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Extreme Osmotolerance and Halotolerance in Food-Relevant Yeasts and the Role of Glycerol-Dependent Cell Individuality.

Stratford M, Steels H, Novodvorska M, Archer DB, Avery SV.

Front Microbiol. 2019 Jan 9;9:3238. doi: 10.3389/fmicb.2018.03238. eCollection 2018.


Focused Ultrasound Hyperthermia for Targeted Drug Release from Thermosensitive Liposomes: Results from a Phase I Trial.

Gray MD, Lyon PC, Mannaris C, Folkes LK, Stratford M, Campo L, Chung DYF, Scott S, Anderson M, Goldin R, Carlisle R, Wu F, Middleton MR, Gleeson FV, Coussios CC.

Radiology. 2019 Apr;291(1):232-238. doi: 10.1148/radiol.2018181445. Epub 2019 Jan 15.


A phase 1 study to assess the safety, tolerability, and pharmacokinetics of CXD101 in patients with advanced cancer.

Eyre TA, Collins GP, Gupta A, Coupe N, Sheikh S, Whittaker J, Wang LM, Campo L, Soilleux E, Tysoe F, Cousins R, La Thangue N, Folkes LK, Stratford MRL, Kerr D, Middleton MR.

Cancer. 2019 Jan 1;125(1):99-108. doi: 10.1002/cncr.31791. Epub 2018 Oct 17.


Safety and feasibility of ultrasound-triggered targeted drug delivery of doxorubicin from thermosensitive liposomes in liver tumours (TARDOX): a single-centre, open-label, phase 1 trial.

Lyon PC, Gray MD, Mannaris C, Folkes LK, Stratford M, Campo L, Chung DYF, Scott S, Anderson M, Goldin R, Carlisle R, Wu F, Middleton MR, Gleeson FV, Coussios CC.

Lancet Oncol. 2018 Aug;19(8):1027-1039. doi: 10.1016/S1470-2045(18)30332-2. Epub 2018 Jul 11.


A first-in-human phase I study to determine the maximum tolerated dose of the oral Src/ABL inhibitor AZD0424.

Woodcock VK, Clive S, Wilson RH, Coyle VM, Stratford MRL, Folkes LK, Eastell R, Barton C, Jones P, Kazmi-Stokes S, Turner H, Halford S, Harris AL, Middleton MR.

Br J Cancer. 2018 Mar 20;118(6):770-776. doi: 10.1038/bjc.2017.484. Epub 2018 Feb 13.


Radiosensitization In Vivo by Histone Deacetylase Inhibition with No Increase in Early Normal Tissue Radiation Toxicity.

Groselj B, Ruan JL, Scott H, Gorrill J, Nicholson J, Kelly J, Anbalagan S, Thompson J, Stratford MRL, Jevons SJ, Hammond EM, Scudamore CL, Kerr M, Kiltie AE.

Mol Cancer Ther. 2018 Feb;17(2):381-392. doi: 10.1158/1535-7163.MCT-17-0011. Epub 2017 Aug 24.


The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia.

Ashton TM, Fokas E, Kunz-Schughart LA, Folkes LK, Anbalagan S, Huether M, Kelly CJ, Pirovano G, Buffa FM, Hammond EM, Stratford M, Muschel RJ, Higgins GS, McKenna WG.

Nat Commun. 2016 Jul 25;7:12308. doi: 10.1038/ncomms12308.


Metabolic activity in dormant conidia of Aspergillus niger and developmental changes during conidial outgrowth.

Novodvorska M, Stratford M, Blythe MJ, Wilson R, Beniston RG, Archer DB.

Fungal Genet Biol. 2016 Sep;94:23-31. doi: 10.1016/j.fgb.2016.07.002. Epub 2016 Jul 1.


The radiosensitizing effects of Nelfinavir on pancreatic cancer with and without pancreatic stellate cells.

Al-Assar O, Bittner MI, Lunardi S, Stratford MR, McKenna WG, Brunner TB.

