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Methylmercury and long chain polyunsaturated fatty acids are associated with immune dysregulation in young adults from the Seychelles child development study.

McSorley EM, van Wijngaarden E, Yeates AJ, Spence T, Mulhern MS, Harrington D, Thurston SW, Love T, Jusko TA, Allsopp PJ, Conway MC, Davidson PW, Myers GJ, Watson GE, Shamlaye CF, Strain JJ.

Environ Res. 2020 Jan 7;183:109072. doi: 10.1016/j.envres.2019.109072. [Epub ahead of print]


Association of Audiometric Measures with plasma long chain polyunsaturated fatty acids in a high-fish eating population: The Seychelles Child Development Study.

Orlando MS, Dziorny AC, Love T, Harrington D, Shamlaye CF, Watson G, van Wijngaarden E, Zareba G, Davidson PW, Mulhern MS, McSorley EM, Yeates AJ, Strain JJ, Myers GJ.

Neurotoxicology. 2020 Mar;77:137-144. doi: 10.1016/j.neuro.2020.01.005. Epub 2020 Jan 23. Review.


Influence of nutrients involved in one-carbon metabolism on DNA methylation in adults-a systematic review and meta-analysis.

Amenyah SD, Hughes CF, Ward M, Rosborough S, Deane J, Thursby SJ, Walsh CP, Kok DE, Strain JJ, McNulty H, Lees-Murdock DJ.

Nutr Rev. 2020 Jan 23. pii: nuz094. doi: 10.1093/nutrit/nuz094. [Epub ahead of print]


Evidence of a Role for One-Carbon Metabolism in Blood Pressure: Can B Vitamin Intervention Address the Genetic Risk of Hypertension Owing to a Common Folate Polymorphism?

McNulty H, Strain JJ, Hughes CF, Pentieva K, Ward M.

Curr Dev Nutr. 2019 Sep 16;4(1):nzz102. doi: 10.1093/cdn/nzz102. eCollection 2020 Jan. Review.


Influence of fatty acid desaturase (FADS) genotype on maternal and child polyunsaturated fatty acids (PUFA) status and child health outcomes: a systematic review.

Conway MC, McSorley EM, Mulhern MS, Strain JJ, van Wijngaarden E, Yeates AJ.

Nutr Rev. 2020 Jan 16. pii: nuz086. doi: 10.1093/nutrit/nuz086. [Epub ahead of print]


The Adjustment Disorder Diagnosis, Its Importance to Liaison Psychiatry, and its Psychobiology.

Strain JJ.

Int J Environ Res Public Health. 2019 Nov 22;16(23). pii: E4645. doi: 10.3390/ijerph16234645.


Relationships between seafood consumption during pregnancy and childhood and neurocognitive development: Two systematic reviews.

Hibbeln JR, Spiller P, Brenna JT, Golding J, Holub BJ, Harris WS, Kris-Etherton P, Lands B, Connor SL, Myers G, Strain JJ, Crawford MA, Carlson SE.

Prostaglandins Leukot Essent Fatty Acids. 2019 Dec;151:14-36. doi: 10.1016/j.plefa.2019.10.002. Epub 2019 Oct 11. Review.


Associations between maternal inflammation during pregnancy and infant birth outcomes in the Seychelles Child Development Study.

Yeates AJ, McSorley EM, Mulhern MS, Spence T, Crowe W, Grzesik K, Thurston SW, Watson GE, Myers GJ, Davidson PW, Shamlaye CF, van Wijngaarden E, Strain JJ.

J Reprod Immunol. 2020 Feb;137:102623. doi: 10.1016/j.jri.2019.102623. Epub 2019 Oct 23.


Putting findings from the Seychelles Child Development Study into perspective: The importance of a historical special issue of the Seychelles Medical and Dental Journal.

Davidson PW, van Wijngaarden E, Shamlaye C, Strain JJ, Myers GJ.

Neurotoxicology. 2020 Jan;76:111-113. doi: 10.1016/j.neuro.2019.10.010. Epub 2019 Nov 7. Review.


Effect of continued folic acid supplementation beyond the first trimester of pregnancy on cognitive performance in the child: a follow-up study from a randomized controlled trial (FASSTT Offspring Trial).

McNulty H, Rollins M, Cassidy T, Caffrey A, Marshall B, Dornan J, McLaughlin M, McNulty BA, Ward M, Strain JJ, Molloy AM, Lees-Murdock DJ, Walsh CP, Pentieva K.

