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Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.

Weckbach LT, Grabmaier U, Uhl A, Gess S, Boehm F, Zehrer A, Pick R, Salvermoser M, Czermak T, Pircher J, Sorrelle N, Migliorini M, Strickland DK, Klingel K, Brinkmann V, Abu Abed U, Eriksson U, Massberg S, Brunner S, Walzog B.

J Exp Med. 2019 Feb 4;216(2):350-368. doi: 10.1084/jem.20181102. Epub 2019 Jan 15.


Macrophage LRP1 Promotes Diet-Induced Hepatic Inflammation and Metabolic Dysfunction by Modulating Wnt Signaling.

Au DT, Migliorini M, Strickland DK, Muratoglu SC.

Mediators Inflamm. 2018 Nov 4;2018:7902841. doi: 10.1155/2018/7902841. eCollection 2018.


Pathogen Identification Direct From Polymicrobial Specimens Using Membrane Glycolipids.

Fondrie WE, Liang T, Oyler BL, Leung LM, Ernst RK, Strickland DK, Goodlett DR.

Sci Rep. 2018 Oct 26;8(1):15857. doi: 10.1038/s41598-018-33681-8.


LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Regulates Smooth Muscle Contractility by Modulating Ca2+ Signaling and Expression of Cytoskeleton-Related Proteins.

Au DT, Ying Z, Hernández-Ochoa EO, Fondrie WE, Hampton B, Migliorini M, Galisteo R, Schneider MF, Daugherty A, Rateri DL, Strickland DK, Muratoglu SC.

Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2651-2664. doi: 10.1161/ATVBAHA.118.311197.


Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection.

Aicher BO, Mukhopadhyay S, Lu X, Muratoglu SC, Strickland DK, Ucuzian AA.

J Vis Exp. 2018 Jul 16;(137). doi: 10.3791/57589.


Role of the LDL Receptor-Related Protein 1 in Regulating Protease Activity and Signaling Pathways in the Vasculature.

Au DT, Arai AL, Fondrie WE, Muratoglu SC, Strickland DK.

Curr Drug Targets. 2018;19(11):1276-1288. doi: 10.2174/1389450119666180511162048.


Decreased non-specific adhesivity, receptor targeted (DART) nanoparticles exhibit improved dispersion, cellular uptake, and tumor retention in invasive gliomas.

Wadajkar AS, Dancy JG, Roberts NB, Connolly NP, Strickland DK, Winkles JA, Woodworth GF, Kim AJ.

J Control Release. 2017 Dec 10;267:144-153. doi: 10.1016/j.jconrel.2017.09.006. Epub 2017 Sep 5.


Identification of the ESKAPE pathogens by mass spectrometric analysis of microbial membrane glycolipids.

Leung LM, Fondrie WE, Doi Y, Johnson JK, Strickland DK, Ernst RK, Goodlett DR.

Sci Rep. 2017 Jul 25;7(1):6403. doi: 10.1038/s41598-017-04793-4.


Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke.

Su EJ, Cao C, Fredriksson L, Nilsson I, Stefanitsch C, Stevenson TK, Zhao J, Ragsdale M, Sun YY, Yepes M, Kuan CY, Eriksson U, Strickland DK, Lawrence DA, Zhang L.

Acta Neuropathol. 2017 Oct;134(4):585-604. doi: 10.1007/s00401-017-1749-z. Epub 2017 Jul 19.


Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function.

Yu D, Makkar G, Sarkar R, Strickland DK, Monahan TS.

J Vis Exp. 2017 Jun 11;(124). doi: 10.3791/55201.


The LDL Receptor-Related Protein 1: At the Crossroads of Lipoprotein Metabolism and Insulin Signaling.

Au DT, Strickland DK, Muratoglu SC.

J Diabetes Res. 2017;2017:8356537. doi: 10.1155/2017/8356537. Epub 2017 May 11. Review.


ORAL02.01: Safety and Efficacy of Single-Agent Rovalpituzumab Tesirine, a DLL3-Targeted ADC, in Recurrent or Refractory SCLC: Topic: Medical Oncology.

Bauer TM, Spigel D, Ready N, Morgensztern D, Glisson BS, Byers LA, Burris H, Robert F, Strickland DK, Pietanza MC, Govindan R, Dylla SJ, Peng S, Rudin C.