Radiother Oncol. 2016 May;119(2):300-5. doi: 10.1016/j.radonc.2016.03.024. Epub 2016 May 28.


Investigation of the anomalous action of 5-hydroxyresorcinol on tyrosinase.

Land EJ, Ramsden CA, Riley PA, Stratford MR.

Pigment Cell Melanoma Res. 2016 Jul;29(4):474-6. doi: 10.1111/pcmr.12490. No abstract available.


Design, synthesis and evaluation of molecularly targeted hypoxia-activated prodrugs.

O'Connor LJ, Cazares-Körner C, Saha J, Evans CN, Stratford MR, Hammond EM, Conway SJ.

Nat Protoc. 2016 Apr;11(4):781-94. doi: 10.1038/nprot.2016.034. Epub 2016 Mar 24.


Prebiotic administration normalizes lipopolysaccharide (LPS)-induced anxiety and cortical 5-HT2A receptor and IL1-β levels in male mice.

Savignac HM, Couch Y, Stratford M, Bannerman DM, Tzortzis G, Anthony DC, Burnet PWJ.

Brain Behav Immun. 2016 Feb;52:120-131. doi: 10.1016/j.bbi.2015.10.007.


A Multicenter Randomized Trial of Ibandronate Compared With Single-Dose Radiotherapy for Localized Metastatic Bone Pain in Prostate Cancer.

Hoskin P, Sundar S, Reczko K, Forsyth S, Mithal N, Sizer B, Bloomfield D, Upadhyay S, Wilson P, Kirkwood A, Stratford M, Jitlal M, Hackshaw A.

J Natl Cancer Inst. 2015 Aug 4;107(10). pii: djv197. doi: 10.1093/jnci/djv197. Print 2015 Oct.


Oxidative calcium release from catechol.

Riley PA, Stratford MR.

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1453-4. doi: 10.1016/j.bmcl.2015.02.036. Epub 2015 Feb 23.


Development of an enzymatic pretargeting strategy for dual-modality imaging.

Knight JC, Mosley M, Stratford MR, Uyeda HT, Benink HA, Cong M, Fan F, Faulkner S, Cornelissen B.

Chem Commun (Camb). 2015 Mar 7;51(19):4055-8. doi: 10.1039/c4cc10265g.


Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread.

Wong PP, Demircioglu F, Ghazaly E, Alrawashdeh W, Stratford MR, Scudamore CL, Cereser B, Crnogorac-Jurcevic T, McDonald S, Elia G, Hagemann T, Kocher HM, Hodivala-Dilke KM.

Cancer Cell. 2015 Jan 12;27(1):123-37. doi: 10.1016/j.ccell.2014.10.015.


A novel biosensor for quantitative monitoring of on-target activity of paclitaxel.

Townley HE, Zheng Y, Goldsmith J, Zheng YY, Stratford MR, Dobson PJ, Ahmed AA.

Nanoscale. 2015 Jan 21;7(3):1127-35. doi: 10.1039/c4nr01105h.


Deoxycytidine kinase expression underpins response to gemcitabine in bladder cancer.

Kerr M, Scott HE, Groselj B, Stratford MR, Karaszi K, Sharma NL, Kiltie AE.

Clin Cancer Res. 2014 Nov 1;20(21):5435-45. doi: 10.1158/1078-0432.CCR-14-0542. Epub 2014 Sep 15.


Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.

Maniam S, Coutts AS, Stratford MR, McGouran J, Kessler B, La Thangue NB.

Cell Death Differ. 2015 Jan;22(1):156-63. doi: 10.1038/cdd.2014.135. Epub 2014 Aug 29.


Germination of Aspergillus niger conidia is triggered by nitrogen compounds related to L-amino acids.

Hayer K, Stratford M, Archer DB.

Appl Environ Microbiol. 2014 Oct;80(19):6046-53. doi: 10.1128/AEM.01078-14. Epub 2014 Jul 25.


