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Items: 22

1.

Structure-Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes.

Rueda-Zubiaurre A, Yahiya S, Fischer OJ, Hu X, Saunders CN, Sharma S, Straschil U, Shen J, Tate EW, Delves MJ, Baum J, Barnard A, Fuchter MJ.

J Med Chem. 2019 Sep 20. doi: 10.1021/acs.jmedchem.9b00898. [Epub ahead of print]

PMID:
31490680
2.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Baragaña B, Forte B, Choi R, Nakazawa Hewitt S, Bueren-Calabuig JA, Pisco JP, Peet C, Dranow DM, Robinson DA, Jansen C, Norcross NR, Vinayak S, Anderson M, Brooks CF, Cooper CA, Damerow S, Delves M, Dowers K, Duffy J, Edwards TE, Hallyburton I, Horst BG, Hulverson MA, Ferguson L, Jiménez-Díaz MB, Jumani RS, Lorimer DD, Love MS, Maher S, Matthews H, McNamara CW, Miller P, O'Neill S, Ojo KK, Osuna-Cabello M, Pinto E, Post J, Riley J, Rottmann M, Sanz LM, Scullion P, Sharma A, Shepherd SM, Shishikura Y, Simeons FRC, Stebbins EE, Stojanovski L, Straschil U, Tamaki FK, Tamjar J, Torrie LS, Vantaux A, Witkowski B, Wittlin S, Yogavel M, Zuccotto F, Angulo-Barturen I, Sinden R, Baum J, Gamo FJ, Mäser P, Kyle DE, Winzeler EA, Myler PJ, Wyatt PG, Floyd D, Matthews D, Sharma A, Striepen B, Huston CD, Gray DW, Fairlamb AH, Pisliakov AV, Walpole C, Read KD, Van Voorhis WC, Gilbert IH.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7015-7020. doi: 10.1073/pnas.1814685116. Epub 2019 Mar 20.

3.

A high throughput screen for next-generation leads targeting malaria parasite transmission.

Delves MJ, Miguel-Blanco C, Matthews H, Molina I, Ruecker A, Yahiya S, Straschil U, Abraham M, León ML, Fischer OJ, Rueda-Zubiaurre A, Brandt JR, Cortés Á, Barnard A, Fuchter MJ, Calderón F, Winzeler EA, Sinden RE, Herreros E, Gamo FJ, Baum J.

Nat Commun. 2018 Sep 18;9(1):3805. doi: 10.1038/s41467-018-05777-2.

4.

An inexpensive open source 3D-printed membrane feeder for human malaria transmission studies.

Witmer K, Sherrard-Smith E, Straschil U, Tunnicliff M, Baum J, Delves M.

Malar J. 2018 Aug 3;17(1):282. doi: 10.1186/s12936-018-2436-9.

5.

Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes.

Bargieri DY, Thiberge S, Tay CL, Carey AF, Rantz A, Hischen F, Lorthiois A, Straschil U, Singh P, Singh S, Triglia T, Tsuboi T, Cowman A, Chitnis C, Alano P, Baum J, Pradel G, Lavazec C, Ménard R.

Cell Host Microbe. 2016 Nov 9;20(5):618-630. doi: 10.1016/j.chom.2016.10.015.

6.

Routine in vitro culture of P. falciparum gametocytes to evaluate novel transmission-blocking interventions.

Delves MJ, Straschil U, Ruecker A, Miguel-Blanco C, Marques S, Dufour AC, Baum J, Sinden RE.

Nat Protoc. 2016 Sep;11(9):1668-80. doi: 10.1038/nprot.2016.096. Epub 2016 Aug 18.

PMID:
27560172
7.

Comparative assessment of transmission-blocking vaccine candidates against Plasmodium falciparum.

Kapulu MC, Da DF, Miura K, Li Y, Blagborough AM, Churcher TS, Nikolaeva D, Williams AR, Goodman AL, Sangare I, Turner AV, Cottingham MG, Nicosia A, Straschil U, Tsuboi T, Gilbert SC, Long CA, Sinden RE, Draper SJ, Hill AV, Cohuet A, Biswas S.

Sci Rep. 2015 Jun 11;5:11193. doi: 10.1038/srep11193.

8.

Changes in metabolic phenotypes of Plasmodium falciparum in vitro cultures during gametocyte development.

Lamour SD, Straschil U, Saric J, Delves MJ.

Malar J. 2014 Dec 1;13:468. doi: 10.1186/1475-2875-13-468.

9.

A male and female gametocyte functional viability assay to identify biologically relevant malaria transmission-blocking drugs.

Ruecker A, Mathias DK, Straschil U, Churcher TS, Dinglasan RR, Leroy D, Sinden RE, Delves MJ.

Antimicrob Agents Chemother. 2014 Dec;58(12):7292-302. doi: 10.1128/AAC.03666-14. Epub 2014 Sep 29.

10.

Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation.