BMC Med. 2019 Oct 31;17(1):196. doi: 10.1186/s12916-019-1432-4.


An abundance of seafood consumption studies presents new opportunities to evaluate effects on neurocognitive development.

Spiller P, Hibbeln JR, Myers G, Vannice G, Golding J, Crawford MA, Strain JJ, Connor SL, Brenna JT, Kris-Etherton P, Holub BJ, Harris WS, Lands B, McNamara RK, Tlusty MF, Salem N Jr, Carlson SE.

Prostaglandins Leukot Essent Fatty Acids. 2019 Dec;151:8-13. doi: 10.1016/j.plefa.2019.10.001. Epub 2019 Oct 11. Review.


Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study.

Irwin JL, McSorley EM, Yeates AJ, Mulhern MS, Strain JJ, Watson GE, Grzesik K, Thurston SW, Love TM, Smith TH, Broberg K, Shamlaye CF, Myers GJ, Davidson PW, van Wijngaarden E.

J Neuroimmunol. 2019 Oct 15;335:577023. doi: 10.1016/j.jneuroim.2019.577023. Epub 2019 Aug 14.


Prenatal and recent methylmercury exposure and heart rate variability in young adults: the Seychelles Child Development Study.

Zareba W, Thurston SW, Zareba G, Couderc JP, Evans K, Xia J, Watson GE, Strain JJ, McSorley E, Yeates A, Mulhern M, Shamlaye CF, Bovet P, van Wijngaarden E, Davidson PW, Myers GJ.

Neurotoxicol Teratol. 2019 Jul - Aug;74:106810. doi: 10.1016/ Epub 2019 May 23.


Serum levels of miR-199a-5p correlates with blood pressure in premature cardiovascular disease patients homozygous for the MTHFR 677C > T polymorphism.

Lynch SM, Ward M, McNulty H, Angel CZ, Horigan G, Strain JJ, Purvis J, Tackett M, McKenna DJ.

Genomics. 2020 Jan;112(1):669-676. doi: 10.1016/j.ygeno.2019.04.019. Epub 2019 Apr 25.


B-vitamins in Relation to Depression in Older Adults Over 60 Years of Age: The Trinity Ulster Department of Agriculture (TUDA) Cohort Study.

Moore K, Hughes CF, Hoey L, Ward M, Cunningham C, Molloy AM, Strain JJ, McCarroll K, Casey MC, Tracey F, Laird E, O'Kane M, McNulty H.

J Am Med Dir Assoc. 2019 May;20(5):551-557.e1. doi: 10.1016/j.jamda.2018.11.031. Epub 2019 Jan 25.


Associations of blood mercury and fatty acid concentrations with blood mitochondrial DNA copy number in the Seychelles Child Development Nutrition Study.

Xu Y, Wahlberg K, Love TM, Watson GE, Yeates AJ, Mulhern MS, McSorley EM, Strain JJ, Davidson PW, Shamlaye CF, Rand MD, Myers GJ, van Wijngaarden E, Broberg K.

Environ Int. 2019 Mar;124:278-283. doi: 10.1016/j.envint.2019.01.019. Epub 2019 Jan 17.


Maternal Gestational Immune Response and Autism Spectrum Disorder Phenotypes at 7 Years of Age in the Seychelles Child Development Study.

Irwin JL, Yeates AJ, Mulhern MS, McSorley EM, Strain JJ, Watson GE, Grzesik K, Thurston SW, Love TM, Smith TH, Mruzek DW, Shamlaye CF, Monthy C, Myers GJ, Davidson PW, van Wijngaarden E.

Mol Neurobiol. 2019 Jul;56(7):5000-5008. doi: 10.1007/s12035-018-1424-y. Epub 2018 Nov 14.


Temperament and character in patients with acute abdominal pain.

Lexne E, Brudin L, Strain JJ, Nylander PO, Marteinsdottir I.

Compr Psychiatry. 2018 Nov;87:128-133. doi: 10.1016/j.comppsych.2018.09.008. Epub 2018 Sep 26.


Analysis of Nonlinear Associations between Prenatal Methylmercury Exposure from Fish Consumption and Neurodevelopmental Outcomes in the Seychelles Main Cohort at 17 Years.

Huang LS, Cory-Slechta DA, Cox C, Thurston SW, Shamlaye CF, Watson GE, van Wijngaarden E, Zareba G, Strain JJ, Myers GJ, Davidson PW.

