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Items: 1 to 50 of 64

1.

Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1).

Koumantou D, Barnea E, Martin-Esteban A, Maben Z, Papakyriakou A, Mpakali A, Kokkala P, Pratsinis H, Georgiadis D, Stern LJ, Admon A, Stratikos E.

Cancer Immunol Immunother. 2019 Aug;68(8):1245-1261. doi: 10.1007/s00262-019-02358-0. Epub 2019 Jun 20.

PMID:
31222486
2.

High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor.

Giastas P, Neu M, Rowland P, Stratikos E.

ACS Med Chem Lett. 2019 Feb 13;10(5):708-713. doi: 10.1021/acsmedchemlett.9b00002. eCollection 2019 May 9.

3.

Endoplasmic reticulum aminopeptidases as a double-faced tool to increase or decrease efficiency of antigen presentation in health and disease.

Kuśnierczyk P, Stratikos E.

Hum Immunol. 2019 May;80(5):277-280. doi: 10.1016/j.humimm.2019.03.011. Epub 2019 Mar 27. No abstract available.

PMID:
30928619
4.

Functional characterization of CHEK2 variants in a Saccharomyces cerevisiae system.

Delimitsou A, Fostira F, Kalfakakou D, Apostolou P, Konstantopoulou I, Kroupis C, Papavassiliou AG, Kleibl Z, Stratikos E, Voutsinas GE, Yannoukakos D.

Hum Mutat. 2019 May;40(5):631-648. doi: 10.1002/humu.23728. Epub 2019 Mar 9.

PMID:
30851065
5.

Endoplasmic reticulum aminopeptidase 1 polymorphism Ile276Met is associated with atopic dermatitis and affects the generation of an HLA-C associated antigenic epitope in vitro.

Niepiekło-Miniewska W, Mpakali A, Stratikos E, Matusiak Ł, Narbutt J, Lesiak A, Kuna P, Wilczyńska K, Nowak I, Wiśniewski A, Zwolińska K, Ponińska J, Płoski R, Szepietowski JC, Kuśnierczyk P.

J Eur Acad Dermatol Venereol. 2019 May;33(5):906-911. doi: 10.1111/jdv.15449. Epub 2019 Mar 4.

PMID:
30680818
6.

Intracellular antigen processing by ERAP2: Molecular mechanism and roles in health and disease.

de Castro JAL, Stratikos E.

Hum Immunol. 2019 May;80(5):310-317. doi: 10.1016/j.humimm.2018.11.001. Epub 2018 Nov 7. Review.

PMID:
30414458
7.

Aminobenzosuberone Scaffold as a Modular Chemical Tool for the Inhibition of Therapeutically Relevant M1 Aminopeptidases.

Salomon E, Schmitt M, Marapaka AK, Stamogiannos A, Revelant G, Schmitt C, Alavi S, Florent I, Addlagatta A, Stratikos E, Tarnus C, Albrecht S.

Molecules. 2018 Oct 11;23(10). pii: E2607. doi: 10.3390/molecules23102607.

8.

Thermodynamic destabilization and aggregation propensity as the mechanism behind the association of apoE3 mutants and lipoprotein glomerulopathy.

Katsarou M, Stratikos E, Chroni A.

J Lipid Res. 2018 Dec;59(12):2339-2348. doi: 10.1194/jlr.M088732. Epub 2018 Oct 11.

PMID:
30309894
9.

Contribution of RAD51D germline mutations in breast and ovarian cancer in Greece.

Konstanta I, Fostira F, Apostolou P, Stratikos E, Kalfakakou D, Pampanos A, Kollia P, Papadimitriou C, Konstantopoulou I, Yannoukakos D.

J Hum Genet. 2018 Nov;63(11):1149-1158. doi: 10.1038/s10038-018-0498-8. Epub 2018 Aug 15.

PMID:
30111881
10.

Self-Healing pH- and Enzyme Stimuli-Responsive Hydrogels for Targeted Delivery of Gemcitabine To Treat Pancreatic Cancer.

Bilalis P, Skoulas D, Karatzas A, Marakis J, Stamogiannos A, Tsimblouli C, Sereti E, Stratikos E, Dimas K, Vlassopoulos D, Iatrou H.

Biomacromolecules. 2018 Sep 10;19(9):3840-3852. doi: 10.1021/acs.biomac.8b00959. Epub 2018 Aug 27.

PMID:
30095907
11.

Molecular pathways for antigenic peptide generation by ER aminopeptidase 1.

Mpakali A, Maben Z, Stern LJ, Stratikos E.

Mol Immunol. 2018 Apr 17. pii: S0161-5890(18)30105-6. doi: 10.1016/j.molimm.2018.03.026. [Epub ahead of print]

PMID:
29678301
12.