Rapid identification of the genus Dekkera/Brettanomyces, the Dekkera subgroup and all individual species.

Hulin M, Harrison E, Stratford M, Wheals AE.

Int J Food Microbiol. 2014 Sep 18;187:7-14. doi: 10.1016/j.ijfoodmicro.2014.06.028. Epub 2014 Jul 4.


Corrigendum to "Systemic inflammation alters central 5-HT function as determined by pharmacological MRI" [Neuroimage 75 (2013) 177-186].

Couch Y, Martin CJ, Howarth C, Raley J, Khrapitchev AA, Stratford M, Sharp T, Sibson NR, Anthony DC.

Neuroimage. 2014 Jul 1;94:413. doi: 10.1016/j.neuroimage.2014.03.021. Epub 2014 Mar 18. No abstract available.


Population heterogeneity and dynamics in starter culture and lag phase adaptation of the spoilage yeast Zygosaccharomyces bailii to weak acid preservatives.

Stratford M, Steels H, Nebe-von-Caron G, Avery SV, Novodvorska M, Archer DB.

Int J Food Microbiol. 2014 Jul 2;181:40-7. doi: 10.1016/j.ijfoodmicro.2014.04.017. Epub 2014 Apr 21.


Regulation of O2 consumption by the PI3K and mTOR pathways contributes to tumor hypoxia.

Kelly CJ, Hussien K, Fokas E, Kannan P, Shipley RJ, Ashton TM, Stratford M, Pearson N, Muschel RJ.

Radiother Oncol. 2014 Apr;111(1):72-80. doi: 10.1016/j.radonc.2014.02.007. Epub 2014 Mar 13.


Structural features of sugars that trigger or support conidial germination in the filamentous fungus Aspergillus niger.

Hayer K, Stratford M, Archer DB.

Appl Environ Microbiol. 2013 Nov;79(22):6924-31. doi: 10.1128/AEM.02061-13. Epub 2013 Aug 30.


Extreme resistance to weak-acid preservatives in the spoilage yeast Zygosaccharomyces bailii.

Stratford M, Steels H, Nebe-von-Caron G, Novodvorska M, Hayer K, Archer DB.

Int J Food Microbiol. 2013 Aug 16;166(1):126-34. doi: 10.1016/j.ijfoodmicro.2013.06.025. Epub 2013 Jul 2.


A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia.

Adam J, Yang M, Bauerschmidt C, Kitagawa M, O'Flaherty L, Maheswaran P, Özkan G, Sahgal N, Baban D, Kato K, Saito K, Iino K, Igarashi K, Stratford M, Pugh C, Tennant DA, Ludwig C, Davies B, Ratcliffe PJ, El-Bahrawy M, Ashrafian H, Soga T, Pollard PJ.

Cell Rep. 2013 May 30;3(5):1440-8. doi: 10.1016/j.celrep.2013.04.006. Epub 2013 May 2.


Trancriptional landscape of Aspergillus niger at breaking of conidial dormancy revealed by RNA-sequencing.

Novodvorska M, Hayer K, Pullan ST, Wilson R, Blythe MJ, Stam H, Stratford M, Archer DB.

BMC Genomics. 2013 Apr 11;14:246. doi: 10.1186/1471-2164-14-246.


Systemic inflammation alters central 5-HT function as determined by pharmacological MRI.

Couch Y, Martin CJ, Howarth C, Raley J, Khrapitchev AA, Stratford M, Sharp T, Sibson NR, Anthony DC.

Neuroimage. 2013 Jul 15;75:177-186. doi: 10.1016/j.neuroimage.2013.02.046. Epub 2013 Mar 5. Erratum in: Neuroimage. 2014 Jul 1;94:413.


Mechanistic studies of the inactivation of tyrosinase by resorcinol.

Stratford MR, Ramsden CA, Riley PA.

Bioorg Med Chem. 2013 Mar 1;21(5):1166-73. doi: 10.1016/j.bmc.2012.12.031. Epub 2013 Jan 3.


