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Items: 1 to 50 of 91

1.

A high-throughput, bead-based, antigen-specific assay to assess the ability of antibodies to induce complement activation.

Fischinger S, Fallon JK, Michell AR, Broge T, Suscovich TJ, Streeck H, Alter G.

J Immunol Methods. 2019 Jul 10:112630. doi: 10.1016/j.jim.2019.07.002. [Epub ahead of print]

2.

Effect of HIV infection and antiretroviral therapy on immune cellular functions.

Korencak M, Byrne M, Richter E, Schultz BT, Juszczak P, Ake JA, Ganesan A, Okulicz JF, Robb ML, de Los Reyes B, Winning S, Fandrey J, Burgess TH, Esser S, Michael NL, Agan BK, Streeck H.

JCI Insight. 2019 Jun 20;4(12). pii: 126675. doi: 10.1172/jci.insight.126675. eCollection 2019 Jun 20.

3.

Expansion of Stem Cell-Like CD4+ Memory T Cells during Acute HIV-1 Infection Is Linked to Rapid Disease Progression.

Pušnik J, Eller MA, Tassaneetrithep B, Schultz BT, Eller LA, Nitayaphan S, Kosgei J, Maganga L, Kibuuka H, Alter G, Michael NL, Robb ML, Streeck H.

J Virol. 2019 Jun 28;93(14). pii: e00377-19. doi: 10.1128/JVI.00377-19. Print 2019 Jul 15.

PMID:
31043532
4.

B-type natriuretic peptides for the prediction of cardiovascular events and mortality in patients living with HIV: Results from the HIV-HEART study.

Reinsch N, Streeck H, Holzendorf V, Schulze C, Neumann T, Brockmeyer NH, Kehrmann J, Schadendorf D, Esser S; HIV HEART Study Group.

Int J Cardiol. 2019 Apr 15;281:127-132. doi: 10.1016/j.ijcard.2019.01.066. Epub 2019 Jan 23.

PMID:
30711264
5.

Sex differences in vaccine-induced humoral immunity.

Fischinger S, Boudreau CM, Butler AL, Streeck H, Alter G.

Semin Immunopathol. 2019 Mar;41(2):239-249. doi: 10.1007/s00281-018-0726-5. Epub 2018 Dec 13. Review.

6.

Modulation of Vaccine-Induced CD4 T Cell Functional Profiles by Changes in Components of HIV Vaccine Regimens in Humans.

Pissani F, Schulte B, Eller MA, Schultz BT, Ratto-Kim S, Marovich M, Thongcharoen P, Sriplienchan S, Rerks-Ngarm S, Pitisuttithum P, Esser S, Alter G, Robb ML, Kim JH, Michael NL, Streeck H.

J Virol. 2018 Nov 12;92(23). pii: e01143-18. doi: 10.1128/JVI.01143-18. Print 2018 Dec 1.

7.

Gut Microbiota in Human Immunodeficiency Virus-Infected Individuals Linked to Coronary Heart Disease.

Kehrmann J, Menzel J, Saeedghalati M, Obeid R, Schulze C, Holzendorf V, Farahpour F, Reinsch N, Klein-Hitpass L, Streeck H, Hoffmann D, Buer J, Esser S; HIV-HEART Study Group.

J Infect Dis. 2019 Jan 9;219(3):497-508. doi: 10.1093/infdis/jiy524.

PMID:
30202890
8.

Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement.

Lofano G, Gorman MJ, Yousif AS, Yu WH, Fox JM, Dugast AS, Ackerman ME, Suscovich TJ, Weiner J, Barouch D, Streeck H, Little S, Smith D, Richman D, Lauffenburger D, Walker BD, Diamond MS, Alter G.

Sci Immunol. 2018 Aug 17;3(26). pii: eaat7796. doi: 10.1126/sciimmunol.aat7796.

9.

Distinct biomarker signatures in HIV acute infection associate with viral dynamics and reservoir size.

Teigler JE, Leyre L, Chomont N, Slike B, Jian N, Eller MA, Phanuphak N, Kroon E, Pinyakorn S, Eller LA, Robb ML, Ananworanich J, Michael NL, Streeck H, Krebs SJ; RV254/RV217 study groups.

JCI Insight. 2018 May 17;3(10). pii: 98420. doi: 10.1172/jci.insight.98420. eCollection 2018 May 17.

10.

Exploiting glycan topography for computational design of Env glycoprotein antigenicity.

