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Items: 1 to 50 of 67

1.

Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8- and 9-Deoxygenated 2,3-Difluoro- N-acetylneuraminic Acid Derivatives.

McKimm-Breschkin JL, Barrett S, Pilling PA, Hader S, Watts AG, Streltsov VA.

J Med Chem. 2018 Mar 8;61(5):1921-1933. doi: 10.1021/acs.jmedchem.7b01467. Epub 2018 Feb 15.

PMID:
29397718
2.

Nanocrystallography measurements of early stage synthetic malaria pigment.

Dilanian RA, Streltsov V, Coughlan HD, Quiney HM, Martin AV, Klonis N, Dogovski C, Boutet S, Messerschmidt M, Williams GJ, Williams S, Phillips NW, Nugent KA, Tilley L, Abbey B.

J Appl Crystallogr. 2017 Sep 28;50(Pt 5):1533-1540. doi: 10.1107/S1600576717012663. eCollection 2017 Oct 1.

3.

Measurements of Long-range Electronic Correlations During Femtosecond Diffraction Experiments Performed on Nanocrystals of Buckminsterfullerene.

Ryan RA, Williams S, Martin AV, Dilanian RA, Darmanin C, Putkunz CT, Wood D, Streltsov VA, Jones MWM, Gaffney N, Hofmann F, Williams GJ, Boutet S, Messerschmidt M, Seibert MM, Curwood EK, Balaur E, Peele AG, Nugent KA, Quiney HM, Abbey B.

J Vis Exp. 2017 Aug 22;(126). doi: 10.3791/56296.

4.

Lysine post-translational modification of glyceraldehyde-3-phosphate dehydrogenase regulates hepatic and systemic metabolism.

Bond ST, Howlett KF, Kowalski GM, Mason S, Connor T, Cooper A, Streltsov V, Bruce CR, Walder KR, McGee SL.

FASEB J. 2017 Jun;31(6):2592-2602. doi: 10.1096/fj.201601215R. Epub 2017 Mar 3.

PMID:
28258188
5.

Iron, Copper, and Zinc Concentration in Aβ Plaques in the APP/PS1 Mouse Model of Alzheimer's Disease Correlates with Metal Levels in the Surrounding Neuropil.

James SA, Churches QI, de Jonge MD, Birchall IE, Streltsov V, McColl G, Adlard PA, Hare DJ.

ACS Chem Neurosci. 2017 Mar 15;8(3):629-637. doi: 10.1021/acschemneuro.6b00362. Epub 2016 Dec 22.

PMID:
27958708
6.

Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D.

Davydova N, Harris NC, Roufail S, Paquet-Fifield S, Ishaq M, Streltsov VA, Williams SP, Karnezis T, Stacker SA, Achen MG.

J Biol Chem. 2016 Dec 30;291(53):27265-27278. doi: 10.1074/jbc.M116.736801. Epub 2016 Nov 16.

7.

X-ray laser-induced electron dynamics observed by femtosecond diffraction from nanocrystals of Buckminsterfullerene.

Abbey B, Dilanian RA, Darmanin C, Ryan RA, Putkunz CT, Martin AV, Wood D, Streltsov V, Jones MW, Gaffney N, Hofmann F, Williams GJ, Boutet S, Messerschmidt M, Seibert MM, Williams S, Curwood E, Balaur E, Peele AG, Nugent KA, Quiney HM.

Sci Adv. 2016 Sep 9;2(9):e1601186. doi: 10.1126/sciadv.1601186. eCollection 2016 Sep.

8.

Whole-pattern fitting technique in serial femtosecond nanocrystallography.

Dilanian RA, Williams SR, Martin AV, Streltsov VA, Quiney HM.

IUCrJ. 2016 Feb 12;3(Pt 2):127-38. doi: 10.1107/S2052252516001238. eCollection 2016 Mar 1.

9.

