaling and histone acetylation promotes long-term rescue of deficient fear extinction.

Whittle N, Maurer V, Murphy C, Rainer J, Bindreither D, Hauschild M, Scharinger A, Oberhauser M, Keil T, Brehm C, Valovka T, Striessnig J, Singewald N.

Transl Psychiatry. 2016 Dec 6;6(12):e974. doi: 10.1038/tp.2016.231.

11.

Voltage-gated calcium channels - from basic mechanisms to disease.

Striessnig J.

J Physiol. 2016 Oct 15;594(20):5817-5821. doi: 10.1113/JP272619. No abstract available.

12.

Splice variants of the CaV1.3 L-type calcium channel regulate dendritic spine morphology.

Stanika R, Campiglio M, Pinggera A, Lee A, Striessnig J, Flucher BE, Obermair GJ.

Sci Rep. 2016 Oct 6;6:34528. doi: 10.1038/srep34528.

13.

Cav 1.3 (CACNA1D) L-type Ca2+ channel dysfunction in CNS disorders.

Pinggera A, Striessnig J.

J Physiol. 2016 Oct 15;594(20):5839-5849. doi: 10.1113/JP270672. Epub 2016 Feb 29. Review.

14.

G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.

Mesirca P, Bidaud I, Briec F, Evain S, Torrente AG, Le Quang K, Leoni AL, Baudot M, Marger L, Chung You Chong A, Nargeot J, Striessnig J, Wickman K, Charpentier F, Mangoni ME.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E932-41. doi: 10.1073/pnas.1517181113. Epub 2016 Feb 1.

15.

L-type Cav1.3 channels regulate ryanodine receptor-dependent Ca2+ release during sino-atrial node pacemaker activity.

Torrente AG, Mesirca P, Neco P, Rizzetto R, Dubel S, Barrere C, Sinegger-Brauns M, Striessnig J, Richard S, Nargeot J, Gomez AM, Mangoni ME.

Cardiovasc Res. 2016 Mar 1;109(3):451-61. doi: 10.1093/cvr/cvw006. Epub 2016 Jan 19.

PMID:
26786159
16.

The L-type calcium channel Cav1.3 is required for proper hippocampal neurogenesis and cognitive functions.

Marschallinger J, Sah A, Schmuckermair C, Unger M, Rotheneichner P, Kharitonova M, Waclawiczek A, Gerner P, Jaksch-Bogensperger H, Berger S, Striessnig J, Singewald N, Couillard-Despres S, Aigner L.

Cell Calcium. 2015 Dec;58(6):606-16. doi: 10.1016/j.ceca.2015.09.007. Epub 2015 Oct 3.

PMID:
26459417
17.

Compensatory T-type Ca2+ channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca2+ channel KO mice.

Poetschke C, Dragicevic E, Duda J, Benkert J, Dougalis A, DeZio R, Snutch TP, Striessnig J, Liss B.

Sci Rep. 2015 Sep 18;5:13688. doi: 10.1038/srep13688.

18.

Cell-type-specific tuning of Cav1.3 Ca(2+)-channels by a C-terminal automodulatory domain.

Scharinger A, Eckrich S, Vandael DH, Schönig K, Koschak A, Hecker D, Kaur G, Lee A, Sah A, Bartsch D, Benedetti B, Lieb A, Schick B, Singewald N, Sinnegger-Brauns MJ, Carbone E, Engel J, Striessnig J.

Front Cell Neurosci. 2015 Aug 24;9:309. doi: 10.3389/fncel.2015.00309. eCollection 2015.

19.

The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential.

Zamponi GW, Striessnig J, Koschak A, Dolphin AC.

Pharmacol Rev. 2015 Oct;67(4):821-70. doi: 10.1124/pr.114.009654. Review.

20.

A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated CaV1.2 Calcium Channel Function.

Kaur G, Pinggera A, Ortner NJ, Lieb A, Sinnegger-Brauns MJ, Yarov-Yarovoy V, Obermair GJ, Flucher BE, Striessnig J.

