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Items: 40

1.

Development of a non-human primate model to support CNS translational research: Demonstration with D-amphetamine exposure and dopamine response.

Folgering JH, Choi M, Schlumbohm C, van Gaalen MM, Stratford RE Jr.

J Neurosci Methods. 2019 Feb 12;317:71-81. doi: 10.1016/j.jneumeth.2019.02.005. [Epub ahead of print]

2.

Mechanism-Based Pharmacokinetic-Pharmacodynamic Model Describing Dextroamphetamine Exposure and Striatal Dopamine Response in Rats and Non-Human Primates following a Single Intravenous Dose of Dextroamphetamine.

van Gaalen M, Schlumbohm C, Folgering J, Adhikari S, Bhattacharya C, Steinbach D, Stratford RE.

J Pharmacol Exp Ther. 2019 Feb 7. pii: jpet.118.254508. doi: 10.1124/jpet.118.254508. [Epub ahead of print]

3.

Comparison of In Vitro Stereoselective Metabolism of Bupropion in Human, Monkey, Rat, and Mouse Liver Microsomes.

Bhattacharya C, Kirby D, Van Stipdonk M, Stratford RE.

Eur J Drug Metab Pharmacokinet. 2018 Oct 8. doi: 10.1007/s13318-018-0516-4. [Epub ahead of print]

PMID:
30298475
4.

Drug conjugates-an emerging approach to treat breast cancer.

Hasan M, Leak RK, Stratford RE, Zlotos DP, Witt-Enderby PA.

Pharmacol Res Perspect. 2018 Jul 5;6(4):e00417. doi: 10.1002/prp2.417. eCollection 2018 Jul. Review.

5.

Cellular Pharmacokinetic Model-Based Analysis of Genistein, Glyceollin, and MK-571 Effects on 5 (and 6)-Carboxy-2',7'-Dichloroflourescein Disposition in Caco-2 Cells.

Drennen C, Gorse E, Stratford RE Jr.

J Pharm Sci. 2018 Apr;107(4):1194-1203. doi: 10.1016/j.xphs.2017.12.004. Epub 2017 Dec 14.

PMID:
29247742
6.

Development of a Rat Plasma and Brain Extracellular Fluid Pharmacokinetic Model for Bupropion and Hydroxybupropion Based on Microdialysis Sampling, and Application to Predict Human Brain Concentrations.

Cremers TI, Flik G, Folgering JH, Rollema H, Stratford RE Jr.

Drug Metab Dispos. 2016 May;44(5):624-33. doi: 10.1124/dmd.115.068932. Epub 2016 Feb 25.

PMID:
26916207
7.

Genistein and Glyceollin Effects on ABCC2 (MRP2) and ABCG2 (BCRP) in Caco-2 Cells.

Schexnayder C, Stratford RE.

Int J Environ Res Public Health. 2015 Dec 22;13(1):ijerph13010017. doi: 10.3390/ijerph13010017.

8.

Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M₁ agonists.

Liu B, Croy CH, Hitchcock SA, Allen JR, Rao Z, Evans D, Bures MG, McKinzie DL, Watt ML, Stuart Gregory G, Hansen MM, Hoogestraat PJ, Jamison JA, Okha-Mokube FM, Stratford RE, Turner W, Bymaster F, Felder CC.

Bioorg Med Chem Lett. 2015 Oct 1;25(19):4158-63. doi: 10.1016/j.bmcl.2015.08.011. Epub 2015 Aug 8.

PMID:
26299349
9.

Glyceollin Effects on MRP2 and BCRP in Caco-2 Cells, and Implications for Metabolic and Transport Interactions.

Chimezie C, Ewing A, Schexnayder C, Bratton M, Glotser E, Skripnikova E, Sá P, Boué S, Stratford RE Jr.

J Pharm Sci. 2016 Feb;105(2):972-981. doi: 10.1002/jps.24605. Epub 2016 Jan 11.

10.

Prediction of brain clozapine and norclozapine concentrations in humans from a scaled pharmacokinetic model for rat brain and plasma pharmacokinetics.

Li CH, Stratford RE Jr, Velez de Mendizabal N, Cremers TI, Pollock BG, Mulsant BH, Remington G, Bies RR.

J Transl Med. 2014 Aug 20;12:203. doi: 10.1186/1479-5876-12-203.

11.
12.

Glyceollin transport, metabolism, and effects on p-glycoprotein function in Caco-2 cells.

Chimezie C, Ewing AC, Quadri SS, Cole RB, Boué SM, Omari CF, Bratton M, Glotser E, Skripnikova E, Townley I, Stratford RE Jr.

