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Items: 28

1.

HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagy.

Strappazzon F, Di Rita A, Peschiaroli A, Leoncini PP, Locatelli F, Melino G, Cecconi F.

Cell Death Differ. 2019 Aug 21. doi: 10.1038/s41418-019-0404-8. [Epub ahead of print]

PMID:
31434979
2.

Reversible induction of mitophagy by an optogenetic bimodular system.

D'Acunzo P, Strappazzon F, Caruana I, Meneghetti G, Di Rita A, Simula L, Weber G, Del Bufalo F, Dalla Valle L, Campello S, Locatelli F, Cecconi F.

Nat Commun. 2019 Apr 4;10(1):1533. doi: 10.1038/s41467-019-09487-1.

3.

Mitophagy could fight Parkinson's disease through antioxidant action.

Di Rita A, Strappazzon F.

Rev Neurosci. 2019 Mar 6. pii: /j/revneuro.ahead-of-print/revneuro-2018-0095/revneuro-2018-0095.xml. doi: 10.1515/revneuro-2018-0095. [Epub ahead of print]

PMID:
30840597
4.

AMBRA1 Controls Regulatory T-Cell Differentiation and Homeostasis Upstream of the FOXO3-FOXP3 Axis.

Becher J, Simula L, Volpe E, Procaccini C, La Rocca C, D'Acunzo P, Cianfanelli V, Strappazzon F, Caruana I, Nazio F, Weber G, Gigantino V, Botti G, Ciccosanti F, Borsellino G, Campello S, Mandolesi G, De Bardi M, Fimia GM, D'Amelio M, Ruffini F, Furlan R, Centonze D, Martino G, Braghetta P, Chrisam M, Bonaldo P, Matarese G, Locatelli F, Battistini L, Cecconi F.

Dev Cell. 2018 Dec 3;47(5):592-607.e6. doi: 10.1016/j.devcel.2018.11.010.

PMID:
30513302
5.

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα.

Di Rita A, Peschiaroli A, D Acunzo P, Strobbe D, Hu Z, Gruber J, Nygaard M, Lambrughi M, Melino G, Papaleo E, Dengjel J, El Alaoui S, Campanella M, Dötsch V, Rogov VV, Strappazzon F, Cecconi F.

Nat Commun. 2018 Sep 14;9(1):3755. doi: 10.1038/s41467-018-05722-3.

6.

AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells.

Di Rita A, D'Acunzo P, Simula L, Campello S, Strappazzon F, Cecconi F.

Front Cell Neurosci. 2018 Apr 18;12:92. doi: 10.3389/fncel.2018.00092. eCollection 2018.

7.

ATM kinase sustains breast cancer stem-like cells by promoting ATG4C expression and autophagy.

Antonelli M, Strappazzon F, Arisi I, Brandi R, D'Onofrio M, Sambucci M, Manic G, Vitale I, Barilà D, Stagni V.

Oncotarget. 2017 Mar 28;8(13):21692-21709. doi: 10.18632/oncotarget.15537.

8.

AMBRA1, a Novel BH3-Like Protein: New Insights Into the AMBRA1-BCL2-Family Proteins Relationship.

Di Rita A, Strappazzon F.

Int Rev Cell Mol Biol. 2017;330:85-113. doi: 10.1016/bs.ircmb.2016.09.002. Epub 2016 Nov 15. Review.

PMID:
28215535
9.

MIR7-3HG, a MYC-dependent modulator of cell proliferation, inhibits autophagy by a regulatory loop involving AMBRA1.

Capizzi M, Strappazzon F, Cianfanelli V, Papaleo E, Cecconi F.

Autophagy. 2017 Mar 4;13(3):554-566. doi: 10.1080/15548627.2016.1269989. Epub 2017 Jan 6.

10.

Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation.

Nazio F, Carinci M, Valacca C, Bielli P, Strappazzon F, Antonioli M, Ciccosanti F, Rodolfo C, Campello S, Fimia GM, Sette C, Bonaldo P, Cecconi F.

J Cell Biol. 2016 Dec 19;215(6):841-856. Epub 2016 Dec 8.

11.

Prosurvival AMBRA1 turns into a proapoptotic BH3-like protein during mitochondrial apoptosis.

Strappazzon F, Di Rita A, Cianfanelli V, D'Orazio M, Nazio F, Fimia GM, Cecconi F.

Autophagy. 2016 Jun 2;12(6):963-75. doi: 10.1080/15548627.2016.1164359. Epub 2016 Apr 28.

12.

Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans.

Schiavi A, Maglioni S, Palikaras K, Shaik A, Strappazzon F, Brinkmann V, Torgovnick A, Castelein N, De Henau S, Braeckman BP, Cecconi F, Tavernarakis N, Ventura N.

Curr Biol. 2015 Jul 20;25(14):1810-22. doi: 10.1016/j.cub.2015.05.059. Epub 2015 Jul 2.

13.

Ambra1 at a glance.

Cianfanelli V, De Zio D, Di Bartolomeo S, Nazio F, Strappazzon F, Cecconi F.

J Cell Sci. 2015 Jun 1;128(11):2003-8. doi: 10.1242/jcs.168153. Review.

14.

AMBRA1-induced mitophagy: A new mechanism to cope with cancer?

Strappazzon F, Cecconi F.

