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Items: 1 to 50 of 134

1.

Polybromo-1 (PBRM1) bromodomains variably influence nucleosome interactions and cellular function.

Slaughter MJ, Shanle EK, McFadden AW, Hollis ES, Suttle LE, Strahl BD, Davis IJ.

J Biol Chem. 2018 Jul 9. pii: jbc.RA118.003381. doi: 10.1074/jbc.RA118.003381. [Epub ahead of print]

2.

Spt6 Association with RNA Polymerase II Directs mRNA Turnover During Transcription.

Dronamraju R, Hepperla AJ, Shibata Y, Adams AT, Magnuson T, Davis IJ, Strahl BD.

Mol Cell. 2018 Jun 21;70(6):1054-1066.e4. doi: 10.1016/j.molcel.2018.05.020.

PMID:
29932900
3.

SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma.

Chiang YC, Park IY, Terzo EA, Tripathi DN, Mason FM, Fahey CC, Karki M, Shuster CB, Sohn BH, Chowdhury P, Powell RT, Ohi R, Tsai YS, de Cubas AA, Khan A, Davis IJ, Strahl BD, Parker JS, Dere R, Walker CL, Rathmell WK.

Cancer Res. 2018 Jun 15;78(12):3135-3146. doi: 10.1158/0008-5472.CAN-17-3460. Epub 2018 May 3.

PMID:
29724720
4.

Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1.

Suh JL, Watts B, Stuckey JI, Norris-Drouin JL, Cholensky SH, Dickson BM, An Y, Mathea S, Salah E, Knapp S, Khan A, Adams AT, Strahl BD, Sagum CA, Bedford MT, James LI, Kireev DB, Frye SV.

Biochemistry. 2018 Apr 10;57(14):2140-2149. doi: 10.1021/acs.biochem.8b00150. Epub 2018 Mar 28.

5.

Transcription start site profiling uncovers divergent transcription and enhancer-associated RNAs in Drosophila melanogaster.

Meers MP, Adelman K, Duronio RJ, Strahl BD, McKay DJ, Matera AG.

BMC Genomics. 2018 Feb 21;19(1):157. doi: 10.1186/s12864-018-4510-7.

6.

Set2 methyltransferase facilitates cell cycle progression by maintaining transcriptional fidelity.

Dronamraju R, Jha DK, Eser U, Adams AT, Dominguez D, Choudhury R, Chiang YC, Rathmell WK, Emanuele MJ, Churchman LS, Strahl BD.

Nucleic Acids Res. 2018 Feb 16;46(3):1331-1344. doi: 10.1093/nar/gkx1276.

7.

The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer.

Veland N, Hardikar S, Zhong Y, Gayatri S, Dan J, Strahl BD, Rothbart SB, Bedford MT, Chen T.

Cell Rep. 2017 Dec 19;21(12):3390-3397. doi: 10.1016/j.celrep.2017.11.082.

8.

Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain.

Klein BJ, Ahmad S, Vann KR, Andrews FH, Mayo ZA, Bourriquen G, Bridgers JB, Zhang J, Strahl BD, Côté J, Kutateladze TG.

Nucleic Acids Res. 2018 Jan 9;46(1):421-430. doi: 10.1093/nar/gkx1151.

9.

Functional Redundancy of Variant and Canonical Histone H3 Lysine 9 Modification in Drosophila.

Penke TJR, McKay DJ, Strahl BD, Matera AG, Duronio RJ.

Genetics. 2018 Jan;208(1):229-244. doi: 10.1534/genetics.117.300480. Epub 2017 Nov 13.

PMID:
29133298
10.

Covalent Modifications of Histone H3K9 Promote Binding of CHD3.

Tencer AH, Cox KL, Di L, Bridgers JB, Lyu J, Wang X, Sims JK, Weaver TM, Allen HF, Zhang Y, Gatchalian J, Darcy MA, Gibson MD, Ikebe J, Li W, Wade PA, Hayes JJ, Strahl BD, Kono H, Poirier MG, Musselman CA, Kutateladze TG.

Cell Rep. 2017 Oct 10;21(2):455-466. doi: 10.1016/j.celrep.2017.09.054.

11.

A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO.

Tencer AH, Gatchalian J, Klein BJ, Khan A, Zhang Y, Strahl BD, van Wely KHM, Kutateladze TG.

Structure. 2017 Oct 3;25(10):1530-1539.e3. doi: 10.1016/j.str.2017.08.009. Epub 2017 Sep 14.

PMID:
28919441
12.

Redundant Functions for Nap1 and Chz1 in H2A.Z Deposition.

Dronamraju R, Ramachandran S, Jha DK, Adams AT, DiFiore JV, Parra MA, Dokholyan NV, Strahl BD.

