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Influence of the extracellular matrix on cell-intrinsic circadian clocks.

Streuli CH, Meng QJ.

J Cell Sci. 2019 Feb 1;132(3). pii: jcs207498. doi: 10.1242/jcs.207498. Review.


Disrupted circadian clocks and altered tissue mechanics in primary human breast tumours.

Broadberry E, McConnell J, Williams J, Yang N, Zindy E, Leek A, Waddington R, Joseph L, Howe M, Meng QJ, Streuli CH.

Breast Cancer Res. 2018 Oct 22;20(1):125. doi: 10.1186/s13058-018-1053-4.


Integrin-Rac signalling for mammary epithelial stem cell self-renewal.

Olabi S, Ucar A, Brennan K, Streuli CH.

Breast Cancer Res. 2018 Oct 22;20(1):128. doi: 10.1186/s13058-018-1048-1.


Epithelial and stromal circadian clocks are inversely regulated by their mechano-matrix environment.

Williams J, Yang N, Wood A, Zindy E, Meng QJ, Streuli CH.

J Cell Sci. 2018 Mar 6;131(5). pii: jcs208223. doi: 10.1242/jcs.208223.


Extracellular matrix promotes clathrin-dependent endocytosis of prolactin and STAT5 activation in differentiating mammary epithelial cells.

Bridgewater RE, Streuli CH, Caswell PT.

Sci Rep. 2017 Jul 4;7(1):4572. doi: 10.1038/s41598-017-04783-6.


The requirement of integrins for breast epithelial proliferation.

Moreno-Layseca P, Ucar A, Sun H, Wood A, Olabi S, Gilmore AP, Brennan K, Streuli CH.

Eur J Cell Biol. 2017 May;96(3):227-239. doi: 10.1016/j.ejcb.2017.03.005. Epub 2017 Mar 14.


Cellular mechano-environment regulates the mammary circadian clock.

Yang N, Williams J, Pekovic-Vaughan V, Wang P, Olabi S, McConnell J, Gossan N, Hughes A, Cheung J, Streuli CH, Meng QJ.

Nat Commun. 2017 Jan 30;8:14287. doi: 10.1038/ncomms14287.


Integrins as architects of cell behavior.

Streuli CH.

Mol Biol Cell. 2016 Oct 1;27(19):2885-8. doi: 10.1091/mbc.E15-06-0369. Review.


Rac1 Controls Both the Secretory Function of the Mammary Gland and Its Remodeling for Successive Gestations.

Akhtar N, Li W, Mironov A, Streuli CH.

Dev Cell. 2016 Sep 12;38(5):522-35. doi: 10.1016/j.devcel.2016.08.005.


Oncogenic activation of FAK drives apoptosis suppression in a 3D-culture model of breast cancer initiation.

Walker S, Foster F, Wood A, Owens T, Brennan K, Streuli CH, Gilmore AP.

Oncotarget. 2016 Oct 25;7(43):70336-70352. doi: 10.18632/oncotarget.11856.


Circadian clocks and breast cancer.

Blakeman V, Williams JL, Meng QJ, Streuli CH.

Breast Cancer Res. 2016 Sep 2;18(1):89. doi: 10.1186/s13058-016-0743-z. Review.


Raised mammographic density: causative mechanisms and biological consequences.

Sherratt MJ, McConnell JC, Streuli CH.

Breast Cancer Res. 2016 May 3;18(1):45. doi: 10.1186/s13058-016-0701-9. Review.


The Integrin-Mediated ILK-Parvin-αPix Signaling Axis Controls Differentiation in Mammary Epithelial Cells.

Rooney N, Wang P, Brennan K, Gilmore AP, Streuli CH.

J Cell Physiol. 2016 Nov;231(11):2408-17. doi: 10.1002/jcp.25390. Epub 2016 Jun 10.


Cellular microenvironment controls the nuclear architecture of breast epithelia through β1-integrin.

Maya-Mendoza A, Bartek J, Jackson DA, Streuli CH.