Catalytic mechanism and novel receptor binding sites of human parainfluenza virus type 3 hemagglutinin-neuraminidase (hPIV3 HN).

Streltsov VA, Pilling P, Barrett S, McKimm-Breschkin JL.

Antiviral Res. 2015 Nov;123:216-23. doi: 10.1016/j.antiviral.2015.08.014. Epub 2015 Sep 10.

PMID:
26364554
10.

Alkoxide coordination of iron(III) protoporphyrin IX by antimalarial quinoline methanols: a key interaction observed in the solid-state and solution.

Gildenhuys J, Sammy CJ, Müller R, Streltsov VA, le Roex T, Kuter D, de Villiers KA.

Dalton Trans. 2015 Oct 14;44(38):16767-77. doi: 10.1039/c5dt02671g. Epub 2015 Sep 3.

PMID:
26335948
11.

Solution structures of chloroquine-ferriheme complexes modeled using MD simulation and investigated by EXAFS spectroscopy.

Kuter D, Streltsov V, Davydova N, Venter GA, Naidoo KJ, Egan TJ.

J Inorg Biochem. 2016 Jan;154:114-25. doi: 10.1016/j.jinorgbio.2015.06.010. Epub 2015 Jun 11.

PMID:
26088729
12.

Design of non-aggregating variants of Aβ peptide.

Caine JM, Churches Q, Waddington L, Nigro J, Breheney K, Masters CL, Nuttall SD, Streltsov VA.

Biochem Biophys Res Commun. 2014 Oct 24;453(3):449-54. doi: 10.1016/j.bbrc.2014.09.102. Epub 2014 Oct 1.

PMID:
25281534
13.

Molecular structures and solvation of free monomeric and dimeric ferriheme in aqueous solution: insights from molecular dynamics simulations and extended X-ray absorption fine structure spectroscopy.

Kuter D, Streltsov V, Davydova N, Venter GA, Naidoo KJ, Egan TJ.

Inorg Chem. 2014 Oct 20;53(20):10811-24. doi: 10.1021/ic500454d. Epub 2014 Oct 2.

PMID:
25275882
14.

Unprecedented conformational flexibility revealed in the ligand-binding domains of the Bovicola ovis ecdysone receptor (EcR) and ultraspiracle (USP) subunits.

Ren B, Peat TS, Streltsov VA, Pollard M, Fernley R, Grusovin J, Seabrook S, Pilling P, Phan T, Lu L, Lovrecz GO, Graham LD, Hill RJ.

Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):1954-64. doi: 10.1107/S1399004714009626. Epub 2014 Jun 29.

PMID:
25004972
15.

Naturally occurring polyphenolic inhibitors of amyloid beta aggregation.

Churches QI, Caine J, Cavanagh K, Epa VC, Waddington L, Tranberg CE, Meyer AG, Varghese JN, Streltsov V, Duggan PJ.

Bioorg Med Chem Lett. 2014 Jul 15;24(14):3108-12. doi: 10.1016/j.bmcl.2014.05.008. Epub 2014 May 13.

PMID:
24878198
16.

Structural insights into the interaction of platinum-based inhibitors with the Alzheimer's disease amyloid-β peptide.

Streltsov VA, Chandana Epa V, James SA, Churches QI, Caine JM, Kenche VB, Barnham KJ.

Chem Commun (Camb). 2013 Dec 18;49(97):11364-6. doi: 10.1039/c3cc47326k.

PMID:
24161993
17.

Inhibition of amyloid beta-induced synaptotoxicity by a pentapeptide derived from the glycine zipper region of the neurotoxic peptide.

Peters C, Fernandez-Perez EJ, Burgos CF, Espinoza MP, Castillo C, Urrutia JC, Streltsov VA, Opazo C, Aguayo LG.

Neurobiol Aging. 2013 Dec;34(12):2805-14. doi: 10.1016/j.neurobiolaging.2013.06.001. Epub 2013 Jul 12.