Mol Cell Oncol. 2015 Feb 25;2(2):e975647. doi: 10.4161/23723556.2014.975647. eCollection 2015 Apr-Jun.

15.

The multifaceted mitochondrion: An attractive candidate for therapeutic strategies.

Strappazzon F, Cecconi F.

Pharmacol Res. 2015 Sep;99:425-33. doi: 10.1016/j.phrs.2015.03.007. Epub 2015 Mar 24. Review.

PMID:
25818167
16.

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1.

Strappazzon F, Nazio F, Corrado M, Cianfanelli V, Romagnoli A, Fimia GM, Campello S, Nardacci R, Piacentini M, Campanella M, Cecconi F.

Cell Death Differ. 2015 Mar;22(3):517. doi: 10.1038/cdd.2014.190. No abstract available.

17.

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1.

Strappazzon F, Nazio F, Corrado M, Cianfanelli V, Romagnoli A, Fimia GM, Campello S, Nardacci R, Piacentini M, Campanella M, Cecconi F.

Cell Death Differ. 2015 Mar;22(3):419-32. doi: 10.1038/cdd.2014.139. Epub 2014 Sep 12. Erratum in: Cell Death Differ. 2015 Mar;22(3):517.

18.

Mitochondrial dismissal in mammals, from protein degradation to mitophagy.

Campello S, Strappazzon F, Cecconi F.

Biochim Biophys Acta. 2014 Apr;1837(4):451-60. doi: 10.1016/j.bbabio.2013.11.010. Epub 2013 Nov 22. Review.

19.

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.

Nazio F, Strappazzon F, Antonioli M, Bielli P, Cianfanelli V, Bordi M, Gretzmeier C, Dengjel J, Piacentini M, Fimia GM, Cecconi F.

Nat Cell Biol. 2013 Apr;15(4):406-16. doi: 10.1038/ncb2708. Epub 2013 Mar 24.

PMID:
23524951
20.

Non-apoptotic roles for death-related molecules: when mitochondria chose cell fate.

Strappazzon F, Campello S, Cecconi F.

Exp Cell Res. 2012 Jul 1;318(11):1309-15. doi: 10.1016/j.yexcr.2012.01.027. Epub 2012 Feb 8. Review.

PMID:
22342457
21.

Type 2 transglutaminase is involved in the autophagy-dependent clearance of ubiquitinated proteins.

D'Eletto M, Farrace MG, Rossin F, Strappazzon F, Giacomo GD, Cecconi F, Melino G, Sepe S, Moreno S, Fimia GM, Falasca L, Nardacci R, Piacentini M.

Cell Death Differ. 2012 Jul;19(7):1228-38. doi: 10.1038/cdd.2012.2. Epub 2012 Feb 10.

22.

Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy.

Strappazzon F, Vietri-Rudan M, Campello S, Nazio F, Florenzano F, Fimia GM, Piacentini M, Levine B, Cecconi F.

EMBO J. 2011 Apr 6;30(7):1195-208. doi: 10.1038/emboj.2011.49. Epub 2011 Feb 25.

23.

Alix is involved in caspase 9 activation during calcium-induced apoptosis.

Strappazzon F, Torch S, Chatellard-Causse C, Petiot A, Thibert C, Blot B, Verna JM, Sadoul R.

Biochem Biophys Res Commun. 2010 Jun 18;397(1):64-9. doi: 10.1016/j.bbrc.2010.05.062. Epub 2010 May 21.

24.

Alix and ALG-2 make a link between endosomes and neuronal death.

Mahul-Mellier AL, Strappazzon F, Chatellard-Causse C, Blot B, Béal D, Torch S, Hemming F, Petiot A, Verna JM, Fraboulet S, Sadoul R.

Biochem Soc Trans. 2009 Feb;37(Pt 1):200-3. doi: 10.1042/BST0370200. Review.

PMID:
19143631
25.

Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death.

Mahul-Mellier AL, Strappazzon F, Petiot A, Chatellard-Causse C, Torch S, Blot B, Freeman K, Kuhn L, Garin J, Verna JM, Fraboulet S, Sadoul R.

J Biol Chem. 2008 Dec 12;283(50):34954-65. doi: 10.1074/jbc.M803140200. Epub 2008 Oct 20.

26.

Alix differs from ESCRT proteins in the control of autophagy.

Petiot A, Strappazzon F, Chatellard-Causse C, Blot B, Torch S, Verna JM, Sadoul R.

Biochem Biophys Res Commun. 2008 Oct 10;375(1):63-8. doi: 10.1016/j.bbrc.2008.07.136. Epub 2008 Aug 3.

PMID:
18684393
27.

Critical amino acid residues of maurocalcine involved in pharmacology, lipid interaction and cell penetration.

Mabrouk K, Ram N, Boisseau S, Strappazzon F, Rehaim A, Sadoul R, Darbon H, Ronjat M, De Waard M.

Biochim Biophys Acta. 2007 Oct;1768(10):2528-40. Epub 2007 Jul 10.

28.

Survival response-linked Pyk2 activation during potassium depletion-induced apoptosis of cerebellar granule neurons.

Strappazzon F, Torch S, Trioulier Y, Blot B, Sadoul R, Verna JM.

Mol Cell Neurosci. 2007 Mar;34(3):355-65. Epub 2006 Dec 22.

PMID:
17188509

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