Sci Rep. 2017 Sep 7;7(1):10791. doi: 10.1038/s41598-017-11003-8.

13.

H3K36 Methylation Regulates Nutrient Stress Response in Saccharomyces cerevisiae by Enforcing Transcriptional Fidelity.

McDaniel SL, Hepperla AJ, Huang J, Dronamraju R, Adams AT, Kulkarni VG, Davis IJ, Strahl BD.

Cell Rep. 2017 Jun 13;19(11):2371-2382. doi: 10.1016/j.celrep.2017.05.057.

14.

Shaping the cellular landscape with Set2/SETD2 methylation.

McDaniel SL, Strahl BD.

Cell Mol Life Sci. 2017 Sep;74(18):3317-3334. doi: 10.1007/s00018-017-2517-x. Epub 2017 Apr 6. Review.

15.

Expanding the Reader Landscape of Histone Acylation.

Khan A, Bridgers JB, Strahl BD.

Structure. 2017 Apr 4;25(4):571-573. doi: 10.1016/j.str.2017.03.010.

16.

Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity.

Meers MP, Henriques T, Lavender CA, McKay DJ, Strahl BD, Duronio RJ, Adelman K, Matera AG.

Elife. 2017 Mar 27;6. pii: e23249. doi: 10.7554/eLife.23249.

17.

Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions.

Shanle EK, Shinsky SA, Bridgers JB, Bae N, Sagum C, Krajewski K, Rothbart SB, Bedford MT, Strahl BD.

Epigenetics Chromatin. 2017 Mar 14;10:12. doi: 10.1186/s13072-017-0117-5. eCollection 2017.

18.

Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.

Savitsky P, Krojer T, Fujisawa T, Lambert JP, Picaud S, Wang CY, Shanle EK, Krajewski K, Friedrichsen H, Kanapin A, Goding C, Schapira M, Samsonova A, Strahl BD, Gingras AC, Filippakopoulos P.

Cell Rep. 2016 Dec 6;17(10):2724-2737. doi: 10.1016/j.celrep.2016.11.014.

19.

Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a.

Strikoudis A, Lazaris C, Trimarchi T, Galvao Neto AL, Yang Y, Ntziachristos P, Rothbart S, Buckley S, Dolgalev I, Stadtfeld M, Strahl BD, Dynlacht BD, Tsirigos A, Aifantis I.

Nat Cell Biol. 2016 Nov;18(11):1127-1138. doi: 10.1038/ncb3424. Epub 2016 Oct 17.

20.

Potent and Selective Peptide-based Inhibition of the G Protein Gαq.

Charpentier TH, Waldo GL, Lowery-Gionta EG, Krajewski K, Strahl BD, Kash TL, Harden TK, Sondek J.

J Biol Chem. 2016 Dec 2;291(49):25608-25616. Epub 2016 Oct 14.

21.

Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.

Andrews FH, Tong Q, Sullivan KD, Cornett EM, Zhang Y, Ali M, Ahn J, Pandey A, Guo AH, Strahl BD, Costello JC, Espinosa JM, Rothbart SB, Kutateladze TG.

Cell Rep. 2016 Sep 20;16(12):3195-3207. doi: 10.1016/j.celrep.2016.08.050.

22.

Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1.

Harrison JS, Cornett EM, Goldfarb D, DaRosa PA, Li ZM, Yan F, Dickson BM, Guo AH, Cantu DV, Kaustov L, Brown PJ, Arrowsmith CH, Erie DA, Major MB, Klevit RE, Krajewski K, Kuhlman B, Strahl BD, Rothbart SB.

Elife. 2016 Sep 6;5. pii: e17101. doi: 10.7554/eLife.17101.

23.

Direct interrogation of the role of H3K9 in metazoan heterochromatin function.

Penke TJ, McKay DJ, Strahl BD, Matera AG, Duronio RJ.

Genes Dev. 2016 Aug 15;30(16):1866-80. doi: 10.1101/gad.286278.116. Epub 2016 Aug 26.

24.

Histone H3 and TORC1 prevent organelle dysfunction and cell death by promoting nuclear retention of HMGB proteins.

Chen H, Workman JJ, Strahl BD, Laribee RN.

Epigenetics Chromatin. 2016 Aug 17;9:34. doi: 10.1186/s13072-016-0083-3. eCollection 2016.

25.

Insights into newly discovered marks and readers of epigenetic information.

Andrews FH, Strahl BD, Kutateladze TG.

Nat Chem Biol. 2016 Aug 18;12(9):662-8. doi: 10.1038/nchembio.2149. Review.

26.

Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation.

Hacker KE, Fahey CC, Shinsky SA, Chiang YJ, DiFiore JV, Jha DK, Vo AH, Shavit JA, Davis IJ, Strahl BD, Rathmell WK.

