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Items: 1 to 50 of 126

1.

Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell.

Pawlowic MC, Somepalli M, Sateriale A, Herbert GT, Gibson AR, Cuny GD, Hedstrom L, Striepen B.

Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21160-21165. doi: 10.1073/pnas.1908239116. Epub 2019 Sep 30.

2.

A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites.

Suarez C, Lentini G, Ramaswamy R, Maynadier M, Aquilini E, Berry-Sterkers L, Cipriano M, Chen AL, Bradley P, Striepen B, Boulanger MJ, Lebrun M.

Nat Commun. 2019 Sep 6;10(1):4041. doi: 10.1038/s41467-019-11979-z.

3.

The cat is out of the bag: How parasites know their hosts.

English ED, Striepen B.

PLoS Biol. 2019 Sep 5;17(9):e3000446. doi: 10.1371/journal.pbio.3000446. eCollection 2019 Sep.

4.

Life cycle progression and sexual development of the apicomplexan parasite Cryptosporidium parvum.

Tandel J, English ED, Sateriale A, Gullicksrud JA, Beiting DP, Sullivan MC, Pinkston B, Striepen B.

Nat Microbiol. 2019 Dec;4(12):2226-2236. doi: 10.1038/s41564-019-0539-x. Epub 2019 Sep 2.

5.

Genetic Manipulation of Cryptosporidium parvum with CRISPR/Cas9.

Sateriale A, Pawlowic M, Vinayak S, Brooks C, Striepen B.

Methods Mol Biol. 2020;2052:219-228. doi: 10.1007/978-1-4939-9748-0_13.

PMID:
31452165
6.

A Genetically Tractable, Natural Mouse Model of Cryptosporidiosis Offers Insights into Host Protective Immunity.

Sateriale A, Šlapeta J, Baptista R, Engiles JB, Gullicksrud JA, Herbert GT, Brooks CF, Kugler EM, Kissinger JC, Hunter CA, Striepen B.

Cell Host Microbe. 2019 Jul 10;26(1):135-146.e5. doi: 10.1016/j.chom.2019.05.006. Epub 2019 Jun 20.

7.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Baragaña B, Forte B, Choi R, Nakazawa Hewitt S, Bueren-Calabuig JA, Pisco JP, Peet C, Dranow DM, Robinson DA, Jansen C, Norcross NR, Vinayak S, Anderson M, Brooks CF, Cooper CA, Damerow S, Delves M, Dowers K, Duffy J, Edwards TE, Hallyburton I, Horst BG, Hulverson MA, Ferguson L, Jiménez-Díaz MB, Jumani RS, Lorimer DD, Love MS, Maher S, Matthews H, McNamara CW, Miller P, O'Neill S, Ojo KK, Osuna-Cabello M, Pinto E, Post J, Riley J, Rottmann M, Sanz LM, Scullion P, Sharma A, Shepherd SM, Shishikura Y, Simeons FRC, Stebbins EE, Stojanovski L, Straschil U, Tamaki FK, Tamjar J, Torrie LS, Vantaux A, Witkowski B, Wittlin S, Yogavel M, Zuccotto F, Angulo-Barturen I, Sinden R, Baum J, Gamo FJ, Mäser P, Kyle DE, Winzeler EA, Myler PJ, Wyatt PG, Floyd D, Matthews D, Sharma A, Striepen B, Huston CD, Gray DW, Fairlamb AH, Pisliakov AV, Walpole C, Read KD, Van Voorhis WC, Gilbert IH.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7015-7020. doi: 10.1073/pnas.1814685116. Epub 2019 Mar 20.

8.

Cryptosporidium.

Gibson AR, Striepen B.

Curr Biol. 2018 Mar 5;28(5):R193-R194. doi: 10.1016/j.cub.2017.11.070. Review.

9.

Two essential Thioredoxins mediate apicoplast biogenesis, protein import, and gene expression in Toxoplasma gondii.

Biddau M, Bouchut A, Major J, Saveria T, Tottey J, Oka O, van-Lith M, Jennings KE, Ovciarikova J, DeRocher A, Striepen B, Waller RF, Parsons M, Sheiner L.

PLoS Pathog. 2018 Feb 22;14(2):e1006836. doi: 10.1371/journal.ppat.1006836. eCollection 2018 Feb.

10.

PfClpC Is an Essential Clp Chaperone Required for Plastid Integrity and Clp Protease Stability in Plasmodium falciparum.

Florentin A, Cobb DW, Fishburn JD, Cipriano MJ, Kim PS, Fierro MA, Striepen B, Muralidharan V.

Cell Rep. 2017 Nov 14;21(7):1746-1756. doi: 10.1016/j.celrep.2017.10.081.

11.

Generating and Maintaining Transgenic Cryptosporidium parvum Parasites.