Guttery DS, Poulin B, Ramaprasad A, Wall RJ, Ferguson DJ, Brady D, Patzewitz EM, Whipple S, Straschil U, Wright MH, Mohamed AM, Radhakrishnan A, Arold ST, Tate EW, Holder AA, Wickstead B, Pain A, Tewari R.

Cell Host Microbe. 2014 Jul 9;16(1):128-40. doi: 10.1016/j.chom.2014.05.020.

11.

RON12, a novel Plasmodium-specific rhoptry neck protein important for parasite proliferation.

Knuepfer E, Suleyman O, Dluzewski AR, Straschil U, O'Keeffe AH, Ogun SA, Green JL, Grainger M, Tewari R, Holder AA.

Cell Microbiol. 2014 May;16(5):657-72. doi: 10.1111/cmi.12181. Epub 2013 Aug 28.

12.

Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugs.

Delves MJ, Ruecker A, Straschil U, Lelièvre J, Marques S, López-Barragán MJ, Herreros E, Sinden RE.

Antimicrob Agents Chemother. 2013 Jul;57(7):3268-74. doi: 10.1128/AAC.00325-13. Epub 2013 Apr 29.

13.

A unique protein phosphatase with kelch-like domains (PPKL) in Plasmodium modulates ookinete differentiation, motility and invasion.

Guttery DS, Poulin B, Ferguson DJ, Szöőr B, Wickstead B, Carroll PL, Ramakrishnan C, Brady D, Patzewitz EM, Straschil U, Solyakov L, Green JL, Sinden RE, Tobin AB, Holder AA, Tewari R.

PLoS Pathog. 2012 Sep;8(9):e1002948. doi: 10.1371/journal.ppat.1002948. Epub 2012 Sep 20.

14.

A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development.

Guttery DS, Ferguson DJ, Poulin B, Xu Z, Straschil U, Klop O, Solyakov L, Sandrini SM, Brady D, Nieduszynski CA, Janse CJ, Holder AA, Tobin AB, Tewari R.

PLoS Pathog. 2012 Feb;8(2):e1002554. doi: 10.1371/journal.ppat.1002554. Epub 2012 Feb 23. Erratum in: PLoS Pathog. 2012 Mar;8(3). doi: 10.1371/annotation/ef70d427-0816-4a63-aeaf-874b734793b0.

15.

Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycle.

Slavic K, Delves MJ, Prudêncio M, Talman AM, Straschil U, Derbyshire ET, Xu Z, Sinden RE, Mota MM, Morin C, Tewari R, Krishna S, Staines HM.

Antimicrob Agents Chemother. 2011 Jun;55(6):2824-30. doi: 10.1128/AAC.01739-10. Epub 2011 Mar 14.

16.

Regulation of IL-17 in chronic inflammation in the human lung.

Pridgeon C, Bugeon L, Donnelly L, Straschil U, Tudhope SJ, Fenwick P, Lamb JR, Barnes PJ, Dallman MJ.

Clin Sci (Lond). 2011 Jun;120(12):515-24. doi: 10.1042/CS20100417.

PMID:
21208193
17.

The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission.

Tewari R, Straschil U, Bateman A, Böhme U, Cherevach I, Gong P, Pain A, Billker O.

Cell Host Microbe. 2010 Oct 21;8(4):377-87. doi: 10.1016/j.chom.2010.09.006.

18.

The Armadillo repeat protein PF16 is essential for flagellar structure and function in Plasmodium male gametes.

Straschil U, Talman AM, Ferguson DJ, Bunting KA, Xu Z, Bailes E, Sinden RE, Holder AA, Smith EF, Coates JC, Rita Tewari.

PLoS One. 2010 Sep 23;5(9):e12901. doi: 10.1371/journal.pone.0012901.

19.

Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality.

Slavic K, Straschil U, Reininger L, Doerig C, Morin C, Tewari R, Krishna S.

Mol Microbiol. 2010 Mar;75(6):1402-13. doi: 10.1111/j.1365-2958.2010.07060.x. Epub 2009 Feb 1.

20.

Characterization of two Autographa californica nucleopolyhedrovirus proteins, Ac145 and Ac150, which affect oral infectivity in a host-dependent manner.

Lapointe R, Popham HJ, Straschil U, Goulding D, O'Reilly DR, Olszewski JA.

J Virol. 2004 Jun;78(12):6439-48.

21.

Comparative susceptibility to penicillin and quinolones of 1385 Streptococcus pneumoniae isolates. Austrian Bacterial Surveillance Network.

Buxbaum A, Straschil U, Moser C, Graninger W, Georgopoulos A.

J Antimicrob Chemother. 1999 May;43 Suppl B:13-8.

PMID:
10382870
22.

Austrian national survey of prevalence of antimicrobial resistance among clinical isolates of Streptococcus pneumoniae 1994-96.

Georgopoulos A, Buxbaum A, Straschil U, Graninger W.

Scand J Infect Dis. 1998;30(4):345-9.

PMID:
9817512

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