Yu WH, Zhao P, Draghi M, Arevalo C, Karsten CB, Suscovich TJ, Gunn B, Streeck H, Brass AL, Tiemeyer M, Seaman M, Mascola JR, Wells L, Lauffenburger DA, Alter G.

PLoS Comput Biol. 2018 Apr 20;14(4):e1006093. doi: 10.1371/journal.pcbi.1006093. eCollection 2018 Apr.

11.

Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease.

Buggert M, Nguyen S, McLane LM, Steblyanko M, Anikeeva N, Paquin-Proulx D, Del Rio Estrada PM, Ablanedo-Terrazas Y, Noyan K, Reuter MA, Demers K, Sandberg JK, Eller MA, Streeck H, Jansson M, Nowak P, Sönnerborg A, Canaday DH, Naji A, Wherry EJ, Robb ML, Deeks SG, Reyes-Teran G, Sykulev Y, Karlsson AC, Betts MR.

PLoS Pathog. 2018 Apr 13;14(4):e1006973. doi: 10.1371/journal.ppat.1006973. eCollection 2018 Apr.

12.

Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination.

Costanzo MC, Kim D, Creegan M, Lal KG, Ake JA, Currier JR, Streeck H, Robb ML, Michael NL, Bolton DL, Steers NJ, Eller MA.

Nat Commun. 2018 Mar 23;9(1):1212. doi: 10.1038/s41467-018-03618-w.

13.

Expression Pattern of Individual IFNA Subtypes in Chronic HIV Infection.

Li Y, Sun B, Esser S, Jessen H, Streeck H, Widera M, Yang R, Dittmer U, Sutter K.

J Interferon Cytokine Res. 2017 Dec;37(12):541-549. doi: 10.1089/jir.2017.0076.

PMID:
29252127
14.

Temporal variation in HIV-specific IgG subclass antibodies during acute infection differentiates spontaneous controllers from chronic progressors.

Sadanand S, Das J, Chung AW, Schoen MK, Lane S, Suscovich TJ, Streeck H, Smith DM, Little SJ, Lauffenburger DA, Richman DD, Alter G.

AIDS. 2018 Feb 20;32(4):443-450. doi: 10.1097/QAD.0000000000001716.

15.

Differential Inhibitory Receptor Expression on T Cells Delineates Functional Capacities in Chronic Viral Infection.

Teigler JE, Zelinskyy G, Eller MA, Bolton DL, Marovich M, Gordon AD, Alrubayyi A, Alter G, Robb ML, Martin JN, Deeks SG, Michael NL, Dittmer U, Streeck H.

J Virol. 2017 Nov 14;91(23). pii: e01263-17. doi: 10.1128/JVI.01263-17. Print 2017 Dec 1.

16.

Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection.

Malyshkina A, Littwitz-Salomon E, Sutter K, Zelinskyy G, Windmann S, Schimmer S, Paschen A, Streeck H, Hasenkrug KJ, Dittmer U.

Sci Rep. 2017 Aug 10;7(1):7785. doi: 10.1038/s41598-017-08578-7.

17.

Preexposure prophylaxis failure with tenofovir disoproxil.

Esser S, Streeck H.

AIDS. 2017 Jun 1;31(9):1344. doi: 10.1097/QAD.0000000000001468. No abstract available.

PMID:
28492396
18.

Preservation of Peripheral T Follicular Helper Cell Function in HIV Controllers.

Buranapraditkun S, Pissani F, Teigler JE, Schultz BT, Alter G, Marovich M, Robb ML, Eller MA, Martin J, Deeks S, Michael NL, Streeck H.

J Virol. 2017 Jun 26;91(14). pii: e00497-17. doi: 10.1128/JVI.00497-17. Print 2017 Jul 15.

19.

Pre-exposure prophylaxis failure with tenofovir disoproxil.

Streeck H, Verheyen J, Storim J, Dittmer U, Jochum C, Timm J, Esser S.

AIDS. 2017 Jan 2;31(1):176-177. No abstract available.

PMID:
27898596
20.

Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion.

Ranasinghe S, Lamothe PA, Soghoian DZ, Kazer SW, Cole MB, Shalek AK, Yosef N, Jones RB, Donaghey F, Nwonu C, Jani P, Clayton GM, Crawford F, White J, Montoya A, Power K, Allen TM, Streeck H, Kaufmann DE, Picker LJ, Kappler JW, Walker BD.