Pawlowic MC, Vinayak S, Sateriale A, Brooks CF, Striepen B.

Curr Protoc Microbiol. 2017 Aug 11;46:20B.2.1-20B.2.32. doi: 10.1002/cpmc.33.

12.

A Plastid Protein That Evolved from Ubiquitin and Is Required for Apicoplast Protein Import in Toxoplasma gondii.

Fellows JD, Cipriano MJ, Agrawal S, Striepen B.

MBio. 2017 Jun 27;8(3). pii: e00950-17. doi: 10.1128/mBio.00950-17.

13.

A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis.

Manjunatha UH, Vinayak S, Zambriski JA, Chao AT, Sy T, Noble CG, Bonamy GMC, Kondreddi RR, Zou B, Gedeck P, Brooks CF, Herbert GT, Sateriale A, Tandel J, Noh S, Lakshminarayana SB, Lim SH, Goodman LB, Bodenreider C, Feng G, Zhang L, Blasco F, Wagner J, Leong FJ, Striepen B, Diagana TT.

Nature. 2017 Jun 15;546(7658):376-380. doi: 10.1038/nature22337. Epub 2017 May 31.

14.

Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection.

Arnold SLM, Choi R, Hulverson MA, Schaefer DA, Vinayak S, Vidadala RSR, McCloskey MC, Whitman GR, Huang W, Barrett LK, Ojo KK, Fan E, Maly DJ, Riggs MW, Striepen B, Van Voorhis WC.

J Infect Dis. 2017 Jul 1;216(1):55-63. doi: 10.1093/infdis/jix247.

15.

Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy.

Hulverson MA, Vinayak S, Choi R, Schaefer DA, Castellanos-Gonzalez A, Vidadala RSR, Brooks CF, Herbert GT, Betzer DP, Whitman GR, Sparks HN, Arnold SLM, Rivas KL, Barrett LK, White AC Jr, Maly DJ, Riggs MW, Striepen B, Van Voorhis WC, Ojo KK.

J Infect Dis. 2017 Apr 15;215(8):1275-1284. doi: 10.1093/infdis/jix120. Erratum in: J Infect Dis. 2018 Jan 4;217(2):340.

16.

In Vitro and In Vivo Activities of Sulfur-Containing Linear Bisphosphonates against Apicomplexan Parasites.

Szajnman SH, Galaka T, Li ZH, Li C, Howell NM, Chao MN, Striepen B, Muralidharan V, Moreno SN, Rodriguez JB.

Antimicrob Agents Chemother. 2017 Jan 24;61(2). pii: e01590-16. doi: 10.1128/AAC.01590-16. Print 2017 Feb.

17.

The Import of Proteins into the Mitochondrion of Toxoplasma gondii.

van Dooren GG, Yeoh LM, Striepen B, McFadden GI.

J Biol Chem. 2016 Sep 9;291(37):19335-50. doi: 10.1074/jbc.M116.725069. Epub 2016 Jul 25.

18.

Beg, Borrow and Steal: Three Aspects of Horizontal Gene Transfer in the Protozoan Parasite, Cryptosporidium parvum.

Sateriale A, Striepen B.

PLoS Pathog. 2016 Mar 3;12(3):e1005429. doi: 10.1371/journal.ppat.1005429. eCollection 2016 Mar. No abstract available.

19.

Autophagy-Related Protein ATG8 Has a Noncanonical Function for Apicoplast Inheritance in Toxoplasma gondii.

Lévêque MF, Berry L, Cipriano MJ, Nguyen HM, Striepen B, Besteiro S.

MBio. 2015 Oct 27;6(6):e01446-15. doi: 10.1128/mBio.01446-15.

20.

Toxoplasma gondii Toc75 Functions in Import of Stromal but not Peripheral Apicoplast Proteins.

Sheiner L, Fellows JD, Ovciarikova J, Brooks CF, Agrawal S, Holmes ZC, Bietz I, Flinner N, Heiny S, Mirus O, Przyborski JM, Striepen B.

Traffic. 2015 Dec;16(12):1254-69. doi: 10.1111/tra.12333. Epub 2015 Nov 2.

21.

Two Essential Light Chains Regulate the MyoA Lever Arm To Promote Toxoplasma Gliding Motility.

Williams MJ, Alonso H, Enciso M, Egarter S, Sheiner L, Meissner M, Striepen B, Smith BJ, Tonkin CJ.

MBio. 2015 Sep 15;6(5):e00845-15. doi: 10.1128/mBio.00845-15.

22.

Teaching old drugs new tricks to stop malaria invasion in its tracks.

Muralidharan V, Striepen B.

BMC Biol. 2015 Sep 8;13:72. doi: 10.1186/s12915-015-0185-6.

23.

Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum.