PMID:
23855983
18.

Ammonium hydroxide treatment of Aβ produces an aggregate free solution suitable for biophysical and cell culture characterization.

Ryan TM, Caine J, Mertens HD, Kirby N, Nigro J, Breheney K, Waddington LJ, Streltsov VA, Curtain C, Masters CL, Roberts BR.

PeerJ. 2013 May 7;1:e73. doi: 10.7717/peerj.73. Print 2013.

19.

Structural studies of the tethered N-terminus of the Alzheimer's disease amyloid-β peptide.

Nisbet RM, Nuttall SD, Robert R, Caine JM, Dolezal O, Hattarki M, Pearce LA, Davydova N, Masters CL, Varghese JN, Streltsov VA.

Proteins. 2013 Oct;81(10):1748-58. doi: 10.1002/prot.24312. Epub 2013 Jul 22.

PMID:
23609990
20.

Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity.

Kim JH, Resende R, Wennekes T, Chen HM, Bance N, Buchini S, Watts AG, Pilling P, Streltsov VA, Petric M, Liggins R, Barrett S, McKimm-Breschkin JL, Niikura M, Withers SG.

Science. 2013 Apr 5;340(6128):71-5. doi: 10.1126/science.1232552. Epub 2013 Feb 21.

21.

Continuous X-ray diffractive field in protein nanocrystallography.

Dilanian RA, Streltsov VA, Quiney HM, Nugent KA.

Acta Crystallogr A. 2013 Jan;69(Pt 1):108-18. doi: 10.1107/S0108767312042535. Epub 2012 Nov 16.

PMID:
23250067
22.

In vitro passaging of a pandemic H1N1/09 virus selects for viruses with neuraminidase mutations conferring high-level resistance to oseltamivir and peramivir, but not to zanamivir.

McKimm-Breschkin JL, Rootes C, Mohr PG, Barrett S, Streltsov VA.

J Antimicrob Chemother. 2012 Aug;67(8):1874-83. doi: 10.1093/jac/dks150. Epub 2012 May 4.

PMID:
22563014
23.

Preparation of human vascular endothelial growth factor-D for structural and preclinical therapeutic studies.

Davydova N, Streltsov VA, Roufail S, Lovrecz GO, Stacker SA, Adams TE, Achen MG.

Protein Expr Purif. 2012 Mar;82(1):232-9. doi: 10.1016/j.pep.2012.01.001. Epub 2012 Jan 10.

PMID:
22261343
24.

Oligomerization and toxicity of Aβ fusion proteins.

Caine JM, Bharadwaj PR, Sankovich SE, Ciccotosto GD, Streltsov VA, Varghese J.

Biochem Biophys Res Commun. 2011 Jun 10;409(3):477-82. doi: 10.1016/j.bbrc.2011.05.029. Epub 2011 May 12.

PMID:
21600886
25.

Isolation, kinetic analysis, and structural characterization of an antibody targeting the Bacillus anthracis major spore surface protein BclA.

Nuttall SD, Wilkins ML, Streltsov VA, Pontes-Braz L, Dolezal O, Tran H, Liu CQ.

Proteins. 2011 Apr;79(4):1306-17. doi: 10.1002/prot.22971. Epub 2011 Feb 14.

PMID:
21322055
26.

The VD1 neutralizing antibody to vascular endothelial growth factor-D: binding epitope and relationship to receptor binding.

Davydova N, Roufail S, Streltsov VA, Stacker SA, Achen MG.

J Mol Biol. 2011 Apr 8;407(4):581-93. doi: 10.1016/j.jmb.2011.02.009. Epub 2011 Feb 18.

PMID:
21315726
27.

Crystal structure of the amyloid-β p3 fragment provides a model for oligomer formation in Alzheimer's disease.

Streltsov VA, Varghese JN, Masters CL, Nuttall SD.