Immunity. 2016 Oct 18;45(4):917-930. doi: 10.1016/j.immuni.2016.09.015.

21.

A Functional Role for Antibodies in Tuberculosis.

Lu LL, Chung AW, Rosebrock TR, Ghebremichael M, Yu WH, Grace PS, Schoen MK, Tafesse F, Martin C, Leung V, Mahan AE, Sips M, Kumar MP, Tedesco J, Robinson H, Tkachenko E, Draghi M, Freedberg KJ, Streeck H, Suscovich TJ, Lauffenburger DA, Restrepo BI, Day C, Fortune SM, Alter G.

Cell. 2016 Oct 6;167(2):433-443.e14. doi: 10.1016/j.cell.2016.08.072. Epub 2016 Sep 22.

22.

Barriers to HIV Cure.

Stein J, Storcksdieck Genannt Bonsmann M, Streeck H.

HLA. 2016 Oct;88(4):155-63. doi: 10.1111/tan.12867. Review.

PMID:
27620852
23.

TGF-β receptor maintains CD4 T helper cell identity during chronic viral infections.

Lewis GM, Wehrens EJ, Labarta-Bajo L, Streeck H, Zuniga EI.

J Clin Invest. 2016 Oct 3;126(10):3799-3813. doi: 10.1172/JCI87041. Epub 2016 Sep 6.

24.

Designing optimal HIV-vaccine T-cell responses.

Streeck H.

Curr Opin HIV AIDS. 2016 Nov;11(6):593-600. Review.

PMID:
27559707
25.

Correction: Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination.

Mahan AE, Jennewein MF, Suscovich T, Dionne K, Tedesco J, Chung AW, Streeck H, Pau M, Schuitemaker H, Francis D, Fast P, Laufer D, Walker BD, Baden L, Barouch DH, Alter G.

PLoS Pathog. 2016 Jun 2;12(6):e1005694. doi: 10.1371/journal.ppat.1005694. eCollection 2016 Jun.

26.

Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination.

Mahan AE, Jennewein MF, Suscovich T, Dionne K, Tedesco J, Chung AW, Streeck H, Pau M, Schuitemaker H, Francis D, Fast P, Laufer D, Walker BD, Baden L, Barouch DH, Alter G.

PLoS Pathog. 2016 Mar 16;12(3):e1005456. doi: 10.1371/journal.ppat.1005456. eCollection 2016 Mar. Erratum in: PLoS Pathog. 2016 Jun;12(6):e1005694.

27.

Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16.

Gunn B, Schneider J, Shansab M, Bastian AR, Fahrbach K, Smith A 4th, Mahan A, Karim M, Licht A, Zvonar I, Tedesco J, Anderson M, Chapel A, Suscovich T, Malaspina D, Streeck H, Walker BD, Kim A, Lauer G, Altfeld M, Pillai S, Szleifer I, Kelleher NL, Kiser PF, Hope TJ, Alter G.

Mucosal Immunol. 2016 Nov;9(6):1549-1558. doi: 10.1038/mi.2016.8. Epub 2016 Mar 9.

28.

Subdominant Gag-specific anti-HIV efficacy in an HLA-B*57-positive elite controller.

Leitman EM, Willberg CB, De Burgh-Thomas A, Streeck H, Goulder PJ, Matthews PC.

AIDS. 2016 Mar 27;30(6):972-4. doi: 10.1097/QAD.0000000000001022. No abstract available.

29.

Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies.

Sips M, Krykbaeva M, Diefenbach TJ, Ghebremichael M, Bowman BA, Dugast AS, Boesch AW, Streeck H, Kwon DS, Ackerman ME, Suscovich TJ, Brouckaert P, Schacker TW, Alter G.

Mucosal Immunol. 2016 Nov;9(6):1584-1595. doi: 10.1038/mi.2016.12. Epub 2016 Feb 17.

30.

Expansion of Inefficient HIV-Specific CD8 T Cells during Acute Infection.

Eller MA, Goonetilleke N, Tassaneetrithep B, Eller LA, Costanzo MC, Johnson S, Betts MR, Krebs SJ, Slike BM, Nitayaphan S, Rono K, Tovanabutra S, Maganga L, Kibuuka H, Jagodzinski L, Peel S, Rolland M, Marovich MA, Kim JH, Michael NL, Robb ML, Streeck H.

J Virol. 2016 Mar 28;90(8):4005-4016. doi: 10.1128/JVI.02785-15. Print 2016 Apr.

31.

