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Items: 8


Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape.

Martin CJ, Datta A, Littlefield C, Kalra A, Chapron C, Wawersik S, Dagbay KB, Brueckner CT, Nikiforov A, Danehy FT Jr, Streich FC Jr, Boston C, Simpson A, Jackson JW, Lin S, Danek N, Faucette RR, Raman P, Capili AD, Buckler A, Carven GJ, Schürpf T.

Sci Transl Med. 2020 Mar 25;12(536). pii: eaay8456. doi: 10.1126/scitranslmed.aay8456.


Structural basis for specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015.

Dagbay KB, Treece E, Streich FC Jr, Jackson JW, Faucette RR, Nikiforov A, Lin SC, Boston CJ, Nicholls SB, Capili AD, Carven GJ.

J Biol Chem. 2020 Feb 19. pii: jbc.RA119.012293. doi: 10.1074/jbc.RA119.012293. [Epub ahead of print]


Strategies to Trap Enzyme-Substrate Complexes that Mimic Michaelis Intermediates During E3-Mediated Ubiquitin-Like Protein Ligation.

Streich FC Jr, Lima CD.

Methods Mol Biol. 2018;1844:169-196. doi: 10.1007/978-1-4939-8706-1_12.


Capturing a substrate in an activated RING E3/E2-SUMO complex.

Streich FC Jr, Lima CD.

Nature. 2016 Aug 18;536(7616):304-8. Epub 2016 Aug 10.


Convergent evolution in the assembly of polyubiquitin degradation signals by the Shigella flexneri IpaH9.8 ligase.

Edwards DJ, Streich FC Jr, Ronchi VP, Todaro DR, Haas AL.

J Biol Chem. 2014 Dec 5;289(49):34114-28. doi: 10.1074/jbc.M114.609164. Epub 2014 Oct 23.


Structural and functional insights to ubiquitin-like protein conjugation.

Streich FC Jr, Lima CD.

Annu Rev Biophys. 2014;43:357-79. doi: 10.1146/annurev-biophys-051013-022958. Review.


Tripartite motif ligases catalyze polyubiquitin chain formation through a cooperative allosteric mechanism.

Streich FC Jr, Ronchi VP, Connick JP, Haas AL.

J Biol Chem. 2013 Mar 22;288(12):8209-21. doi: 10.1074/jbc.M113.451567. Epub 2013 Feb 13.


Activation of ubiquitin and ubiquitin-like proteins.

Streich FC Jr, Haas AL.

Subcell Biochem. 2010;54:1-16. doi: 10.1007/978-1-4419-6676-6_1.


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