J Biol Chem. 2016 Sep 30;291(40):21283-21295. Epub 2016 Aug 15.

27.

Substrate Specificity Profiling of Histone-Modifying Enzymes by Peptide Microarray.

Cornett EM, Dickson BM, Vaughan RM, Krishnan S, Trievel RC, Strahl BD, Rothbart SB.

Methods Enzymol. 2016;574:31-52. doi: 10.1016/bs.mie.2016.01.008. Epub 2016 Feb 16.

28.

Combinatorial Histone Readout by the Dual Plant Homeodomain (PHD) Fingers of Rco1 Mediates Rpd3S Chromatin Recruitment and the Maintenance of Transcriptional Fidelity.

McDaniel SL, Fligor JE, Ruan C, Cui H, Bridgers JB, DiFiore JV, Guo AH, Li B, Strahl BD.

J Biol Chem. 2016 Jul 8;291(28):14796-802. doi: 10.1074/jbc.M116.720193. Epub 2016 May 16.

29.

Quantitative Analysis of Dynamic Protein Interactions during Transcription Reveals a Role for Casein Kinase II in Polymerase-associated Factor (PAF) Complex Phosphorylation and Regulation of Histone H2B Monoubiquitylation.

Bedard LG, Dronamraju R, Kerschner JL, Hunter GO, Axley ED, Boyd AK, Strahl BD, Mosley AL.

J Biol Chem. 2016 Jun 24;291(26):13410-20. doi: 10.1074/jbc.M116.727735. Epub 2016 May 3.

30.

Light-induced nuclear export reveals rapid dynamics of epigenetic modifications.

Yumerefendi H, Lerner AM, Zimmerman SP, Hahn K, Bear JE, Strahl BD, Kuhlman B.

Nat Chem Biol. 2016 Jun;12(6):399-401. doi: 10.1038/nchembio.2068. Epub 2016 Apr 18.

31.

The Taf14 YEATS domain is a reader of histone crotonylation.

Andrews FH, Shinsky SA, Shanle EK, Bridgers JB, Gest A, Tsun IK, Krajewski K, Shi X, Strahl BD, Kutateladze TG.

Nat Chem Biol. 2016 Jun;12(6):396-8. doi: 10.1038/nchembio.2065. Epub 2016 Apr 18.

32.

Chromatin condensation and recruitment of PHD finger proteins to histone H3K4me3 are mutually exclusive.

Gatchalian J, Gallardo CM, Shinsky SA, Ospina RR, Liendo AM, Krajewski K, Klein BJ, Andrews FH, Strahl BD, M van Wely KH, Kutateladze TG.

Nucleic Acids Res. 2016 Jul 27;44(13):6102-12. doi: 10.1093/nar/gkw193. Epub 2016 Mar 25.

33.

The essential role of acetyllysine binding by the YEATS domain in transcriptional regulation.

Andrews FH, Shanle EK, Strahl BD, Kutateladze TG.

Transcription. 2016;7(1):14-20. doi: 10.1080/21541264.2015.1125987.

34.

Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation.

Hattori T, Lai D, Dementieva IS, Montaño SP, Kurosawa K, Zheng Y, Akin LR, Świst-Rosowska KM, Grzybowski AT, Koide A, Krajewski K, Strahl BD, Kelleher NL, Ruthenburg AJ, Koide S.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2092-7. doi: 10.1073/pnas.1522691113. Epub 2016 Feb 9.

35.

Histone H3K36 methylation regulates pre-mRNA splicing in Saccharomyces cerevisiae.

Sorenson MR, Jha DK, Ucles SA, Flood DM, Strahl BD, Stevens SW, Kress TL.

RNA Biol. 2016;13(4):412-26. doi: 10.1080/15476286.2016.1144009. Epub 2016 Jan 29.

36.

Regulation of Methyllysine Readers through Phosphorylation.

Andrews FH, Gatchalian J, Krajewski K, Strahl BD, Kutateladze TG.

ACS Chem Biol. 2016 Mar 18;11(3):547-53. doi: 10.1021/acschembio.5b00802. Epub 2016 Jan 6.

37.

Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation.

Cliffe AR, Arbuckle JH, Vogel JL, Geden MJ, Rothbart SB, Cusack CL, Strahl BD, Kristie TM, Deshmukh M.

Cell Host Microbe. 2015 Dec 9;18(6):649-58. doi: 10.1016/j.chom.2015.11.007.

38.

A course-based undergraduate research experience investigating p300 bromodomain mutations.

Shanle EK, Tsun IK, Strahl BD.

Biochem Mol Biol Educ. 2016 Jan-Feb;44(1):68-74. doi: 10.1002/bmb.20927. Epub 2015 Nov 5.

39.

The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79.