J Thorac Oncol. 2016 Nov;11(11S):S252-S253. doi: 10.1016/j.jtho.2016.09.010. Epub 2016 Oct 28. No abstract available.


Rovalpituzumab tesirine, a DLL3-targeted antibody-drug conjugate, in recurrent small-cell lung cancer: a first-in-human, first-in-class, open-label, phase 1 study.

Rudin CM, Pietanza MC, Bauer TM, Ready N, Morgensztern D, Glisson BS, Byers LA, Johnson ML, Burris HA 3rd, Robert F, Han TH, Bheddah S, Theiss N, Watson S, Mathur D, Vennapusa B, Zayed H, Lally S, Strickland DK, Govindan R, Dylla SJ, Peng SL, Spigel DR; SCRX16-001 investigators.

Lancet Oncol. 2017 Jan;18(1):42-51. doi: 10.1016/S1470-2045(16)30565-4. Epub 2016 Dec 5.


Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.

Doherty CM, Visse R, Dinakarpandian D, Strickland DK, Nagase H, Troeberg L.

J Biol Chem. 2016 Oct 14;291(42):22160-22172. Epub 2016 Aug 31.


Anti-VLDL receptor monoclonal antibodies inhibit fibrin-VLDL receptor interaction and reduce fibrin-dependent leukocyte transmigration.

Yakovlev S, Belkin AM, Chen L, Cao C, Zhang L, Strickland DK, Medved L.

Thromb Haemost. 2016 Nov 30;116(6):1122-1130. Epub 2016 Sep 1.


MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1.

Yamamoto K, Okano H, Miyagawa W, Visse R, Shitomi Y, Santamaria S, Dudhia J, Troeberg L, Strickland DK, Hirohata S, Nagase H.

Matrix Biol. 2016 Dec;56:57-73. doi: 10.1016/j.matbio.2016.03.007. Epub 2016 Apr 12.


Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3.

Noyes NC, Hampton B, Migliorini M, Strickland DK.

Biochemistry. 2016 Mar 1;55(8):1204-13. doi: 10.1021/acs.biochem.5b01218. Epub 2016 Feb 17.


LRP in Endothelial Cells: A Little Goes a Long Way.

Strickland DK, Muratoglu SC.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):213-6. doi: 10.1161/ATVBAHA.115.306895. No abstract available.


Correction: LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages.

Lillis AP, Muratoglu SC, Au DT, Migliorini M, Lee MJ, Fried SK, Mikhailenko I, Strickland DK.

PLoS One. 2016 Jan 21;11(1):e0147457. doi: 10.1371/journal.pone.0147457. eCollection 2016. No abstract available.


MARCKS Signaling Differentially Regulates Vascular Smooth Muscle and Endothelial Cell Proliferation through a KIS-, p27kip1- Dependent Mechanism.

Yu D, Makkar G, Dong T, Strickland DK, Sarkar R, Monahan TS.

PLoS One. 2015 Nov 3;10(11):e0141397. doi: 10.1371/journal.pone.0141397. eCollection 2015.


Myristoylated Alanine-Rich Protein Kinase Substrate (MARCKS) Regulates Small GTPase Rac1 and Cdc42 Activity and Is a Critical Mediator of Vascular Smooth Muscle Cell Migration in Intimal Hyperplasia Formation.

Yu D, Makkar G, Strickland DK, Blanpied TA, Stumpo DJ, Blackshear PJ, Sarkar R, Monahan TS.

J Am Heart Assoc. 2015 Oct 8;4(10):e002255. doi: 10.1161/JAHA.115.002255.


Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1.

Kang LI, Isse K, Koral K, Bowen WC, Muratoglu S, Strickland DK, Michalopoulos GK, Mars WM.

Lab Invest. 2015 Oct;95(10):1117-29. doi: 10.1038/labinvest.2015.94. Epub 2015 Aug 3.


Mac-1 Regulates IL-13 Activity in Macrophages by Directly Interacting with IL-13Rα1.

Cao C, Zhao J, Doughty EK, Migliorini M, Strickland DK, Kann MG, Zhang L.

J Biol Chem. 2015 Aug 28;290(35):21642-51. doi: 10.1074/jbc.M115.645796. Epub 2015 Jul 9.


LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages.

Lillis AP, Muratoglu SC, Au DT, Migliorini M, Lee MJ, Fried SK, Mikhailenko I, Strickland DK.