Inhibitors of ER Aminopeptidase 1 and 2: From Design to Clinical Application.

Georgiadis D, Mpakali A, Koumantou D, Stratikos E.

Curr Med Chem. 2019;26(15):2715-2729. doi: 10.2174/0929867325666180214111849. Review.

PMID:
29446724
13.

The role of endoplasmic reticulum aminopeptidase 2 in modulating immune detection of choriocarcinoma.

Warthan MD, Washington SL, Franzese SE, Ramus RM, Kim KR, York TP, Stratikos E, Strauss JF 3rd, Lee ED.

Biol Reprod. 2018 Mar 1;98(3):309-322. doi: 10.1093/biolre/ioy001.

14.

The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases.

Papakyriakou A, Stratikos E.

Front Immunol. 2017 Aug 7;8:946. doi: 10.3389/fimmu.2017.00946. eCollection 2017. Review.

15.

Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency.

Mpakali A, Giastas P, Deprez-Poulain R, Papakyriakou A, Koumantou D, Gealageas R, Tsoukalidou S, Vourloumis D, Mavridis IM, Stratikos E, Saridakis E.

ACS Med Chem Lett. 2017 Feb 21;8(3):333-337. doi: 10.1021/acsmedchemlett.6b00505. eCollection 2017 Mar 9.

16.

Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.

Mpakali A, Saridakis E, Harlos K, Zhao Y, Kokkala P, Georgiadis D, Giastas P, Papakyriakou A, Stratikos E.

J Med Chem. 2017 Apr 13;60(7):2963-2972. doi: 10.1021/acs.jmedchem.6b01890. Epub 2017 Apr 3.

PMID:
28328206
17.

The Pivotal Role of Protein Phosphorylation in the Control of Yeast Central Metabolism.

Vlastaridis P, Papakyriakou A, Chaliotis A, Stratikos E, Oliver SG, Amoutzias GD.

G3 (Bethesda). 2017 Apr 3;7(4):1239-1249. doi: 10.1534/g3.116.037218.

18.

Critical Role of Interdomain Interactions in the Conformational Change and Catalytic Mechanism of Endoplasmic Reticulum Aminopeptidase 1.

Stamogiannos A, Maben Z, Papakyriakou A, Mpakali A, Kokkala P, Georgiadis D, Stern LJ, Stratikos E.

Biochemistry. 2017 Mar 14;56(10):1546-1558. doi: 10.1021/acs.biochem.6b01170. Epub 2017 Mar 2.

19.

Optimization and Structure-Activity Relationships of Phosphinic Pseudotripeptide Inhibitors of Aminopeptidases That Generate Antigenic Peptides.

Kokkala P, Mpakali A, Mauvais FX, Papakyriakou A, Daskalaki I, Petropoulou I, Kavvalou S, Papathanasopoulou M, Agrotis S, Fonsou TM, van Endert P, Stratikos E, Georgiadis D.

J Med Chem. 2016 Oct 13;59(19):9107-9123. Epub 2016 Sep 20.

PMID:
27606717
20.

The ability of apolipoprotein E fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific.

Dafnis I, Argyri L, Sagnou M, Tzinia A, Tsilibary EC, Stratikos E, Chroni A.

Sci Rep. 2016 Aug 1;6:30654. doi: 10.1038/srep30654.

21.

Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1.

Stamogiannos A, Papakyriakou A, Mauvais FX, van Endert P, Stratikos E.

ACS Med Chem Lett. 2016 May 31;7(7):681-5. doi: 10.1021/acsmedchemlett.6b00084. eCollection 2016 Jul 14.

22.

Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2.

Mpakali A, Giastas P, Mathioudakis N, Mavridis IM, Saridakis E, Stratikos E.

J Biol Chem. 2015 Oct 23;290(43):26021-32. doi: 10.1074/jbc.M115.685909. Epub 2015 Sep 17.

23.

Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing.

Mpakali A, Saridakis E, Harlos K, Zhao Y, Papakyriakou A, Kokkala P, Georgiadis D, Stratikos E.

J Immunol. 2015 Sep 15;195(6):2842-51. doi: 10.4049/jimmunol.1501103. Epub 2015 Aug 10.

24.

Impaired Antiatherogenic Functions of High-density Lipoprotein in Patients with Ankylosing Spondylitis.

Gkolfinopoulou C, Stratikos E, Theofilatos D, Kardassis D, Voulgari PV, Drosos AA, Chroni A.

J Rheumatol. 2015 Sep;42(9):1652-60. doi: 10.3899/jrheum.141532. Epub 2015 Aug 1.