Circulating HIV-Specific Interleukin-21(+)CD4(+) T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions.

Schultz BT, Teigler JE, Pissani F, Oster AF, Kranias G, Alter G, Marovich M, Eller MA, Dittmer U, Robb ML, Kim JH, Michael NL, Bolton D, Streeck H.

Immunity. 2016 Jan 19;44(1):167-178. doi: 10.1016/j.immuni.2015.12.011. Epub 2016 Jan 12.

32.

CD137 Agonist Therapy Can Reprogram Regulatory T Cells into Cytotoxic CD4+ T Cells with Antitumor Activity.

Akhmetzyanova I, Zelinskyy G, Littwitz-Salomon E, Malyshkina A, Dietze KK, Streeck H, Brandau S, Dittmer U.

J Immunol. 2016 Jan 1;196(1):484-92. doi: 10.4049/jimmunol.1403039. Epub 2015 Nov 25.

33.

Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology.

Chung AW, Kumar MP, Arnold KB, Yu WH, Schoen MK, Dunphy LJ, Suscovich TJ, Frahm N, Linde C, Mahan AE, Hoffner M, Streeck H, Ackerman ME, McElrath MJ, Schuitemaker H, Pau MG, Baden LR, Kim JH, Michael NL, Barouch DH, Lauffenburger DA, Alter G.

Cell. 2015 Nov 5;163(4):988-98. doi: 10.1016/j.cell.2015.10.027.

34.

Enhancing the Quality of Antibodies to HIV-1 Envelope by GagPol-Specific Th Cells.

Storcksdieck genannt Bonsmann M, Niezold T, Temchura V, Pissani F, Ehrhardt K, Brown EP, Osei-Owusu NY, Hannaman D, Hengel H, Ackerman ME, Streeck H, Nabi G, Tenbusch M, Überla K.

J Immunol. 2015 Nov 15;195(10):4861-72. doi: 10.4049/jimmunol.1501377. Epub 2015 Oct 14.

35.

IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection.

Adoro S, Cubillos-Ruiz JR, Chen X, Deruaz M, Vrbanac VD, Song M, Park S, Murooka TT, Dudek TE, Luster AD, Tager AM, Streeck H, Bowman B, Walker BD, Kwon DS, Lazarevic V, Glimcher LH.

Nat Commun. 2015 Jun 25;6:7562. doi: 10.1038/ncomms8562.

36.

Cooperativity of HIV-Specific Cytolytic CD4 T Cells and CD8 T Cells in Control of HIV Viremia.

Johnson S, Eller M, Teigler JE, Maloveste SM, Schultz BT, Soghoian DZ, Lu R, Oster AF, Chenine AL, Alter G, Dittmer U, Marovich M, Robb ML, Michael NL, Bolton D, Streeck H.

J Virol. 2015 Aug;89(15):7494-505. doi: 10.1128/JVI.00438-15. Epub 2015 May 13.

37.

AIDS virus seeks refuge in B cell follicles.

Streeck H.

Nat Med. 2015 Feb;21(2):111-2. doi: 10.1038/nm.3795. No abstract available.

PMID:
25654598
38.

Emergence of individual HIV-specific CD8 T cell responses during primary HIV-1 infection can determine long-term disease outcome.

Streeck H, Lu R, Beckwith N, Milazzo M, Liu M, Routy JP, Little S, Jessen H, Kelleher AD, Hecht F, Sekaly RP, Alter G, Heckerman D, Carrington M, Rosenberg ES, Altfeld M.

J Virol. 2014 Nov;88(21):12793-801. doi: 10.1128/JVI.02016-14. Epub 2014 Aug 27.

39.

Independent evolution of Fc- and Fab-mediated HIV-1-specific antiviral antibody activity following acute infection.

Dugast AS, Stamatatos L, Tonelli A, Suscovich TJ, Licht AF, Mikell I, Ackerman ME, Streeck H, Klasse PJ, Moore JP, Alter G.

Eur J Immunol. 2014 Oct;44(10):2925-37. doi: 10.1002/eji.201344305. Epub 2014 Aug 11.

40.

Lack of protection following passive transfer of polyclonal highly functional low-dose non-neutralizing antibodies.

Dugast AS, Chan Y, Hoffner M, Licht A, Nkolola J, Li H, Streeck H, Suscovich TJ, Ghebremichael M, Ackerman ME, Barouch DH, Alter G.

PLoS One. 2014 May 12;9(5):e97229. doi: 10.1371/journal.pone.0097229. eCollection 2014.

