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Return of sleep apnoea and sleep fragmentation following CPAP withdrawal in patients with obstructive sleep apnoea.

Turnbull C, Pattenden S, Gaisl T, Rossi V, Thiel S, Kohler M, Stradling J.

Eur Respir J. 2019 May 9;53(5). pii: 1802351. doi: 10.1183/13993003.02351-2018. Print 2019 May. No abstract available.


Effects of short-term continuous positive airway pressure withdrawal on cerebral vascular reactivity measured by blood oxygen level-dependent magnetic resonance imaging in obstructive sleep apnoea: a randomised controlled trial.

Thiel S, Lettau F, Rejmer P, Rossi C, Haile SR, Schwarz EI, Stöberl AS, Sievi NA, Boss A, Becker AS, Winklhofer S, Stradling JR, Kohler M.

Eur Respir J. 2019 Feb 21;53(2). pii: 1801854. doi: 10.1183/13993003.01854-2018. Print 2019 Feb.


Understanding effects of obstructive sleep apnoea and its treatment on the brain and autonomic regulation needs further research.

Schwarz EI, Turnbull CD, Stradling JR, Kohler M.

J Thorac Dis. 2018 Aug;10(8):E664-E665. doi: 10.21037/jtd.2018.07.51. No abstract available.


Effect of continuous positive airway pressure therapy on circadian patterns of cardiac repolarization in patients with obstructive sleep apnoea: data from a randomized trial.

Schlatzer C, Bratton DJ, Schwarz EI, Gaisl T, Pepperell JCT, Stradling JR, Kohler M.

J Thorac Dis. 2018 Aug;10(8):4940-4948. doi: 10.21037/jtd.2018.07.17.


Reply to Jin et al.: Supplemental Oxygen in Obstructive Sleep Apnea: Much to Be Done.

Turnbull CD, Petousi N, Stradling JR.

Am J Respir Crit Care Med. 2019 Jan 1;199(1):127. doi: 10.1164/rccm.201808-1487LE. No abstract available.


Continuous positive airway pressure effect on visual acuity in patients with type 2 diabetes and obstructive sleep apnoea: a multicentre randomised controlled trial.

West SD, Prudon B, Hughes J, Gupta R, Mohammed SB, Gerry S, Stradling JR; ROSA trial investigators.

Eur Respir J. 2018 Oct 25;52(4). pii: 1801177. doi: 10.1183/13993003.01177-2018. Print 2018 Oct.


Minimum important difference of the Epworth Sleepiness Scale in obstructive sleep apnoea: estimation from three randomised controlled trials.

Crook S, Sievi NA, Bloch KE, Stradling JR, Frei A, Puhan MA, Kohler M.

Thorax. 2019 Apr;74(4):390-396. doi: 10.1136/thoraxjnl-2018-211959. Epub 2018 Aug 12.


Effect of Supplemental Oxygen on Blood Pressure in Obstructive Sleep Apnea (SOX). A Randomized Continuous Positive Airway Pressure Withdrawal Trial.

Turnbull CD, Sen D, Kohler M, Petousi N, Stradling JR.

Am J Respir Crit Care Med. 2019 Jan 15;199(2):211-219. doi: 10.1164/rccm.201802-0240OC.


Nocturnal cerebral hypoxia in obstructive sleep apnoea: a randomised controlled trial.

Schwarz EI, Furian M, Schlatzer C, Stradling JR, Kohler M, Bloch KE.

Eur Respir J. 2018 May 30;51(5). pii: 1800032. doi: 10.1183/13993003.00032-2018. Print 2018 May.


Physiological consequences of CPAP therapy withdrawal in patients with obstructive sleep apnoea-an opportunity for an efficient experimental model.

Schwarz EI, Stradling JR, Kohler M.

J Thorac Dis. 2018 Jan;10(Suppl 1):S24-S32. doi: 10.21037/jtd.2017.12.142. Review.


Can postural OSA be usefully identified from its severity alone?

Johar A, Turnbull CD, Stradling JR.

BMJ Open Respir Res. 2017 Dec 20;4(1):e000259. doi: 10.1136/bmjresp-2017-000259. eCollection 2017.


Relationships between MRI fat distributions and sleep apnea and obesity hypoventilation syndrome in very obese patients.

Turnbull CD, Wang SH, Manuel AR, Keenan BT, McIntyre AG, Schwab RJ, Stradling JR.

Sleep Breath. 2018 Sep;22(3):673-681. doi: 10.1007/s11325-017-1599-x. Epub 2017 Dec 2.