PMID:
26233507
25.

Effects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1.

Stamogiannos A, Koumantou D, Papakyriakou A, Stratikos E.

Mol Immunol. 2015 Oct;67(2 Pt B):426-35. doi: 10.1016/j.molimm.2015.07.010. Epub 2015 Jul 26.

PMID:
26224046
26.

3,4-diaminobenzoic acid derivatives as inhibitors of the oxytocinase subfamily of M1 aminopeptidases with immune-regulating properties.

Papakyriakou A, Zervoudi E, Tsoukalidou S, Mauvais FX, Sfyroera G, Mastellos DC, van Endert P, Theodorakis EA, Vourloumis D, Stratikos E.

J Med Chem. 2015 Feb 12;58(3):1524-43. doi: 10.1021/jm501867s. Epub 2015 Jan 30.

27.

Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells.

Aldhamen YA, Pepelyayeva Y, Rastall DP, Seregin SS, Zervoudi E, Koumantou D, Aylsworth CF, Quiroga D, Godbehere S, Georgiadis D, Stratikos E, Amalfitano A.

J Innate Immun. 2015;7(3):275-89. doi: 10.1159/000368899. Epub 2015 Jan 14.

28.

A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition.

Stratikos E, Stamogiannos A, Zervoudi E, Fruci D.

Front Oncol. 2014 Dec 19;4:363. doi: 10.3389/fonc.2014.00363. eCollection 2014. Review.

29.

Regulating adaptive immune responses using small molecule modulators of aminopeptidases that process antigenic peptides.

Stratikos E.

Curr Opin Chem Biol. 2014 Dec;23:1-7. doi: 10.1016/j.cbpa.2014.08.007. Epub 2014 Aug 29. Review.

PMID:
25173825
30.

Modulating antigen processing for cancer immunotherapy.

Stratikos E.

Oncoimmunology. 2014 Jan 1;3(1):e27568. Epub 2014 Jan 3.

31.

Molecular basis for increased risk for late-onset Alzheimer disease due to the naturally occurring L28P mutation in apolipoprotein E4.

Argyri L, Dafnis I, Theodossiou TA, Gantz D, Stratikos E, Chroni A.

J Biol Chem. 2014 May 2;289(18):12931-45. doi: 10.1074/jbc.M113.538124. Epub 2014 Mar 18.

32.

Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses.

Zervoudi E, Saridakis E, Birtley JR, Seregin SS, Reeves E, Kokkala P, Aldhamen YA, Amalfitano A, Mavridis IM, James E, Georgiadis D, Stratikos E.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19890-5. doi: 10.1073/pnas.1309781110. Epub 2013 Nov 18.

33.

A possible structural basis behind the pathogenic role of apolipoprotein E hereditary mutations associated with lipoprotein glomerulopathy.

Stratikos E, Chroni A.

Clin Exp Nephrol. 2014 Apr;18(2):225-9. doi: 10.1007/s10157-013-0886-5. Epub 2013 Oct 23. Review.

PMID:
24149834
34.

Significance of the hydrophobic residues 225-230 of apoA-I for the biogenesis of HDL.

Fotakis P, Tiniakou I, Kateifides AK, Gkolfinopoulou C, Chroni A, Stratikos E, Zannis VI, Kardassis D.

J Lipid Res. 2013 Dec;54(12):3293-302. doi: 10.1194/jlr.M043489. Epub 2013 Oct 12.

35.

A Novel ERAP2 Haplotype Structure in a Chilean Population: Implications for ERAP2 Protein Expression and Preeclampsia Risk.

Vanhille DL, Hill LD, Hilliard DD, Lee ED, Teves ME, Srinivas S, Kusanovic JP, Gomez R, Stratikos E, Elovitz MA, Romero R, Strauss JF 3rd.

Mol Genet Genomic Med. 2013 Jul 1;1(2):98-107.

36.

Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.

Seregin SS, Rastall DP, Evnouchidou I, Aylsworth CF, Quiroga D, Kamal RP, Godbehere-Roosa S, Blum CF, York IA, Stratikos E, Amalfitano A.

Autoimmunity. 2013 Dec;46(8):497-508. doi: 10.3109/08916934.2013.819855. Epub 2013 Sep 13.

37.

Role of the hydrophobic and charged residues in the 218-226 region of apoA-I in the biogenesis of HDL.

Fotakis P, Kateifides AK, Gkolfinopoulou C, Georgiadou D, Beck M, Gründler K, Chroni A, Stratikos E, Kardassis D, Zannis VI.

J Lipid Res. 2013 Dec;54(12):3281-92. doi: 10.1194/jlr.M038356. Epub 2013 Aug 29. Erratum in: J Lipid Res. 2014 Jan;55(1):163.