41.

Induction of Gag-specific CD4 T cell responses during acute HIV infection is associated with improved viral control.

Schieffer M, Jessen HK, Oster AF, Pissani F, Soghoian DZ, Lu R, Jessen AB, Zedlack C, Schultz BT, Davis I, Ranasinghe S, Rosenberg ES, Alter G, Schumann RR, Streeck H.

J Virol. 2014 Jul;88(13):7357-66. doi: 10.1128/JVI.00728-14. Epub 2014 Apr 16.

42.

Emerging concepts on T follicular helper cell dynamics in HIV infection.

Pissani F, Streeck H.

Trends Immunol. 2014 Jun;35(6):278-86. doi: 10.1016/j.it.2014.02.010. Epub 2014 Apr 2. Review.

43.

Polyfunctional Fc-effector profiles mediated by IgG subclass selection distinguish RV144 and VAX003 vaccines.

Chung AW, Ghebremichael M, Robinson H, Brown E, Choi I, Lane S, Dugast AS, Schoen MK, Rolland M, Suscovich TJ, Mahan AE, Liao L, Streeck H, Andrews C, Rerks-Ngarm S, Nitayaphan S, de Souza MS, Kaewkungwal J, Pitisuttithum P, Francis D, Michael NL, Kim JH, Bailey-Kellogg C, Ackerman ME, Alter G.

Sci Transl Med. 2014 Mar 19;6(228):228ra38. doi: 10.1126/scitranslmed.3007736.

44.

How a single patient influenced HIV research--15-year follow-up.

Jessen H, Allen TM, Streeck H.

N Engl J Med. 2014 Feb 13;370(7):682-3. doi: 10.1056/NEJMc1308413.

45.

Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection.

Vaidya SA, Streeck H, Beckwith N, Ghebremichael M, Pereyra F, Kwon DS, Addo MM, Rychert J, Routy JP, Jessen H, Kelleher AD, Hecht F, Sekaly RP, Carrington M, Walker BD, Allen TM, Rosenberg ES, Altfeld M.

Retrovirology. 2013 Nov 18;10:139. doi: 10.1186/1742-4690-10-139.

46.

Association of HLA-DRB1-restricted CD4⁺ T cell responses with HIV immune control.

Ranasinghe S, Cutler S, Davis I, Lu R, Soghoian DZ, Qi Y, Sidney J, Kranias G, Flanders MD, Lindqvist M, Kuhl B, Alter G, Deeks SG, Walker BD, Gao X, Sette A, Carrington M, Streeck H.

Nat Med. 2013 Jul;19(7):930-3. doi: 10.1038/nm.3229. Epub 2013 Jun 23.

47.

Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity.

Ackerman ME, Crispin M, Yu X, Baruah K, Boesch AW, Harvey DJ, Dugast AS, Heizen EL, Ercan A, Choi I, Streeck H, Nigrovic PA, Bailey-Kellogg C, Scanlan C, Alter G.

J Clin Invest. 2013 May;123(5):2183-92. doi: 10.1172/JCI65708. Epub 2013 Apr 8.

48.

Harnessing CD4⁺ T cell responses in HIV vaccine development.

Streeck H, D'Souza MP, Littman DR, Crotty S.

Nat Med. 2013 Feb;19(2):143-9. doi: 10.1038/nm.3054. Epub 2013 Feb 6. Review.

49.

A Blueprint for HIV Vaccine Discovery.

Burton DR, Ahmed R, Barouch DH, Butera ST, Crotty S, Godzik A, Kaufmann DE, McElrath MJ, Nussenzweig MC, Pulendran B, Scanlan CN, Schief WR, Silvestri G, Streeck H, Walker BD, Walker LM, Ward AB, Wilson IA, Wyatt R.

Cell Host Microbe. 2012 Oct 18;12(4):396-407. doi: 10.1016/j.chom.2012.09.008. Review.

50.

Expansion of HIV-specific T follicular helper cells in chronic HIV infection.

Lindqvist M, van Lunzen J, Soghoian DZ, Kuhl BD, Ranasinghe S, Kranias G, Flanders MD, Cutler S, Yudanin N, Muller MI, Davis I, Farber D, Hartjen P, Haag F, Alter G, Schulze zur Wiesch J, Streeck H.

J Clin Invest. 2012 Sep;122(9):3271-80. doi: 10.1172/JCI64314. Epub 2012 Aug 27.

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