Night-to-night variability of obstructive sleep apnea.

Stöberl AS, Schwarz EI, Haile SR, Turnbull CD, Rossi VA, Stradling JR, Kohler M.

J Sleep Res. 2017 Dec;26(6):782-788. doi: 10.1111/jsr.12558. Epub 2017 May 26.


Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation: A Randomized Clinical Trial.

Murphy PB, Rehal S, Arbane G, Bourke S, Calverley PMA, Crook AM, Dowson L, Duffy N, Gibson GJ, Hughes PD, Hurst JR, Lewis KE, Mukherjee R, Nickol A, Oscroft N, Patout M, Pepperell J, Smith I, Stradling JR, Wedzicha JA, Polkey MI, Elliott MW, Hart N.

JAMA. 2017 Jun 6;317(21):2177-2186. doi: 10.1001/jama.2017.4451.


To screen or not to screen for obstructive sleep apnea, that is the question.

Turnbull CD, Stradling JR.

Sleep Med Rev. 2017 Dec;36:125-127. doi: 10.1016/j.smrv.2017.03.002. Epub 2017 Mar 22. No abstract available.


Blood Pressure Variability in Obstructive Sleep Apnoea: Data from 4 Randomised Controlled CPAP Withdrawal Trials.

Lettau F, Schwarz EI, Stradling JR, Kohler M.

Respiration. 2017;93(5):311-318. doi: 10.1159/000465528. Epub 2017 Mar 29.


Overnight urinary isoprostanes as a marker of oxidative stress in obstructive sleep apnoea.

Turnbull CD, Akoumianakis I, Antoniades C, Stradling JR.

Eur Respir J. 2017 Feb 2;49(2). pii: 1601787. doi: 10.1183/13993003.01787-2016. Print 2017 Feb. No abstract available.


Effect of OSA on hypoxic and inflammatory markers during CPAP withdrawal: Further evidence from three randomized control trials.

Turnbull CD, Rossi VA, Santer P, Schwarz EI, Stradling JR, Petousi N, Kohler M.

Respirology. 2017 May;22(4):793-799. doi: 10.1111/resp.12946. Epub 2016 Nov 18.


Effect of CPAP Withdrawal on BP in OSA: Data from Three Randomized Controlled Trials.

Schwarz EI, Schlatzer C, Rossi VA, Stradling JR, Kohler M.

Chest. 2016 Dec;150(6):1202-1210. doi: 10.1016/j.chest.2016.07.012. Epub 2016 Jul 21.


DiPALS: Diaphragm Pacing in patients with Amyotrophic Lateral Sclerosis - a randomised controlled trial.

McDermott CJ, Bradburn MJ, Maguire C, Cooper CL, Baird WO, Baxter SK, Cohen J, Cantrill H, Dixon S, Ackroyd R, Baudouin S, Bentley A, Berrisford R, Bianchi S, Bourke SC, Darlison R, Ealing J, Elliott M, Fitzgerald P, Galloway S, Hamdalla H, Hanemann CO, Hughes P, Imam I, Karat D, Leek R, Maynard N, Orrell RW, Sarela A, Stradling J, Talbot K, Taylor L, Turner M, Simonds AK, Williams T, Wedzicha W, Young C, Shaw PJ.

Health Technol Assess. 2016 Jun;20(45):1-186. doi: 10.3310/hta20450.


Exploratory study into the effect of abdominal mass loading on airways resistance and ventilatory failure.

Dattani RS, Swerner CB, Stradling JR, Manuel AR.

BMJ Open Respir Res. 2016 Jun 9;3(1):e000138. doi: 10.1136/bmjresp-2016-000138. eCollection 2016.


Withdrawal of Continuous Positive Airway Pressure Therapy for 2 Weeks in Obstructive Sleep Apnoea Patients Results in Increased Circulating Platelet and Leucocyte-Derived Microvesicles.

Ayers L, Turnbull C, Petousi N, Ferry B, Kohler M, Stradling J.

Respiration. 2016;91(5):412-3. doi: 10.1159/000446077. Epub 2016 May 12. No abstract available.


Effect of CPAP Withdrawal on myocardial perfusion in OSA: A randomized controlled trial.

Schwarz EI, Schlatzer C, Stehli J, Kaufmann PA, Bloch KE, Stradling JR, Kohler M.

Respirology. 2016 Aug;21(6):1126-33. doi: 10.1111/resp.12798. Epub 2016 Apr 20.