38.

Novel selective inhibitors of aminopeptidases that generate antigenic peptides.

Papakyriakou A, Zervoudi E, Theodorakis EA, Saveanu L, Stratikos E, Vourloumis D.

Bioorg Med Chem Lett. 2013 Sep 1;23(17):4832-6. doi: 10.1016/j.bmcl.2013.07.024. Epub 2013 Jul 23.

39.

Antigenic peptide trimming by ER aminopeptidases--insights from structural studies.

Stratikos E, Stern LJ.

Mol Immunol. 2013 Oct;55(3-4):212-9. doi: 10.1016/j.molimm.2013.03.002. Epub 2013 Mar 29. Review.

40.

Allele-dependent thermodynamic and structural perturbations in ApoE variants associated with the correction of dyslipidemia and formation of spherical ApoE-containing HDL particles.

Georgiadou D, Chroni A, Drosatos K, Kypreos KE, Zannis VI, Stratikos E.

Atherosclerosis. 2013 Feb;226(2):385-91. doi: 10.1016/j.atherosclerosis.2012.11.013. Epub 2012 Nov 23.

41.

ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCAT.

Duka A, Fotakis P, Georgiadou D, Kateifides A, Tzavlaki K, von Eckardstein L, Stratikos E, Kardassis D, Zannis VI.

J Lipid Res. 2013 Jan;54(1):107-15. doi: 10.1194/jlr.M030114. Epub 2012 Nov 6.

42.

Thermodynamic and structural destabilization of apoE3 by hereditary mutations associated with the development of lipoprotein glomerulopathy.

Georgiadou D, Stamatakis K, Efthimiadou EK, Kordas G, Gantz D, Chroni A, Stratikos E.

J Lipid Res. 2013 Jan;54(1):164-76. doi: 10.1194/jlr.M030965. Epub 2012 Oct 30. Erratum in: J Lipid Res. 2014 Sep;55(9):1981.

43.

A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing.

Evnouchidou I, Birtley J, Seregin S, Papakyriakou A, Zervoudi E, Samiotaki M, Panayotou G, Giastas P, Petrakis O, Georgiadis D, Amalfitano A, Saridakis E, Mavridis IM, Stratikos E.

J Immunol. 2012 Sep 1;189(5):2383-92. doi: 10.4049/jimmunol.1200918. Epub 2012 Jul 25.

44.

The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing.

Birtley JR, Saridakis E, Stratikos E, Mavridis IM.

Biochemistry. 2012 Jan 10;51(1):286-95. doi: 10.1021/bi201230p. Epub 2011 Dec 9.

PMID:
22106953
45.

Biophysical analysis of apolipoprotein E3 variants linked with development of type III hyperlipoproteinemia.

Georgiadou D, Chroni A, Vezeridis A, Zannis VI, Stratikos E.

PLoS One. 2011;6(11):e27037. doi: 10.1371/journal.pone.0027037. Epub 2011 Nov 1.

46.

Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1.

Kim S, Lee S, Shin J, Kim Y, Evnouchidou I, Kim D, Kim YK, Kim YE, Ahn JH, Riddell SR, Stratikos E, Kim VN, Ahn K.

Nat Immunol. 2011 Sep 4;12(10):984-91. doi: 10.1038/ni.2097.

47.

A simple approach for human recombinant apolipoprotein E4 expression and purification.

Argyri L, Skamnaki V, Stratikos E, Chroni A.

Protein Expr Purif. 2011 Oct;79(2):251-7. doi: 10.1016/j.pep.2011.06.011. Epub 2011 Jun 25.

PMID:
21712092
48.

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1.

Nguyen TT, Chang SC, Evnouchidou I, York IA, Zikos C, Rock KL, Goldberg AL, Stratikos E, Stern LJ.

Nat Struct Mol Biol. 2011 May;18(5):604-13. doi: 10.1038/nsmb.2021. Epub 2011 Apr 10.

49.

Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.

Zervoudi E, Papakyriakou A, Georgiadou D, Evnouchidou I, Gajda A, Poreba M, Salvesen GS, Drag M, Hattori A, Swevers L, Vourloumis D, Stratikos E.

Biochem J. 2011 Apr 15;435(2):411-20. doi: 10.1042/BJ20102049.

50.

Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme.

Evnouchidou I, Kamal RP, Seregin SS, Goto Y, Tsujimoto M, Hattori A, Voulgari PV, Drosos AA, Amalfitano A, York IA, Stratikos E.

J Immunol. 2011 Feb 15;186(4):1909-13. doi: 10.4049/jimmunol.1003337. Epub 2011 Jan 17.

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