Weak-acid preservatives: pH and proton movements in the yeast Saccharomyces cerevisiae.

Stratford M, Nebe-von-Caron G, Steels H, Novodvorska M, Ueckert J, Archer DB.

Int J Food Microbiol. 2013 Feb 15;161(3):164-71. doi: 10.1016/j.ijfoodmicro.2012.12.013. Epub 2012 Dec 28.


Mapping the structural requirements of inducers and substrates for decarboxylation of weak acid preservatives by the food spoilage mould Aspergillus niger.

Stratford M, Plumridge A, Pleasants MW, Novodvorska M, Baker-Glenn CA, Pattenden G, Archer DB.

Int J Food Microbiol. 2012 Jul 16;157(3):375-83. doi: 10.1016/j.ijfoodmicro.2012.06.007. Epub 2012 Jun 15.


The influence of hydroquinone on tyrosinase kinetics.

Stratford MR, Ramsden CA, Riley PA.

Bioorg Med Chem. 2012 Jul 15;20(14):4364-70. doi: 10.1016/j.bmc.2012.05.041. Epub 2012 May 24.


Quantitative determination of the anticancer prodrug combretastatin A1 phosphate (OXi4503, CA1P), the active CA1 and its glucuronide metabolites in human urine and of CA1 in plasma by HPLC with mass spectrometric detection.

Stratford MR, Folkes LK.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:1-6. doi: 10.1016/j.jchromb.2012.03.040. Epub 2012 Apr 24.


A validated HPLC method with fluorescence detection for the glucuronides of Combretastatin A1 in human plasma, and studies on their cis-trans isomerisation.

Stratford MR, Folkes LK.

J Pharm Biomed Anal. 2012 Mar 25;62:114-8. doi: 10.1016/j.jpba.2011.12.022. Epub 2011 Dec 24.


Phase I clinical and pharmacokinetic evaluation of the vascular-disrupting agent OXi4503 in patients with advanced solid tumors.

Patterson DM, Zweifel M, Middleton MR, Price PM, Folkes LK, Stratford MR, Ross P, Halford S, Peters J, Balkissoon J, Chaplin DJ, Padhani AR, Rustin GJ.

Clin Cancer Res. 2012 Mar 1;18(5):1415-25. doi: 10.1158/1078-0432.CCR-11-2414. Epub 2012 Jan 10.


Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature.

Fokas E, Im JH, Hill S, Yameen S, Stratford M, Beech J, Hackl W, Maira SM, Bernhard EJ, McKenna WG, Muschel RJ.

Cancer Res. 2012 Jan 1;72(1):239-48. doi: 10.1158/0008-5472.CAN-11-2263. Epub 2011 Nov 22.


Modulation of the tumor microvasculature by phosphoinositide-3 kinase inhibition increases doxorubicin delivery in vivo.

Qayum N, Im J, Stratford MR, Bernhard EJ, McKenna WG, Muschel RJ.

Clin Cancer Res. 2012 Jan 1;18(1):161-9. doi: 10.1158/1078-0432.CCR-11-1413. Epub 2011 Nov 7.


Validation of a method for the determination of the anticancer agent Combretastatin A1 phosphate (CA1P, OXi4503) in human plasma by HPLC with post-column photolysis and fluorescence detection.

Stratford MR, Folkes LK.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Sep 1;879(25):2673-6. doi: 10.1016/j.jchromb.2011.07.014. Epub 2011 Jul 18.


Yeast identification: reassessment of assimilation tests as sole universal identifiers.

Spencer J, Rawling S, Stratford M, Steels H, Novodvorska M, Archer DB, Chandra S.

Lett Appl Microbiol. 2011 Nov;53(5):503-8. doi: 10.1111/j.1472-765X.2011.03130.x. Epub 2011 Sep 23.


Species-specific PCR primers for the rapid identification of yeasts of the genus Zygosaccharomyces.

Harrison E, Muir A, Stratford M, Wheals A.