ECG risk markers for atrial fibrillation and sudden cardiac death in minimally symptomatic obstructive sleep apnoea: the MOSAIC randomised trial.

Schlatzer C, Bratton DJ, Craig SE, Kohler M, Stradling JR.

BMJ Open. 2016 Mar 16;6(3):e010150. doi: 10.1136/bmjopen-2015-010150.


Paradoxical decrease in isoprostane and increase in superoxide dismutase following CPAP withdrawal in OSA.

Antoniades C, Lee R, Kohler M, Stradling J.

Eur Respir J. 2016 Mar;47(3):1014-5. doi: 10.1183/13993003.01725-2015. No abstract available.


Correlates of obesity-related chronic ventilatory failure.

Manuel AR, Hart N, Stradling JR.

BMJ Open Respir Res. 2016 Feb 18;3(1):e000110. doi: 10.1136/bmjresp-2015-000110. eCollection 2016.


In patients with minimally symptomatic OSA can baseline characteristics and early patterns of CPAP usage predict those who are likely to be longer-term users of CPAP.

Turnbull CD, Bratton DJ, Craig SE, Kohler M, Stradling JR.

J Thorac Dis. 2016 Feb;8(2):276-81. doi: 10.3978/j.issn.2072-1439.2016.01.54.


Obstructive sleep apnoea: is it moving into primary care?

Stradling J.

Br J Gen Pract. 2016 Feb;66(643):e149-51. doi: 10.3399/bjgp16X683785. Review. No abstract available.


Does continuous positive airway pressure therapy improve non-alcoholic fatty liver disease?

Kohler M, Stradling JR.

Respirology. 2016 Feb;21(2):209-10. doi: 10.1111/resp.12720. No abstract available.


Efficacy of EPAP.

Turnbull CD, Kohler M, Stradling JR.

Sleep Breath. 2016 Mar;20(1):259-60. doi: 10.1007/s11325-015-1308-6. Epub 2016 Jan 11. No abstract available.


Effects of CPAP therapy withdrawal on exhaled breath pattern in obstructive sleep apnoea.

Schwarz EI, Martinez-Lozano Sinues P, Bregy L, Gaisl T, Garcia Gomez D, Gaugg MT, Suter Y, Stebler N, Nussbaumer-Ochsner Y, Bloch KE, Stradling JR, Zenobi R, Kohler M.

Thorax. 2016 Feb;71(2):110-7. doi: 10.1136/thoraxjnl-2015-207597. Epub 2015 Dec 15.


Quality of life, diet and exercise measurements in obese individuals with and without ventilatory failure.

Turnbull C, Manuel A, Stradling J.

Obes Res Clin Pract. 2015 Nov-Dec;9(6):639-40. doi: 10.1016/j.orcp.2015.10.001. Epub 2015 Nov 12. No abstract available.


Does either obesity or OSA severity influence the response of autotitrating CPAP machines in very obese subjects?

Turnbull CD, Manuel AR, Stradling JR.

Sleep Breath. 2016 May;20(2):647-52. doi: 10.1007/s11325-015-1267-y. Epub 2015 Oct 8.


Effect of CPAP therapy on endothelial function in obstructive sleep apnoea: A systematic review and meta-analysis.

Schwarz EI, Puhan MA, Schlatzer C, Stradling JR, Kohler M.

Respirology. 2015 Aug;20(6):889-95. doi: 10.1111/resp.12573. Epub 2015 Jun 15. Review.


A multicentre randomised controlled trial and economic evaluation of continuous positive airway pressure for the treatment of obstructive sleep apnoea syndrome in older people: PREDICT.

McMillan A, Bratton DJ, Faria R, Laskawiec-Szkonter M, Griffin S, Davies RJ, Nunn AJ, Stradling JR, Riha RL, Morrell MJ.

Health Technol Assess. 2015 Jun;19(40):1-188. doi: 10.3310/hta19400.


Biomarkers of oxidative stress following continuous positive airway pressure withdrawal: data from two randomised trials.

Stradling JR, Schwarz EI, Schlatzer C, Manuel AR, Lee R, Antoniades C, Kohler M.

Eur Respir J. 2015 Oct;46(4):1065-71. doi: 10.1183/09031936.00023215. Epub 2015 May 28.


Intrathoracic pressure swings induced by simulated obstructive sleep apnoea promote arrhythmias in paroxysmal atrial fibrillation.

Schlatzer C, Schwarz EI, Sievi NA, Clarenbach CF, Gaisl T, Haegeli LM, Duru F, Stradling JR, Kohler M.