J Biol Chem. 2015 Aug 21;290(34):21086-100. doi: 10.1074/jbc.M115.645671. Epub 2015 Jun 22.

21.

L-type calcium channels as drug targets in CNS disorders.

Ortner NJ, Striessnig J.

Channels (Austin). 2016;10(1):7-13. doi: 10.1080/19336950.2015.1048936. Epub 2015 Jun 3. Review.

22.

Pharmacology of L-type Calcium Channels: Novel Drugs for Old Targets?

Striessnig J, Ortner NJ, Pinggera A.

Curr Mol Pharmacol. 2015;8(2):110-22. Review.

23.

CACNA1D de novo mutations in autism spectrum disorders activate Cav1.3 L-type calcium channels.

Pinggera A, Lieb A, Benedetti B, Lampert M, Monteleone S, Liedl KR, Tuluc P, Striessnig J.

Biol Psychiatry. 2015 May 1;77(9):816-22. doi: 10.1016/j.biopsych.2014.11.020. Epub 2014 Dec 8.

24.

Generation of a neuro-specific microarray reveals novel differentially expressed noncoding RNAs in mouse models for neurodegenerative diseases.

Gstir R, Schafferer S, Scheideler M, Misslinger M, Griehl M, Daschil N, Humpel C, Obermair GJ, Schmuckermair C, Striessnig J, Flucher BE, Hüttenhofer A.

RNA. 2014 Dec;20(12):1929-43. doi: 10.1261/rna.047225.114. Epub 2014 Oct 24.

25.

CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum.

Yang G, Shi Y, Yu J, Li Y, Yu L, Welling A, Hofmann F, Striessnig J, Juntti-Berggren L, Berggren PO, Yang SN.

Cell Mol Life Sci. 2015 Mar;72(6):1197-207. doi: 10.1007/s00018-014-1737-6. Epub 2014 Oct 8.

PMID:
25292336
26.

Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators.

Ortner NJ, Bock G, Vandael DH, Mauersberger R, Draheim HJ, Gust R, Carbone E, Tuluc P, Striessnig J.

Nat Commun. 2014 Jun 19;5:3897. doi: 10.1038/ncomms4897.

27.

Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons.

Dragicevic E, Poetschke C, Duda J, Schlaudraff F, Lammel S, Schiemann J, Fauler M, Hetzel A, Watanabe M, Lujan R, Malenka RC, Striessnig J, Liss B.

Brain. 2014 Aug;137(Pt 8):2287-302. doi: 10.1093/brain/awu131. Epub 2014 Jun 16.

28.

Cav1.2 and Cav1.3 L-type calcium channels regulate dopaminergic firing activity in the mouse ventral tegmental area.

Liu Y, Harding M, Pittman A, Dore J, Striessnig J, Rajadhyaksha A, Chen X.

J Neurophysiol. 2014 Sep 1;112(5):1119-30. doi: 10.1152/jn.00757.2013. Epub 2014 May 21.

29.

C-terminal modulatory domain controls coupling of voltage-sensing to pore opening in Cav1.3 L-type Ca(2+) channels.

Lieb A, Ortner N, Striessnig J.

Biophys J. 2014 Apr 1;106(7):1467-75. doi: 10.1016/j.bpj.2014.02.017.

30.

L-type Ca2+ channels in heart and brain.

Striessnig J, Pinggera A, Kaur G, Bock G, Tuluc P.

Wiley Interdiscip Rev Membr Transp Signal. 2014 Mar 1;3(2):15-38.

31.

Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension.

Azizan EA, Poulsen H, Tuluc P, Zhou J, Clausen MV, Lieb A, Maniero C, Garg S, Bochukova EG, Zhao W, Shaikh LH, Brighton CA, Teo AE, Davenport AP, Dekkers T, Tops B, Küsters B, Ceral J, Yeo GS, Neogi SG, McFarlane I, Rosenfeld N, Marass F, Hadfield J, Margas W, Chaggar K, Solar M, Deinum J, Dolphin AC, Farooqi IS, Striessnig J, Nissen P, Brown MJ.