FEMS Yeast Res. 2011 Jun;11(4):356-65. doi: 10.1111/j.1567-1364.2011.00724.x. Epub 2011 Mar 16.


Rapid halogen substitution and dibenzodioxin formation during tyrosinase-catalyzed oxidation of 4-halocatechols.

Stratford MR, Riley PA, Ramsden CA.

Chem Res Toxicol. 2011 Mar 21;24(3):350-6. doi: 10.1021/tx100315n. Epub 2011 Feb 9.


Break-induced ATR and Ddb1-Cul4(Cdt)² ubiquitin ligase-dependent nucleotide synthesis promotes homologous recombination repair in fission yeast.

Moss J, Tinline-Purvis H, Walker CA, Folkes LK, Stratford MR, Hayles J, Hoe KL, Kim DU, Park HO, Kearsey SE, Fleck O, Holmberg C, Nielsen O, Humphrey TC.

Genes Dev. 2010 Dec 1;24(23):2705-16. doi: 10.1101/gad.1970810.


The decarboxylation of the weak-acid preservative, sorbic acid, is encoded by linked genes in Aspergillus spp.

Plumridge A, Melin P, Stratford M, Novodvorska M, Shunburne L, Dyer PS, Roubos JA, Menke H, Stark J, Stam H, Archer DB.

Fungal Genet Biol. 2010 Aug;47(8):683-92. doi: 10.1016/j.fgb.2010.04.011. Epub 2010 May 7.


A Phase Ib trial of CA4P (combretastatin A-4 phosphate), carboplatin, and paclitaxel in patients with advanced cancer.

Rustin GJ, Shreeves G, Nathan PD, Gaya A, Ganesan TS, Wang D, Boxall J, Poupard L, Chaplin DJ, Stratford MR, Balkissoon J, Zweifel M.

Br J Cancer. 2010 Apr 27;102(9):1355-60. doi: 10.1038/sj.bjc.6605650. Epub 2010 Apr 13.


Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability.

Pires IM, Bencokova Z, Milani M, Folkes LK, Li JL, Stratford MR, Harris AL, Hammond EM.

Cancer Res. 2010 Feb 1;70(3):925-35. doi: 10.1158/0008-5472.CAN-09-2715. Epub 2010 Jan 26.


In vivo characterization of horseradish peroxidase with indole-3-acetic acid and 5-bromoindole-3-acetic acid for gene therapy of cancer.

Tupper J, Stratford MR, Hill S, Tozer GM, Dachs GU.

Cancer Gene Ther. 2010 Jun;17(6):420-8. doi: 10.1038/cgt.2009.86. Epub 2010 Jan 15.


Inhibition of spoilage mould conidia by acetic acid and sorbic acid involves different modes of action, requiring modification of the classical weak-acid theory.

Stratford M, Plumridge A, Nebe-von-Caron G, Archer DB.

Int J Food Microbiol. 2009 Nov 30;136(1):37-43. doi: 10.1016/j.ijfoodmicro.2009.09.025. Epub 2009 Oct 4.


The influence of catechol structure on the suicide-inactivation of tyrosinase.

Ramsden CA, Stratford MR, Riley PA.

Org Biomol Chem. 2009 Sep 7;7(17):3388-90. doi: 10.1039/b910500j. Epub 2009 Jul 9.


A phase I trial of radioimmunotherapy with 131I-A5B7 anti-CEA antibody in combination with combretastatin-A4-phosphate in advanced gastrointestinal carcinomas.

Meyer T, Gaya AM, Dancey G, Stratford MR, Othman S, Sharma SK, Wellsted D, Taylor NJ, Stirling JJ, Poupard L, Folkes LK, Chan PS, Pedley RB, Chester KA, Owen K, Violet JA, Malaroda A, Green AJ, Buscombe J, Padhani AR, Rustin GJ, Begent RH.

Clin Cancer Res. 2009 Jul 1;15(13):4484-92. doi: 10.1158/1078-0432.CCR-09-0035. Epub 2009 Jun 23.

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