Vinayak S, Pawlowic MC, Sateriale A, Brooks CF, Studstill CJ, Bar-Peled Y, Cipriano MJ, Striepen B.

Nature. 2015 Jul 23;523(7561):477-80. doi: 10.1038/nature14651. Epub 2015 Jul 15.

24.

The intracellular parasite Toxoplasma gondii depends on the synthesis of long-chain and very long-chain unsaturated fatty acids not supplied by the host cell.

Ramakrishnan S, Docampo MD, MacRae JI, Ralton JE, Rupasinghe T, McConville MJ, Striepen B.

Mol Microbiol. 2015 Jul;97(1):64-76. doi: 10.1111/mmi.13010. Epub 2015 Apr 23.

25.

A novel bipartite centrosome coordinates the apicomplexan cell cycle.

Suvorova ES, Francia M, Striepen B, White MW.

PLoS Biol. 2015 Mar 3;13(3):e1002093. doi: 10.1371/journal.pbio.1002093. eCollection 2015 Mar.

26.

Genetic manipulation of the Toxoplasma gondii genome by fosmid recombineering.

Vinayak S, Brooks CF, Naumov A, Suvorova ES, White MW, Striepen B.

MBio. 2014 Dec 2;5(6):e02021. doi: 10.1128/mBio.02021-14.

27.

Lipid kinases are essential for apicoplast homeostasis in Toxoplasma gondii.

Daher W, Morlon-Guyot J, Sheiner L, Lentini G, Berry L, Tawk L, Dubremetz JF, Wengelnik K, Striepen B, Lebrun M.

Cell Microbiol. 2015 Apr;17(4):559-78. doi: 10.1111/cmi.12383. Epub 2014 Nov 22.

28.

A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium.

Checkley W, White AC Jr, Jaganath D, Arrowood MJ, Chalmers RM, Chen XM, Fayer R, Griffiths JK, Guerrant RL, Hedstrom L, Huston CD, Kotloff KL, Kang G, Mead JR, Miller M, Petri WA Jr, Priest JW, Roos DS, Striepen B, Thompson RC, Ward HD, Van Voorhis WA, Xiao L, Zhu G, Houpt ER.

Lancet Infect Dis. 2015 Jan;15(1):85-94. doi: 10.1016/S1473-3099(14)70772-8. Epub 2014 Sep 29. Review.

29.

Identification and characterization of Toxoplasma SIP, a conserved apicomplexan cytoskeleton protein involved in maintaining the shape, motility and virulence of the parasite.

Lentini G, Kong-Hap M, El Hajj H, Francia M, Claudet C, Striepen B, Dubremetz JF, Lebrun M.

Cell Microbiol. 2015 Jan;17(1):62-78. doi: 10.1111/cmi.12337. Epub 2014 Aug 30.

30.

Cell division in apicomplexan parasites.

Francia ME, Striepen B.

Nat Rev Microbiol. 2014 Feb;12(2):125-36. doi: 10.1038/nrmicro3184. Epub 2014 Jan 2. Review.

PMID:
24384598
31.

Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis.

Gorla SK, McNair NN, Yang G, Gao S, Hu M, Jala VR, Haribabu B, Striepen B, Cuny GD, Mead JR, Hedstrom L.

Antimicrob Agents Chemother. 2014;58(3):1603-14. doi: 10.1128/AAC.02075-13. Epub 2013 Dec 23.

32.

Antiapicoplast and gametocytocidal screening to identify the mechanisms of action of compounds within the malaria box.

Bowman JD, Merino EF, Brooks CF, Striepen B, Carlier PR, Cassera MB.

Antimicrob Agents Chemother. 2014;58(2):811-9. doi: 10.1128/AAC.01500-13. Epub 2013 Nov 18.

33.

Parasitic infections: Time to tackle cryptosporidiosis.

Striepen B.

Nature. 2013 Nov 14;503(7475):189-91. No abstract available.

PMID:
24236315
34.

Toxoplasma gondii relies on both host and parasite isoprenoids and can be rendered sensitive to atorvastatin.

Li ZH, Ramakrishnan S, Striepen B, Moreno SN.

PLoS Pathog. 2013;9(10):e1003665. doi: 10.1371/journal.ppat.1003665. Epub 2013 Oct 17.

35.

A nucleolar AAA-NTPase is required for parasite division.

Suvorova ES, Radke JB, Ting LM, Vinayak S, Alvarez CA, Kratzer S, Kim K, Striepen B, White MW.

Mol Microbiol. 2013 Oct;90(2):338-55. doi: 10.1111/mmi.12367. Epub 2013 Sep 11.

36.

Lipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexans.

Ramakrishnan S, Serricchio M, Striepen B, Bütikofer P.