J Neurosci. 2011 Jan 26;31(4):1419-26. doi: 10.1523/JNEUROSCI.4259-10.2011.

28.

Crystallisation of wild-type and variant forms of a recombinant plant enzyme β-D-glucan glucohydrolase from barley (Hordeum vulgare L.) and preliminary X-ray analysis.

Luang S, Ketudat Cairns JR, Streltsov VA, Hrmova M.

Int J Mol Sci. 2010 Jul 19;11(7):2759-69. doi: 10.3390/ijms11072759.

29.

Structural and functional basis of resistance to neuraminidase inhibitors of influenza B viruses.

Oakley AJ, Barrett S, Peat TS, Newman J, Streltsov VA, Waddington L, Saito T, Tashiro M, McKimm-Breschkin JL.

J Med Chem. 2010 Sep 9;53(17):6421-31. doi: 10.1021/jm100621s.

30.

Hematin-hematin self-association states involved in the formation and reactivity of the malaria parasite pigment, hemozoin.

Klonis N, Dilanian R, Hanssen E, Darmanin C, Streltsov V, Deed S, Quiney H, Tilley L.

Biochemistry. 2010 Aug 10;49(31):6804-11. doi: 10.1021/bi100567j.

PMID:
20593810
31.

Germline humanization of a murine Abeta antibody and crystal structure of the humanized recombinant Fab fragment.

Robert R, Streltsov VA, Newman J, Pearce LA, Wark KL, Dolezal O.

Protein Sci. 2010 Feb;19(2):299-308. doi: 10.1002/pro.312.

32.

The structure of the amyloid-beta peptide high-affinity copper II binding site in Alzheimer disease.

Streltsov VA, Titmuss SJ, Epa VC, Barnham KJ, Masters CL, Varghese JN.

Biophys J. 2008 Oct;95(7):3447-56. doi: 10.1529/biophysj.108.134429. Epub 2008 Jul 3.

33.

Substrate mediated reduction of copper-amyloid-beta complex in Alzheimer's disease.

Streltsov VA, Varghese JN.

Chem Commun (Camb). 2008 Jul 21;(27):3169-71. doi: 10.1039/b803911a. Epub 2008 May 14.

PMID:
18594731
34.

Structural insights into ligand-induced activation of the insulin receptor.

Ward C, Lawrence M, Streltsov V, Garrett T, McKern N, Lou MZ, Lovrecz G, Adams T.

Acta Physiol (Oxf). 2008 Jan;192(1):3-9. doi: 10.1111/j.1748-1716.2007.01781.x. Review.

PMID:
18171424
35.

X-ray absorption and diffraction studies of the metal binding sites in amyloid beta-peptide.

Streltsov V.

Eur Biophys J. 2008 Mar;37(3):257-63. Epub 2007 Nov 15. Review.

PMID:
18004559
36.

Structure of an IgNAR-AMA1 complex: targeting a conserved hydrophobic cleft broadens malarial strain recognition.

Henderson KA, Streltsov VA, Coley AM, Dolezal O, Hudson PJ, Batchelor AH, Gupta A, Bai T, Murphy VJ, Anders RF, Foley M, Nuttall SD.

Structure. 2007 Nov;15(11):1452-66.

37.

Domain I of ribosomal protein L1 is sufficient for specific RNA binding.

Tishchenko S, Nikonova E, Kljashtorny V, Kostareva O, Nevskaya N, Piendl W, Davydova N, Streltsov V, Garber M, Nikonov S.

Nucleic Acids Res. 2007;35(21):7389-95. Epub 2007 Oct 25.

38.

Shark IgNAR antibody mimotopes target a murine immunoglobulin through extended CDR3 loop structures.

Simmons DP, Streltsov VA, Dolezal O, Hudson PJ, Coley AM, Foley M, Proll DF, Nuttall SD.

Proteins. 2008 Apr;71(1):119-30.

PMID:
17932913
39.