Stoch Environ Res Risk Assess. 2018 Apr;32(4):893-904. doi: 10.1007/s00477-017-1451-7. Epub 2017 Sep 6.


Associations of maternal immune response with MeHg exposure at 28 weeks' gestation in the Seychelles Child Development Study.

McSorley EM, Yeates AJ, Mulhern MS, van Wijngaarden E, Grzesik K, Thurston SW, Spence T, Crowe W, Davidson PW, Zareba G, Myers GJ, Watson GE, Shamlaye CF, Strain JJ.

Am J Reprod Immunol. 2018 Nov;80(5):e13046. doi: 10.1111/aji.13046. Epub 2018 Sep 17.


Vitamin D status is associated with muscle strength and quality of life in patients with COPD: a seasonal prospective observation study.

Carson EL, Pourshahidi LK, Madigan SM, Baldrick FR, Kelly MG, Laird E, Healy M, Strain JJ, Mulhern MS.

Int J Chron Obstruct Pulmon Dis. 2018 Aug 28;13:2613-2622. doi: 10.2147/COPD.S166919. eCollection 2018.


The psychobiology of stress, depression, adjustment disorders and resilience.

Strain JJ.

World J Biol Psychiatry. 2018;19(sup1):S14-S20. doi: 10.1080/15622975.2018.1459049. Review.


The relationship between adiposity and cognitive function in a large community-dwelling population: data from the Trinity Ulster Department of Agriculture (TUDA) ageing cohort study.

Ntlholang O, McCarroll K, Laird E, Molloy AM, Ward M, McNulty H, Hoey L, Hughes CF, Strain JJ, Casey M, Cunningham C.

Br J Nutr. 2018 Sep;120(5):517-527. doi: 10.1017/S0007114518001848. Epub 2018 Jul 30.


Dietary Determinants of Polyunsaturated Fatty Acid (PUFA) Status in a High Fish-Eating Cohort during Pregnancy.

Conway MC, Mulhern MS, McSorley EM, van Wijngaarden E, Strain JJ, Myers GJ, Davidson PW, Shamlaye CF, Yeates AJ.

Nutrients. 2018 Jul 20;10(7). pii: E927. doi: 10.3390/nu10070927.


Inflammatory response following in vitro exposure to methylmercury with and without n-3 long chain polyunsaturated fatty acids in peripheral blood mononuclear cells from systemic lupus erythematosus patients compared to healthy controls.

Crowe W, Allsopp PJ, Nyland JF, Magee PJ, Strain JJ, Doherty LC, Watson GE, Ball E, Riddell C, Armstrong DJ, Penta K, Todd JJ, Spence T, McSorley EM.

Toxicol In Vitro. 2018 Oct;52:272-278. doi: 10.1016/j.tiv.2018.05.008. Epub 2018 May 17.


Gene-specific DNA methylation in newborns in response to folic acid supplementation during the second and third trimesters of pregnancy: epigenetic analysis from a randomized controlled trial.

Caffrey A, Irwin RE, McNulty H, Strain JJ, Lees-Murdock DJ, McNulty BA, Ward M, Walsh CP, Pentieva K.

Am J Clin Nutr. 2018 Apr 1;107(4):566-575. doi: 10.1093/ajcn/nqx069.


Micronutrients, iodine status and concentrations of thyroid hormones: a systematic review.

O'Kane SM, Mulhern MS, Pourshahidi LK, Strain JJ, Yeates AJ.

Nutr Rev. 2018 Jun 1;76(6):418-431. doi: 10.1093/nutrit/nuy008.


Maternal polymorphisms in glutathione-related genes are associated with maternal mercury concentrations and early child neurodevelopment in a population with a fish-rich diet.

Wahlberg K, Love TM, Pineda D, Engström K, Watson GE, Thurston SW, Yeates AJ, Mulhern MS, McSorley EM, Strain JJ, Smith TH, Davidson PW, Shamlaye CF, Myers GJ, Rand MD, van Wijngaarden E, Broberg K.

Environ Int. 2018 Jun;115:142-149. doi: 10.1016/j.envint.2018.03.015. Epub 2018 Mar 21.


Cow Milk Consumption Increases Iodine Status in Women of Childbearing Age in a Randomized Controlled Trial.

O'Kane SM, Pourshahidi LK, Mulhern MS, Strain JJ, Mackle EM, Koca D, Schomburg L, Hill S, O'Reilly J, Kmiotek D, Deitrich C, Bath SC, Yeates AJ.