Chen S, Yang Z, Wilkinson AW, Deshpande AJ, Sidoli S, Krajewski K, Strahl BD, Garcia BA, Armstrong SA, Patel DJ, Gozani O.

Mol Cell. 2015 Oct 15;60(2):319-27. doi: 10.1016/j.molcel.2015.08.019. Epub 2015 Oct 1.

40.

Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response.

Shanle EK, Andrews FH, Meriesh H, McDaniel SL, Dronamraju R, DiFiore JV, Jha D, Wozniak GG, Bridgers JB, Kerschner JL, Krajewski K, Martín GM, Morrison AJ, Kutateladze TG, Strahl BD.

Genes Dev. 2015 Sep 1;29(17):1795-800. doi: 10.1101/gad.269977.115.

41.

A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin.

Simon JM, Parker JS, Liu F, Rothbart SB, Ait-Si-Ali S, Strahl BD, Jin J, Davis IJ, Mosley AL, Pattenden SG.

J Biol Chem. 2015 Oct 23;290(43):26088-102. doi: 10.1074/jbc.M115.654459. Epub 2015 Sep 3.

42.

An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1.

Zhang ZM, Rothbart SB, Allison DF, Cai Q, Harrison JS, Li L, Wang Y, Strahl BD, Wang GG, Song J.

Cell Rep. 2015 Sep 1;12(9):1400-6. doi: 10.1016/j.celrep.2015.07.046. Epub 2015 Aug 20.

43.

Molecular Insights into Inhibition of the Methylated Histone-Plant Homeodomain Complexes by Calixarenes.

Ali M, Daze KD, Strongin DE, Rothbart SB, Rincon-Arano H, Allen HF, Li J, Strahl BD, Hof F, Kutateladze TG.

J Biol Chem. 2015 Sep 18;290(38):22919-30. doi: 10.1074/jbc.M115.669333. Epub 2015 Jul 30.

44.

An Interactive Database for the Assessment of Histone Antibody Specificity.

Rothbart SB, Dickson BM, Raab JR, Grzybowski AT, Krajewski K, Guo AH, Shanle EK, Josefowicz SZ, Fuchs SM, Allis CD, Magnuson TR, Ruthenburg AJ, Strahl BD.

Mol Cell. 2015 Aug 6;59(3):502-11. doi: 10.1016/j.molcel.2015.06.022. Epub 2015 Jul 23.

45.

Non-canonical Bromodomain within DNA-PKcs Promotes DNA Damage Response and Radioresistance through Recognizing an IR-Induced Acetyl-Lysine on H2AX.

Wang L, Xie L, Ramachandran S, Lee Y, Yan Z, Zhou L, Krajewski K, Liu F, Zhu C, Chen DJ, Strahl BD, Jin J, Dokholyan NV, Chen X.

Chem Biol. 2015 Jul 23;22(7):849-61. doi: 10.1016/j.chembiol.2015.05.014. Epub 2015 Jun 25.

46.

From histones to ribosomes: a chromatin regulator tangoes with translation.

Rothbart SB, Dickson BM, Strahl BD.

Cancer Discov. 2015 Mar;5(3):228-30. doi: 10.1158/2159-8290.CD-15-0073.

47.

Interrogating the function of metazoan histones using engineered gene clusters.

McKay DJ, Klusza S, Penke TJ, Meers MP, Curry KP, McDaniel SL, Malek PY, Cooper SW, Tatomer DC, Lieb JD, Strahl BD, Duronio RJ, Matera AG.

Dev Cell. 2015 Feb 9;32(3):373-86. doi: 10.1016/j.devcel.2014.12.025.

48.

Erratum: An RNA polymerase II-coupled function for histone H3K36 methylation in checkpoint activation and DSB repair.

Jha DK, Strahl BD.

Nat Commun. 2015 Feb 6;6:6015. doi: 10.1038/ncomms7015. No abstract available.

PMID:
25655584
49.

An acetyl-methyl switch drives a conformational change in p53.

Tong Q, Mazur SJ, Rincon-Arano H, Rothbart SB, Kuznetsov DM, Cui G, Liu WH, Gete Y, Klein BJ, Jenkins L, Mer G, Kutateladze AG, Strahl BD, Groudine M, Appella E, Kutateladze TG.

Structure. 2015 Feb 3;23(2):322-31. doi: 10.1016/j.str.2014.12.010.

50.

Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.

Perfetti MT, Baughman BM, Dickson BM, Mu Y, Cui G, Mader P, Dong A, Norris JL, Rothbart SB, Strahl BD, Brown PJ, Janzen WP, Arrowsmith CH, Mer G, McBride KM, James LI, Frye SV.

ACS Chem Biol. 2015 Apr 17;10(4):1072-81. doi: 10.1021/cb500956g. Epub 2015 Jan 28.

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