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Items: 20

1.

PHARMACOLOGICAL CHARACTERIZATION OF APROCITENTAN, A DUAL ENDOTHELIN RECEPTOR ANTAGONIST, ALONE AND IN COMBINATION WITH BLOCKERS OF THE RENIN ANGIOTENSIN SYSTEM, IN TWO MODELS OF EXPERIMENTAL HYPERTENSION.

Trensz F, Bortolamiol C, Kramberg M, Wanner D, Hadana H, Rey M, Strasser DS, Delahaye S, Hess P, Vezzali E, Mentzel U, Menard J, Clozel M, Iglarz M.

J Pharmacol Exp Ther. 2019 Jan 8. pii: jpet.118.253864. doi: 10.1124/jpet.118.253864. [Epub ahead of print]

2.

Eosinophilic oesophagitis: relevance of mast cell infiltration.

Strasser DS, Seger S, Bussmann C, Pierlot GM, Groenen PMA, Stalder AK, Straumann A.

Histopathology. 2018 Sep;73(3):454-463. doi: 10.1111/his.13653. Epub 2018 Jun 22.

PMID:
29772120
3.

Granulomatous lung inflammation is nanoparticle type-dependent.

Pacheco Y, Ponchon M, Lebecque S, Calender A, Bernaudin JF, Valeyre D, Iglarz M, Strasser DS, Studer R, Freti D, Renno T, Bentaher A.

Exp Lung Res. 2018 Feb;44(1):25-39. doi: 10.1080/01902148.2017.1412541. Epub 2018 Jan 11.

PMID:
29324063
4.

Monitoring inflammatory heterogeneity with multiple biomarkers for multidimensional endotyping of asthma.

Agache I, Strasser DS, Pierlot GM, Farine H, Izuhara K, Akdis CA.

J Allergy Clin Immunol. 2018 Jan;141(1):442-445. doi: 10.1016/j.jaci.2017.08.027. Epub 2017 Oct 5. No abstract available.

PMID:
28987809
5.

Endothelin ETA Receptor Blockade, by Activating ETB Receptors, Increases Vascular Permeability and Induces Exaggerated Fluid Retention.

Vercauteren M, Trensz F, Pasquali A, Cattaneo C, Strasser DS, Hess P, Iglarz M, Clozel M.

J Pharmacol Exp Ther. 2017 May;361(2):322-333. doi: 10.1124/jpet.116.234930. Epub 2017 Feb 21.

6.

Modeling the Effect of the Selective S1P1 Receptor Modulator Ponesimod on Subsets of Blood Lymphocytes.

Lott D, Krause A, Seemayer CA, Strasser DS, Dingemanse J, Lehr T.

Pharm Res. 2017 Mar;34(3):599-609. doi: 10.1007/s11095-016-2087-x. Epub 2016 Dec 27.

PMID:
28028771
7.

Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949.

Stalder AK, Lott D, Strasser DS, Cruz HG, Krause A, Groenen PM, Dingemanse J.

Br J Clin Pharmacol. 2017 Mar;83(3):476-486. doi: 10.1111/bcp.13149. Epub 2016 Nov 15.

8.

Serum IL-5 and IL-13 consistently serve as the best predictors for the blood eosinophilia phenotype in adult asthmatics.

Agache I, Strasser DS, Klenk A, Agache C, Farine H, Ciobanu C, Groenen PM, Akdis CA.

Allergy. 2016 Aug;71(8):1192-202. doi: 10.1111/all.12906. Epub 2016 Apr 29.

PMID:
27060452
9.

Pharmacokinetic/Pharmacodynamic Modelling of Receptor Internalization with CRTH2 Antagonists to Optimize Dose Selection.

Krause A, Zisowsky J, Strasser DS, Gehin M, Sidharta PN, Groenen PMA, Dingemanse J.

Clin Pharmacokinet. 2016 Jul;55(7):813-821. doi: 10.1007/s40262-015-0354-3.

PMID:
26692193
10.

A novel CRTH2 antagonist: Single- and multiple-dose tolerability, pharmacokinetics, and pharmacodynamics of ACT-453859 in healthy subjects.

Géhin M, Strasser DS, Zisowsky J, Farine H, Groenen PM, Dingemanse J, Sidharta PN.

J Clin Pharmacol. 2015 Jul;55(7):787-97. doi: 10.1002/jcph.478. Epub 2015 Mar 30.

PMID:
25655470
11.