Cell Cycle. 2016;15(3):345-56. doi: 10.1080/15384101.2015.1121354.


Increased peri-ductal collagen micro-organization may contribute to raised mammographic density.

McConnell JC, O'Connell OV, Brennan K, Weiping L, Howe M, Joseph L, Knight D, O'Cualain R, Lim Y, Leek A, Waddington R, Rogan J, Astley SM, Gandhi A, Kirwan CC, Sherratt MJ, Streuli CH.

Breast Cancer Res. 2016 Jan 8;18(1):5. doi: 10.1186/s13058-015-0664-2.


Integrin α4β1 controls G9a activity that regulates epigenetic changes and nuclear properties required for lymphocyte migration.

Zhang X, Cook PC, Zindy E, Williams CJ, Jowitt TA, Streuli CH, MacDonald AS, Redondo-Muñoz J.

Nucleic Acids Res. 2016 Apr 20;44(7):3031-44. doi: 10.1093/nar/gkv1348. Epub 2015 Dec 10.


The Immunology of Breast Development.

Travis MA, Streuli CH.

Dev Cell. 2015 Sep 14;34(5):487-8. doi: 10.1016/j.devcel.2015.08.015.


A role for β3-integrins in linking breast development and cancer.

Ucar A, Streuli CH.

Dev Cell. 2014 Aug 11;30(3):251-2. doi: 10.1016/j.devcel.2014.07.009.


FGF ligands of the postnatal mammary stroma regulate distinct aspects of epithelial morphogenesis.

Zhang X, Martinez D, Koledova Z, Qiao G, Streuli CH, Lu P.

Development. 2014 Sep;141(17):3352-62. doi: 10.1242/dev.106732. Epub 2014 Jul 30.


Immortalised breast epithelia survive prolonged DNA replication stress and return to cycle from a senescent-like state.

Maya-Mendoza A, Merchut-Maya JM, Bartkova J, Bartek J, Streuli CH, Jackson DA.

Cell Death Dis. 2014 Jul 24;5:e1351. doi: 10.1038/cddis.2014.315.


Integrins and epithelial cell polarity.

Lee JL, Streuli CH.

J Cell Sci. 2014 Aug 1;127(Pt 15):3217-25. doi: 10.1242/jcs.146142. Epub 2014 Jul 2. Review.


Phosphorylation of the proapoptotic BH3-only protein bid primes mitochondria for apoptosis during mitotic arrest.

Wang P, Lindsay J, Owens TW, Mularczyk EJ, Warwood S, Foster F, Streuli CH, Brennan K, Gilmore AP.

Cell Rep. 2014 May 8;7(3):661-71. doi: 10.1016/j.celrep.2014.03.050. Epub 2014 Apr 24.


Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K, Brown NJ, Bryant HE, Bundred NJ, Burchell JM, Campbell AM, Carroll JS, Clarke RB, Coles CE, Cook GJ, Cox A, Curtin NJ, Dekker LV, Silva Idos S, Duffy SW, Easton DF, Eccles DM, Edwards DR, Edwards J, Evans D, Fenlon DF, Flanagan JM, Foster C, Gallagher WM, Garcia-Closas M, Gee JM, Gescher AJ, Goh V, Groves AM, Harvey AJ, Harvie M, Hennessy BT, Hiscox S, Holen I, Howell SJ, Howell A, Hubbard G, Hulbert-Williams N, Hunter MS, Jasani B, Jones LJ, Key TJ, Kirwan CC, Kong A, Kunkler IH, Langdon SP, Leach MO, Mann DJ, Marshall JF, Martin L, Martin SG, Macdougall JE, Miles DW, Miller WR, Morris JR, Moss SM, Mullan P, Natrajan R, O'Connor JP, O'Connor R, Palmieri C, Pharoah PD, Rakha EA, Reed E, Robinson SP, Sahai E, Saxton JM, Schmid P, Smalley MJ, Speirs V, Stein R, Stingl J, Streuli CH, Tutt AN, Velikova G, Walker RA, Watson CJ, Williams KJ, Young LS, Thompson AM.