PLoS One. 2015 Jun 10;10(6):e0128903. doi: 10.1371/journal.pone.0128903. eCollection 2015. Erratum in: PLoS One. 2016;11(1):e0147457.


Generation of a Potent Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Antagonist by Engineering a Stable Form of the Receptor-associated Protein (RAP) D3 Domain.

Prasad JM, Migliorini M, Galisteo R, Strickland DK.

J Biol Chem. 2015 Jul 10;290(28):17262-8. doi: 10.1074/jbc.M115.660084. Epub 2015 May 26.


Smooth muscle cell deletion of low-density lipoprotein receptor-related protein 1 augments angiotensin II-induced superior mesenteric arterial and ascending aortic aneurysms.

Davis FM, Rateri DL, Balakrishnan A, Howatt DA, Strickland DK, Muratoglu SC, Haggerty CM, Fornwalt BK, Cassis LA, Daugherty A.

Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):155-62. doi: 10.1161/ATVBAHA.114.304683. Epub 2014 Nov 13.


Enhanced venous thrombus resolution in plasminogen activator inhibitor type-2 deficient mice.

Siefert SA, Chabasse C, Mukhopadhyay S, Hoofnagle MH, Strickland DK, Sarkar R, Antalis TM.

J Thromb Haemost. 2014 Oct;12(10):1706-16. doi: 10.1111/jth.12657. Epub 2014 Sep 30.


Low-density lipoprotein receptor-related protein-1: role in the regulation of vascular integrity.

Strickland DK, Au DT, Cunfer P, Muratoglu SC.

Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):487-98. doi: 10.1161/ATVBAHA.113.301924. Epub 2014 Feb 6. Review.


Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding.

Yamamoto K, Owen K, Parker AE, Scilabra SD, Dudhia J, Strickland DK, Troeberg L, Nagase H.

J Biol Chem. 2014 Mar 7;289(10):6462-74. doi: 10.1074/jbc.M113.545376. Epub 2014 Jan 28.


The LDL receptor-related protein 1 (LRP1) regulates the PDGF signaling pathway by binding the protein phosphatase SHP-2 and modulating SHP-2- mediated PDGF signaling events.

Craig J, Mikhailenko I, Noyes N, Migliorini M, Strickland DK.

PLoS One. 2013 Jul 26;8(7):e70432. doi: 10.1371/journal.pone.0070432. Print 2013.


LRP1 protects the vasculature by regulating levels of connective tissue growth factor and HtrA1.

Muratoglu SC, Belgrave S, Hampton B, Migliorini M, Coksaygan T, Chen L, Mikhailenko I, Strickland DK.

Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2137-46. doi: 10.1161/ATVBAHA.113.301893. Epub 2013 Jul 18.


Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1).

Wahler A, Beyer AS, Keller IE, Schnack C, von Einem B, Pröpper C, Boeckers TM, Peltan ID, Strickland DK, Hyman BT, von Arnim CA.

Biochem J. 2013 Mar 1;450(2):333-43. doi: 10.1042/BJ20121100.


Differential regulation of extracellular tissue inhibitor of metalloproteinases-3 levels by cell membrane-bound and shed low density lipoprotein receptor-related protein 1.

Scilabra SD, Troeberg L, Yamamoto K, Emonard H, Thøgersen I, Enghild JJ, Strickland DK, Nagase H.

J Biol Chem. 2013 Jan 4;288(1):332-42. doi: 10.1074/jbc.M112.393322. Epub 2012 Nov 19.


LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.

Yamamoto K, Troeberg L, Scilabra SD, Pelosi M, Murphy CL, Strickland DK, Nagase H.

FASEB J. 2013 Feb;27(2):511-21. doi: 10.1096/fj.12-216671. Epub 2012 Oct 11.


Macrophage LRP1 suppresses neo-intima formation during vascular remodeling by modulating the TGF-β signaling pathway.

Muratoglu SC, Belgrave S, Lillis AP, Migliorini M, Robinson S, Smith E, Zhang L, Strickland DK.

PLoS One. 2011;6(12):e28846. doi: 10.1371/journal.pone.0028846. Epub 2011 Dec 9.


Identification of VLDLR as a novel endothelial cell receptor for fibrin that modulates fibrin-dependent transendothelial migration of leukocytes.

Yakovlev S, Mikhailenko I, Cao C, Zhang L, Strickland DK, Medved L.