Genetic screening for Niemann-Pick disease type C in adults with neurological and psychiatric symptoms: findings from the ZOOM study.

Bauer P, Balding DJ, Klünemann HH, Linden DE, Ory DS, Pineda M, Priller J, Sedel F, Muller A, Chadha-Boreham H, Welford RW, Strasser DS, Patterson MC.

Hum Mol Genet. 2013 Nov 1;22(21):4349-56. doi: 10.1093/hmg/ddt284. Epub 2013 Jun 16.

12.

Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.

Surivet JP, Lange R, Hubschwerlen C, Keck W, Specklin JL, Ritz D, Bur D, Locher H, Seiler P, Strasser DS, Prade L, Kohl C, Schmitt C, Chapoux G, Ilhan E, Ekambaram N, Athanasiou A, Knezevic A, Sabato D, Chambovey A, Gaertner M, Enderlin M, Boehme M, Sippel V, Wyss P.

Bioorg Med Chem Lett. 2012 Nov 1;22(21):6705-11. doi: 10.1016/j.bmcl.2012.08.094. Epub 2012 Sep 4.

PMID:
23006603
13.

Examining the role of endogenous orexins in hypothalamus-pituitary-adrenal axis endocrine function using transient dual orexin receptor antagonism in the rat.

Steiner MA, Sciarretta C, Brisbare-Roch C, Strasser DS, Studer R, Jenck F.

Psychoneuroendocrinology. 2013 Apr;38(4):560-71. doi: 10.1016/j.psyneuen.2012.07.016. Epub 2012 Aug 20.

PMID:
22917622
14.

Sex comparison on long-lasting behavioral and physiological disturbances induced by single shock experience in rats.

Viviani D, Haegler P, Strasser DS, Steiner MA.

Physiol Behav. 2012 Sep 10;107(2):243-51. doi: 10.1016/j.physbeh.2012.06.018. Epub 2012 Jul 6.

PMID:
22776621
15.

Identification of cathepsin L as a potential sex-specific biomarker for renal damage.

Bauer Y, Hess P, Qiu C, Klenk A, Renault B, Wanner D, Studer R, Killer N, Stalder AK, Stritt M, Strasser DS, Farine H, Kauser K, Clozel M, Fischli W, Nayler O.

Hypertension. 2011 Apr;57(4):795-801. doi: 10.1161/HYPERTENSIONAHA.110.157206. Epub 2011 Feb 28.

PMID:
21357272
16.

Differential effects of the dual orexin receptor antagonist almorexant and the GABA(A)-α1 receptor modulator zolpidem, alone or combined with ethanol, on motor performance in the rat.

Steiner MA, Lecourt H, Strasser DS, Brisbare-Roch C, Jenck F.

Neuropsychopharmacology. 2011 Mar;36(4):848-56. doi: 10.1038/npp.2010.224. Epub 2010 Dec 8.

17.

A fragment-based in situ combinatorial approach to identify high-affinity ligands for unknown binding sites.

Shelke SV, Cutting B, Jiang X, Koliwer-Brandl H, Strasser DS, Schwardt O, Kelm S, Ernst B.

Angew Chem Int Ed Engl. 2010 Aug 2;49(33):5721-5. doi: 10.1002/anie.200907254. No abstract available.

PMID:
20818756
18.

Kinetic and thermodynamic properties of MAG antagonists.

Mesch S, Lemme K, Koliwer-Brandl H, Strasser DS, Schwardt O, Kelm S, Ernst B.

Carbohydr Res. 2010 Jul 2;345(10):1348-59. doi: 10.1016/j.carres.2010.03.010. Epub 2010 Mar 16.

PMID:
20359700
19.

Low molecular weight antagonists of the myelin-associated glycoprotein: synthesis, docking, and biological evaluation.

Mesch S, Moser D, Strasser DS, Kelm A, Cutting B, Rossato G, Vedani A, Koliwer-Brandl H, Wittwer M, Rabbani S, Schwardt O, Kelm S, Ernst B.

J Med Chem. 2010 Feb 25;53(4):1597-615. doi: 10.1021/jm901517k.

PMID:
20095613
20.

Comparative epitope mapping with saturation transfer difference NMR of sialyl Lewis(a) compounds and derivatives bound to a monoclonal antibody.

Herfurth L, Ernst B, Wagner B, Ricklin D, Strasser DS, Magnani JL, Benie AJ, Peters T.

J Med Chem. 2005 Nov 3;48(22):6879-86.

PMID:
16250646

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