Breast Cancer Res. 2013 Oct 1;15(5):R92. doi: 10.1186/bcr3493. Review.


Signalling pathways linking integrins with cell cycle progression.

Moreno-Layseca P, Streuli CH.

Matrix Biol. 2014 Feb;34:144-53. doi: 10.1016/j.matbio.2013.10.011. Epub 2013 Oct 30. Review.


How integrins control breast biology.

Glukhova MA, Streuli CH.

Curr Opin Cell Biol. 2013 Oct;25(5):633-41. doi: 10.1016/ Epub 2013 Jul 22. Review.


Inhibitor of Apoptosis Proteins: Promising Targets for Cancer Therapy.

Owens TW, Gilmore AP, Streuli CH, Foster FM.

J Carcinog Mutagen. 2013 May 27;Suppl 14. pii: S14-004.


Bax exists in a dynamic equilibrium between the cytosol and mitochondria to control apoptotic priming.

Schellenberg B, Wang P, Keeble JA, Rodriguez-Enriquez R, Walker S, Owens TW, Foster F, Tanianis-Hughes J, Brennan K, Streuli CH, Gilmore AP.

Mol Cell. 2013 Mar 7;49(5):959-71. doi: 10.1016/j.molcel.2012.12.022. Epub 2013 Jan 31.


Specific β-containing integrins exert differential control on proliferation and two-dimensional collective cell migration in mammary epithelial cells.

Jeanes AI, Wang P, Moreno-Layseca P, Paul N, Cheung J, Tsang R, Akhtar N, Foster FM, Brennan K, Streuli CH.

J Biol Chem. 2012 Jul 13;287(29):24103-12. doi: 10.1074/jbc.M112.360834. Epub 2012 Apr 16.


The C terminus of talin links integrins to cell cycle progression.

Wang P, Ballestrem C, Streuli CH.

J Cell Biol. 2011 Oct 31;195(3):499-513. doi: 10.1083/jcb.201104128.


The RhoA-Rok-myosin II pathway is involved in extracellular matrix-mediated regulation of prolactin signaling in mammary epithelial cells.

Du JY, Chen MC, Hsu TC, Wang JH, Brackenbury L, Lin TH, Wu YY, Yang Z, Streuli CH, Lee YJ.

J Cell Physiol. 2012 Apr;227(4):1553-60. doi: 10.1002/jcp.22886.


How integrins control mammary epithelial differentiation: a possible role for the ILK-PINCH-Parvin complex.

Rooney N, Streuli CH.

FEBS Lett. 2011 Jun 6;585(11):1663-72. doi: 10.1016/j.febslet.2011.05.014. Epub 2011 May 10. Review.


Cellular microenvironment influences the ability of mammary epithelia to undergo cell cycle.

Jeanes AI, Maya-Mendoza A, Streuli CH.

PLoS One. 2011 Mar 29;6(3):e18144. doi: 10.1371/journal.pone.0018144.


Cell-matrix interactions in mammary gland development and breast cancer.

Muschler J, Streuli CH.

Cold Spring Harb Perspect Biol. 2010 Oct;2(10):a003202. doi: 10.1101/cshperspect.a003202. Epub 2010 Aug 11. Review.


Analysis of inhibitor of apoptosis protein family expression during mammary gland development.

Owens TW, Foster FM, Tanianis-Hughes J, Cheung JY, Brackenbury L, Streuli CH.

BMC Dev Biol. 2010 Jun 28;10:71. doi: 10.1186/1471-213X-10-71.


Role for X-linked Inhibitor of apoptosis protein upstream of mitochondrial permeabilization.

Owens TW, Foster FM, Valentijn A, Gilmore AP, Streuli CH.

J Biol Chem. 2010 Jan 8;285(2):1081-8. doi: 10.1074/jbc.M109.072322. Epub 2009 Oct 29.