Nat Genet. 2013 Sep;45(9):1055-60. doi: 10.1038/ng.2716. Epub 2013 Aug 4.

PMID:
23913004
32.

Lonely but diverse: Cav1.3 L-type Ca(2+) channels in cochlear inner hair cells.

Striessnig J.

Channels (Austin). 2013 May-Jun;7(3):133-4. doi: 10.4161/chan.24457. Epub 2013 Apr 8. No abstract available.

33.

Ca(V)1.3-driven SK channel activation regulates pacemaking and spike frequency adaptation in mouse chromaffin cells.

Vandael DH, Zuccotti A, Striessnig J, Carbone E.

J Neurosci. 2012 Nov 14;32(46):16345-59. doi: 10.1523/JNEUROSCI.3715-12.2012.

34.

Distinct localization and modulation of Cav1.2 and Cav1.3 L-type Ca2+ channels in mouse sinoatrial node.

Christel CJ, Cardona N, Mesirca P, Herrmann S, Hofmann F, Striessnig J, Ludwig A, Mangoni ME, Lee A.

J Physiol. 2012 Dec 15;590(24):6327-42. doi: 10.1113/jphysiol.2012.239954. Epub 2012 Oct 8.

35.

Structural determinants of CaV1.3 L-type calcium channel gating.

Lieb A, Scharinger A, Sartori S, Sinnegger-Brauns MJ, Striessnig J.

Channels (Austin). 2012 May-Jun;6(3):197-205. doi: 10.4161/chan.21002. Epub 2012 May 1.

36.

Repertoire of high voltage-activated Ca2+ channels in the lateral superior olive: functional analysis in wild-type, Ca(v)1.3(-/-), and Ca(v)1.2DHP(-/-) mice.

Jurkovičová-Tarabová B, Griesemer D, Pirone A, Sinnegger-Brauns MJ, Striessnig J, Friauf E.

J Neurophysiol. 2012 Jul;108(2):365-79. doi: 10.1152/jn.00948.2011. Epub 2012 Apr 25.

37.

Cav 1.3 L-type Ca ( 2+) channels mediate long-term adaptation in dopamine D2L-mediated GluA1 trafficking in the dorsal striatum following cocaine exposure.

Schierberl K, Giordano T, Satpute S, Hao J, Kaur G, Hofmann F, Moosmang S, Striessnig J, Rajadhyaksha A.

Channels (Austin). 2012 Jan-Feb;6(1):11-7. doi: 10.4161/chan.19324. Epub 2012 Jan 1.

38.

Prevalence of hypovitaminosis D and folate deficiency in healthy young female Austrian students in a health care profession.

Kaehler ST, Baumgartner H, Jeske M, Anliker M, Schennach H, Marschang P, Ratt A, Colvin AC, Falk J, Gasser A, Kirchebner J, Scherer C, Purtscher AE, Griesmacher A, Striessnig J.

Eur J Nutr. 2012 Dec;51(8):1021-31. doi: 10.1007/s00394-011-0281-5. Epub 2011 Nov 25.

PMID:
22116202
39.

Functional properties of a newly identified C-terminal splice variant of Cav1.3 L-type Ca2+ channels.

Bock G, Gebhart M, Scharinger A, Jangsangthong W, Busquet P, Poggiani C, Sartori S, Mangoni ME, Sinnegger-Brauns MJ, Herzig S, Striessnig J, Koschak A.

J Biol Chem. 2011 Dec 9;286(49):42736-48. doi: 10.1074/jbc.M111.269951. Epub 2011 Oct 13.

40.

Cav1.2 L-type Ca²⁺ channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca(v)1.3 channels.

Schierberl K, Hao J, Tropea TF, Ra S, Giordano TP, Xu Q, Garraway SM, Hofmann F, Moosmang S, Striessnig J, Inturrisi CE, Rajadhyaksha AM.

J Neurosci. 2011 Sep 21;31(38):13562-75. doi: 10.1523/JNEUROSCI.2315-11.2011.

41.

Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation.