Blood. 2012 Jan 12;119(2):637-44. doi: 10.1182/blood-2011-09-382580. Epub 2011 Nov 17.


LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking.

Ranganathan S, Noyes NC, Migliorini M, Winkles JA, Battey FD, Hyman BT, Smith E, Yepes M, Mikhailenko I, Strickland DK.

J Neurosci. 2011 Jul 27;31(30):10836-46. doi: 10.1523/JNEUROSCI.5065-10.2011.


Interaction of fibrin with VE-cadherin and anti-inflammatory effect of fibrin-derived fragments.

Yakovlev S, Gao Y, Cao C, Chen L, Strickland DK, Zhang L, Medved L.

J Thromb Haemost. 2011 Sep;9(9):1847-55. doi: 10.1111/j.1538-7836.2011.04438.x.


Murine missing in metastasis (MIM) mediates cell polarity and regulates the motility response to growth factors.

Yu D, Zhan XH, Niu S, Mikhailenko I, Strickland DK, Zhu J, Cao M, Zhan X.

PLoS One. 2011;6(6):e20845. doi: 10.1371/journal.pone.0020845. Epub 2011 Jun 9.


Serpin-Enzyme Receptors LDL Receptor-Related Protein 1.

Strickland DK, Muratoglu SC, Antalis TM.

Methods Enzymol. 2011;499:17-31. doi: 10.1016/B978-0-12-386471-0.00002-X.


Molecular basis for the interaction of low density lipoprotein receptor-related protein 1 (LRP1) with integrin alphaMbeta2: identification of binding sites within alphaMbeta2 for LRP1.

Ranganathan S, Cao C, Catania J, Migliorini M, Zhang L, Strickland DK.

J Biol Chem. 2011 Sep 2;286(35):30535-41. doi: 10.1074/jbc.M111.265413. Epub 2011 Jun 15.


The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction.

Perman JC, Boström P, Lindbom M, Lidberg U, StÅhlman M, Hägg D, Lindskog H, Scharin Täng M, Omerovic E, Mattsson Hultén L, Jeppsson A, Petursson P, Herlitz J, Olivecrona G, Strickland DK, Ekroos K, Olofsson SO, Borén J.

J Clin Invest. 2011 Jul;121(7):2625-40. doi: 10.1172/JCI43068. Epub 2011 Jun 13.


Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling.

Meng H, Zhang X, Lee SJ, Strickland DK, Lawrence DA, Wang MM.

J Biol Chem. 2010 Jul 23;285(30):23047-55. doi: 10.1074/jbc.M110.144634. Epub 2010 May 14.


Low density lipoprotein receptor-related protein 1 (LRP1) forms a signaling complex with platelet-derived growth factor receptor-beta in endosomes and regulates activation of the MAPK pathway.

Muratoglu SC, Mikhailenko I, Newton C, Migliorini M, Strickland DK.

J Biol Chem. 2010 May 7;285(19):14308-17. doi: 10.1074/jbc.M109.046672. Epub 2010 Mar 10.


A new plasminogen receptor.

Strickland DK.

Blood. 2010 Feb 18;115(7):1315-6. doi: 10.1182/blood-2009-11-254045.


Inhibition of Abeta aggregation and neurotoxicity by the 39-kDa receptor-associated protein.

Kerr ML, Gasperini R, Gibbs ME, Hou X, Shepherd CE, Strickland DK, Foa L, Lawen A, Small DH.

J Neurochem. 2010 Mar;112(5):1199-209. doi: 10.1111/j.1471-4159.2009.06540.x. Epub 2009 Dec 10.


Microglial low-density lipoprotein receptor-related protein 1 mediates the effect of tissue-type plasminogen activator on matrix metalloproteinase-9 activity in the ischemic brain.

Zhang C, An J, Haile WB, Echeverry R, Strickland DK, Yepes M.

J Cereb Blood Flow Metab. 2009 Dec;29(12):1946-54. doi: 10.1038/jcbfm.2009.174. Epub 2009 Aug 12.


Microglial low-density lipoprotein receptor-related protein 1 modulates c-Jun N-terminal kinase activation.

Pocivavsek A, Mikhailenko I, Strickland DK, Rebeck GW.

J Neuroimmunol. 2009 Sep 29;214(1-2):25-32. doi: 10.1016/j.jneuroim.2009.06.010. Epub 2009 Jul 7.

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