Advanced glycation end products in extracellular matrix proteins contribute to the failure of sensory nerve regeneration in diabetes.

Duran-Jimenez B, Dobler D, Moffatt S, Rabbani N, Streuli CH, Thornalley PJ, Tomlinson DR, Gardiner NJ.

Diabetes. 2009 Dec;58(12):2893-903. doi: 10.2337/db09-0320. Epub 2009 Aug 31.


Targeting inhibitor of apoptosis proteins in combination with ErbB antagonists in breast cancer.

Foster FM, Owens TW, Tanianis-Hughes J, Clarke RB, Brennan K, Bundred NJ, Streuli CH.

Breast Cancer Res. 2009;11(3):R41. doi: 10.1186/bcr2328. Epub 2009 Jun 29.


Extracellular matrix controls insulin signaling in mammary epithelial cells through the RhoA/Rok pathway.

Lee YJ, Hsu TC, Du JY, Valentijn AJ, Wu TY, Cheng CF, Yang Z, Streuli CH.

J Cell Physiol. 2009 Aug;220(2):476-84. doi: 10.1002/jcp.21793.


Analyzing how cell adhesion controls mammary gland function by transplantation of embryonic mammary tissue from knockout mice.

Klinowska TC, Streuli CH.

Methods Mol Biol. 2009;522:331-45. doi: 10.1007/978-1-59745-413-1_22.


Signal co-operation between integrins and other receptor systems.

Streuli CH, Akhtar N.

Biochem J. 2009 Mar 15;418(3):491-506. doi: 10.1042/BJ20081948. Review.


Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation.

Akhtar N, Marlow R, Lambert E, Schatzmann F, Lowe ET, Cheung J, Katz E, Li W, Wu C, Dedhar S, Naylor MJ, Streuli CH.

Development. 2009 Mar;136(6):1019-27. doi: 10.1242/dev.028423. Epub 2009 Feb 11.


FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: differential roles for paxillin and p130Cas.

Zouq NK, Keeble JA, Lindsay J, Valentijn AJ, Zhang L, Mills D, Turner CE, Streuli CH, Gilmore AP.

J Cell Sci. 2009 Feb 1;122(Pt 3):357-67. doi: 10.1242/jcs.030478. Epub 2009 Jan 6.


Integrins and cell-fate determination.

Streuli CH.

J Cell Sci. 2009 Jan 15;122(Pt 2):171-7. doi: 10.1242/jcs.018945. Review.


The Mcf1 toxin induces apoptosis via the mitochondrial pathway and apoptosis is attenuated by mutation of the BH3-like domain.

Dowling AJ, Waterfield NR, Hares MC, Le Goff G, Streuli CH, ffrench-Constant RH.

Cell Microbiol. 2007 Oct;9(10):2470-84.


Preconditioning injury-induced neurite outgrowth of adult rat sensory neurons on fibronectin is mediated by mobilisation of axonal alpha5 integrin.

Gardiner NJ, Moffatt S, Fernyhough P, Humphries MJ, Streuli CH, Tomlinson DR.

Mol Cell Neurosci. 2007 Jun;35(2):249-60. Epub 2007 Mar 6.


The extracellular matrix as an adhesion checkpoint for mammary epithelial function.

Katz E, Streuli CH.

Int J Biochem Cell Biol. 2007;39(4):715-26. Epub 2006 Nov 23. Review.


Ablation of beta1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation.

Naylor MJ, Li N, Cheung J, Lowe ET, Lambert E, Marlow R, Wang P, Schatzmann F, Wintermantel T, Schüetz G, Clarke AR, Mueller U, Hynes NE, Streuli CH.

J Cell Biol. 2005 Nov 21;171(4):717-28.


Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli.

Li N, Zhang Y, Naylor MJ, Schatzmann F, Maurer F, Wintermantel T, Schuetz G, Mueller U, Streuli CH, Hynes NE.

EMBO J. 2005 Jun 1;24(11):1942-53. Epub 2005 May 12.

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