J Med Food. 2014 Apr;17(4):462-71. doi: 10.1089/jmf.2013.0115. Epub 2014 Jan 29.

13.

GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy.

Martinez-Perez JA, Iyengar S, Shannon HE, Bleakman D, Alt A, Clawson DK, Arnold BM, Bell MG, Bleisch TJ, Castaño AM, Del Prado M, Dominguez E, Escribano AM, Filla SA, Ho KH, Hudziak KJ, Jones CK, Mateo A, Mathes BM, Mattiuz EL, Ogden AM, Simmons RM, Stack DR, Stratford RE, Winter MA, Wu Z, Ornstein PL.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6463-6. doi: 10.1016/j.bmcl.2013.09.045. Epub 2013 Sep 24.

PMID:
24140446
14.

GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models.

Martinez-Perez JA, Iyengar S, Shannon HE, Bleakman D, Alt A, Arnold BM, Bell MG, Bleisch TJ, Castaño AM, Del Prado M, Dominguez E, Escribano AM, Filla SA, Ho KH, Hudziak KJ, Jones CK, Mateo A, Mathes BM, Mattiuz EL, Ogden AM, Simmons RM, Stack DR, Stratford RE, Winter MA, Wu Z, Ornstein PL.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6459-62. doi: 10.1016/j.bmcl.2013.09.046. Epub 2013 Sep 25.

PMID:
24119554
15.

Screening and identification of glyceollins and their metabolites by electrospray ionization tandem mass spectrometry with precursor ion scanning.

Quadri SS, Stratford RE, Boué SM, Cole RB.

Anal Chem. 2013 Feb 5;85(3):1727-33. doi: 10.1021/ac3030398. Epub 2013 Jan 7.

16.

Microdialysis evaluation of clozapine and N-desmethylclozapine pharmacokinetics in rat brain.

Cremers TI, Flik G, Hofland C, Stratford RE Jr.

Drug Metab Dispos. 2012 Oct;40(10):1909-16. doi: 10.1124/dmd.112.045682. Epub 2012 Jun 26.

PMID:
22736307
17.

Exploratory translational modeling approach in drug development to predict human brain pharmacokinetics and pharmacologically relevant clinical doses.

Kielbasa W, Stratford RE Jr.

Drug Metab Dispos. 2012 May;40(5):877-83. doi: 10.1124/dmd.111.043554. Epub 2012 Jan 27.

PMID:
22287668
18.

Anxiolytic-like effects through a GLUK5 kainate receptor mechanism.

Alt A, Weiss B, Ornstein PL, Gleason SD, Bleakman D, Stratford RE Jr, Witkin JM.

Neuropharmacology. 2007 Jun;52(7):1482-7. Epub 2007 Mar 2.

PMID:
17418283
19.

Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo.

Weiss B, Alt A, Ogden AM, Gates M, Dieckman DK, Clemens-Smith A, Ho KH, Jarvie K, Rizkalla G, Wright RA, Calligaro DO, Schoepp D, Mattiuz EL, Stratford RE, Johnson B, Salhoff C, Katofiasc M, Phebus LA, Schenck K, Cohen M, Filla SA, Ornstein PL, Johnson KW, Bleakman D.

J Pharmacol Exp Ther. 2006 Aug;318(2):772-81. Epub 2006 May 11.

PMID:
16690725
20.

Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist.

Bueno AB, Collado I, de Dios A, Domínguez C, Martín JA, Martín LM, Martínez-Grau MA, Montero C, Pedregal C, Catlow J, Coffey DS, Clay MP, Dantzig AH, Lindstrom T, Monn JA, Jiang H, Schoepp DD, Stratford RE, Tabas LB, Tizzano JP, Wright RA, Herin MF.

J Med Chem. 2005 Aug 11;48(16):5305-20.

PMID:
16078848
21.

Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain.

Dominguez E, Iyengar S, Shannon HE, Bleakman D, Alt A, Arnold BM, Bell MG, Bleisch TJ, Buckmaster JL, Castano AM, Del Prado M, Escribano A, Filla SA, Ho KH, Hudziak KJ, Jones CK, Martinez-Perez JA, Mateo A, Mathes BM, Mattiuz EL, Ogden AM, Simmons RM, Stack DR, Stratford RE, Winter MA, Wu Z, Ornstein PL.

J Med Chem. 2005 Jun 30;48(13):4200-3.

PMID:
15974569
22.

Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine.