Construction, crystal structure and application of a recombinant protein that lacks the collagen-like region of BclA from Bacillus anthracis spores.

Liu CQ, Nuttall SD, Tran H, Wilkins M, Streltsov VA, Alderton MR.

Biotechnol Bioeng. 2008 Mar 1;99(4):774-82.

PMID:
17879302
40.

The insulin and EGF receptor structures: new insights into ligand-induced receptor activation.

Ward CW, Lawrence MC, Streltsov VA, Adams TE, McKern NM.

Trends Biochem Sci. 2007 Mar;32(3):129-37. Epub 2007 Feb 5. Review.

PMID:
17280834
41.

In vitro improvement of a shark IgNAR antibody by Qbeta replicase mutation and ribosome display mimics in vivo affinity maturation.

Kopsidas G, Roberts AS, Coia G, Streltsov VA, Nuttall SD.

Immunol Lett. 2006 Nov 15;107(2):163-8. Epub 2006 Oct 16.

PMID:
17069896
42.

Dimerisation strategies for shark IgNAR single domain antibody fragments.

Simmons DP, Abregu FA, Krishnan UV, Proll DF, Streltsov VA, Doughty L, Hattarki MK, Nuttall SD.

J Immunol Methods. 2006 Aug 31;315(1-2):171-84. Epub 2006 Aug 28.

PMID:
16962608
43.

Structure of the insulin receptor ectodomain reveals a folded-over conformation.

McKern NM, Lawrence MC, Streltsov VA, Lou MZ, Adams TE, Lovrecz GO, Elleman TC, Richards KM, Bentley JD, Pilling PA, Hoyne PA, Cartledge KA, Pham TM, Lewis JL, Sankovich SE, Stoichevska V, Da Silva E, Robinson CP, Frenkel MJ, Sparrow LG, Fernley RT, Epa VC, Ward CW.

Nature. 2006 Sep 14;443(7108):218-21. Epub 2006 Sep 6.

PMID:
16957736
44.

Synchrotron X-ray imaging of the electron density in RFeO3 (R = Y, Ho) using an APD detector.

Streltsov VA, Ishizawa N, Kishimoto S.

J Synchrotron Radiat. 1998 Sep 1;5(Pt 5):1309-16.

PMID:
16687839
45.

Structural rationale for low-nanomolar binding of transition state mimics to a family GH3 beta-D-glucan glucohydrolase from barley.

Hrmova M, Streltsov VA, Smith BJ, Vasella A, Varghese JN, Fincher GB.

Biochemistry. 2005 Dec 20;44(50):16529-39.

PMID:
16342944
46.

Structure of a shark IgNAR antibody variable domain and modeling of an early-developmental isotype.

Streltsov VA, Carmichael JA, Nuttall SD.

Protein Sci. 2005 Nov;14(11):2901-9. Epub 2005 Sep 30.

47.

Crystal structure study of a beta'-copper vanadium bronze, Cu(x)V2O5 (x = 0.63), by X-ray and convergent beam electron diffraction.

Streltsov VA, Nakashima PN, Sobolev AN, Ozerov RP.

Acta Crystallogr B. 2005 Feb;61(Pt 1):17-24. Epub 2005 Jan 19.

PMID:
15659853
48.

Do sharks have a new antibody lineage?

Streltsov V, Nuttall S.

Immunol Lett. 2005 Feb 15;97(1):159-60. No abstract available.

PMID:
15626489
49.

Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor.

Streltsov VA, Varghese JN, Carmichael JA, Irving RA, Hudson PJ, Nuttall SD.

Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12444-9. Epub 2004 Aug 10.

50.

Synchrotron X-ray and ab initio studies of beta-Si3N4.

du Boulay D, Ishizawa N, Atake T, Streltsov V, Furuya K, Munakata F.

Acta Crystallogr B. 2004 Aug;60(Pt 4):388-405. Epub 2004 Jul 19.

PMID:
15258397

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