J Nutr. 2018 Mar 1;148(3):401-408. doi: 10.1093/jn/nxx043.


The Effect of Processing and Seasonality on the Iodine and Selenium Concentration of Cow's Milk Produced in Northern Ireland (NI): Implications for Population Dietary Intake.

O'Kane SM, Pourshahidi LK, Mulhern MS, Weir RR, Hill S, O'Reilly J, Kmiotek D, Deitrich C, Mackle EM, Fitzgerald E, Lowis C, Johnston M, Strain JJ, Yeates AJ.

Nutrients. 2018 Mar 1;10(3). pii: E287. doi: 10.3390/nu10030287.


Effect of Area-Level Socioeconomic Deprivation on Risk of Cognitive Dysfunction in Older Adults.

McCann A, McNulty H, Rigby J, Hughes CF, Hoey L, Molloy AM, Cunningham CJ, Casey MC, Tracey F, O'Kane MJ, McCarroll K, Ward M, Moore K, Strain JJ, Moore A.

J Am Geriatr Soc. 2018 Jul;66(7):1269-1275. doi: 10.1111/jgs.15258. Epub 2018 Feb 12.


Ideology and Palliative Care: Moral Hazards at the Bedside.

Rhodes R, Strain JJ.

Camb Q Healthc Ethics. 2018 Jan;27(1):137-144. doi: 10.1017/S0963180117000469.


The effect of weight change over a 2-year period on inflammatory status in postmenopausal women.

Cronin BE, Allsopp PJ, Slevin MM, Magee PJ, McCaffrey TA, Livingstone MBE, Strain JJ, McSorley EM.

Eur J Clin Nutr. 2018 Mar;72(3):388-393. doi: 10.1038/s41430-017-0014-9. Epub 2017 Nov 23.


Maternal Vitamin D Status and the Relationship with Neonatal Anthropometric and Childhood Neurodevelopmental Outcomes: Results from the Seychelles Child Development Nutrition Study.

Laird E, Thurston SW, van Wijngaarden E, Shamlaye CF, Myers GJ, Davidson PW, Watson GE, McSorley EM, Mulhern MS, Yeates AJ, Ward M, McNulty H, Strain JJ.

Nutrients. 2017 Nov 11;9(11). pii: E1235. doi: 10.3390/nu9111235.


Dairy Intakes in Older Irish Adults and Effects on Vitamin Micronutrient Status: Data from the TUDA Study.

Laird E, Casey MC, Ward M, Hoey L, Hughes CF, McCarroll K, Cunningham C, Strain JJ, McNulty H, Molloy AM.

J Nutr Health Aging. 2017;21(9):954-961. doi: 10.1007/s12603-016-0845-4.


PUFA Status and Methylmercury Exposure Are Not Associated with Leukocyte Telomere Length in Mothers or Their Children in the Seychelles Child Development Study.

Yeates AJ, Thurston SW, Li H, Mulhern MS, McSorley EM, Watson GE, Shamlaye CF, Strain JJ, Myers GJ, Davidson PW, van Wijngaarden E, Broberg K.

J Nutr. 2017 Nov;147(11):2018-2024. doi: 10.3945/jn.117.253021. Epub 2017 Oct 4.


Globalization of psychosomatic medicine.

Strain JJ.

Gen Hosp Psychiatry. 2017 Sep;48:62-64. doi: 10.1016/j.genhosppsych.2017.07.003. Epub 2017 Jul 21. No abstract available.


Application of Liquid Chromatography-Tandem Mass Spectrometry To Determine Urinary Concentrations of Five Commonly Used Low-Calorie Sweeteners: A Novel Biomarker Approach for Assessing Recent Intakes?

Logue C, Dowey LRC, Strain JJ, Verhagen H, McClean S, Gallagher AM.

J Agric Food Chem. 2017 Jun 7;65(22):4516-4525. doi: 10.1021/acs.jafc.7b00404. Epub 2017 May 24.


Greater yogurt consumption is associated with increased bone mineral density and physical function in older adults.

Laird E, Molloy AM, McNulty H, Ward M, McCarroll K, Hoey L, Hughes CF, Cunningham C, Strain JJ, Casey MC.

Osteoporos Int. 2017 Aug;28(8):2409-2419. doi: 10.1007/s00198-017-4049-5. Epub 2017 May 1.


Ambient UVB Dose and Sun Enjoyment Are Important Predictors of Vitamin D Status in an Older Population.