Rose RA, Sellan M, Simpson JA, Izaddoustdar F, Cifelli C, Panama BK, Davis M, Zhao D, Markhani M, Murphy GG, Striessnig J, Liu PP, Heximer SP, Backx PH.

Circ Arrhythm Electrophysiol. 2011 Oct;4(5):733-42. doi: 10.1161/CIRCEP.110.960401. Epub 2011 Jul 11.

42.

Cav1.3 calcium channels are required for normal development of the auditory brainstem.

Hirtz JJ, Boesen M, Braun N, Deitmer JW, Kramer F, Lohr C, Müller B, Nothwang HG, Striessnig J, Löhrke S, Friauf E.

J Neurosci. 2011 Jun 1;31(22):8280-94. doi: 10.1523/JNEUROSCI.5098-10.2011.

43.

Are Ca(v)1.3 pacemaker channels in chromaffin cells? Possible bias from resting cell conditions and DHP blockers usage.

Mahapatra S, Marcantoni A, Vandael DH, Striessnig J, Carbone E.

Channels (Austin). 2011 May-Jun;5(3):219-24. Epub 2011 May 1.

44.

Functional roles of Ca(v)1.3, Ca(v)3.1 and HCN channels in automaticity of mouse atrioventricular cells: insights into the atrioventricular pacemaker mechanism.

Marger L, Mesirca P, Alig J, Torrente A, Dubel S, Engeland B, Kanani S, Fontanaud P, Striessnig J, Shin HS, Isbrandt D, Ehmke H, Nargeot J, Mangoni ME.

Channels (Austin). 2011 May-Jun;5(3):251-61. Epub 2011 May 1.

45.

Pacemaker activity and ionic currents in mouse atrioventricular node cells.

Marger L, Mesirca P, Alig J, Torrente A, Dubel S, Engeland B, Kanani S, Fontanaud P, Striessnig J, Shin HS, Isbrandt D, Ehmke H, Nargeot J, Mangoni ME.

Channels (Austin). 2011 May-Jun;5(3):241-50. Epub 2011 May 1.

46.

Molecular switch from L-type Ca v 1.3 to Ca v 1.2 Ca2+ channel signaling underlies long-term psychostimulant-induced behavioral and molecular plasticity.

Giordano TP, Tropea TF, Satpute SS, Sinnegger-Brauns MJ, Striessnig J, Kosofsky BE, Rajadhyaksha AM.

J Neurosci. 2010 Dec 15;30(50):17051-62. doi: 10.1523/JNEUROSCI.2255-10.2010.

47.

Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness.

Baig SM, Koschak A, Lieb A, Gebhart M, Dafinger C, Nürnberg G, Ali A, Ahmad I, Sinnegger-Brauns MJ, Brandt N, Engel J, Mangoni ME, Farooq M, Khan HU, Nürnberg P, Striessnig J, Bolz HJ.

Nat Neurosci. 2011 Jan;14(1):77-84. doi: 10.1038/nn.2694. Epub 2010 Dec 5.

PMID:
21131953
48.

Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain.

Müller CS, Haupt A, Bildl W, Schindler J, Knaus HG, Meissner M, Rammner B, Striessnig J, Flockerzi V, Fakler B, Schulte U.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):14950-7. doi: 10.1073/pnas.1005940107. Epub 2010 Jul 28.

49.

Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting molecule.

Gebhart M, Juhasz-Vedres G, Zuccotti A, Brandt N, Engel J, Trockenbacher A, Kaur G, Obermair GJ, Knipper M, Koschak A, Striessnig J.

Mol Cell Neurosci. 2010 Jul;44(3):246-59. doi: 10.1016/j.mcn.2010.03.011. Epub 2010 Apr 2.

PMID:
20363327
50.

Channelopathies in Cav1.1, Cav1.3, and Cav1.4 voltage-gated L-type Ca2+ channels.

Striessnig J, Bolz HJ, Koschak A.

Pflugers Arch. 2010 Jul;460(2):361-74. doi: 10.1007/s00424-010-0800-x. Epub 2010 Mar 7. Review.

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