Prog Lipid Res. 2013 Oct;52(4):488-512. doi: 10.1016/j.plipres.2013.06.003. Epub 2013 Jul 1. Review.

37.

The algal past and parasite present of the apicoplast.

van Dooren GG, Striepen B.

Annu Rev Microbiol. 2013;67:271-89. doi: 10.1146/annurev-micro-092412-155741. Epub 2013 Jun 26. Review.

PMID:
23808340
38.

An apicoplast localized ubiquitylation system is required for the import of nuclear-encoded plastid proteins.

Agrawal S, Chung DW, Ponts N, van Dooren GG, Prudhomme J, Brooks CF, Rodrigues EM, Tan JC, Ferdig MT, Striepen B, Le Roch KG.

PLoS Pathog. 2013;9(6):e1003426. doi: 10.1371/journal.ppat.1003426. Epub 2013 Jun 13.

39.

Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase.

Gorla SK, Kavitha M, Zhang M, Chin JE, Liu X, Striepen B, Makowska-Grzyska M, Kim Y, Joachimiak A, Hedstrom L, Cuny GD.

J Med Chem. 2013 May 23;56(10):4028-43. doi: 10.1021/jm400241j. Epub 2013 May 13.

40.

Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice reveal a potential mechanism for parasite spread.

Coombes JL, Charsar BA, Han SJ, Halkias J, Chan SW, Koshy AA, Striepen B, Robey EA.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1913-22. doi: 10.1073/pnas.1220272110. Epub 2013 May 6.

41.

Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase.

Cai G, Deng L, Xue J, Moreno SN, Striepen B, Song Y.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2158-61. doi: 10.1016/j.bmcl.2013.01.097. Epub 2013 Jan 30.

42.

Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum.

Johnson CR, Gorla SK, Kavitha M, Zhang M, Liu X, Striepen B, Mead JR, Cuny GD, Hedstrom L.

Bioorg Med Chem Lett. 2013 Feb 15;23(4):1004-7. doi: 10.1016/j.bmcl.2012.12.037. Epub 2012 Dec 27.

43.

Cell division in Apicomplexan parasites is organized by a homolog of the striated rootlet fiber of algal flagella.

Francia ME, Jordan CN, Patel JD, Sheiner L, Demerly JL, Fellows JD, de Leon JC, Morrissette NS, Dubremetz JF, Striepen B.

PLoS Biol. 2012;10(12):e1001444. doi: 10.1371/journal.pbio.1001444. Epub 2012 Dec 11.

44.

Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii.

MacRae JI, Sheiner L, Nahid A, Tonkin C, Striepen B, McConville MJ.

Cell Host Microbe. 2012 Nov 15;12(5):682-92. doi: 10.1016/j.chom.2012.09.013.

45.

Tic22 is an essential chaperone required for protein import into the apicoplast.

Glaser S, van Dooren GG, Agrawal S, Brooks CF, McFadden GI, Striepen B, Higgins MK.

J Biol Chem. 2012 Nov 16;287(47):39505-12. doi: 10.1074/jbc.M112.405100. Epub 2012 Oct 1.

46.

Selective and potent urea inhibitors of cryptosporidium parvum inosine 5'-monophosphate dehydrogenase.

Gorla SK, Kavitha M, Zhang M, Liu X, Sharling L, Gollapalli DR, Striepen B, Hedstrom L, Cuny GD.

J Med Chem. 2012 Sep 13;55(17):7759-71. doi: 10.1021/jm3007917. Epub 2012 Sep 5.

47.

Protein sorting in complex plastids.

Sheiner L, Striepen B.

Biochim Biophys Acta. 2013 Feb;1833(2):352-9. doi: 10.1016/j.bbamcr.2012.05.030. Epub 2012 Jun 7. Review.

48.

The HU protein is important for apicoplast genome maintenance and inheritance in Toxoplasma gondii.

Reiff SB, Vaishnava S, Striepen B.

Eukaryot Cell. 2012 Jul;11(7):905-15. doi: 10.1128/EC.00029-12. Epub 2012 May 18.

49.

Conditional mutagenesis of a novel choline kinase demonstrates plasticity of phosphatidylcholine biogenesis and gene expression in Toxoplasma gondii.

Sampels V, Hartmann A, Dietrich I, Coppens I, Sheiner L, Striepen B, Herrmann A, Lucius R, Gupta N.

J Biol Chem. 2012 May 11;287(20):16289-99. doi: 10.1074/jbc.M112.347138. Epub 2012 Mar 26.

50.

Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH.

Kirubakaran S, Gorla SK, Sharling L, Zhang M, Liu X, Ray SS, Macpherson IS, Striepen B, Hedstrom L, Cuny GD.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):1985-8. doi: 10.1016/j.bmcl.2012.01.029. Epub 2012 Jan 24.

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