O'Sullivan F, Laird E, Kelly D, van Geffen J, van Weele M, McNulty H, Hoey L, Healy M, McCarroll K, Cunningham C, Casey M, Ward M, Strain JJ, Molloy AM, Zgaga L.

J Nutr. 2017 May;147(5):858-868. doi: 10.3945/jn.116.244079. Epub 2017 Mar 22.


Environmental and genetic factors influence the vitamin D content of cows' milk.

Weir RR, Strain JJ, Johnston M, Lowis C, Fearon AM, Stewart S, Pourshahidi LK.

Proc Nutr Soc. 2017 Feb;76(1):76-82. doi: 10.1017/S0029665116000811. Epub 2016 Dec 20. Review.


Methyl mercury exposure and neurodevelopmental outcomes in the Seychelles Child Development Study Main cohort at age 22 and 24years.

van Wijngaarden E, Thurston SW, Myers GJ, Harrington D, Cory-Slechta DA, Strain JJ, Watson GE, Zareba G, Love T, Henderson J, Shamlaye CF, Davidson PW.

Neurotoxicol Teratol. 2017 Jan - Feb;59:35-42. doi: 10.1016/ Epub 2016 Oct 28.


Iodine knowledge is positively associated with dietary iodine intake among women of childbearing age in the UK and Ireland.

O'Kane SM, Pourshahidi LK, Farren KM, Mulhern MS, Strain JJ, Yeates AJ.

Br J Nutr. 2016 Nov 18:1-8. [Epub ahead of print]


Novel Approaches to Investigate One-Carbon Metabolism and Related B-Vitamins in Blood Pressure.

McMahon A, McNulty H, Hughes CF, Strain JJ, Ward M.

Nutrients. 2016 Nov 11;8(11). pii: E720. Review.


Riboflavin, MTHFR genotype and blood pressure: A personalized approach to prevention and treatment of hypertension.

McNulty H, Strain JJ, Hughes CF, Ward M.

Mol Aspects Med. 2017 Feb;53:2-9. doi: 10.1016/j.mam.2016.10.002. Epub 2016 Oct 6. Review.


Mercury as an environmental stimulus in the development of autoimmunity - A systematic review.

Crowe W, Allsopp PJ, Watson GE, Magee PJ, Strain JJ, Armstrong DJ, Ball E, McSorley EM.

Autoimmun Rev. 2017 Jan;16(1):72-80. doi: 10.1016/j.autrev.2016.09.020. Epub 2016 Sep 23. Review.


The Frontal Assessment Battery: Normative Performance in a Large Sample of Older Community-Dwelling Hospital Outpatient or General Practitioner Attenders.

Coen RF, McCarroll K, Casey M, McNulty H, Laird E, Molloy AM, Ward M, Strain JJ, Hoey L, Hughes C, Cunningham CJ.

J Geriatr Psychiatry Neurol. 2016 Nov;29(6):338-343. doi: 10.1177/0891988716666381. Epub 2016 Sep 21.


Polymorphisms in ATP-binding cassette transporters associated with maternal methylmercury disposition and infant neurodevelopment in mother-infant pairs in the Seychelles Child Development Study.

Engström K, Love TM, Watson GE, Zareba G, Yeates A, Wahlberg K, Alhamdow A, Thurston SW, Mulhern M, McSorley EM, Strain JJ, Davidson PW, Shamlaye CF, Myers GJ, Rand MD, van Wijngaarden E, Broberg K.

Environ Int. 2016 Sep;94:224-229. doi: 10.1016/j.envint.2016.05.027. Epub 2016 Jun 2.


Riboflavin status, MTHFR genotype and blood pressure: current evidence and implications for personalised nutrition.

McAuley E, McNulty H, Hughes C, Strain JJ, Ward M.

Proc Nutr Soc. 2016 Aug;75(3):405-14. doi: 10.1017/S0029665116000197. Epub 2016 May 12. Review.


A Common Polymorphism in HIBCH Influences Methylmalonic Acid Concentrations in Blood Independently of Cobalamin.

Molloy AM, Pangilinan F, Mills JL, Shane B, O'Neill MB, McGaughey DM, Velkova A, Abaan HO, Ueland PM, McNulty H, Ward M, Strain JJ, Cunningham C, Casey M, Cropp CD, Kim Y, Bailey-Wilson JE, Wilson AF, Brody LC.

Am J Hum Genet. 2016 May 5;98(5):869-882. doi: 10.1016/j.ajhg.2016.03.005. Epub 2016 Apr 28.

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