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Items: 15


Follicular B2 Cell Activation and Class Switch Recombination Depend on Autocrine C3ar1/C5ar1 Signaling in B2 Cells.

Paiano J, Harland M, Strainic MG, Nedrud J, Hussain W, Medof ME.

J Immunol. 2019 Jul 15;203(2):379-388. doi: 10.4049/jimmunol.1900276. Epub 2019 Jun 19.


CD55 Is Essential for CD103+ Dendritic Cell Tolerogenic Responses that Protect against Autoimmunity.

Strainic MG, Liu J, An F, Bailey E, Esposito A, Hamann J, Heeger PS, Medof ME.

Am J Pathol. 2019 Jul;189(7):1386-1401. doi: 10.1016/j.ajpath.2019.04.008. Epub 2019 May 17.


VEGFR2 survival and mitotic signaling depends on joint activation of associated C3ar1/C5ar1 and IL-6R-gp130.

Hwang MS, Strainic MG, Pohlmann E, Kim H, Pluskota E, Ramirez-Bergeron DL, Plow EF, Medof ME.

J Cell Sci. 2019 Mar 28;132(6). pii: jcs219352. doi: 10.1242/jcs.219352.


TLR-Induced Murine Dendritic Cell (DC) Activation Requires DC-Intrinsic Complement.

Sheen JH, Strainic MG, Liu J, Zhang W, Yi Z, Medof ME, Heeger PS.

J Immunol. 2017 Jul 1;199(1):278-291. doi: 10.4049/jimmunol.1700339. Epub 2017 May 24.


Differential contribution of complement receptor C5aR in myeloid and non-myeloid cells in chronic ethanol-induced liver injury in mice.

McCullough RL, McMullen MR, Das D, Roychowdhury S, Strainic MG, Medof ME, Nagy LE.

Mol Immunol. 2016 Jul;75:122-32. doi: 10.1016/j.molimm.2016.05.006. Epub 2016 Jun 6.


Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.

Strainic MG, Shevach EM, An F, Lin F, Medof ME.

Nat Immunol. 2013 Feb;14(2):162-71. doi: 10.1038/ni.2499. Epub 2012 Dec 23.


Complement regulates CD4 T-cell help to CD8 T cells required for murine allograft rejection.

Vieyra M, Leisman S, Raedler H, Kwan WH, Yang M, Strainic MG, Medof ME, Heeger PS.

Am J Pathol. 2011 Aug;179(2):766-74. doi: 10.1016/j.ajpath.2011.04.038. Epub 2011 Jun 23.


Decay accelerating factor is essential for successful corneal engraftment.

Esposito A, Suedekum B, Liu J, An F, Lass J, Strainic MG, Lin F, Heeger P, Medof ME.

Am J Transplant. 2010 Mar;10(3):527-34. doi: 10.1111/j.1600-6143.2009.02961.x. Epub 2010 Jan 5.


Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis.

Lalli PN, Strainic MG, Yang M, Lin F, Medof ME, Heeger PS.

Blood. 2008 Sep 1;112(5):1759-66. doi: 10.1182/blood-2008-04-151068. Epub 2008 Jun 20.


IFN-gamma and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production.

Liu J, Lin F, Strainic MG, An F, Miller RH, Altuntas CZ, Heeger PS, Tuohy VK, Medof ME.

J Immunol. 2008 May 1;180(9):5882-9.


Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells.

Strainic MG, Liu J, Huang D, An F, Lalli PN, Muqim N, Shapiro VS, Dubyak GR, Heeger PS, Medof ME.

Immunity. 2008 Mar;28(3):425-35. doi: 10.1016/j.immuni.2008.02.001. Epub 2008 Mar 6.


RNA polymerase alters the mobility of an A-residue crucial to polymerase-induced melting of promoter DNA.

Tsujikawa L, Strainic MG, Watrob H, Barkley MD, DeHaseth PL.

Biochemistry. 2002 Dec 24;41(51):15334-41.


Promoter interference in a bacteriophage lambda control region: effects of a range of interpromoter distances.

Strainic MG Jr, Sullivan JJ, Collado-Vides J, deHaseth PL.

J Bacteriol. 2000 Jan;182(1):216-20.


Promoter recognition by Escherichia coli RNA polymerase: effects of the UP element on open complex formation and promoter clearance.

Strainic MG Jr, Sullivan JJ, Velevis A, deHaseth PL.

Biochemistry. 1998 Dec 22;37(51):18074-80.


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