Europace. 2016 Jan;18(1):64-70. doi: 10.1093/europace/euv122. Epub 2015 May 19.


Effect of CPAP on Cardiac Function in Minimally Symptomatic Patients with OSA: Results from a Subset of the MOSAIC Randomized Trial.

Craig S, Kylintireas I, Kohler M, Nicoll D, Bratton DJ, Nunn AJ, Leeson P, Neubauer S, Stradling JR.

J Clin Sleep Med. 2015 Sep 15;11(9):967-73. doi: 10.5664/jcsm.5004.


Defining the minimal important difference for the visual analogue scale assessing dyspnea in patients with malignant pleural effusions.

Mishra EK, Corcoran JP, Hallifax RJ, Stradling J, Maskell NA, Rahman NM.

PLoS One. 2015 Apr 15;10(4):e0123798. doi: 10.1371/journal.pone.0123798. eCollection 2015.


CPAP holiday: are we there yet?

Rossi VA, Stradling J, Kohler M.

Eur Respir J. 2015 Feb;45(2):575-6. doi: 10.1183/09031936.00146514. No abstract available.


SleepAp: an automated obstructive sleep apnoea screening application for smartphones.

Behar J, Roebuck A, Shahid M, Daly J, Hallack A, Palmius N, Stradling J, Clifford GD.

IEEE J Biomed Health Inform. 2015 Jan;19(1):325-31. doi: 10.1109/JBHI.2014.2307913.


Sleep apnoea in the elderly - authors' reply.

McMillan A, Bratton DJ, Faria R, Laskawiec-Szkonter M, Griffin S, Nunn AJ, Stradling JR, Riha RL, Morrell MJ.

Lancet Respir Med. 2014 Nov;2(11):e21-e22. doi: 10.1016/S2213-2600(14)70240-1. Epub 2014 Nov 3. No abstract available.


Markers of inflammation: data from the MOSAIC randomised trial of CPAP for minimally symptomatic OSA.

Stradling JR, Craig SE, Kohler M, Nicoll D, Ayers L, Nunn AJ, Bratton DJ.

Thorax. 2015 Feb;70(2):181-2. doi: 10.1136/thoraxjnl-2014-205958. Epub 2014 Sep 2. Erratum in: Thorax. 2015 Apr;70(4):319.


Continuous positive airway pressure in older people with obstructive sleep apnoea syndrome (PREDICT): a 12-month, multicentre, randomised trial.

McMillan A, Bratton DJ, Faria R, Laskawiec-Szkonter M, Griffin S, Davies RJ, Nunn AJ, Stradling JR, Riha RL, Morrell MJ; PREDICT Investigators.

Lancet Respir Med. 2014 Oct;2(10):804-12. doi: 10.1016/S2213-2600(14)70172-9. Epub 2014 Aug 26.


Is a raised bicarbonate, without hypercapnia, part of the physiologic spectrum of obesity-related hypoventilation?

Manuel ARG, Hart N, Stradling JR.

Chest. 2015 Feb;147(2):362-368. doi: 10.1378/chest.14-1279.


Effect of CPAP on blood pressure in patients with minimally symptomatic obstructive sleep apnoea: a meta-analysis using individual patient data from four randomised controlled trials.

Bratton DJ, Stradling JR, Barbé F, Kohler M.

Thorax. 2014 Dec;69(12):1128-35. doi: 10.1136/thoraxjnl-2013-204993. Epub 2014 Jun 19.


Rebuttal: 'Obesity hypoventilation syndrome (OHS): does the current definition need revisiting?'.

Hart N, Mandal S, Manuel A, Mokhlesi B, Pepin JL, Piper A, Stradling J.

Thorax. 2014 Oct;69(10):955. doi: 10.1136/thoraxjnl-2014-205656. Epub 2014 May 23. No abstract available.


Clinical outcomes and cost-effectiveness of continuous positive airway pressure to manage obstructive sleep apnea in patients with type 2 diabetes in the U.K.

Guest JF, Panca M, Sladkevicius E, Taheri S, Stradling J.

Diabetes Care. 2014;37(5):1263-71. doi: 10.2337/dc13-2539. Epub 2014 Apr 4.


Cardiovascular event rates in the MOSAIC trial: 2-year follow-up data.

Turnbull CD, Craig SE, Kohler M, Nicoll D, Stradling J.

Thorax. 2014 Oct;69(10):950. doi: 10.1136/thoraxjnl-2013-204826. Epub 2014 Feb 7.


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