Filla SA, Winter MA, Johnson KW, Bleakman D, Bell MG, Bleisch TJ, Castaño AM, Clemens-Smith A, del Prado M, Dieckman DK, Dominguez E, Escribano A, Ho KH, Hudziak KJ, Katofiasc MA, Martinez-Perez JA, Mateo A, Mathes BM, Mattiuz EL, Ogden AM, Phebus LA, Stack DR, Stratford RE, Ornstein PL.

J Med Chem. 2002 Sep 26;45(20):4383-6.

PMID:
12238915
23.

Three-dimensional quantitative structure-permeability relationship analysis for a series of inhibitors of rhinovirus replication.

Ekins S, Durst GL, Stratford RE, Thorner DA, Lewis R, Loncharich RJ, Wikel JH.

J Chem Inf Comput Sci. 2001 Nov-Dec;41(6):1578-86.

PMID:
11749585
24.

Regional-dependent intestinal absorption and meal composition effects on systemic availability of LY303366, a lipopeptide antifungal agent, in dogs.

Li C, Fleisher D, Li L, Schwier JR, Sweetana SA, Vasudevan V, Zornes LL, Pao LH, Zhou SY, Stratford RE.

J Pharm Sci. 2001 Jan;90(1):47-57.

25.

Application of oral bioavailability surrogates in the design of orally active inhibitors of rhinovirus replication.

Stratford RE Jr, Clay MP, Heinz BA, Kuhfeld MT, Osborne SJ, Phillips DL, Sweetana SA, Tebbe MJ, Vasudevan V, Zornes LL, Lindstrom TD.

J Pharm Sci. 1999 Aug;88(8):747-53.

PMID:
10430536
28.

Activities of the semisynthetic glycopeptide LY191145 against vancomycin-resistant enterococci and other gram-positive bacteria.

Nicas TI, Mullen DL, Flokowitsch JE, Preston DA, Snyder NJ, Stratford RE, Cooper RD.

Antimicrob Agents Chemother. 1995 Nov;39(11):2585-7. Erratum in: Antimicrob Agents Chemother 1996 May;40(5):1330.

29.

Mechanisms of transport of quinapril in Caco-2 cell monolayers: comparison with cephalexin.

Hu M, Zheng L, Chen J, Liu L, Zhu Y, Dantzig AH, Stratford RE Jr.

Pharm Res. 1995 Aug;12(8):1120-5.

PMID:
7494822
30.

Peptide transporter function and prolidase activities in Caco-2 cells: a lack of coordinated expression.

Hu M, Zheng L, Chen J, Liu L, Li Y, Dantzig AH, Stratford RE Jr.

J Drug Target. 1995;3(4):291-300.

PMID:
8821003
31.
32.

Systemic absorption of ocularly administered enkephalinamide and inulin in the albino rabbit: extent, pathways, and vehicle effects.

Stratford RE Jr, Carson LW, Dodda-Kashi S, Lee VH.

J Pharm Sci. 1988 Oct;77(10):838-42.

PMID:
3236225
33.

Metabolic and permeation barriers to the ocular absorption of topically applied enkephalins in albino rabbits.

Lee VH, Carson LW, Kashi SD, Stratford RE Jr.

J Ocul Pharmacol. 1986 Fall;2(4):345-52.

PMID:
3503119
34.

Ocular aminopeptidase activity and distribution in the albino rabbit.

Stratford RE Jr, Lee VH.

Curr Eye Res. 1985 Sep;4(9):995-9.

PMID:
4064737
35.

Aminopeptidase activity in albino rabbit extraocular tissues relative to the small intestine.

Stratford RE Jr, Lee VH.

J Pharm Sci. 1985 Jul;74(7):731-4.

PMID:
4032244
36.

Disposition of topically applied sodium cromoglycate in the albino rabbit eye.

Lee VH, Swarbrick J, Stratford RE Jr, Morimoto KW.

J Pharm Pharmacol. 1983 Jul;35(7):445-50.

PMID:
6136586
37.

Esterase distribution in the rabbit cornea and its implications in ocular drug bioavailability.

Lee VH, Morimoto KW, Stratford RE Jr.

Biopharm Drug Dispos. 1982 Oct-Dec;3(4):291-300.

PMID:
7159685
38.

Ocular distribution of liposome-encapsulated epinephrine and inulin in the albino rabbit.

Stratford RE Jr, Yang DC, Redell MA, Lee VH.

Curr Eye Res. 1982-1983;2(6):377-86.

PMID:
7188304
39.
40.

A novel response to propranolol: contractile response in the isolated rabbit ear artery.

Ashbrook DW, Purdy RE, Hurlbut DE, Rains LA, Reidy JP, Stratford RE.

Life Sci. 1980 Jan 14;26(2):155-63. No abstract available.

PMID:
7366323

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